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The map label for this gene is iunH [H]

Identifier: 126699288

GI number: 126699288

Start: 1956556

End: 1957524

Strand: Direct

Name: iunH [H]

Synonym: CD1682

Alternate gene names: 126699288

Gene position: 1956556-1957524 (Clockwise)

Preceding gene: 126699280

Following gene: 126699289

Centisome position: 45.6

GC content: 31.79

Gene sequence:

>969_bases
ATGGAAAAGAGAAAAGTAATAATTGATTGTGACCCAGGAATTGATGATTCTTTGGCAATTCTTCTGGCTTTAAACTCACC
AGAGTTAGAAGTAATTGGAATTACCACATGTTGTGGAAATGTCCCAGCAAATATAGGTGCAGAAAATGCACTAAAAACAC
TTCAAATGTGTTCTTCACTAAATATTCCAGTATATATAGGAGAAGAAGCACCACTAAAAAGAAAACTTGTAACAGCTCAA
GATACACATGGAGAAGATGGTATTGGAGAAAACTTTTATCAAAAGGTTGTAGGAGCTAAAGCAAAAAATGGAGCAGTGGA
TTTTATAATAAATACTTTATATAATCATGAAAAAGTATCAATAATAGCACTTGCACCACTTACAAACATAGCTAAAGCAC
TTATTAAAGATAAGAAAGCATTTGAAAATCTCGATGAGTTTGTATCTATGGGAGGAGCATTTAGGATTCATGGAAATTGC
TCTCCAGTAGCAGAGTTTAATTATTGGGTAGACCCACATGGAGCAGATTATGTTTACAAGAATTTATCTAAAAAAATCCA
CATGGTAGGTTTAGATGTAACTAGAAAAATTGTACTTACTCCTAATATTATTGAGTTTATAAATAGACTTGATAAGAAGA
TGGCAAAGTATATAACTGAAATAACTAGATTTTATATTGATTTCCATTGGGAACAGGAGGGAATAATTGGCTGTGTGATA
AATGACCCTCTAGCAGTAGCATACTTTATAGATAGAAGTATATGTAAAGGATTTGAATCATATGTAGAAGTTGTAGAAGA
TGGAATAGCTATGGGTCAGTCTATAGTGGATTCTTTCAATTTCTATAAAAAAAATCCTAATGCAATTGTTCTAAATGAAG
TTGATGAGAAGAAATTTATGTACATGTTTTTAAAGAGGCTTTTTAAAGGTTATGAAGACATTATAGACTCTGTGGAAGGA
GTGATATAG

Upstream 100 bases:

>100_bases
ATATAGTGGCAGTATATAATTAATACCCTTAGACACACCTTTTTGAAAGTGGAAAAAAGATGTGTAGTTCTCCTCGACCA
CAAATCAAGGAGGATAAAAA

Downstream 100 bases:

>100_bases
TGTGAAAAGAAAAATATGTGTAAAAACTATTACACTTATAGCTTTTGGTATTTCTATAAATATAATAGGCGCTTTTATAG
CTATGGGATTAAGATTACCT

Product: inosine-uridine preferring nucleoside hydrolase

Products: cytosine; ribose; uracil [C]

Alternate protein names: Cytidine/uridine-specific hydrolase [H]

Number of amino acids: Translated: 322; Mature: 322

Protein sequence:

>322_residues
MEKRKVIIDCDPGIDDSLAILLALNSPELEVIGITTCCGNVPANIGAENALKTLQMCSSLNIPVYIGEEAPLKRKLVTAQ
DTHGEDGIGENFYQKVVGAKAKNGAVDFIINTLYNHEKVSIIALAPLTNIAKALIKDKKAFENLDEFVSMGGAFRIHGNC
SPVAEFNYWVDPHGADYVYKNLSKKIHMVGLDVTRKIVLTPNIIEFINRLDKKMAKYITEITRFYIDFHWEQEGIIGCVI
NDPLAVAYFIDRSICKGFESYVEVVEDGIAMGQSIVDSFNFYKKNPNAIVLNEVDEKKFMYMFLKRLFKGYEDIIDSVEG
VI

Sequences:

