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The map label for this gene is lldD [H]

Identifier: 126698860

GI number: 126698860

Start: 1468890

End: 1469906

Strand: Direct

Name: lldD [H]

Synonym: CD1263

Alternate gene names: 126698860

Gene position: 1468890-1469906 (Clockwise)

Preceding gene: 126698859

Following gene: 126698861

Centisome position: 34.24

GC content: 33.33

Gene sequence:

>1017_bases
ATGGAATATAATGAATTATTAAAAAGTGCTAGAGAAAATTTAAATGGAAGTTGTAAAGTTTGTAAGGTTTGTAATGGGGT
TGCTTGTGCAGGTGAAGTGCCTGGCATGGGAGGTAAAGGAAGTGGTTCTTCTTTTATAGAAAATAGCAAGAGTTTAGAAA
AAGTAAAAGTAAATATGAGAGTAATACATGATGTATCAAATCCTGATACATCTATAGAGATGTTTGGAAAGAAAATGAGT
GCACCTATATTTGCAGCTCCAGTAACAGGAACTACTTTAAATATGGGTGGAAAAATTAATGAAAGAGATTACATAGAACC
AGTAGTTGCAGGATGTGCTAATAGTGGTATTTATGCAATGGTTGGTGATACGGCAGTAGATGCTTTTTTAATGGAAAATT
TAGATGTAGTCAAAAAGTATAATGGAGCTGGAATTGTATTTATTAAACCTTGGGATAATGAAAATATTATAAAAAAGATA
AGATTAGCTGAAGAAGCTGGTGCATTTGCAGTTGGAGTTGATATAGATGCCTGTGGTCTAGTAACTTTATCATTACATGG
AAAACCAGTACTTCCTAAAAATGTTAAACAAATAAAGGAGTTAGTAAAGTCTACTAAACTACCATTTATATTGAAAGGTA
TAATGACTGTTGAAGATGCTTTAATGGCAGTAGAAGCAGGTGTGGATGCAATAGTTGTATCAAATCATGGAGGAAGAGTG
CTTGACTGTACACCAGGAGCATGTGAAGTTTTACCAAAAATTGCTGATGCTGTTAAAGGTAAAGTTACAATACTTGCAGA
TGGTGGAGTGAGAACTGGTTTAGACGTACTAAAAATGATAGGTTTAGGTGCAGATGCAGTATTAATAGGAAGACCTTTTG
TGACTGCTTCTTTTGGTGGTGCAACTGATGGTGTAGAAACTTATGTAAATAAACTTCAATCAGAGCTAAGTAGTTCTATG
ATATTAACTGGATGTCAAACTATAAAAGATATTGATGGAAAAGTTATATACAAATAA

Upstream 100 bases:

>100_bases
AACTCCTATCCACAGAAAAAGTTTTTTGAAAAATATACTGTAAATATAATATGATATAATGTATATAATATAAATTACTA
TAGTTAATGGGGGATTAAAG

Downstream 100 bases:

>100_bases
AATTTTATACAAAAAAGAGGAAAAATCATTTTAATGTAGAATAATTGTACAAAGGGGGAATTTATATGAGTAGAAAAGCT
TATGAAGAAGCCTTAGTAGA

Product: FMN-dependent dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MEYNELLKSARENLNGSCKVCKVCNGVACAGEVPGMGGKGSGSSFIENSKSLEKVKVNMRVIHDVSNPDTSIEMFGKKMS
APIFAAPVTGTTLNMGGKINERDYIEPVVAGCANSGIYAMVGDTAVDAFLMENLDVVKKYNGAGIVFIKPWDNENIIKKI
RLAEEAGAFAVGVDIDACGLVTLSLHGKPVLPKNVKQIKELVKSTKLPFILKGIMTVEDALMAVEAGVDAIVVSNHGGRV
LDCTPGACEVLPKIADAVKGKVTILADGGVRTGLDVLKMIGLGADAVLIGRPFVTASFGGATDGVETYVNKLQSELSSSM
ILTGCQTIKDIDGKVIYK

Sequences:

>Translated_338_residues
MEYNELLKSARENLNGSCKVCKVCNGVACAGEVPGMGGKGSGSSFIENSKSLEKVKVNMRVIHDVSNPDTSIEMFGKKMS
APIFAAPVTGTTLNMGGKINERDYIEPVVAGCANSGIYAMVGDTAVDAFLMENLDVVKKYNGAGIVFIKPWDNENIIKKI
RLAEEAGAFAVGVDIDACGLVTLSLHGKPVLPKNVKQIKELVKSTKLPFILKGIMTVEDALMAVEAGVDAIVVSNHGGRV
LDCTPGACEVLPKIADAVKGKVTILADGGVRTGLDVLKMIGLGADAVLIGRPFVTASFGGATDGVETYVNKLQSELSSSM
ILTGCQTIKDIDGKVIYK
>Mature_338_residues
MEYNELLKSARENLNGSCKVCKVCNGVACAGEVPGMGGKGSGSSFIENSKSLEKVKVNMRVIHDVSNPDTSIEMFGKKMS
APIFAAPVTGTTLNMGGKINERDYIEPVVAGCANSGIYAMVGDTAVDAFLMENLDVVKKYNGAGIVFIKPWDNENIIKKI
RLAEEAGAFAVGVDIDACGLVTLSLHGKPVLPKNVKQIKELVKSTKLPFILKGIMTVEDALMAVEAGVDAIVVSNHGGRV
LDCTPGACEVLPKIADAVKGKVTILADGGVRTGLDVLKMIGLGADAVLIGRPFVTASFGGATDGVETYVNKLQSELSSSM
ILTGCQTIKDIDGKVIYK

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI11068137, Length=345, Percent_Identity=28.9855072463768, Blast_Score=128, Evalue=7e-30,
Organism=Homo sapiens, GI54234014, Length=132, Percent_Identity=45.4545454545455, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI7705393, Length=132, Percent_Identity=45.4545454545455, Blast_Score=119, Evalue=6e-27,
Organism=Escherichia coli, GI1790033, Length=139, Percent_Identity=46.7625899280576, Blast_Score=124, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI193208036, Length=338, Percent_Identity=29.8816568047337, Blast_Score=127, Evalue=6e-30,
Organism=Saccharomyces cerevisiae, GI6323587, Length=141, Percent_Identity=42.5531914893617, Blast_Score=107, Evalue=3e-24,
Organism=Drosophila melanogaster, GI78707188, Length=342, Percent_Identity=28.0701754385965, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI281363140, Length=342, Percent_Identity=28.0701754385965, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI78707190, Length=342, Percent_Identity=28.0701754385965, Blast_Score=110, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259
- InterPro:   IPR020920 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.1.2.3 [H]

Molecular weight: Translated: 35530; Mature: 35530

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEYNELLKSARENLNGSCKVCKVCNGVACAGEVPGMGGKGSGSSFIENSKSLEKVKVNMR
CCHHHHHHHHHHCCCCCEEHHHHCCCEEECCCCCCCCCCCCCCHHHHCCCCHHHHEEEEE
VIHDVSNPDTSIEMFGKKMSAPIFAAPVTGTTLNMGGKINERDYIEPVVAGCANSGIYAM
EEEECCCCCCHHHHHHHHHCCCEEEECCCCCEEECCCCCCCHHHHHHHHHHCCCCCEEEE
VGDTAVDAFLMENLDVVKKYNGAGIVFIKPWDNENIIKKIRLAEEAGAFAVGVDIDACGL
ECHHHHHHHHHHCHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEECCCCCCCE
VTLSLHGKPVLPKNVKQIKELVKSTKLPFILKGIMTVEDALMAVEAGVDAIVVSNHGGRV
EEEEECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEE
LDCTPGACEVLPKIADAVKGKVTILADGGVRTGLDVLKMIGLGADAVLIGRPFVTASFGG
EECCCCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHCCCCCEEEECCCEEEEECCC
ATDGVETYVNKLQSELSSSMILTGCQTIKDIDGKVIYK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECC
>Mature Secondary Structure
MEYNELLKSARENLNGSCKVCKVCNGVACAGEVPGMGGKGSGSSFIENSKSLEKVKVNMR
CCHHHHHHHHHHCCCCCEEHHHHCCCEEECCCCCCCCCCCCCCHHHHCCCCHHHHEEEEE
VIHDVSNPDTSIEMFGKKMSAPIFAAPVTGTTLNMGGKINERDYIEPVVAGCANSGIYAM
EEEECCCCCCHHHHHHHHHCCCEEEECCCCCEEECCCCCCCHHHHHHHHHHCCCCCEEEE
VGDTAVDAFLMENLDVVKKYNGAGIVFIKPWDNENIIKKIRLAEEAGAFAVGVDIDACGL
ECHHHHHHHHHHCHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEECCCCCCCE
VTLSLHGKPVLPKNVKQIKELVKSTKLPFILKGIMTVEDALMAVEAGVDAIVVSNHGGRV
EEEEECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEE
LDCTPGACEVLPKIADAVKGKVTILADGGVRTGLDVLKMIGLGADAVLIGRPFVTASFGG
EECCCCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHCCCCCEEEECCCEEEEECCC
ATDGVETYVNKLQSELSSSMILTGCQTIKDIDGKVIYK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]