| Definition | Clostridium difficile 630 chromosome, complete genome. |
|---|---|
| Accession | NC_009089 |
| Length | 4,290,252 |
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The map label for this gene is uvrA [H]
Identifier: 126700814
GI number: 126700814
Start: 3739054
End: 3741474
Strand: Direct
Name: uvrA [H]
Synonym: CD3195
Alternate gene names: 126700814
Gene position: 3739054-3741474 (Clockwise)
Preceding gene: 126700813
Following gene: 126700815
Centisome position: 87.15
GC content: 32.34
Gene sequence:
>2421_bases ATGAAAGAAATAAAAATTAATGGAGCAAAGATACACAATCTTAAAAATATAGATGTTTCTATTCCAAAAGATAAGCTTGT TGTTGCAACAGGTGTCAGTGGCTCAGGTAAGTCTAGCCTTATGTTTGACATTGTATTTGAGGAAGGGCGTAAACAATATC TGCAATCTTTAGGTATACTTGCAGGTATTGATAGTGAAGATAAGTTTGATAATATTCAAGGTTTAGCTCCCACTATAGCT GTTCAACAAAATATTATTCGCCAGAGCAATCCTCGTTCAACAGTAGGCACAAGAACCAATATTCTCAACATGCTTACACT ATTGTATTCAGTGGAAGGTCAAATAATGTGTACTATGTGTGATACTCCTGTAAGCGATAATCTAATTTGCAATAATTGTG GATATGAGGAAGAACGATTAAGACCAAGTTATTTCTCATACAACTCTTCAGATGGAATGTGTATGAAGTGCTCTGGACAT GGTGCATATTTTGAGATTAATATTGAAAAATTAGTCCTTGATAAGCATGATACCCTAAAACAAGTCTTAGATAGAGCAAA GATTACACCTGGATATTTGAGAGTATTTTCTAAAAAATTCAATGATTATTTAGACATACAATTCTTACAACTACCTGAAG AAATAAGAAATGAAGTACTCTATGGTCATTATGAAAATGGTAAAAAAAGTTCCTCTTTATCAAAGGTATTTCACAATCGT TACAAAAGGGGCGAAGATTTAAATGGAGTTTATACTATGACTGCCTGTTCAGATTGCAATGGTTTTAAAATTGGTGAAGA AGCACGTAGAGTACTTTTAAACGGAAAACATATTGGAGAACTTGGAAAAATGACGATTTTAGAAATTGATGATTTCCTTA AACTCTTAATAAATCAAGGTAATTTAAACACATTTGGTACAAATCTTGTAAATGATATTTTATCCAAAACTCAACATTTA ATAGAATCACGATTAGGTCATCTATCCTTATACCGAGAAATGTCAACTTTGAGTGGTGGGGAAATGCAAAGACTATTTTT AAATTCACATCTCGATTCAGAGATGGACTCATTAATTTATGTGCTTGATGAACCAACAGCTGGATTGCATGAATCAGAAA AAATAGACATCTTAAAATCACTAAAGAAACTTAAAGATTTAGGCAATACGGTCATAGTAGTTGAGCATGATAAAAACACA ATTGAAATGGCAGAACATATTATTGATATTGGTCCAAAAGCTGGTGTTGAAGGTGGTCAATTAGTATATCAAGGAGATTT AGAAGGTCTACTTCAATCCGACAAATCACTTACTGGACAGTATCTATCTGGAAAATATCCAATGCCTAATAGAACAAGCA ATAAAAACATTACACATACTGATAAAATACCTTGTATAACTATTCAAAATGCAAATACAAATAATCTTAAAAATGTAACT GTATCATTACCTTTGGGTGCTATGGTTGGAATATCTGGAAAATCAGGTAGTGGCAAGAGTTCACTTATATCAGACACCCT ACTTCCTCTTCTTAGAAGCCAATTTAATAACCATACTATCAATAATCAAATAAATTCTTCAGAGAGTGAAATAGGTGAGG AAGACGATTATGCAGTTGTTGAAACTATTGCAGATAGACTGATTGGTACTAAACATATTTCTGGATATTCAGAGATATCT CAATCTCCTATAGGCAAAAATATGAACTCAACTCCTGCTTCTTATATTGGTATATGGGATAAGATACGTACACTATTTGC AGGTCAGCCAGAATCGTTAGAACAAGGATTTACAGCTGGTCATTTCTCATTTAACTCCAAAGGGGCTTGTCCTAAATGTA GTGGTAGTGGATATGAAAAGGTCTGGTTGGGAAATAATCTAAGTATAGACCATATATGCAGTGAATGTCAGGGAAAAAGA TTTAATGATGAATCTTTATCTATTAAATATAAAAATAAAAATATACATGATATTTTAAATATGAGTGTTTCTGAATCTGT ACATTTCTTCAAAGATATTCCAAATATTGTTTCACACTTAAATGTATTAGAACAAATAGGTATGGGGTATATAAAATTAG GCCAACCTACACCGACTTTAAGTGGTGGTGAATCCCAAAGAATCAAACTTGCAAAAGAAATTGGTAAAAAACGAAATGGT AATATCCTTTATGTATTGGATGAGCCAACTACTGGTCTAAGTCTATATGATACTTCTAAGTTGATTCAATTATTAGATGA ATTGGTTGAAAATGGAAATTCTGTAATTGTTGTTGAACATGATATAGATGTATTAAATGTTTGTGACTGGATTGTTGAGC TTGGTCCAGAAGGTGGTGACAAAGGAGGTTATATAATTGCAGAAGGTTCTCCAAAAACTCTAAAAGAAAATCCAAAATCT ATAACAGGGAGGTATCTTTAA
Upstream 100 bases:
>100_bases ATAGAACCTTTTTAATAACCTCACCTAATCTATTCTTGTATTAAGGATTAATATATCCCTATTTTACGGTTTGATAAAAT TGATAAAATGAGGTGAACCA
Downstream 100 bases:
>100_bases TGAATAAAAACAATTGCTTAGACTTAATTTTTGAAAAAGTAGACCCTTCAAGTGTTGGTATGAGTTCAGAAAAGCTTTCA CAACTTGAACCTTTAATAAT
Product: excinuclease ABC subunit A
Products: NA
Alternate protein names: UvrA protein; Excinuclease ABC subunit A [H]
Number of amino acids: Translated: 806; Mature: 806
Protein sequence:
>806_residues MKEIKINGAKIHNLKNIDVSIPKDKLVVATGVSGSGKSSLMFDIVFEEGRKQYLQSLGILAGIDSEDKFDNIQGLAPTIA VQQNIIRQSNPRSTVGTRTNILNMLTLLYSVEGQIMCTMCDTPVSDNLICNNCGYEEERLRPSYFSYNSSDGMCMKCSGH GAYFEINIEKLVLDKHDTLKQVLDRAKITPGYLRVFSKKFNDYLDIQFLQLPEEIRNEVLYGHYENGKKSSSLSKVFHNR YKRGEDLNGVYTMTACSDCNGFKIGEEARRVLLNGKHIGELGKMTILEIDDFLKLLINQGNLNTFGTNLVNDILSKTQHL IESRLGHLSLYREMSTLSGGEMQRLFLNSHLDSEMDSLIYVLDEPTAGLHESEKIDILKSLKKLKDLGNTVIVVEHDKNT IEMAEHIIDIGPKAGVEGGQLVYQGDLEGLLQSDKSLTGQYLSGKYPMPNRTSNKNITHTDKIPCITIQNANTNNLKNVT VSLPLGAMVGISGKSGSGKSSLISDTLLPLLRSQFNNHTINNQINSSESEIGEEDDYAVVETIADRLIGTKHISGYSEIS QSPIGKNMNSTPASYIGIWDKIRTLFAGQPESLEQGFTAGHFSFNSKGACPKCSGSGYEKVWLGNNLSIDHICSECQGKR FNDESLSIKYKNKNIHDILNMSVSESVHFFKDIPNIVSHLNVLEQIGMGYIKLGQPTPTLSGGESQRIKLAKEIGKKRNG NILYVLDEPTTGLSLYDTSKLIQLLDELVENGNSVIVVEHDIDVLNVCDWIVELGPEGGDKGGYIIAEGSPKTLKENPKS ITGRYL
Sequences:
>Translated_806_residues MKEIKINGAKIHNLKNIDVSIPKDKLVVATGVSGSGKSSLMFDIVFEEGRKQYLQSLGILAGIDSEDKFDNIQGLAPTIA VQQNIIRQSNPRSTVGTRTNILNMLTLLYSVEGQIMCTMCDTPVSDNLICNNCGYEEERLRPSYFSYNSSDGMCMKCSGH GAYFEINIEKLVLDKHDTLKQVLDRAKITPGYLRVFSKKFNDYLDIQFLQLPEEIRNEVLYGHYENGKKSSSLSKVFHNR YKRGEDLNGVYTMTACSDCNGFKIGEEARRVLLNGKHIGELGKMTILEIDDFLKLLINQGNLNTFGTNLVNDILSKTQHL IESRLGHLSLYREMSTLSGGEMQRLFLNSHLDSEMDSLIYVLDEPTAGLHESEKIDILKSLKKLKDLGNTVIVVEHDKNT IEMAEHIIDIGPKAGVEGGQLVYQGDLEGLLQSDKSLTGQYLSGKYPMPNRTSNKNITHTDKIPCITIQNANTNNLKNVT VSLPLGAMVGISGKSGSGKSSLISDTLLPLLRSQFNNHTINNQINSSESEIGEEDDYAVVETIADRLIGTKHISGYSEIS QSPIGKNMNSTPASYIGIWDKIRTLFAGQPESLEQGFTAGHFSFNSKGACPKCSGSGYEKVWLGNNLSIDHICSECQGKR FNDESLSIKYKNKNIHDILNMSVSESVHFFKDIPNIVSHLNVLEQIGMGYIKLGQPTPTLSGGESQRIKLAKEIGKKRNG NILYVLDEPTTGLSLYDTSKLIQLLDELVENGNSVIVVEHDIDVLNVCDWIVELGPEGGDKGGYIIAEGSPKTLKENPKS ITGRYL >Mature_806_residues MKEIKINGAKIHNLKNIDVSIPKDKLVVATGVSGSGKSSLMFDIVFEEGRKQYLQSLGILAGIDSEDKFDNIQGLAPTIA VQQNIIRQSNPRSTVGTRTNILNMLTLLYSVEGQIMCTMCDTPVSDNLICNNCGYEEERLRPSYFSYNSSDGMCMKCSGH GAYFEINIEKLVLDKHDTLKQVLDRAKITPGYLRVFSKKFNDYLDIQFLQLPEEIRNEVLYGHYENGKKSSSLSKVFHNR YKRGEDLNGVYTMTACSDCNGFKIGEEARRVLLNGKHIGELGKMTILEIDDFLKLLINQGNLNTFGTNLVNDILSKTQHL IESRLGHLSLYREMSTLSGGEMQRLFLNSHLDSEMDSLIYVLDEPTAGLHESEKIDILKSLKKLKDLGNTVIVVEHDKNT IEMAEHIIDIGPKAGVEGGQLVYQGDLEGLLQSDKSLTGQYLSGKYPMPNRTSNKNITHTDKIPCITIQNANTNNLKNVT VSLPLGAMVGISGKSGSGKSSLISDTLLPLLRSQFNNHTINNQINSSESEIGEEDDYAVVETIADRLIGTKHISGYSEIS QSPIGKNMNSTPASYIGIWDKIRTLFAGQPESLEQGFTAGHFSFNSKGACPKCSGSGYEKVWLGNNLSIDHICSECQGKR FNDESLSIKYKNKNIHDILNMSVSESVHFFKDIPNIVSHLNVLEQIGMGYIKLGQPTPTLSGGESQRIKLAKEIGKKRNG NILYVLDEPTTGLSLYDTSKLIQLLDELVENGNSVIVVEHDIDVLNVCDWIVELGPEGGDKGGYIIAEGSPKTLKENPKS ITGRYL
Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion h
COG id: COG0178
COG function: function code L; Excinuclease ATPase subunit
Gene ontology:
Cell location: Cytoplasm [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 ABC transporter domain [H]
Homologues:
Organism=Escherichia coli, GI2367343, Length=714, Percent_Identity=37.8151260504202, Blast_Score=457, Evalue=1e-129,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003439 - InterPro: IPR017871 - InterPro: IPR013815 - InterPro: IPR003593 - InterPro: IPR004602 [H]
Pfam domain/function: PF00005 ABC_tran [H]
EC number: NA
Molecular weight: Translated: 89158; Mature: 89158
Theoretical pI: Translated: 6.16; Mature: 6.16
Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.7 %Cys (Translated Protein) 2.2 %Met (Translated Protein) 4.0 %Cys+Met (Translated Protein) 1.7 %Cys (Mature Protein) 2.2 %Met (Mature Protein) 4.0 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKEIKINGAKIHNLKNIDVSIPKDKLVVATGVSGSGKSSLMFDIVFEEGRKQYLQSLGIL CCEEEECCEEEECCCCCEEECCCCCEEEEECCCCCCCCCEEEEEHHHHHHHHHHHHCCCE AGIDSEDKFDNIQGLAPTIAVQQNIIRQSNPRSTVGTRTNILNMLTLLYSVEGQIMCTMC ECCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEE DTPVSDNLICNNCGYEEERLRPSYFSYNSSDGMCMKCSGHGAYFEINIEKLVLDKHDTLK CCCCCCCEEECCCCCHHHHCCCCCCCCCCCCCEEEEECCCCEEEEEEEHEEEECCHHHHH QVLDRAKITPGYLRVFSKKFNDYLDIQFLQLPEEIRNEVLYGHYENGKKSSSLSKVFHNR HHHHHHCCCHHHHHHHHHHCCCHHCEEHHHCCHHHHCCEEEEECCCCCCHHHHHHHHHHH YKRGEDLNGVYTMTACSDCNGFKIGEEARRVLLNGKHIGELGKMTILEIDDFLKLLINQG HHCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHCCC NLNTFGTNLVNDILSKTQHLIESRLGHLSLYREMSTLSGGEMQRLFLNSHLDSEMDSLIY CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCEEE VLDEPTAGLHESEKIDILKSLKKLKDLGNTVIVVEHDKNTIEMAEHIIDIGPKAGVEGGQ EECCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHCCCCCCCCCCE LVYQGDLEGLLQSDKSLTGQYLSGKYPMPNRTSNKNITHTDKIPCITIQNANTNNLKNVT EEEECCHHHHHHCCHHHCCHHHCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCEEE VSLPLGAMVGISGKSGSGKSSLISDTLLPLLRSQFNNHTINNQINSSESEIGEEDDYAVV EEECCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCCCCHHHH ETIADRLIGTKHISGYSEISQSPIGKNMNSTPASYIGIWDKIRTLFAGQPESLEQGFTAG HHHHHHHHCCHHCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHCCCCCC HFSFNSKGACPKCSGSGYEKVWLGNNLSIDHICSECQGKRFNDESLSIKYKNKNIHDILN EECCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHC MSVSESVHFFKDIPNIVSHLNVLEQIGMGYIKLGQPTPTLSGGESQRIKLAKEIGKKRNG CCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHHCCCCCC NILYVLDEPTTGLSLYDTSKLIQLLDELVENGNSVIVVEHDIDVLNVCDWIVELGPEGGD CEEEEECCCCCCCEEHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHCCCCCCC KGGYIIAEGSPKTLKENPKSITGRYL CCCEEEECCCCCHHHCCCCCCCCCCC >Mature Secondary Structure MKEIKINGAKIHNLKNIDVSIPKDKLVVATGVSGSGKSSLMFDIVFEEGRKQYLQSLGIL CCEEEECCEEEECCCCCEEECCCCCEEEEECCCCCCCCCEEEEEHHHHHHHHHHHHCCCE AGIDSEDKFDNIQGLAPTIAVQQNIIRQSNPRSTVGTRTNILNMLTLLYSVEGQIMCTMC ECCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEE DTPVSDNLICNNCGYEEERLRPSYFSYNSSDGMCMKCSGHGAYFEINIEKLVLDKHDTLK CCCCCCCEEECCCCCHHHHCCCCCCCCCCCCCEEEEECCCCEEEEEEEHEEEECCHHHHH QVLDRAKITPGYLRVFSKKFNDYLDIQFLQLPEEIRNEVLYGHYENGKKSSSLSKVFHNR HHHHHHCCCHHHHHHHHHHCCCHHCEEHHHCCHHHHCCEEEEECCCCCCHHHHHHHHHHH YKRGEDLNGVYTMTACSDCNGFKIGEEARRVLLNGKHIGELGKMTILEIDDFLKLLINQG HHCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHCCC NLNTFGTNLVNDILSKTQHLIESRLGHLSLYREMSTLSGGEMQRLFLNSHLDSEMDSLIY CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCEEE VLDEPTAGLHESEKIDILKSLKKLKDLGNTVIVVEHDKNTIEMAEHIIDIGPKAGVEGGQ EECCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHCCCCCCCCCCE LVYQGDLEGLLQSDKSLTGQYLSGKYPMPNRTSNKNITHTDKIPCITIQNANTNNLKNVT EEEECCHHHHHHCCHHHCCHHHCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCEEE VSLPLGAMVGISGKSGSGKSSLISDTLLPLLRSQFNNHTINNQINSSESEIGEEDDYAVV EEECCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCCCCHHHH ETIADRLIGTKHISGYSEISQSPIGKNMNSTPASYIGIWDKIRTLFAGQPESLEQGFTAG HHHHHHHHCCHHCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHCCCCCC HFSFNSKGACPKCSGSGYEKVWLGNNLSIDHICSECQGKRFNDESLSIKYKNKNIHDILN EECCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHC MSVSESVHFFKDIPNIVSHLNVLEQIGMGYIKLGQPTPTLSGGESQRIKLAKEIGKKRNG CCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHHCCCCCC NILYVLDEPTTGLSLYDTSKLIQLLDELVENGNSVIVVEHDIDVLNVCDWIVELGPEGGD CEEEEECCCCCCCEEHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHCCCCCCC KGGYIIAEGSPKTLKENPKSITGRYL CCCEEEECCCCCHHHCCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: DNA [C]
Specific reaction: Protein + DNA = Protein-DNA [C]
General reaction: Hydrolase; Acting on ester bonds [C]
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 12552129 [H]