>Translated_322_residues
MEKRKVIIDCDPGIDDSLAILLALNSPELEVIGITTCCGNVPANIGAENALKTLQMCSSLNIPVYIGEEAPLKRKLVTAQ
DTHGEDGIGENFYQKVVGAKAKNGAVDFIINTLYNHEKVSIIALAPLTNIAKALIKDKKAFENLDEFVSMGGAFRIHGNC
SPVAEFNYWVDPHGADYVYKNLSKKIHMVGLDVTRKIVLTPNIIEFINRLDKKMAKYITEITRFYIDFHWEQEGIIGCVI
NDPLAVAYFIDRSICKGFESYVEVVEDGIAMGQSIVDSFNFYKKNPNAIVLNEVDEKKFMYMFLKRLFKGYEDIIDSVEG
VI
>Mature_322_residues
MEKRKVIIDCDPGIDDSLAILLALNSPELEVIGITTCCGNVPANIGAENALKTLQMCSSLNIPVYIGEEAPLKRKLVTAQ
DTHGEDGIGENFYQKVVGAKAKNGAVDFIINTLYNHEKVSIIALAPLTNIAKALIKDKKAFENLDEFVSMGGAFRIHGNC
SPVAEFNYWVDPHGADYVYKNLSKKIHMVGLDVTRKIVLTPNIIEFINRLDKKMAKYITEITRFYIDFHWEQEGIIGCVI
NDPLAVAYFIDRSICKGFESYVEVVEDGIAMGQSIVDSFNFYKKNPNAIVLNEVDEKKFMYMFLKRLFKGYEDIIDSVEG
VI

Specific function: Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively [H]

COG id: COG1957

COG function: function code F; Inosine-uridine nucleoside N-ribohydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IUNH family. RihA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788486, Length=313, Percent_Identity=32.2683706070287, Blast_Score=171, Evalue=7e-44,
Organism=Escherichia coli, GI1786871, Length=305, Percent_Identity=32.7868852459016, Blast_Score=169, Evalue=2e-43,
Organism=Escherichia coli, GI1786213, Length=302, Percent_Identity=31.1258278145695, Blast_Score=105, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI32565474, Length=296, Percent_Identity=30.4054054054054, Blast_Score=98, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17565698, Length=199, Percent_Identity=30.1507537688442, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320608, Length=276, Percent_Identity=31.5217391304348, Blast_Score=115, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24641839, Length=330, Percent_Identity=25.1515151515152, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24583915, Length=195, Percent_Identity=28.2051282051282, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24641837, Length=320, Percent_Identity=26.5625, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015910
- InterPro:   IPR023186
- InterPro:   IPR001910
- InterPro:   IPR022975 [H]

Pfam domain/function: PF01156 IU_nuc_hydro [H]

EC number: NA

Molecular weight: Translated: 36051; Mature: 36051

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKRKVIIDCDPGIDDSLAILLALNSPELEVIGITTCCGNVPANIGAENALKTLQMCSSL
CCCCEEEEECCCCCCCCEEEEEEECCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHCC
NIPVYIGEEAPLKRKLVTAQDTHGEDGIGENFYQKVVGAKAKNGAVDFIINTLYNHEKVS
CCCEEECCCCCCHHHEEECCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEE
IIALAPLTNIAKALIKDKKAFENLDEFVSMGGAFRIHGNCSPVAEFNYWVDPHGADYVYK
EEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCEEECCCCCHHHHH
NLSKKIHMVGLDVTRKIVLTPNIIEFINRLDKKMAKYITEITRFYIDFHWEQEGIIGCVI
HHHHEEEEEEECCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCEEEEEE
NDPLAVAYFIDRSICKGFESYVEVVEDGIAMGQSIVDSFNFYKKNPNAIVLNEVDEKKFM
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHH
YMFLKRLFKGYEDIIDSVEGVI
HHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MEKRKVIIDCDPGIDDSLAILLALNSPELEVIGITTCCGNVPANIGAENALKTLQMCSSL
CCCCEEEEECCCCCCCCEEEEEEECCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHCC
NIPVYIGEEAPLKRKLVTAQDTHGEDGIGENFYQKVVGAKAKNGAVDFIINTLYNHEKVS
CCCEEECCCCCCHHHEEECCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEE
IIALAPLTNIAKALIKDKKAFENLDEFVSMGGAFRIHGNCSPVAEFNYWVDPHGADYVYK
EEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCEEECCCCCHHHHH
NLSKKIHMVGLDVTRKIVLTPNIIEFINRLDKKMAKYITEITRFYIDFHWEQEGIIGCVI
HHHHEEEEEEECCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCEEEEEE
NDPLAVAYFIDRSICKGFESYVEVVEDGIAMGQSIVDSFNFYKKNPNAIVLNEVDEKKFM
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHH
YMFLKRLFKGYEDIIDSVEGVI
HHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: cytidine; H2O; uridine [C]

Specific reaction: cytidine + H2O = cytosine + ribose uridine + H2O = uracil + ribose [C]

General reaction: Pyrimidine-specific nucleoside hydrolase [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA