| Definition | Clostridium difficile 630 chromosome, complete genome. |
|---|---|
| Accession | NC_009089 |
| Length | 4,290,252 |
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The map label for this gene is lytC [H]
Identifier: 126699358
GI number: 126699358
Start: 2028161
End: 2030548
Strand: Direct
Name: lytC [H]
Synonym: CD1751
Alternate gene names: 126699358
Gene position: 2028161-2030548 (Clockwise)
Preceding gene: 126699357
Following gene: 126699359
Centisome position: 47.27
GC content: 30.49
Gene sequence:
>2388_bases GTGAAAAAATTTACTTCAAAAAAAGTAACAAGGTTTGTTGCGCTGTTTTTAATATCTATTTTAGTAATGTCAACAATTCC TGTATCAGCTGACAATAGCAATACATTGAATCAGATAAAAAAAGCAGAATACAGTGAGACGTATAAACAATATCTAAATG ATGCTAAAAATGGACGTACAGAAAAATATAATGGGATTATACCAAATCCATATCAGTTGGAAGGTACTCAAATCCAAAGT AAAGGAAGAACAGCTCCAACATCTTATGACCCTAGAAAATTAGGTCTTATGACATCAATAAAAAATCAAGAGGATTTAGG AATCTGTTGGGATTTTGCTGCAATGGCAACCTTAGAAAGTTTCTTAAAGTTAAATAATTATGGAGACTATGATTTATCAG AAGAACACTTAAGATGGTGGGCTTCAGATGGTGAATATGGATGGTCTGTAGATGATATGAATGGTGCTTTAAATTATGAA GCTATGGGATATTTAACATCTTGGTCAGGTCCTAAATTAGAAAAAGATATCCCATACAATGGTAGAGTATCTAAAGCACA AGGAGCAAAAAAACCAACTAATATGAATACAGCACCTACTGTTTTTAATGTGACAGATGCTGTGTGTGTAAGTAATGACA TAAATTCTACAAAAAATGCTATATTACAGTATGGAGCAGTAACATCTGGTTATTATGAAGATATTAAATATCAAAGTGAT GACCAAAATTCATATTATTGTCCAACAAAAAGTTTTAATACAAATCATGCTATTTCAATTGTAGGTTGGGATGATAACTA TTCTAAAGATAATTTTAATGCAAATATTAGACCATCAAAAAATGGTGCTTGGTTAATAAAAAATAGCTGGGGAGATTATA ATTCTGAGGGTGGATATTTCTGGATATCTTATGAAGACAAGACACTTATGTCTGATATAGATAATTTTTCAATCAAAGGT GGTAAAAAACCAAATGATGATGAGAAGATGTATCAACATGACTATGCAAGTATTGTACCTTTAATTTCAAAAAAGATAAC AGCTGCAAATGTATTTGATTTCAATAGAGGCGATGAAACTCTAAAATCTGTAATGTTCTTAACTGAAAGTATAGGAGCTA AGTATGAAGTATATTATGCTCCAGTAGTAAATGGTATACCTCAAGAAAACAATATGAAAAAATTAAAAGAAGGTACTGCC CAATATTCAGGATACATAACAGTTCCAATTGATTCTTTTGATATACCAGAAGGAAAGGGTGCAATTGTAGTCAGCATAGA GGGGAAAAATGGAGAGTCAACTATAGGTTCTGAGTCAAATGTACCAGGATATGATACATTTAAAGCAAAAGCTAATTTAG GTGAAAGTTATATCATAGATAATACTGGAAAATTCTTTGATATAAATAGAGATAGTAACTTCTATCCATGTAATTTTACT ATAAAAGCTGTTACAGAAAAGTCTTCTGGTGAGAGTATCCCAAATGAGTCTTTAATTGGTAGTGATAGATATGAAACTGC