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The map label for this gene is lytC [H]

Identifier: 126700811

GI number: 126700811

Start: 3734513

End: 3736165

Strand: Direct

Name: lytC [H]

Synonym: CD3192

Alternate gene names: 126700811

Gene position: 3734513-3736165 (Clockwise)

Preceding gene: 126700807

Following gene: 126700813

Centisome position: 87.05

GC content: 26.56

Gene sequence:

>1653_bases
ATGAATAAGAAAAATTTAGCTATATTAATATCAGGTATGATGTTTTTTTCTAGTTCTTCAGCAATTTTTGCAGACAATAC
TACAAAGCAAGAAAGATTAATAGGTAAAACAAGATATGAAACAGCAGTAGAAGTAAGTAAATTGGGATGGGTTCAATCAA
AAACAGCCATTATAGTTAATGGTAATTCTATTCAAAGTGCGCTTTGTGCAAATCCATTTGCTAAGCTAAAGAATGCACCT
ATACTTTTAGTAAACAACAACAGTATTGAAAATTCAACTAAGGCTGAGCTTAAAAGGCTTGGTGTAGATAATGTGTACAT
TGTAGATAGTGGAAATAGCATTTCTTCTAAAGTAGAAAATGAAATAAAATCACTTAACATAAAAATAAATAAAATAGTAG
GAAACAATATATATGAAATGTCTACAAATGTACTTAAAGAAATAGATAAGATAAAAAAGATAGAAAATGTTGCAGTTGTA
AATGGACTAAAGGGACTATCTGATGCAGTTAGTATAGCTTCTCCAGCAGCAATACATAATATGCCTATAATATTAGTATC
AGATGAAAACAGCAATGATAGTAGTATAAATTTCTTAAACAATAGGTCTATAAAAAAATCTTACATAGTTGGAGGAAATA
AGATTTTATCAGACAATACAGTAAAGAAATATCCAAACAGAGAAAGAATCAGTGGTTCAGATAGAAACAATACTAATGCA
AAAATTATTGATAAATTTTATAAAGATAAAAAAATAAATAATGTATTTGTAGCTAAAGATGGTATTAACCAAGAAAATGC
ATTAGTAGATTCATTATCAATAGGAGTACTAGCTGCTAAAGAAAATTCTCCTATAATGATATCTAATGGTAGCCTTGTAA
ATAGTCAAAAAGAATTTATTAAAAATAAAGATATAGATGAAATAACACAAGTAGGAGGAGGATATAATCAAAAAGCATTT
GAAGATATTTTAAAACTAAAAAATGTGAACATAAGAAATAAAACTAAAAAAATATCTTTAATACAGGCTAAAGAAATATT
AAAACAAGCTCTTCCAGGAAGCAATATTTTAGTTTGTTATTATGATGAAGATGATAATGAATATGACTGCAAAGTTATAA
AGGATAATATCCTATATGAGATAGAAATTGATGCCTACTCTGGTAAAATAATAGAAATTGAAAAAGATGATGACTTAAAT
GATAATAATTTAGGTACACAAAATATATCATTGGATAAAGCTAAGTCTATAGCATTAGATGCTGTTCCTAATGGTAATTT
AATCTATTGTAAATATGATGCTGAAGATAACGAATACGAGGCTAAAGTAATAAAAAATAAGAAAACATATGAATTAGAGA
TAAGTGCATTTGATGGAAGAATTGTAGATATTGACATGGACAATGATTCTGATGATGACTTTGATGATAATGATAAGAAT
AACTCTAATACTAATGACAACAGTTCTATTATTAGTGCTGAAAAAGCTAAATCAATAATGCTAGATAAAGTGCCTGGTGG
GAAAATAGTAAAATTTAAGTATGATGAAGATGACAAAGAATATGAAGGTGAAATAATAAAAGGAAAAACTGAATATGAGA
TAACAATTAATGCAATTACTGGTAAAATATTAGAATTTGAAATAGATGATTAA

Upstream 100 bases:

>100_bases
GTTGATTTTGTAACTTCAAACTCAGTATCAATTTGATTTTAAGATTATATTTTATTAAGTATGCTAAATAACAAATTTTT
AAAGATTGTGAGGTAAAAAT

Downstream 100 bases:

>100_bases
TAAAAAATATATATTCTATTAATTATTACAAGCAATAAAGCCATAAATATTGAAATTTTCAATATTTATGGCTTTATTTT
ATTTTTTTAATTTAAATCCA

Product: cell surface protein

Products: NA

Alternate protein names: Cell wall hydrolase; Cell wall-associated polypeptide CWBP49; CWBP49; Major autolysin [H]

Number of amino acids: Translated: 550; Mature: 550

Protein sequence:

>550_residues
MNKKNLAILISGMMFFSSSSAIFADNTTKQERLIGKTRYETAVEVSKLGWVQSKTAIIVNGNSIQSALCANPFAKLKNAP
ILLVNNNSIENSTKAELKRLGVDNVYIVDSGNSISSKVENEIKSLNIKINKIVGNNIYEMSTNVLKEIDKIKKIENVAVV
NGLKGLSDAVSIASPAAIHNMPIILVSDENSNDSSINFLNNRSIKKSYIVGGNKILSDNTVKKYPNRERISGSDRNNTNA
KIIDKFYKDKKINNVFVAKDGINQENALVDSLSIGVLAAKENSPIMISNGSLVNSQKEFIKNKDIDEITQVGGGYNQKAF
EDILKLKNVNIRNKTKKISLIQAKEILKQALPGSNILVCYYDEDDNEYDCKVIKDNILYEIEIDAYSGKIIEIEKDDDLN
DNNLGTQNISLDKAKSIALDAVPNGNLIYCKYDAEDNEYEAKVIKNKKTYELEISAFDGRIVDIDMDNDSDDDFDDNDKN
NSNTNDNSSIISAEKAKSIMLDKVPGGKIVKFKYDEDDKEYEGEIIKGKTEYEITINAITGKILEFEIDD

Sequences:

>Translated_550_residues
MNKKNLAILISGMMFFSSSSAIFADNTTKQERLIGKTRYETAVEVSKLGWVQSKTAIIVNGNSIQSALCANPFAKLKNAP
ILLVNNNSIENSTKAELKRLGVDNVYIVDSGNSISSKVENEIKSLNIKINKIVGNNIYEMSTNVLKEIDKIKKIENVAVV
NGLKGLSDAVSIASPAAIHNMPIILVSDENSNDSSINFLNNRSIKKSYIVGGNKILSDNTVKKYPNRERISGSDRNNTNA
KIIDKFYKDKKINNVFVAKDGINQENALVDSLSIGVLAAKENSPIMISNGSLVNSQKEFIKNKDIDEITQVGGGYNQKAF
EDILKLKNVNIRNKTKKISLIQAKEILKQALPGSNILVCYYDEDDNEYDCKVIKDNILYEIEIDAYSGKIIEIEKDDDLN
DNNLGTQNISLDKAKSIALDAVPNGNLIYCKYDAEDNEYEAKVIKNKKTYELEISAFDGRIVDIDMDNDSDDDFDDNDKN
NSNTNDNSSIISAEKAKSIMLDKVPGGKIVKFKYDEDDKEYEGEIIKGKTEYEITINAITGKILEFEIDD
>Mature_550_residues
MNKKNLAILISGMMFFSSSSAIFADNTTKQERLIGKTRYETAVEVSKLGWVQSKTAIIVNGNSIQSALCANPFAKLKNAP
ILLVNNNSIENSTKAELKRLGVDNVYIVDSGNSISSKVENEIKSLNIKINKIVGNNIYEMSTNVLKEIDKIKKIENVAVV
NGLKGLSDAVSIASPAAIHNMPIILVSDENSNDSSINFLNNRSIKKSYIVGGNKILSDNTVKKYPNRERISGSDRNNTNA
KIIDKFYKDKKINNVFVAKDGINQENALVDSLSIGVLAAKENSPIMISNGSLVNSQKEFIKNKDIDEITQVGGGYNQKAF
EDILKLKNVNIRNKTKKISLIQAKEILKQALPGSNILVCYYDEDDNEYDCKVIKDNILYEIEIDAYSGKIIEIEKDDDLN
DNNLGTQNISLDKAKSIALDAVPNGNLIYCKYDAEDNEYEAKVIKNKKTYELEISAFDGRIVDIDMDNDSDDDFDDNDKN
NSNTNDNSSIISAEKAKSIMLDKVPGGKIVKFKYDEDDKEYEGEIIKGKTEYEITINAITGKILEFEIDD

Specific function: Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation, formation of the flagella - in particular of its basal body - and sporulation. Has a high affinity for teich

COG id: COG2247

COG function: function code M; Putative cell wall-binding domain

Gene ontology:

Cell location: Secreted, cell wall [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007253
- InterPro:   IPR002508 [H]

Pfam domain/function: PF01520 Amidase_3; PF04122 CW_binding_2 [H]

EC number: =3.5.1.28 [H]

Molecular weight: Translated: 61124; Mature: 61124

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKKNLAILISGMMFFSSSSAIFADNTTKQERLIGKTRYETAVEVSKLGWVQSKTAIIVN
CCCCEEEEEEEEEHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCEECCEEEEEE
GNSIQSALCANPFAKLKNAPILLVNNNSIENSTKAELKRLGVDNVYIVDSGNSISSKVEN
CCCHHHHHHCCCHHHHCCCCEEEECCCCCCCCHHHHHHHCCCCEEEEEECCCCHHHHHHH
EIKSLNIKINKIVGNNIYEMSTNVLKEIDKIKKIENVAVVNGLKGLSDAVSIASPAAIHN
HHHEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHEHEECCCCCCHHHHHHCCCHHHHC
MPIILVSDENSNDSSINFLNNRSIKKSYIVGGNKILSDNTVKKYPNRERISGSDRNNTNA
CCEEEEECCCCCCCEEEEECCCCCEEEEEECCCEEECCCCHHHCCCCCCCCCCCCCCCCH
KIIDKFYKDKKINNVFVAKDGINQENALVDSLSIGVLAAKENSPIMISNGSLVNSQKEFI
HHHHHHHCCCCCCEEEEEECCCCCCHHHHEEEEEEEEEECCCCCEEEECCCEECCHHHHH
KNKDIDEITQVGGGYNQKAFEDILKLKNVNIRNKTKKISLIQAKEILKQALPGSNILVCY
CCCCHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHCCCCCEEEEE
YDEDDNEYDCKVIKDNILYEIEIDAYSGKIIEIEKDDDLNDNNLGTQNISLDKAKSIALD
ECCCCCCEEEEEEECCEEEEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEE
AVPNGNLIYCKYDAEDNEYEAKVIKNKKTYELEISAFDGRIVDIDMDNDSDDDFDDNDKN
ECCCCCEEEEEECCCCCCEEEEEECCCCEEEEEEEECCCEEEEEECCCCCCCCCCCCCCC
NSNTNDNSSIISAEKAKSIMLDKVPGGKIVKFKYDEDDKEYEGEIIKGKTEYEITINAIT
CCCCCCCCCEEEHHHHCEEEEECCCCCEEEEEEECCCCCCCCCEEEECCEEEEEEEEEEE
GKILEFEIDD
CEEEEEEECC
>Mature Secondary Structure
MNKKNLAILISGMMFFSSSSAIFADNTTKQERLIGKTRYETAVEVSKLGWVQSKTAIIVN
CCCCEEEEEEEEEHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCEECCEEEEEE
GNSIQSALCANPFAKLKNAPILLVNNNSIENSTKAELKRLGVDNVYIVDSGNSISSKVEN
CCCHHHHHHCCCHHHHCCCCEEEECCCCCCCCHHHHHHHCCCCEEEEEECCCCHHHHHHH
EIKSLNIKINKIVGNNIYEMSTNVLKEIDKIKKIENVAVVNGLKGLSDAVSIASPAAIHN
HHHEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHEHEECCCCCCHHHHHHCCCHHHHC
MPIILVSDENSNDSSINFLNNRSIKKSYIVGGNKILSDNTVKKYPNRERISGSDRNNTNA
CCEEEEECCCCCCCEEEEECCCCCEEEEEECCCEEECCCCHHHCCCCCCCCCCCCCCCCH
KIIDKFYKDKKINNVFVAKDGINQENALVDSLSIGVLAAKENSPIMISNGSLVNSQKEFI
HHHHHHHCCCCCCEEEEEECCCCCCHHHHEEEEEEEEEECCCCCEEEECCCEECCHHHHH
KNKDIDEITQVGGGYNQKAFEDILKLKNVNIRNKTKKISLIQAKEILKQALPGSNILVCY
CCCCHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHCCCCCEEEEE
YDEDDNEYDCKVIKDNILYEIEIDAYSGKIIEIEKDDDLNDNNLGTQNISLDKAKSIALD
ECCCCCCEEEEEEECCEEEEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEE
AVPNGNLIYCKYDAEDNEYEAKVIKNKKTYELEISAFDGRIVDIDMDNDSDDDFDDNDKN
ECCCCCEEEEEECCCCCCEEEEEECCCCEEEEEEEECCCEEEEEECCCCCCCCCCCCCCC
NSNTNDNSSIISAEKAKSIMLDKVPGGKIVKFKYDEDDKEYEGEIIKGKTEYEITINAIT
CCCCCCCCCEEEHHHHCEEEEECCCCCEEEEEEECCCCCCCCCEEEECCEEEEEEEEEEE
GKILEFEIDD
CEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1357079; 1682302; 9384377 [H]