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The map label for this gene is gapA [H]

Identifier: 126699376

GI number: 126699376

Start: 2044418

End: 2045434

Strand: Direct

Name: gapA [H]

Synonym: CD1767

Alternate gene names: 126699376

Gene position: 2044418-2045434 (Clockwise)

Preceding gene: 126699375

Following gene: 126699377

Centisome position: 47.65

GC content: 32.15

Gene sequence:

>1017_bases
ATGAAAATTAAGGTAGGAATGAACGGATTTGGAAGAATAGGAAGAGCTGTATTAAGAATAGCTCAAGAAGAATTAGGAGA
TAATATAGAAATTGTACCCATAAATGCAAGAGCAACAACAGAATCTTTGGCACATTTATTTACATATGATTCATGCTATG
GAACTTTTAGAGGTGAAGTAGAGGCAAAGGATGAAGACACTCTAGTAGTAAACTCTAAAGAGATAAAAATATTAAGATAT
AATGACCCAGAAGAATTACCTTGGAAAGAATTGGGGGTTGATATAGTAATAGAATCAACAGGATTATTTACACAAAGAGA
AAAGGCAGAAAAACATATTAAAGCAGGAGCAAAAAAAGTAATTATAACAGCTCCAGGAAAAAATGAAGATATAACTATAG
TTATCGGAGTTAATGAGAAAGAATATGATAATGAAAAGCACAATATAATTTCAAATGCATCTTGTACTACAAATTGTCTA
GCTCCTTTTGCTAAAGTATTGGACGAAAAATTTGGTATAGTAAAAGGGTTAATGACTACAGTACATTCATATACTAACGA
TCAAAGAATATTAGATAAAAGCCATAAAGATTTGAGAAGAGCAAGAGCAGCGGCTGAATCTATAATACCTACCACTACAG
GAGCAGCAAAAGCTGTGTCAAGAGTACTACCACAATTAGAAGGAAAATTAAATGGTTTTTCACTTAGAGTACCAACACCA
ACAGTTTCACTTGTTGATTTAGTGTGCGAACTTAAAGAAAACGTTACATCTGAGCAAGTTAACTCTGTGTTAAAAGATGC
TGCTGAAGGAGAATTAAAAGGTGTTTTAGGATATTGTGACAAGCCACTTGTTTCTATAGATTATAAAGGAGATTCAAGAT
CATCTATTATAGACGCTCTATCCACAATGGTTATAGAAGACAATATGGTTAAGGTAGTTTCTTGGTATGATAATGAATGG
GGATATTCTTCAAGAACTGTTGACTTAGTAAAATATGTAGCTGAAAAATTAAAATAA

Upstream 100 bases:

>100_bases
TGGAATTTGATTATTTAATCAAGAAAAAGTATTGAACAAATGATTTATTTAGTGTACAATAATCATGTAAAAACATAGTA
ATGGAGGGAGACATTTCATA

Downstream 100 bases:

>100_bases
TATATATTTCTTAAAGCAAATTTTAAAAAAATTTTTTAAAAAAATTATATAAAACTAAAAAAAAAGATTATGAAAAATAT
TGAAGGAAAAATTTTTTCAT

Product: glyceraldehyde-3-phosphate dehydrogenase 1

Products: NA

Alternate protein names: GAPDH [H]

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MKIKVGMNGFGRIGRAVLRIAQEELGDNIEIVPINARATTESLAHLFTYDSCYGTFRGEVEAKDEDTLVVNSKEIKILRY
NDPEELPWKELGVDIVIESTGLFTQREKAEKHIKAGAKKVIITAPGKNEDITIVIGVNEKEYDNEKHNIISNASCTTNCL
APFAKVLDEKFGIVKGLMTTVHSYTNDQRILDKSHKDLRRARAAAESIIPTTTGAAKAVSRVLPQLEGKLNGFSLRVPTP
TVSLVDLVCELKENVTSEQVNSVLKDAAEGELKGVLGYCDKPLVSIDYKGDSRSSIIDALSTMVIEDNMVKVVSWYDNEW
GYSSRTVDLVKYVAEKLK

Sequences:

>Translated_338_residues
MKIKVGMNGFGRIGRAVLRIAQEELGDNIEIVPINARATTESLAHLFTYDSCYGTFRGEVEAKDEDTLVVNSKEIKILRY
NDPEELPWKELGVDIVIESTGLFTQREKAEKHIKAGAKKVIITAPGKNEDITIVIGVNEKEYDNEKHNIISNASCTTNCL
APFAKVLDEKFGIVKGLMTTVHSYTNDQRILDKSHKDLRRARAAAESIIPTTTGAAKAVSRVLPQLEGKLNGFSLRVPTP
TVSLVDLVCELKENVTSEQVNSVLKDAAEGELKGVLGYCDKPLVSIDYKGDSRSSIIDALSTMVIEDNMVKVVSWYDNEW
GYSSRTVDLVKYVAEKLK
>Mature_338_residues
MKIKVGMNGFGRIGRAVLRIAQEELGDNIEIVPINARATTESLAHLFTYDSCYGTFRGEVEAKDEDTLVVNSKEIKILRY
NDPEELPWKELGVDIVIESTGLFTQREKAEKHIKAGAKKVIITAPGKNEDITIVIGVNEKEYDNEKHNIISNASCTTNCL
APFAKVLDEKFGIVKGLMTTVHSYTNDQRILDKSHKDLRRARAAAESIIPTTTGAAKAVSRVLPQLEGKLNGFSLRVPTP
TVSLVDLVCELKENVTSEQVNSVLKDAAEGELKGVLGYCDKPLVSIDYKGDSRSSIIDALSTMVIEDNMVKVVSWYDNEW
GYSSRTVDLVKYVAEKLK

Specific function: Second phase of glycolysis; first step. [C]

COG id: COG0057

COG function: function code G; Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI7657116, Length=339, Percent_Identity=46.9026548672566, Blast_Score=330, Evalue=1e-90,
Organism=Homo sapiens, GI7669492, Length=337, Percent_Identity=48.6646884272997, Blast_Score=321, Evalue=6e-88,
Organism=Escherichia coli, GI1788079, Length=336, Percent_Identity=51.7857142857143, Blast_Score=351, Evalue=3e-98,
Organism=Escherichia coli, GI1789295, Length=331, Percent_Identity=44.1087613293051, Blast_Score=299, Evalue=2e-82,
Organism=Caenorhabditis elegans, GI32566163, Length=342, Percent_Identity=48.8304093567251, Blast_Score=327, Evalue=4e-90,
Organism=Caenorhabditis elegans, GI17534677, Length=342, Percent_Identity=47.953216374269, Blast_Score=327, Evalue=4e-90,
Organism=Caenorhabditis elegans, GI17568413, Length=342, Percent_Identity=48.8304093567251, Blast_Score=327, Evalue=6e-90,
Organism=Caenorhabditis elegans, GI17534679, Length=342, Percent_Identity=47.953216374269, Blast_Score=326, Evalue=1e-89,
Organism=Saccharomyces cerevisiae, GI6322468, Length=335, Percent_Identity=51.044776119403, Blast_Score=338, Evalue=9e-94,
Organism=Saccharomyces cerevisiae, GI6321631, Length=335, Percent_Identity=51.6417910447761, Blast_Score=337, Evalue=1e-93,
Organism=Saccharomyces cerevisiae, GI6322409, Length=335, Percent_Identity=48.3582089552239, Blast_Score=327, Evalue=1e-90,
Organism=Drosophila melanogaster, GI85725000, Length=335, Percent_Identity=46.865671641791, Blast_Score=308, Evalue=5e-84,
Organism=Drosophila melanogaster, GI22023983, Length=335, Percent_Identity=46.865671641791, Blast_Score=308, Evalue=5e-84,
Organism=Drosophila melanogaster, GI17933600, Length=334, Percent_Identity=47.0059880239521, Blast_Score=307, Evalue=7e-84,
Organism=Drosophila melanogaster, GI18110149, Length=334, Percent_Identity=47.0059880239521, Blast_Score=307, Evalue=7e-84,
Organism=Drosophila melanogaster, GI19922412, Length=330, Percent_Identity=45.1515151515152, Blast_Score=286, Evalue=2e-77,

Paralogues:

None

Copy number: 220 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1840 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 740 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1660 Molecules/Cell In: Growth Phase, Min

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020831
- InterPro:   IPR020830
- InterPro:   IPR020829
- InterPro:   IPR020828
- InterPro:   IPR006424
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02800 Gp_dh_C; PF00044 Gp_dh_N [H]

EC number: =1.2.1.12 [H]

Molecular weight: Translated: 37381; Mature: 37381

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS00071 GAPDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIKVGMNGFGRIGRAVLRIAQEELGDNIEIVPINARATTESLAHLFTYDSCYGTFRGEV
CEEEECCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCE
EAKDEDTLVVNSKEIKILRYNDPEELPWKELGVDIVIESTGLFTQREKAEKHIKAGAKKV
ECCCCCEEEEECCEEEEEEECCCCCCCHHHCCEEEEEECCCCCHHHHHHHHHHHCCCCEE
IITAPGKNEDITIVIGVNEKEYDNEKHNIISNASCTTNCLAPFAKVLDEKFGIVKGLMTT
EEECCCCCCCEEEEEECCCHHCCCCHHCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VHSYTNDQRILDKSHKDLRRARAAAESIIPTTTGAAKAVSRVLPQLEGKLNGFSLRVPTP
HHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCC
TVSLVDLVCELKENVTSEQVNSVLKDAAEGELKGVLGYCDKPLVSIDYKGDSRSSIIDAL
HHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHCCCCCEEEEEECCCCHHHHHHHH
STMVIEDNMVKVVSWYDNEWGYSSRTVDLVKYVAEKLK
HHHHHCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MKIKVGMNGFGRIGRAVLRIAQEELGDNIEIVPINARATTESLAHLFTYDSCYGTFRGEV
CEEEECCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCE
EAKDEDTLVVNSKEIKILRYNDPEELPWKELGVDIVIESTGLFTQREKAEKHIKAGAKKV
ECCCCCEEEEECCEEEEEEECCCCCCCHHHCCEEEEEECCCCCHHHHHHHHHHHCCCCEE
IITAPGKNEDITIVIGVNEKEYDNEKHNIISNASCTTNCLAPFAKVLDEKFGIVKGLMTT
EEECCCCCCCEEEEEECCCHHCCCCHHCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VHSYTNDQRILDKSHKDLRRARAAAESIIPTTTGAAKAVSRVLPQLEGKLNGFSLRVPTP
HHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCC
TVSLVDLVCELKENVTSEQVNSVLKDAAEGELKGVLGYCDKPLVSIDYKGDSRSSIIDAL
HHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHCCCCCEEEEEECCCCHHHHHHHH
STMVIEDNMVKVVSWYDNEWGYSSRTVDLVKYVAEKLK
HHHHHCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2684782; 2227448; 2656407; 7408868; 193030; 3586018; 9175858 [H]