TATCAAAGTTAGTCAAAATGGTTTCAATTCTTCAGAAAATGTAGTTTTAGTAAATGGCAGTTCAATAGTAGATGCATTGG CAGCAACTCCTTTTACATCTGCTATAAATTCACCAATATTATTGACACAAAAAGAAGCTTTAAATTCAAAAACTAAAGCT GAGATACAGAGATTAGGTGCTAAGAAAGTATACCTAATAGGTGGAGAAAATTCTATAAGTAAAGAAATTGAACAACAATT AAAAAGCTTAAATATATCGATAGAGAGAATATCAGGAAGTGATAGATACAAGACAAGTTTATTATTAGCTCAAAAGTTAA ATGGTATAAAAAATGTATCTCAAATAGCAGTTGTAAATGGAGTGAAAGGATTAGCTGATGCAATTAGTGTAGGCGCTGCA GCAGCAGAAAATAACATACCAATCATACTTGCAAATGAAAAGAGCGAATTGCAAGGAGCTGATGAATTTCTAAATTCATT AAATATAGAGAAATCTTATATTATTGGAGGAACAGCATCCCTATCAAACAATCTAGAAAGTAAGTTAAAAAATCCAACTA GATTATCTGGTAGTAGTAGAGACGAAACTAATTCAAAGATAATAGATAATTTTTATAAAAAAGATACTTTAAAAAATGCA TTTGTAGTTAAAAATGGAATCAAGAATCAAAATGATTTAATAGATGGATTGGCAGTTGGTCCTTTAGGAGCAAAAACTGG GTCACCAGTAATTTTAGTTGGTGATAAATTAGCTGATAGCCAAAAAGAAGTTCTTAAAAATAAGACTTTAGAAAAAGTAA CTCAAGTTGGTGGAGGAGCAAATAAAAATGCATTTAAAGAGTTAGTAAAATTAAAAAGTGCTAAATAG
Upstream 100 bases:
>100_bases TATAATTGATTTAAATGATTGTATATTTGTAAATACTTGATATTTAGTCATATATAACATTATAATTTTAAAAATTAGCT CAAAATAAGGGGGAGAAAGC
Downstream 100 bases:
>100_bases AGTACTTAAGTATTAACATATATTAGTGTGTATTAGCAACTTATCTTAATAAAAGCTGAAAATAATTACTTTAAATTATT GATAAATAAGATAATCAATG
Product: cell surface-associated cysteine protease
Products: NA
Alternate protein names: Cell wall hydrolase; Cell wall-associated polypeptide CWBP49; CWBP49; Major autolysin [H]
Number of amino acids: Translated: 795; Mature: 795
Protein sequence:
>795_residues MKKFTSKKVTRFVALFLISILVMSTIPVSADNSNTLNQIKKAEYSETYKQYLNDAKNGRTEKYNGIIPNPYQLEGTQIQS KGRTAPTSYDPRKLGLMTSIKNQEDLGICWDFAAMATLESFLKLNNYGDYDLSEEHLRWWASDGEYGWSVDDMNGALNYE AMGYLTSWSGPKLEKDIPYNGRVSKAQGAKKPTNMNTAPTVFNVTDAVCVSNDINSTKNAILQYGAVTSGYYEDIKYQSD DQNSYYCPTKSFNTNHAISIVGWDDNYSKDNFNANIRPSKNGAWLIKNSWGDYNSEGGYFWISYEDKTLMSDIDNFSIKG GKKPNDDEKMYQHDYASIVPLISKKITAANVFDFNRGDETLKSVMFLTESIGAKYEVYYAPVVNGIPQENNMKKLKEGTA QYSGYITVPIDSFDIPEGKGAIVVSIEGKNGESTIGSESNVPGYDTFKAKANLGESYIIDNTGKFFDINRDSNFYPCNFT IKAVTEKSSGESIPNESLIGSDRYETAIKVSQNGFNSSENVVLVNGSSIVDALAATPFTSAINSPILLTQKEALNSKTKA EIQRLGAKKVYLIGGENSISKEIEQQLKSLNISIERISGSDRYKTSLLLAQKLNGIKNVSQIAVVNGVKGLADAISVGAA AAENNIPIILANEKSELQGADEFLNSLNIEKSYIIGGTASLSNNLESKLKNPTRLSGSSRDETNSKIIDNFYKKDTLKNA FVVKNGIKNQNDLIDGLAVGPLGAKTGSPVILVGDKLADSQKEVLKNKTLEKVTQVGGGANKNAFKELVKLKSAK
Sequences:
>Translated_795_residues MKKFTSKKVTRFVALFLISILVMSTIPVSADNSNTLNQIKKAEYSETYKQYLNDAKNGRTEKYNGIIPNPYQLEGTQIQS KGRTAPTSYDPRKLGLMTSIKNQEDLGICWDFAAMATLESFLKLNNYGDYDLSEEHLRWWASDGEYGWSVDDMNGALNYE AMGYLTSWSGPKLEKDIPYNGRVSKAQGAKKPTNMNTAPTVFNVTDAVCVSNDINSTKNAILQYGAVTSGYYEDIKYQSD DQNSYYCPTKSFNTNHAISIVGWDDNYSKDNFNANIRPSKNGAWLIKNSWGDYNSEGGYFWISYEDKTLMSDIDNFSIKG GKKPNDDEKMYQHDYASIVPLISKKITAANVFDFNRGDETLKSVMFLTESIGAKYEVYYAPVVNGIPQENNMKKLKEGTA QYSGYITVPIDSFDIPEGKGAIVVSIEGKNGESTIGSESNVPGYDTFKAKANLGESYIIDNTGKFFDINRDSNFYPCNFT IKAVTEKSSGESIPNESLIGSDRYETAIKVSQNGFNSSENVVLVNGSSIVDALAATPFTSAINSPILLTQKEALNSKTKA EIQRLGAKKVYLIGGENSISKEIEQQLKSLNISIERISGSDRYKTSLLLAQKLNGIKNVSQIAVVNGVKGLADAISVGAA AAENNIPIILANEKSELQGADEFLNSLNIEKSYIIGGTASLSNNLESKLKNPTRLSGSSRDETNSKIIDNFYKKDTLKNA FVVKNGIKNQNDLIDGLAVGPLGAKTGSPVILVGDKLADSQKEVLKNKTLEKVTQVGGGANKNAFKELVKLKSAK >Mature_795_residues MKKFTSKKVTRFVALFLISILVMSTIPVSADNSNTLNQIKKAEYSETYKQYLNDAKNGRTEKYNGIIPNPYQLEGTQIQS KGRTAPTSYDPRKLGLMTSIKNQEDLGICWDFAAMATLESFLKLNNYGDYDLSEEHLRWWASDGEYGWSVDDMNGALNYE AMGYLTSWSGPKLEKDIPYNGRVSKAQGAKKPTNMNTAPTVFNVTDAVCVSNDINSTKNAILQYGAVTSGYYEDIKYQSD DQNSYYCPTKSFNTNHAISIVGWDDNYSKDNFNANIRPSKNGAWLIKNSWGDYNSEGGYFWISYEDKTLMSDIDNFSIKG GKKPNDDEKMYQHDYASIVPLISKKITAANVFDFNRGDETLKSVMFLTESIGAKYEVYYAPVVNGIPQENNMKKLKEGTA QYSGYITVPIDSFDIPEGKGAIVVSIEGKNGESTIGSESNVPGYDTFKAKANLGESYIIDNTGKFFDINRDSNFYPCNFT IKAVTEKSSGESIPNESLIGSDRYETAIKVSQNGFNSSENVVLVNGSSIVDALAATPFTSAINSPILLTQKEALNSKTKA EIQRLGAKKVYLIGGENSISKEIEQQLKSLNISIERISGSDRYKTSLLLAQKLNGIKNVSQIAVVNGVKGLADAISVGAA AAENNIPIILANEKSELQGADEFLNSLNIEKSYIIGGTASLSNNLESKLKNPTRLSGSSRDETNSKIIDNFYKKDTLKNA FVVKNGIKNQNDLIDGLAVGPLGAKTGSPVILVGDKLADSQKEVLKNKTLEKVTQVGGGANKNAFKELVKLKSAK
Specific function: Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation, formation of the flagella - in particular of its basal body - and sporulation. Has a high affinity for teich
COG id: COG4870
COG function: function code O; Cysteine protease
Gene ontology:
Cell location: Secreted, cell wall [H]
Metaboloic importance: NA
Operon status: Not Known
Operon components: None
Similarity: Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family [H]
Homologues:
None
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR007253 - InterPro: IPR002508 [H]
Pfam domain/function: PF01520 Amidase_3; PF04122 CW_binding_2 [H]
EC number: =3.5.1.28 [H]
Molecular weight: Translated: 87268; Mature: 87268
Theoretical pI: Translated: 6.81; Mature: 6.81
Prosite motif: PS00639 THIOL_PROTEASE_HIS
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.5 %Cys (Translated Protein) 1.4 %Met (Translated Protein) 1.9 %Cys+Met (Translated Protein) 0.5 %Cys (Mature Protein) 1.4 %Met (Mature Protein) 1.9 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKKFTSKKVTRFVALFLISILVMSTIPVSADNSNTLNQIKKAEYSETYKQYLNDAKNGRT CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC EKYNGIIPNPYQLEGTQIQSKGRTAPTSYDPRKLGLMTSIKNQEDLGICWDFAAMATLES CCCCCCCCCCEEECCCEECCCCCCCCCCCCCHHHHHHHHCCCCCCCCEEHHHHHHHHHHH FLKLNNYGDYDLSEEHLRWWASDGEYGWSVDDMNGALNYEAMGYLTSWSGPKLEKDIPYN HHHHCCCCCCCCCHHHHHEEECCCCCCCEECCCCCCCCEEEEEEEECCCCCCCCCCCCCC GRVSKAQGAKKPTNMNTAPTVFNVTDAVCVSNDINSTKNAILQYGAVTSGYYEDIKYQSD CCCCCCCCCCCCCCCCCCCCEEECCCCEEECCCCCHHHHHHHHHCCCCCCHHHHCCCCCC DQNSYYCPTKSFNTNHAISIVGWDDNYSKDNFNANIRPSKNGAWLIKNSWGDYNSEGGYF CCCCEECCCCCCCCCCEEEEEECCCCCCCCCCCCEECCCCCCEEEEECCCCCCCCCCCEE WISYEDKTLMSDIDNFSIKGGKKPNDDEKMYQHDYASIVPLISKKITAANVFDFNRGDET EEEECCCHHHHCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHCEEEEEEECCCCHHH LKSVMFLTESIGAKYEVYYAPVVNGIPQENNMKKLKEGTAQYSGYITVPIDSFDIPEGKG HHHHHHHHHHCCCEEEEEEEHHCCCCCCCCCHHHHHHHHHHHCCEEEEEECCCCCCCCCC AIVVSIEGKNGESTIGSESNVPGYDTFKAKANLGESYIIDNTGKFFDINRDSNFYPCNFT EEEEEEECCCCCCCCCCCCCCCCCCEEEHHCCCCCEEEEECCCCEEEECCCCCEEECEEE IKAVTEKSSGESIPNESLIGSDRYETAIKVSQNGFNSSENVVLVNGSSIVDALAATPFTS EEEEEECCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEECCHHHHHHHCCCHHH AINSPILLTQKEALNSKTKAEIQRLGAKKVYLIGGENSISKEIEQQLKSLNISIERISGS HCCCCEEEEEHHHHCCHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCCEEEEECCC DRYKTSLLLAQKLNGIKNVSQIAVVNGVKGLADAISVGAAAAENNIPIILANEKSELQGA CHHHHHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCEEEECCHHHHCCH DEFLNSLNIEKSYIIGGTASLSNNLESKLKNPTRLSGSSRDETNSKIIDNFYKKDTLKNA HHHHHHCCCCCEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCE FVVKNGIKNQNDLIDGLAVGPLGAKTGSPVILVGDKLADSQKEVLKNKTLEKVTQVGGGA EEEECCCCCCHHHHCCEEECCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCCC NKNAFKELVKLKSAK CHHHHHHHHHHHCCC >Mature Secondary Structure MKKFTSKKVTRFVALFLISILVMSTIPVSADNSNTLNQIKKAEYSETYKQYLNDAKNGRT CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC EKYNGIIPNPYQLEGTQIQSKGRTAPTSYDPRKLGLMTSIKNQEDLGICWDFAAMATLES CCCCCCCCCCEEECCCEECCCCCCCCCCCCCHHHHHHHHCCCCCCCCEEHHHHHHHHHHH FLKLNNYGDYDLSEEHLRWWASDGEYGWSVDDMNGALNYEAMGYLTSWSGPKLEKDIPYN HHHHCCCCCCCCCHHHHHEEECCCCCCCEECCCCCCCCEEEEEEEECCCCCCCCCCCCCC GRVSKAQGAKKPTNMNTAPTVFNVTDAVCVSNDINSTKNAILQYGAVTSGYYEDIKYQSD CCCCCCCCCCCCCCCCCCCCEEECCCCEEECCCCCHHHHHHHHHCCCCCCHHHHCCCCCC DQNSYYCPTKSFNTNHAISIVGWDDNYSKDNFNANIRPSKNGAWLIKNSWGDYNSEGGYF CCCCEECCCCCCCCCCEEEEEECCCCCCCCCCCCEECCCCCCEEEEECCCCCCCCCCCEE WISYEDKTLMSDIDNFSIKGGKKPNDDEKMYQHDYASIVPLISKKITAANVFDFNRGDET EEEECCCHHHHCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHCEEEEEEECCCCHHH LKSVMFLTESIGAKYEVYYAPVVNGIPQENNMKKLKEGTAQYSGYITVPIDSFDIPEGKG HHHHHHHHHHCCCEEEEEEEHHCCCCCCCCCHHHHHHHHHHHCCEEEEEECCCCCCCCCC AIVVSIEGKNGESTIGSESNVPGYDTFKAKANLGESYIIDNTGKFFDINRDSNFYPCNFT EEEEEEECCCCCCCCCCCCCCCCCCEEEHHCCCCCEEEEECCCCEEEECCCCCEEECEEE IKAVTEKSSGESIPNESLIGSDRYETAIKVSQNGFNSSENVVLVNGSSIVDALAATPFTS EEEEEECCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEECCHHHHHHHCCCHHH AINSPILLTQKEALNSKTKAEIQRLGAKKVYLIGGENSISKEIEQQLKSLNISIERISGS HCCCCEEEEEHHHHCCHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCCEEEEECCC DRYKTSLLLAQKLNGIKNVSQIAVVNGVKGLADAISVGAAAAENNIPIILANEKSELQGA CHHHHHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCEEEECCHHHHCCH DEFLNSLNIEKSYIIGGTASLSNNLESKLKNPTRLSGSSRDETNSKIIDNFYKKDTLKNA HHHHHHCCCCCEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCE FVVKNGIKNQNDLIDGLAVGPLGAKTGSPVILVGDKLADSQKEVLKNKTLEKVTQVGGGA EEEECCCCCCHHHHCCEEECCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCCC NKNAFKELVKLKSAK CHHHHHHHHHHHCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 1357079; 1682302; 9384377 [H]