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The map label for this gene is hbpA [H]

Identifier: 134298359

GI number: 134298359

Start: 525720

End: 527291

Strand: Reverse

Name: hbpA [H]

Synonym: Dred_0484

Alternate gene names: 134298359

Gene position: 527291-525720 (Counterclockwise)

Preceding gene: 134298361

Following gene: 134298358

Centisome position: 14.61

GC content: 39.57

Gene sequence:

>1572_bases
ATGAAAAACAAATTATTCCAATTGGCCTTTCTGTTTCTATTCTTAAGCTTTTTTTCAGTTGTTGTAAACTATGATAAAGG
GGCTAGTCCCACCTTTTTTAAAAAAGAAATTCCTCAACAAATTGATATAACCTATGCCCTTGCAGAACCATTAAAAAGTC
TAGATCCTGCTGAAGCAAATAATATGTCTGAAGCTAAGGTTTTGTCAAATATCTTCGAAGGACTTGTCCGTTATCAATCA
GGAACCTCTGAAATAGAACCTTGTCTGGCTACCCATTGGGAACTTTCTAAAGATGGCTGCAGTTGGGTTTTTCATTTAAG
GAAAAATGTTACTTTCCACGACGGTACGCCTTTTAATGCACAGGCTGTGAAAATAAGTATTGAGCGGCAACTGCCTCCAC
AAAAAAAAGACACCATGTCCTATGGCAGTTTTACCTTTGGTATGTTGAAAAAAATTGAAGTGATTGATAATTATACCATA
AATTTTTTGTTGACAACACCTTATTCACCCTTTTTAAGAAATCTTGCCATGCCTTGGGCGGCACCCATTATAAGCCCCTC
TTCCCTTAAGAATCTGGGCAATGACAAAATGCTCCTGGCAGGTACGGGCCCCTTTTATCTGGCAGATTGGCGTAACGGTG
CTCCTATACTTTTAGCCAATGAAAAATATTGGGATAAAAAGCCCTTTATTAAATCCTTATCCTTTCTTCCCCAGTCCCCC
CAGCAGAGACTAGCATCGCTTAATAAAGGAACTGTGGAAATGGCTGATGTTTCCGGTCTACCCGGGGATACCATAAAGGC
ACAAAATGTTATAACAACCAGCCAATCGTCAGCATCTCTCAGTTATTTGGGAATGTTTAACAATCGGCCCCCTTTTAACA
ACGATAAGGTCCGTAGGGCCCTTTGCATGGCCATAGATACCCGGGAGTTGACAAAGAACATCTTTGGCGATCAATCACTG
GCTGCCAATAGCATTCTGCCACCAGAAATACTTGGTTATAACAAAAATTTACGGCCTTATTTTGGCGGTCCGGAAAAAGC
AAAAGCCCTGTTAAGTCAATATGGTTATACAGAGGGATTGGATATAACATTAATCACTTATAACACACCCCGTCCCTACA
ACCCTTTAGGTGGAACTGAATTAGCTACGACCATCAAAAAGCAGTTGGCTAAAGCTGGTATTCGGGTCAATGTAAAGGTT
TATCCCTGGCATGAATTTAAATCGGCCCTGCGCAAACAGGAAGGAGATGCTTTTTTATTTGGCTGGGTCAGCGATAACTT
AGACCCGGATAATTTTCTTTATACACTACTGGCATCGGATGAAATTACTAAAACAAACCTCACCCATTATAAAAACAGTG
AAGTAGATCGTTTAATCAGTGCCGCACAAAGAGAACAAGATGAAAAAATACGAAAAAGGTTATATTATCATGCCCAGCAG
ATTATGCTTCAGGATACTCCCATGGTCTTTCTAAACTATGGTCAAGATAAAATTGCTCTTACCAAAAATATTCAAAACTT
GAAATTAAACCCCTTTGGTATTCCTCTCTTTGCCAAGGCTTATATTCAGTAA

Upstream 100 bases:

>100_bases
TTTAAAGATTATAGCTCATAGTTTCTTGCCTAACTGGAAGGATTTTACATTTAAGGGAAGAATTATACATCTGTAAAACC
TTGTTGACGGGGGTTGAAAA

Downstream 100 bases:

>100_bases
TAATTTGGGCAGACTACATTAAAAAACACGAGGTGAAATTCCATGCATAAAAGTCCACGGGTTCTTTGTGAAGTAAACAC
CTGCACACATTGGCTACTAG

Product: extracellular solute-binding protein

Products: ADP; phosphate; dipeptides [Cytoplasm] [C]

Alternate protein names: Hemin-binding lipoprotein [H]

Number of amino acids: Translated: 523; Mature: 523

Protein sequence:

>523_residues
MKNKLFQLAFLFLFLSFFSVVVNYDKGASPTFFKKEIPQQIDITYALAEPLKSLDPAEANNMSEAKVLSNIFEGLVRYQS
GTSEIEPCLATHWELSKDGCSWVFHLRKNVTFHDGTPFNAQAVKISIERQLPPQKKDTMSYGSFTFGMLKKIEVIDNYTI
NFLLTTPYSPFLRNLAMPWAAPIISPSSLKNLGNDKMLLAGTGPFYLADWRNGAPILLANEKYWDKKPFIKSLSFLPQSP
QQRLASLNKGTVEMADVSGLPGDTIKAQNVITTSQSSASLSYLGMFNNRPPFNNDKVRRALCMAIDTRELTKNIFGDQSL
AANSILPPEILGYNKNLRPYFGGPEKAKALLSQYGYTEGLDITLITYNTPRPYNPLGGTELATTIKKQLAKAGIRVNVKV
YPWHEFKSALRKQEGDAFLFGWVSDNLDPDNFLYTLLASDEITKTNLTHYKNSEVDRLISAAQREQDEKIRKRLYYHAQQ
IMLQDTPMVFLNYGQDKIALTKNIQNLKLNPFGIPLFAKAYIQ

Sequences:

>Translated_523_residues
MKNKLFQLAFLFLFLSFFSVVVNYDKGASPTFFKKEIPQQIDITYALAEPLKSLDPAEANNMSEAKVLSNIFEGLVRYQS
GTSEIEPCLATHWELSKDGCSWVFHLRKNVTFHDGTPFNAQAVKISIERQLPPQKKDTMSYGSFTFGMLKKIEVIDNYTI
NFLLTTPYSPFLRNLAMPWAAPIISPSSLKNLGNDKMLLAGTGPFYLADWRNGAPILLANEKYWDKKPFIKSLSFLPQSP
QQRLASLNKGTVEMADVSGLPGDTIKAQNVITTSQSSASLSYLGMFNNRPPFNNDKVRRALCMAIDTRELTKNIFGDQSL
AANSILPPEILGYNKNLRPYFGGPEKAKALLSQYGYTEGLDITLITYNTPRPYNPLGGTELATTIKKQLAKAGIRVNVKV
YPWHEFKSALRKQEGDAFLFGWVSDNLDPDNFLYTLLASDEITKTNLTHYKNSEVDRLISAAQREQDEKIRKRLYYHAQQ
IMLQDTPMVFLNYGQDKIALTKNIQNLKLNPFGIPLFAKAYIQ
>Mature_523_residues
MKNKLFQLAFLFLFLSFFSVVVNYDKGASPTFFKKEIPQQIDITYALAEPLKSLDPAEANNMSEAKVLSNIFEGLVRYQS
GTSEIEPCLATHWELSKDGCSWVFHLRKNVTFHDGTPFNAQAVKISIERQLPPQKKDTMSYGSFTFGMLKKIEVIDNYTI
NFLLTTPYSPFLRNLAMPWAAPIISPSSLKNLGNDKMLLAGTGPFYLADWRNGAPILLANEKYWDKKPFIKSLSFLPQSP
QQRLASLNKGTVEMADVSGLPGDTIKAQNVITTSQSSASLSYLGMFNNRPPFNNDKVRRALCMAIDTRELTKNIFGDQSL
AANSILPPEILGYNKNLRPYFGGPEKAKALLSQYGYTEGLDITLITYNTPRPYNPLGGTELATTIKKQLAKAGIRVNVKV
YPWHEFKSALRKQEGDAFLFGWVSDNLDPDNFLYTLLASDEITKTNLTHYKNSEVDRLISAAQREQDEKIRKRLYYHAQQ
IMLQDTPMVFLNYGQDKIALTKNIQNLKLNPFGIPLFAKAYIQ

Specific function: Important role in heme acquisition or metabolism [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial solute-binding protein 5 family [H]

Homologues:

Organism=Escherichia coli, GI1789966, Length=481, Percent_Identity=30.1455301455301, Blast_Score=211, Evalue=9e-56,
Organism=Escherichia coli, GI1787762, Length=495, Percent_Identity=29.0909090909091, Blast_Score=174, Evalue=8e-45,
Organism=Escherichia coli, GI1787052, Length=483, Percent_Identity=28.5714285714286, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI1787551, Length=520, Percent_Identity=26.5384615384615, Blast_Score=139, Evalue=6e-34,
Organism=Escherichia coli, GI1787495, Length=484, Percent_Identity=26.2396694214876, Blast_Score=132, Evalue=7e-32,
Organism=Escherichia coli, GI1789887, Length=427, Percent_Identity=27.8688524590164, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI87081878, Length=479, Percent_Identity=27.1398747390397, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1789397, Length=496, Percent_Identity=24.1935483870968, Blast_Score=118, Evalue=8e-28,
Organism=Escherichia coli, GI1786650, Length=338, Percent_Identity=23.3727810650888, Blast_Score=70, Evalue=3e-13,

Paralogues:

None

Copy number: 660 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2980 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000914 [H]

Pfam domain/function: PF00496 SBP_bac_5 [H]

EC number: NA

Molecular weight: Translated: 59048; Mature: 59048

Theoretical pI: Translated: 9.57; Mature: 9.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNKLFQLAFLFLFLSFFSVVVNYDKGASPTFFKKEIPQQIDITYALAEPLKSLDPAEAN
CCCHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHCCHHHCCHHHHHHHHHHCCCCCCC
NMSEAKVLSNIFEGLVRYQSGTSEIEPCLATHWELSKDGCSWVFHLRKNVTFHDGTPFNA
CCHHHHHHHHHHHHHHHHCCCCCHHCHHHHHCCCCCCCCCHHHEEHHCCCEECCCCCCCC
QAVKISIERQLPPQKKDTMSYGSFTFGMLKKIEVIDNYTINFLLTTPYSPFLRNLAMPWA
EEEEEEEECCCCCCCHHCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHCCCHH
APIISPSSLKNLGNDKMLLAGTGPFYLADWRNGAPILLANEKYWDKKPFIKSLSFLPQSP
CCCCCHHHHHHCCCCCEEEEECCCEEEEECCCCCCEEEECCCCCCCCHHHHHHHHCCCCH
QQRLASLNKGTVEMADVSGLPGDTIKAQNVITTSQSSASLSYLGMFNNRPPFNNDKVRRA
HHHHHHCCCCCEEEEECCCCCCCCEECCEEEEECCCCCCEEEEEECCCCCCCCCHHHHHH
LCMAIDTRELTKNIFGDQSLAANSILPPEILGYNKNLRPYFGGPEKAKALLSQYGYTEGL
HHHHHHHHHHHHHHCCCCHHCCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCC
DITLITYNTPRPYNPLGGTELATTIKKQLAKAGIRVNVKVYPWHEFKSALRKQEGDAFLF
EEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHCCCCEEEE
GWVSDNLDPDNFLYTLLASDEITKTNLTHYKNSEVDRLISAAQREQDEKIRKRLYYHAQQ
EEECCCCCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
IMLQDTPMVFLNYGQDKIALTKNIQNLKLNPFGIPLFAKAYIQ
HHCCCCCEEEEECCCCEEEEECCCCCCCCCCCCCCHHHHHHCC
>Mature Secondary Structure
MKNKLFQLAFLFLFLSFFSVVVNYDKGASPTFFKKEIPQQIDITYALAEPLKSLDPAEAN
CCCHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHCCHHHCCHHHHHHHHHHCCCCCCC
NMSEAKVLSNIFEGLVRYQSGTSEIEPCLATHWELSKDGCSWVFHLRKNVTFHDGTPFNA
CCHHHHHHHHHHHHHHHHCCCCCHHCHHHHHCCCCCCCCCHHHEEHHCCCEECCCCCCCC
QAVKISIERQLPPQKKDTMSYGSFTFGMLKKIEVIDNYTINFLLTTPYSPFLRNLAMPWA
EEEEEEEECCCCCCCHHCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHCCCHH
APIISPSSLKNLGNDKMLLAGTGPFYLADWRNGAPILLANEKYWDKKPFIKSLSFLPQSP
CCCCCHHHHHHCCCCCEEEEECCCEEEEECCCCCCEEEECCCCCCCCHHHHHHHHCCCCH
QQRLASLNKGTVEMADVSGLPGDTIKAQNVITTSQSSASLSYLGMFNNRPPFNNDKVRRA
HHHHHHCCCCCEEEEECCCCCCCCEECCEEEEECCCCCCEEEEEECCCCCCCCCHHHHHH
LCMAIDTRELTKNIFGDQSLAANSILPPEILGYNKNLRPYFGGPEKAKALLSQYGYTEGL
HHHHHHHHHHHHHHCCCCHHCCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCC
DITLITYNTPRPYNPLGGTELATTIKKQLAKAGIRVNVKVYPWHEFKSALRKQEGDAFLF
EEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHCCCCEEEE
GWVSDNLDPDNFLYTLLASDEITKTNLTHYKNSEVDRLISAAQREQDEKIRKRLYYHAQQ
EEECCCCCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
IMLQDTPMVFLNYGQDKIALTKNIQNLKLNPFGIPLFAKAYIQ
HHCCCCCEEEEECCCCEEEEECCCCCCCCCCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; dipeptides [Periplasm]; H2O [C]

Specific reaction: ATP + dipeptides [Periplasm] + H2O = ADP + phosphate + dipeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1339409; 7542800; 2041470 [H]