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The map label for this gene is folK [H]

Identifier: 126699056

GI number: 126699056

Start: 1681371

End: 1681877

Strand: Direct

Name: folK [H]

Synonym: CD1452

Alternate gene names: 126699056

Gene position: 1681371-1681877 (Clockwise)

Preceding gene: 126699055

Following gene: 126699057

Centisome position: 39.19

GC content: 30.57

Gene sequence:

>507_bases
ATGAATAAGGCTTATTTGGGAATAGGTACTAACATGGGTGATAGATTTGATAATTTATCAAGAGCATGTGAACTTTTGAA
AAATAGTGATTCTATATATAAAGTAAAAGAATCAAGCTTATACGAAACAAAACCATGGGGATATACAGAACAAGCAGATT
TTCTAAATATGTGTGTAGAAATAGAAACAGAGTTTGAACCTTATGAGTTGTTAGAATATTGTCAAGAAATAGAGAGAGAA
CTACATAGAGAGAGAATAGTTCATTGGGGACCAAGAACTATAGATGTAGACGTACTATTTTTTAATGATGTAGTTTCCAC
TGATGAAAGACTAACAATACCTCATCCAAGGATTCAAGATAGAGCTTTCGTTTTGATACCACTTATGGATTTAAATGAAG
AACTTATAATAAATGAAAAAACAATAAAAGAACATTTAAACCTCCTATCTGCTGAAGAAAGAGAAGAAGTAAAGGAGCTT
GTAGGTTATGAAAGAAAACCTATTTAA

Upstream 100 bases:

>100_bases
TTTATACTTATAAATGGAGTTATGGTCAGAGTTAGAAAGCCTGAGGCTCCTGTAAATGGTATTTATGACTATTTTGGTGT
TGAGATAAGGAGAGCAAGAG

Downstream 100 bases:

>100_bases
TAATAATTCAAAGATAGAGATAAATACAAATAACAAAAAGATAACTGTAAAAAAAGATAAACTTATAATAGCTGGACCAT
GTGCAATAGAGAGTTATGAG

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 168; Mature: 168

Protein sequence:

>168_residues
MNKAYLGIGTNMGDRFDNLSRACELLKNSDSIYKVKESSLYETKPWGYTEQADFLNMCVEIETEFEPYELLEYCQEIERE
LHRERIVHWGPRTIDVDVLFFNDVVSTDERLTIPHPRIQDRAFVLIPLMDLNEELIINEKTIKEHLNLLSAEEREEVKEL
VGYERKPI

Sequences:

>Translated_168_residues
MNKAYLGIGTNMGDRFDNLSRACELLKNSDSIYKVKESSLYETKPWGYTEQADFLNMCVEIETEFEPYELLEYCQEIERE
LHRERIVHWGPRTIDVDVLFFNDVVSTDERLTIPHPRIQDRAFVLIPLMDLNEELIINEKTIKEHLNLLSAEEREEVKEL
VGYERKPI
>Mature_168_residues
MNKAYLGIGTNMGDRFDNLSRACELLKNSDSIYKVKESSLYETKPWGYTEQADFLNMCVEIETEFEPYELLEYCQEIERE
LHRERIVHWGPRTIDVDVLFFNDVVSTDERLTIPHPRIQDRAFVLIPLMDLNEELIINEKTIKEHLNLLSAEEREEVKEL
VGYERKPI

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=138, Percent_Identity=37.6811594202899, Blast_Score=106, Evalue=9e-25,
Organism=Saccharomyces cerevisiae, GI6324073, Length=163, Percent_Identity=37.4233128834356, Blast_Score=110, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 19869; Mature: 19869

Theoretical pI: Translated: 4.39; Mature: 4.39

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKAYLGIGTNMGDRFDNLSRACELLKNSDSIYKVKESSLYETKPWGYTEQADFLNMCVE
CCCEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHH
IETEFEPYELLEYCQEIERELHRERIVHWGPRTIDVDVLFFNDVVSTDERLTIPHPRIQD
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCHHCCCCEEECCCCCCCC
RAFVLIPLMDLNEELIINEKTIKEHLNLLSAEEREEVKELVGYERKPI
CEEEEEEECCCCCCEEECHHHHHHHHHHHCCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNKAYLGIGTNMGDRFDNLSRACELLKNSDSIYKVKESSLYETKPWGYTEQADFLNMCVE
CCCEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHH
IETEFEPYELLEYCQEIERELHRERIVHWGPRTIDVDVLFFNDVVSTDERLTIPHPRIQD
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCHHCCCCEEECCCCCCCC
RAFVLIPLMDLNEELIINEKTIKEHLNLLSAEEREEVKELVGYERKPI
CEEEEEEECCCCCCEEECHHHHHHHHHHHCCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9168622 [H]