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The map label for this gene is comEC [H]

Identifier: 126700095

GI number: 126700095

Start: 2859728

End: 2860564

Strand: Direct

Name: comEC [H]

Synonym: CD2478

Alternate gene names: 126700095

Gene position: 2859728-2860564 (Clockwise)

Preceding gene: 126700090

Following gene: 126700100

Centisome position: 66.66

GC content: 23.06

Gene sequence:

>837_bases
TTGAGAAATAAAATTTTTTTATCAATACTTATTATAATATCACTTTTAATCGGCTGTGACAAAAAATCTCTACTATCTAT
ACATATGATTGATGTTGGACAAGGTGATAGTATTTTAGTTCAAACACCCACAAATAAGAATATATTAATTGATGGAGGTG
ATGAAGATAGCGAAAATATAATTATTAGTTATCTTAGACAAAAAAGAATAAAAACTATTGATATTATAATAGCAACTCAT
CCAGATTCAGACCACATAGGAAGTCTTGATAATATTATAAAAAAATTTAATGTAAACTCCATATATATGCCTGAACAATC
AACTGATAGTGAGGCTTATCAAAATCTAATAAATTCTTGTACGGATAAAAACTTATCTATTCAGCATCTCTATAAAAATG
ATGTTTTAAACATAGATAACAATATAAATATATATGTATTAAGTCCATCATATATACAAGAAGAATCTAATTTAAATTCT
ATAGTTTTTAAATTAACTTTTAATGATAATTCTTTTTTATTTATGGGTGATGCTGAAGAAGAAAATGAAAAAGAAATTTT
ACATTCTTTTAAATTAAATAATATTAATTTTATAAAAATAGGTCATCATGGAAGTAATTCTTCTTCATCTTTAGAATTTA
TAAAAAAAATTAGTCCAGATATAGCTGCAATATCATGTGGATATAAAAATCAATATGGTCATCCACATAGGGAGGTTATT
AATAATCTAAAACAAAACCATGTATCAATTTATAGAACAGATAGAATAGGAGATATTGTTTTTTATAGTGATGGAGAAAT
TATATTTACAAAATATAATTATGAAATAGATACATAA

Upstream 100 bases:

>100_bases
CATTTATATTGTTTAAAATATAAAATATAATAAGTCATATATATCTTATATTACCCATCATAAATTTATATAAACATGTA
ATGAATGGAGTGATTTTTTA

Downstream 100 bases:

>100_bases
TCTAAAAAATAAAACTACAACTACATAAAATAAGGTAATATAAAATAATTAGGCTAAAAGTATGAATATAAAATTGCTTT
GTATTCATGCTTCTAGCCTT

Product: metallo beta-lactamase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 278; Mature: 278

Protein sequence:

>278_residues
MRNKIFLSILIIISLLIGCDKKSLLSIHMIDVGQGDSILVQTPTNKNILIDGGDEDSENIIISYLRQKRIKTIDIIIATH
PDSDHIGSLDNIIKKFNVNSIYMPEQSTDSEAYQNLINSCTDKNLSIQHLYKNDVLNIDNNINIYVLSPSYIQEESNLNS
IVFKLTFNDNSFLFMGDAEEENEKEILHSFKLNNINFIKIGHHGSNSSSSLEFIKKISPDIAAISCGYKNQYGHPHREVI
NNLKQNHVSIYRTDRIGDIVFYSDGEIIFTKYNYEIDT

Sequences:

>Translated_278_residues
MRNKIFLSILIIISLLIGCDKKSLLSIHMIDVGQGDSILVQTPTNKNILIDGGDEDSENIIISYLRQKRIKTIDIIIATH
PDSDHIGSLDNIIKKFNVNSIYMPEQSTDSEAYQNLINSCTDKNLSIQHLYKNDVLNIDNNINIYVLSPSYIQEESNLNS
IVFKLTFNDNSFLFMGDAEEENEKEILHSFKLNNINFIKIGHHGSNSSSSLEFIKKISPDIAAISCGYKNQYGHPHREVI
NNLKQNHVSIYRTDRIGDIVFYSDGEIIFTKYNYEIDT
>Mature_278_residues
MRNKIFLSILIIISLLIGCDKKSLLSIHMIDVGQGDSILVQTPTNKNILIDGGDEDSENIIISYLRQKRIKTIDIIIATH
PDSDHIGSLDNIIKKFNVNSIYMPEQSTDSEAYQNLINSCTDKNLSIQHLYKNDVLNIDNNINIYVLSPSYIQEESNLNS
IVFKLTFNDNSFLFMGDAEEENEKEILHSFKLNNINFIKIGHHGSNSSSSLEFIKKISPDIAAISCGYKNQYGHPHREVI
NNLKQNHVSIYRTDRIGDIVFYSDGEIIFTKYNYEIDT

Specific function: The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding [H]

COG id: COG2333

COG function: function code R; Predicted hydrolase (metallo-beta-lactamase superfamily)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 31679; Mature: 31679

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNKIFLSILIIISLLIGCDKKSLLSIHMIDVGQGDSILVQTPTNKNILIDGGDEDSENI
CCCHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCEEEEECCCCCEEEEECCCCCCCHH
IISYLRQKRIKTIDIIIATHPDSDHIGSLDNIIKKFNVNSIYMPEQSTDSEAYQNLINSC
HHHHHHHCCCEEEEEEEEECCCCCCCCCHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHH
TDKNLSIQHLYKNDVLNIDNNINIYVLSPSYIQEESNLNSIVFKLTFNDNSFLFMGDAEE
CCCCCEEEEEECCCCEECCCCEEEEEECCHHHCCCCCCCEEEEEEEECCCEEEEEECCCC
ENEKEILHSFKLNNINFIKIGHHGSNSSSSLEFIKKISPDIAAISCGYKNQYGHPHREVI
CHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHH
NNLKQNHVSIYRTDRIGDIVFYSDGEIIFTKYNYEIDT
HHHHHCCEEEEEECCCCEEEEEECCCEEEEEEEEEECC
>Mature Secondary Structure
MRNKIFLSILIIISLLIGCDKKSLLSIHMIDVGQGDSILVQTPTNKNILIDGGDEDSENI
CCCHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCEEEEECCCCCEEEEECCCCCCCHH
IISYLRQKRIKTIDIIIATHPDSDHIGSLDNIIKKFNVNSIYMPEQSTDSEAYQNLINSC
HHHHHHHCCCEEEEEEEEECCCCCCCCCHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHH
TDKNLSIQHLYKNDVLNIDNNINIYVLSPSYIQEESNLNSIVFKLTFNDNSFLFMGDAEE
CCCCCEEEEEECCCCEECCCCEEEEEECCHHHCCCCCCCEEEEEEEECCCEEEEEECCCC
ENEKEILHSFKLNNINFIKIGHHGSNSSSSLEFIKKISPDIAAISCGYKNQYGHPHREVI
CHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHH
NNLKQNHVSIYRTDRIGDIVFYSDGEIIFTKYNYEIDT
HHHHHCCEEEEEECCCCEEEEEECCCEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]