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The map label for this gene is gcvPB [H]

Identifier: 126699262

GI number: 126699262

Start: 1925216

End: 1926673

Strand: Direct

Name: gcvPB [H]

Synonym: CD1658

Alternate gene names: 126699262

Gene position: 1925216-1926673 (Clockwise)

Preceding gene: 126699261

Following gene: 126699263

Centisome position: 44.87

GC content: 33.4

Gene sequence:

>1458_bases
ATGAAAGAATACAATAGTTTGTTGATAGATATATCTAAAAAAGGTAGGAAAGCATACTCACTTCCAAAGTTAGATATAGA
TGATATAAAAATAGAAGATATGATTGACCAAGATATGGCAAGACAAAGTGAGTTGAATTTGCCAGAAGTTGGTGAATTAG
AATTAGTTAGACATTATACATTATTATCAAATAAAAACTTTGGAGTTGATACAGGTTTTTATCCTTTGGGTTCTTGTACT
ATGAAATATAATCCTAAAATAAATGAAGATATGGCAGCACTTCCAAACTTTACTGGAATGCATCCATACCAATCTTCGGA
TACAGCTCAAGGTTCTCTTTCTTTGATGTATGATTTATCAAGAAGACTTGCAGAAATTACAGGTATGGATGAAGTTACAC
TACAACCTTCAGCAGGTTCTCATGGTGAGTTTACAGGGCTTATGATTATAAAAGCATATCATGAAAATAGAGGTGACCAT
AAGAGAACCAAAGTGATAATTCCAGATTCTGCACATGGAACAAATCCAGCAAGTGCAGCTATGGCAAACTTTGATGTGAT
TCAAATAGCATCTGATAAAAATGGAGCTGTAGACATAAATGTATTAAAAGAGGTTTTGAATGATGAAGTAGCAGCTCTTA
TGCTTACTAATCCAAGTACTCTTGGTTTATTTGAAAAAAATATAAAAGAAATAGCTACTCTTGTACATGAAGCAGGAGGA
CTTTTGTACTATGATGGTGCAAACATGAACGCTATTATGGGGATAACAAGACCTGGAGATATGGGGTTTGATGTGGTTCA
TCTTAATCTTCATAAGACTTTTTCAACTCCTCATGGAGGTGGAGGTCCAGGAGCTGGTCCTGTTGGAGTTAAAAAAGAAT
TAGTACCTTTTTTACCAATACCAGTAATTGAAAGAAAAGAAGATAAGTATGTACTAAATTATGATAGAGAAAAATCTATT
GGGAAAATTAAAAATTTCTATGGTAATTTTGGAGTTCTTGTAAGAGCTTACACATATATACTAACTATGGGAAGGGATGG
ACTTAAAGAGGCTAGTGAAATGGCAGTTTTAAATGCTAATTATATAAAGGAAAGTATAAAAGATGATTATATTTTGCCAA
TAGATACCTTGTGTAAGCATGAGTTTGTATTAGGTGGATTGCCAAGAGGAGAGGCCAATATAAAAACTATCGATATTGCA
AAAAGACTACTAGATTATGGATACCATCCTCCAACAATGTACTTTCCTCTTATTATAAATGAGGCACTTATGATAGAACC
TACAGAAAGTGAGAGTATAGAGACATTAGATAGTTTTATAGAAGCTATGAAAAGTGTTGCTAAAGAGGCAAAGGAAGAAC
CAGAACTATTGAAAACTGCTCCACATAATACTTTGGTCAAAAGAGTAGATGATGCAAGGGCAGTAAAGAAACCTATACTA
ACATGGTCACAAAGATAA

Upstream 100 bases:

>100_bases
ACAATTATCCAGAATTAAAAAATTCAACTTTGCTTTGTGTGACTGAGAAAAGAAGCAAAGAGGAAATAGATAAGTTAGTT
GGAATAATGGAGGGATTATA

Downstream 100 bases:

>100_bases
ATAGTTAAAAAGTAGAGATTTAAAGTATAAAGAGAATTAAATTTATAAGAAAAAGCTATCTAACTTAATCTAGTTTAGAT
AGCTTTTTTGTATATTAGTA

Product: glycine dehydrogenase subunit 2

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 2; Glycine decarboxylase subunit 2 [H]

Number of amino acids: Translated: 485; Mature: 485

Protein sequence:

>485_residues
MKEYNSLLIDISKKGRKAYSLPKLDIDDIKIEDMIDQDMARQSELNLPEVGELELVRHYTLLSNKNFGVDTGFYPLGSCT
MKYNPKINEDMAALPNFTGMHPYQSSDTAQGSLSLMYDLSRRLAEITGMDEVTLQPSAGSHGEFTGLMIIKAYHENRGDH
KRTKVIIPDSAHGTNPASAAMANFDVIQIASDKNGAVDINVLKEVLNDEVAALMLTNPSTLGLFEKNIKEIATLVHEAGG
LLYYDGANMNAIMGITRPGDMGFDVVHLNLHKTFSTPHGGGGPGAGPVGVKKELVPFLPIPVIERKEDKYVLNYDREKSI
GKIKNFYGNFGVLVRAYTYILTMGRDGLKEASEMAVLNANYIKESIKDDYILPIDTLCKHEFVLGGLPRGEANIKTIDIA
KRLLDYGYHPPTMYFPLIINEALMIEPTESESIETLDSFIEAMKSVAKEAKEEPELLKTAPHNTLVKRVDDARAVKKPIL
TWSQR

Sequences:

>Translated_485_residues
MKEYNSLLIDISKKGRKAYSLPKLDIDDIKIEDMIDQDMARQSELNLPEVGELELVRHYTLLSNKNFGVDTGFYPLGSCT
MKYNPKINEDMAALPNFTGMHPYQSSDTAQGSLSLMYDLSRRLAEITGMDEVTLQPSAGSHGEFTGLMIIKAYHENRGDH
KRTKVIIPDSAHGTNPASAAMANFDVIQIASDKNGAVDINVLKEVLNDEVAALMLTNPSTLGLFEKNIKEIATLVHEAGG
LLYYDGANMNAIMGITRPGDMGFDVVHLNLHKTFSTPHGGGGPGAGPVGVKKELVPFLPIPVIERKEDKYVLNYDREKSI
GKIKNFYGNFGVLVRAYTYILTMGRDGLKEASEMAVLNANYIKESIKDDYILPIDTLCKHEFVLGGLPRGEANIKTIDIA
KRLLDYGYHPPTMYFPLIINEALMIEPTESESIETLDSFIEAMKSVAKEAKEEPELLKTAPHNTLVKRVDDARAVKKPIL
TWSQR
>Mature_485_residues
MKEYNSLLIDISKKGRKAYSLPKLDIDDIKIEDMIDQDMARQSELNLPEVGELELVRHYTLLSNKNFGVDTGFYPLGSCT
MKYNPKINEDMAALPNFTGMHPYQSSDTAQGSLSLMYDLSRRLAEITGMDEVTLQPSAGSHGEFTGLMIIKAYHENRGDH
KRTKVIIPDSAHGTNPASAAMANFDVIQIASDKNGAVDINVLKEVLNDEVAALMLTNPSTLGLFEKNIKEIATLVHEAGG
LLYYDGANMNAIMGITRPGDMGFDVVHLNLHKTFSTPHGGGGPGAGPVGVKKELVPFLPIPVIERKEDKYVLNYDREKSI
GKIKNFYGNFGVLVRAYTYILTMGRDGLKEASEMAVLNANYIKESIKDDYILPIDTLCKHEFVLGGLPRGEANIKTIDIA
KRLLDYGYHPPTMYFPLIINEALMIEPTESESIETLDSFIEAMKSVAKEAKEEPELLKTAPHNTLVKRVDDARAVKKPIL
TWSQR

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG1003

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. C-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=429, Percent_Identity=43.5897435897436, Blast_Score=307, Evalue=1e-83,
Organism=Escherichia coli, GI1789269, Length=463, Percent_Identity=40.6047516198704, Blast_Score=305, Evalue=6e-84,
Organism=Caenorhabditis elegans, GI17535605, Length=439, Percent_Identity=43.2801822323462, Blast_Score=314, Evalue=6e-86,
Organism=Caenorhabditis elegans, GI32564013, Length=397, Percent_Identity=43.5768261964735, Blast_Score=289, Evalue=3e-78,
Organism=Saccharomyces cerevisiae, GI6323843, Length=431, Percent_Identity=43.1554524361949, Blast_Score=324, Evalue=2e-89,
Organism=Drosophila melanogaster, GI24645648, Length=411, Percent_Identity=44.2822384428224, Blast_Score=306, Evalue=2e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023012
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF02347 GDC-P [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 53799; Mature: 53799

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEYNSLLIDISKKGRKAYSLPKLDIDDIKIEDMIDQDMARQSELNLPEVGELELVRHYT
CCCCCCEEEEECCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
LLSNKNFGVDTGFYPLGSCTMKYNPKINEDMAALPNFTGMHPYQSSDTAQGSLSLMYDLS
HHCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHH
RRLAEITGMDEVTLQPSAGSHGEFTGLMIIKAYHENRGDHKRTKVIIPDSAHGTNPASAA
HHHHHHCCCCCEEECCCCCCCCCEEEEEEEEEECCCCCCCCEEEEEECCCCCCCCCHHHH
MANFDVIQIASDKNGAVDINVLKEVLNDEVAALMLTNPSTLGLFEKNIKEIATLVHEAGG
HCCCEEEEEECCCCCCEEHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCCC
LLYYDGANMNAIMGITRPGDMGFDVVHLNLHKTFSTPHGGGGPGAGPVGVKKELVPFLPI
EEEECCCCCEEEEEECCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCCHHHCCCCCCC
PVIERKEDKYVLNYDREKSIGKIKNFYGNFGVLVRAYTYILTMGRDGLKEASEMAVLNAN
CCCCCCCCCEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHEEEHHHH
YIKESIKDDYILPIDTLCKHEFVLGGLPRGEANIKTIDIAKRLLDYGYHPPTMYFPLIIN
HHHHHHCCCCEECHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEHHHHC
EALMIEPTESESIETLDSFIEAMKSVAKEAKEEPELLKTAPHNTLVKRVDDARAVKKPIL
CEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHHHHH
TWSQR
CCCCC
>Mature Secondary Structure
MKEYNSLLIDISKKGRKAYSLPKLDIDDIKIEDMIDQDMARQSELNLPEVGELELVRHYT
CCCCCCEEEEECCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
LLSNKNFGVDTGFYPLGSCTMKYNPKINEDMAALPNFTGMHPYQSSDTAQGSLSLMYDLS
HHCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHH
RRLAEITGMDEVTLQPSAGSHGEFTGLMIIKAYHENRGDHKRTKVIIPDSAHGTNPASAA
HHHHHHCCCCCEEECCCCCCCCCEEEEEEEEEECCCCCCCCEEEEEECCCCCCCCCHHHH
MANFDVIQIASDKNGAVDINVLKEVLNDEVAALMLTNPSTLGLFEKNIKEIATLVHEAGG
HCCCEEEEEECCCCCCEEHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCCC
LLYYDGANMNAIMGITRPGDMGFDVVHLNLHKTFSTPHGGGGPGAGPVGVKKELVPFLPI
EEEECCCCCEEEEEECCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCCHHHCCCCCCC
PVIERKEDKYVLNYDREKSIGKIKNFYGNFGVLVRAYTYILTMGRDGLKEASEMAVLNAN
CCCCCCCCCEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHEEEHHHH
YIKESIKDDYILPIDTLCKHEFVLGGLPRGEANIKTIDIAKRLLDYGYHPPTMYFPLIIN
HHHHHHCCCCEECHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEHHHHC
EALMIEPTESESIETLDSFIEAMKSVAKEAKEEPELLKTAPHNTLVKRVDDARAVKKPIL
CEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHHHHH
TWSQR
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA