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The map label for this gene is cocE [H]

Identifier: 126698993

GI number: 126698993

Start: 1610489

End: 1612204

Strand: Direct

Name: cocE [H]

Synonym: CD1391

Alternate gene names: 126698993

Gene position: 1610489-1612204 (Clockwise)

Preceding gene: 126698992

Following gene: 126698995

Centisome position: 37.54

GC content: 30.77

Gene sequence:

>1716_bases
ATGGATGGATATGAAGAGTATACTGTATTAAAAGAATGGGAAAAAACTCATAAAAATGAAGAGATATATTCTATAAGATT
TGGTGGAAATTATATGATTGATATGAAAGATGGTATAAAACTTTCTACAGATGTATATCTCCCTGATTTTGTAGATTCTG
CCAAAAAAGCACCGACAATTCTTATGAGAACTCCATATGGAAAAGAAAATGATAAAGAAATATATTATAAATATGTACAA
AGAGGATATGCTGTTGTAATACAAGATGTTAGGGGAAGAAATGAATCAGAAGGTAAGTGGGAACCTATGATTCATGAGAG
GGAAGATGGAGATAGTACCATAAATTGGATAGTATCACAGGAATGGTCAAGTGGAATAGTTGGAATGCTTGGAGCATCAT
ATCTTGGTTATGTCCAATGGGCAGCTGCATCTTCAGGCAATAAGCATCTTAAAGCTTTAGTTAGTATAGTAACATCAGGA
AGCCCTTTTATTGATATACCAAGAAAAGGAGGAGCTTTTGTATCTGGTATGCTTGCATGGGCATTTATGGTATCAAGAAA
TAAAGTTGATAGAAGCAAAATGGTAAGAGATGATTGGGATGATGTTTTAAACATACGACCAATAGAAAATATACCTGTTG
AAGCTCTTGGATATAGAATTGAATTTCTGGAAGAATGGTTAAAGAGAGTAGAAAAAGATGAGTATTGGGATTTGATGGAC
TGGCATTTACAAAAAGATAAAATAAATGTACCTGCATTGGTTGTATCTGGGTGGTATGATGATAATAGTATGGGAACTAC
AGAGGCCTTAGATGTTATAAAGGACTATGAAAAAGGAAAGAGAAAGGCTATTCTAGGTCCATGGATGCATAATTCAAATA
CTTTAAGAGATATAAATGGTATTTCTTTAGGAAATAGTTCATTAAGATATGATTTGGATTATAATTATCTATTATGGTTT
GATAAATACTTAAAAGGTATAGAAAATAACATAGATACGACTGCTCCAGTAGAGTATTACTCTGTAGGTTCTAATAAGTG
GAAGACAGAAGAAAATTGGCCAATAATAAATAAGATAGATAAAAGTATGTATCTAATAAGTGATGGAAATGCTAACACAT
CTTTAGGAAATGGTAGATTAGTATTTGATAATGATTTAGAAGAAAAGTATGATAGTTATATATATAATCCAAAAGACCCA
TCAGTACAACTAATTGATATGTCAGAGAATGAAGTTGGAGTTCCAAATAACTACAAAGATTTAGAAAAAAGAAGTGATAT
GTTGTGTTATACATCAGATGCTTTTAGTGAAGAATTTACTGTAACAGGTGATATAAAGTTAGAGTTTTTTGCATCAAGTT
CTGCCAAAGATACTGACTGGGTTATAAAAATTATGGACGTGGATTTAGATGGAAATTCAATTAAATTAGCTGATGGTATA
CTTAGTGCTAGATTTAGAAATAGTTTTTATAAGTCAGAGTTTATGGAAGAAGGAGAGATTTATAAGTTTACGATTATAAC
TTCAAAAATATCAAACACGTTTAAAGTTGGTCATAAAATTAGACTAGATATAACGTCTAGTGCTAAAAACTTTATTTTCC
AAAATAGCAACACGACAGAGGGATATAATAGTATTGAATATATAGAAGCAAAGAATATGATTTATCATGGAGGTAAATAT
CCATCTAAATTGATATTGCCAATAGAGAATAAGTAA

Upstream 100 bases:

>100_bases
GGTTCAAAGAAACAAAAAGTTCCCACTAGATATAATTATTGTAGATAATAAAATAGTAGGTTTTATCTGTTTATCTAGAG
AAACTTGTACTATATTAATT

Downstream 100 bases:

>100_bases
ATTTATATAGATTAAATAGTGAGGAGGTGTCTCAAAATGAATTTTTTAGTTCGTGAGACACTTTCTTTTATACGAAATCA
AATATATTTTCATCATTTCA

Product: esterase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 571; Mature: 571

Protein sequence:

>571_residues
MDGYEEYTVLKEWEKTHKNEEIYSIRFGGNYMIDMKDGIKLSTDVYLPDFVDSAKKAPTILMRTPYGKENDKEIYYKYVQ
RGYAVVIQDVRGRNESEGKWEPMIHEREDGDSTINWIVSQEWSSGIVGMLGASYLGYVQWAAASSGNKHLKALVSIVTSG
SPFIDIPRKGGAFVSGMLAWAFMVSRNKVDRSKMVRDDWDDVLNIRPIENIPVEALGYRIEFLEEWLKRVEKDEYWDLMD
WHLQKDKINVPALVVSGWYDDNSMGTTEALDVIKDYEKGKRKAILGPWMHNSNTLRDINGISLGNSSLRYDLDYNYLLWF
DKYLKGIENNIDTTAPVEYYSVGSNKWKTEENWPIINKIDKSMYLISDGNANTSLGNGRLVFDNDLEEKYDSYIYNPKDP
SVQLIDMSENEVGVPNNYKDLEKRSDMLCYTSDAFSEEFTVTGDIKLEFFASSSAKDTDWVIKIMDVDLDGNSIKLADGI
LSARFRNSFYKSEFMEEGEIYKFTIITSKISNTFKVGHKIRLDITSSAKNFIFQNSNTTEGYNSIEYIEAKNMIYHGGKY
PSKLILPIENK

Sequences:

>Translated_571_residues
MDGYEEYTVLKEWEKTHKNEEIYSIRFGGNYMIDMKDGIKLSTDVYLPDFVDSAKKAPTILMRTPYGKENDKEIYYKYVQ
RGYAVVIQDVRGRNESEGKWEPMIHEREDGDSTINWIVSQEWSSGIVGMLGASYLGYVQWAAASSGNKHLKALVSIVTSG
SPFIDIPRKGGAFVSGMLAWAFMVSRNKVDRSKMVRDDWDDVLNIRPIENIPVEALGYRIEFLEEWLKRVEKDEYWDLMD
WHLQKDKINVPALVVSGWYDDNSMGTTEALDVIKDYEKGKRKAILGPWMHNSNTLRDINGISLGNSSLRYDLDYNYLLWF
DKYLKGIENNIDTTAPVEYYSVGSNKWKTEENWPIINKIDKSMYLISDGNANTSLGNGRLVFDNDLEEKYDSYIYNPKDP
SVQLIDMSENEVGVPNNYKDLEKRSDMLCYTSDAFSEEFTVTGDIKLEFFASSSAKDTDWVIKIMDVDLDGNSIKLADGI
LSARFRNSFYKSEFMEEGEIYKFTIITSKISNTFKVGHKIRLDITSSAKNFIFQNSNTTEGYNSIEYIEAKNMIYHGGKY
PSKLILPIENK
>Mature_571_residues
MDGYEEYTVLKEWEKTHKNEEIYSIRFGGNYMIDMKDGIKLSTDVYLPDFVDSAKKAPTILMRTPYGKENDKEIYYKYVQ
RGYAVVIQDVRGRNESEGKWEPMIHEREDGDSTINWIVSQEWSSGIVGMLGASYLGYVQWAAASSGNKHLKALVSIVTSG
SPFIDIPRKGGAFVSGMLAWAFMVSRNKVDRSKMVRDDWDDVLNIRPIENIPVEALGYRIEFLEEWLKRVEKDEYWDLMD
WHLQKDKINVPALVVSGWYDDNSMGTTEALDVIKDYEKGKRKAILGPWMHNSNTLRDINGISLGNSSLRYDLDYNYLLWF
DKYLKGIENNIDTTAPVEYYSVGSNKWKTEENWPIINKIDKSMYLISDGNANTSLGNGRLVFDNDLEEKYDSYIYNPKDP
SVQLIDMSENEVGVPNNYKDLEKRSDMLCYTSDAFSEEFTVTGDIKLEFFASSSAKDTDWVIKIMDVDLDGNSIKLADGI
LSARFRNSFYKSEFMEEGEIYKFTIITSKISNTFKVGHKIRLDITSSAKNFIFQNSNTTEGYNSIEYIEAKNMIYHGGKY
PSKLILPIENK

Specific function: Hydrolyzes cocaine to benzoate and ecgonine methyl ester, endowing the bacteria with the ability to utilize cocaine as a sole source of carbon and energy for growth, as this bacterium lives in the rhizosphere of coca plants [H]

COG id: COG2936

COG function: function code R; Predicted acyl esterases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alpha/beta hydrolase family. Carboxylesterase subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005674
- InterPro:   IPR008979
- InterPro:   IPR013736
- InterPro:   IPR000383 [H]

Pfam domain/function: PF02129 Peptidase_S15; PF08530 PepX_C [H]

EC number: NA

Molecular weight: Translated: 65698; Mature: 65698

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDGYEEYTVLKEWEKTHKNEEIYSIRFGGNYMIDMKDGIKLSTDVYLPDFVDSAKKAPTI
CCCHHHHHHHHHHHHHCCCCEEEEEEECCEEEEEECCCEEEEEEEECCHHHHHHHCCCEE
LMRTPYGKENDKEIYYKYVQRGYAVVIQDVRGRNESEGKWEPMIHEREDGDSTINWIVSQ
EEECCCCCCCCHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEEEC
EWSSGIVGMLGASYLGYVQWAAASSGNKHLKALVSIVTSGSPFIDIPRKGGAFVSGMLAW
CCCCCHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHH
AFMVSRNKVDRSKMVRDDWDDVLNIRPIENIPVEALGYRIEFLEEWLKRVEKDEYWDLMD
HHHHHCCCCCHHHHHHCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHH
WHLQKDKINVPALVVSGWYDDNSMGTTEALDVIKDYEKGKRKAILGPWMHNSNTLRDING
HEECCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHCCCCCEEECCCCCCCCCEEECCC
ISLGNSSLRYDLDYNYLLWFDKYLKGIENNIDTTAPVEYYSVGSNKWKTEENWPIINKID
EEECCCCEEEECCCCEEEHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCHHHCCC
KSMYLISDGNANTSLGNGRLVFDNDLEEKYDSYIYNPKDPSVQLIDMSENEVGVPNNYKD
CEEEEEECCCCCCCCCCCEEEECCCHHHHHHHCEECCCCCCEEEEECCCCCCCCCCCHHH
LEKRSDMLCYTSDAFSEEFTVTGDIKLEFFASSSAKDTDWVIKIMDVDLDGNSIKLADGI
HHHHCCEEEEECCCCCCCEEEEEEEEEEEEECCCCCCCCEEEEEEEEECCCCEEEEHHHH
LSARFRNSFYKSEFMEEGEIYKFTIITSKISNTFKVGHKIRLDITSSAKNFIFQNSNTTE
HHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCEECCCEEEEEEECCCCCEEEECCCCCC
GYNSIEYIEAKNMIYHGGKYPSKLILPIENK
CCCCEEEEEECCEEEECCCCCCEEEEEECCC
>Mature Secondary Structure
MDGYEEYTVLKEWEKTHKNEEIYSIRFGGNYMIDMKDGIKLSTDVYLPDFVDSAKKAPTI
CCCHHHHHHHHHHHHHCCCCEEEEEEECCEEEEEECCCEEEEEEEECCHHHHHHHCCCEE
LMRTPYGKENDKEIYYKYVQRGYAVVIQDVRGRNESEGKWEPMIHEREDGDSTINWIVSQ
EEECCCCCCCCHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEEEC
EWSSGIVGMLGASYLGYVQWAAASSGNKHLKALVSIVTSGSPFIDIPRKGGAFVSGMLAW
CCCCCHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHH
AFMVSRNKVDRSKMVRDDWDDVLNIRPIENIPVEALGYRIEFLEEWLKRVEKDEYWDLMD
HHHHHCCCCCHHHHHHCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHH
WHLQKDKINVPALVVSGWYDDNSMGTTEALDVIKDYEKGKRKAILGPWMHNSNTLRDING
HEECCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHCCCCCEEECCCCCCCCCEEECCC
ISLGNSSLRYDLDYNYLLWFDKYLKGIENNIDTTAPVEYYSVGSNKWKTEENWPIINKID
EEECCCCEEEECCCCEEEHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCHHHCCC
KSMYLISDGNANTSLGNGRLVFDNDLEEKYDSYIYNPKDPSVQLIDMSENEVGVPNNYKD
CEEEEEECCCCCCCCCCCEEEECCCHHHHHHHCEECCCCCCEEEEECCCCCCCCCCCHHH
LEKRSDMLCYTSDAFSEEFTVTGDIKLEFFASSSAKDTDWVIKIMDVDLDGNSIKLADGI
HHHHCCEEEEECCCCCCCEEEEEEEEEEEEECCCCCCCCEEEEEEEEECCCCEEEEHHHH
LSARFRNSFYKSEFMEEGEIYKFTIITSKISNTFKVGHKIRLDITSSAKNFIFQNSNTTE
HHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCEECCCEEEEEEECCCCCEEEECCCCCC
GYNSIEYIEAKNMIYHGGKYPSKLILPIENK
CCCCEEEEEECCEEEECCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10698749; 11742345; 12369817 [H]