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The map label for this gene is ffh [H]

Identifier: 126698849

GI number: 126698849

Start: 1456109

End: 1457461

Strand: Direct

Name: ffh [H]

Synonym: CD1252

Alternate gene names: 126698849

Gene position: 1456109-1457461 (Clockwise)

Preceding gene: 126698848

Following gene: 126698850

Centisome position: 33.94

GC content: 33.33

Gene sequence:

>1353_bases
ATGATATTTGAAGGATTGTCTGATAAACTACAAGGGGCATTTAGTAAGTTAAAATCTAAAGGAAAACTTACAGAAGTAGA
TGTAAAAAATGCTATGAGAGAAGTTAAACTTGCTCTTCTTGAGGCAGATGTTAACTTTAAAGTAGTTAAAGATTTCATAA
AAAAAGTTCAAGAGAGATGTGTTGGGCAAGAAGTTATGCAAAGCTTAACTCCAGCTCAGCATGTAATCAAAATTGTAAAT
GAAGAGCTTACAAGTTTAATGGGAGATGTACAAAGTAAAGTAATGATTTCCTCAAAGCCTCCTACAATTTTAATGATGGT
TGGATTGCAAGGTGCAGGTAAGACTACTACAGCAGGAAAACTTGGAGGATATTTTAAAAAGCAAGGTAAAAAACCTCTAT
TAGTAGCTTGTGATATTTATAGACCAGCAGCTATAAAGCAACTTCAAGTTGTTGGAGAAAAATTGGATATACCTGTATTC
AATATGGGAGATAAAGAAAATCCAGTAAATATTGCGAAAGCAGGTTTAAACCATGCGATTAAAAATGCTAATGATTTAGT
TATTATAGATACAGCTGGTAGACTTCATATAGATGAAGTACTTATGGATGAGTTAAAGTCTATTAAATCAGAAGTTAAGC
CACATGAGATACTTTTGGTTGTAGATTCTATGACAGGTCAAGATGCTGTAAATGTTGCAGAAAGCTTCAATGAGGCACTT
GGTGTTGATGGAGTAGTATTAACTAAATTGGATGGAGATACTAGAGGTGGTGCTGCACTTTCAATAAGAGCAGTTACACA
AAAGCCTATAAAATTTATGGGGATGGGAGAAAAGCTAGATGATATAGAACCTTTCCACCCAGATAGAATGGCATCAAGAA
TATTAGGTATGGGAGATGTCTTAAGTTTAATAGAAAAAGCACAAGAAAATATAGACTTAGAGAAAGCTAAAGAATTAGAG
CAAAAAATTAAAAAACAAGAGCTTGATTTTGAAGATTTCTTACAACAAATGGAACAAATACAAAATATGGGACCTCTTGA
CAAGATACTTGGTATGATACCTGGTATGGGAAATGTAAAAGACCAACTTGGAGATGTAGATTTGAATGGCAAAGAAATGA
AGAGAACAAAAGCCATAATTCAGTCAATGACTACATATGAGAGAAGAAACCCAGGAGTATTAAATGCTTCAAGAAAGAAA
AGAATAGCTAAAGGCAGTGGAACTAGTGTACAAGATGTAAATAGACTTATAAAACAACTTAATGAAATGAAAAAAATGAT
GAAGATGTTTGCTGGTTCACAAAAGAGTATGAAGAAAAGGGGCGGCTTAGGCGGTTTACCTTTTTTTAAATAA

Upstream 100 bases:

>100_bases
AAATTATTGACATTAAAGAAGATTTATTGCACAATAGAGATTGTGCTAATTTAATCCCTAAGCTAGAAAATATAGAAGAT
GTATGTAGGGAGATGATAAA

Downstream 100 bases:

>100_bases
AATATAAAAAAGTAAAAATTATTCGGAGGTGACTGTAATGGCAGTTAAAATAAGATTAAAAAGAATGGGAGCTAACAAAA
AACCTTTCTACAGAATAGTA

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MIFEGLSDKLQGAFSKLKSKGKLTEVDVKNAMREVKLALLEADVNFKVVKDFIKKVQERCVGQEVMQSLTPAQHVIKIVN
EELTSLMGDVQSKVMISSKPPTILMMVGLQGAGKTTTAGKLGGYFKKQGKKPLLVACDIYRPAAIKQLQVVGEKLDIPVF
NMGDKENPVNIAKAGLNHAIKNANDLVIIDTAGRLHIDEVLMDELKSIKSEVKPHEILLVVDSMTGQDAVNVAESFNEAL
GVDGVVLTKLDGDTRGGAALSIRAVTQKPIKFMGMGEKLDDIEPFHPDRMASRILGMGDVLSLIEKAQENIDLEKAKELE
QKIKKQELDFEDFLQQMEQIQNMGPLDKILGMIPGMGNVKDQLGDVDLNGKEMKRTKAIIQSMTTYERRNPGVLNASRKK
RIAKGSGTSVQDVNRLIKQLNEMKKMMKMFAGSQKSMKKRGGLGGLPFFK

Sequences:

>Translated_450_residues
MIFEGLSDKLQGAFSKLKSKGKLTEVDVKNAMREVKLALLEADVNFKVVKDFIKKVQERCVGQEVMQSLTPAQHVIKIVN
EELTSLMGDVQSKVMISSKPPTILMMVGLQGAGKTTTAGKLGGYFKKQGKKPLLVACDIYRPAAIKQLQVVGEKLDIPVF
NMGDKENPVNIAKAGLNHAIKNANDLVIIDTAGRLHIDEVLMDELKSIKSEVKPHEILLVVDSMTGQDAVNVAESFNEAL
GVDGVVLTKLDGDTRGGAALSIRAVTQKPIKFMGMGEKLDDIEPFHPDRMASRILGMGDVLSLIEKAQENIDLEKAKELE
QKIKKQELDFEDFLQQMEQIQNMGPLDKILGMIPGMGNVKDQLGDVDLNGKEMKRTKAIIQSMTTYERRNPGVLNASRKK
RIAKGSGTSVQDVNRLIKQLNEMKKMMKMFAGSQKSMKKRGGLGGLPFFK
>Mature_450_residues
MIFEGLSDKLQGAFSKLKSKGKLTEVDVKNAMREVKLALLEADVNFKVVKDFIKKVQERCVGQEVMQSLTPAQHVIKIVN
EELTSLMGDVQSKVMISSKPPTILMMVGLQGAGKTTTAGKLGGYFKKQGKKPLLVACDIYRPAAIKQLQVVGEKLDIPVF
NMGDKENPVNIAKAGLNHAIKNANDLVIIDTAGRLHIDEVLMDELKSIKSEVKPHEILLVVDSMTGQDAVNVAESFNEAL
GVDGVVLTKLDGDTRGGAALSIRAVTQKPIKFMGMGEKLDDIEPFHPDRMASRILGMGDVLSLIEKAQENIDLEKAKELE
QKIKKQELDFEDFLQQMEQIQNMGPLDKILGMIPGMGNVKDQLGDVDLNGKEMKRTKAIIQSMTTYERRNPGVLNASRKK
RIAKGSGTSVQDVNRLIKQLNEMKKMMKMFAGSQKSMKKRGGLGGLPFFK

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=445, Percent_Identity=35.0561797752809, Blast_Score=241, Evalue=9e-64,
Organism=Homo sapiens, GI226371618, Length=341, Percent_Identity=36.0703812316716, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI89061728, Length=159, Percent_Identity=38.9937106918239, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI23308697, Length=210, Percent_Identity=29.5238095238095, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI295424842, Length=210, Percent_Identity=29.5238095238095, Blast_Score=102, Evalue=7e-22,
Organism=Escherichia coli, GI1788963, Length=430, Percent_Identity=50.6976744186047, Blast_Score=438, Evalue=1e-124,
Organism=Escherichia coli, GI1789874, Length=264, Percent_Identity=35.2272727272727, Blast_Score=166, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17539958, Length=433, Percent_Identity=30.715935334873, Blast_Score=232, Evalue=4e-61,
Organism=Caenorhabditis elegans, GI193206261, Length=258, Percent_Identity=29.4573643410853, Blast_Score=102, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6325345, Length=413, Percent_Identity=36.0774818401937, Blast_Score=242, Evalue=1e-64,
Organism=Saccharomyces cerevisiae, GI6320498, Length=304, Percent_Identity=26.9736842105263, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI17647949, Length=437, Percent_Identity=31.8077803203661, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI24641198, Length=219, Percent_Identity=26.9406392694064, Blast_Score=96, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 49561; Mature: 49561

Theoretical pI: Translated: 9.96; Mature: 9.96

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFEGLSDKLQGAFSKLKSKGKLTEVDVKNAMREVKLALLEADVNFKVVKDFIKKVQERC
CCCCCHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
VGQEVMQSLTPAQHVIKIVNEELTSLMGDVQSKVMISSKPPTILMMVGLQGAGKTTTAGK
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEEEECCCCCCCCCCHH
LGGYFKKQGKKPLLVACDIYRPAAIKQLQVVGEKLDIPVFNMGDKENPVNIAKAGLNHAI
HCCHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHHHH
KNANDLVIIDTAGRLHIDEVLMDELKSIKSEVKPHEILLVVDSMTGQDAVNVAESFNEAL
CCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHH
GVDGVVLTKLDGDTRGGAALSIRAVTQKPIKFMGMGEKLDDIEPFHPDRMASRILGMGDV
CCCCEEEEEECCCCCCCCEEEEEHHHHCCHHHHCCCCCCCCCCCCCHHHHHHHHHCHHHH
LSLIEKAQENIDLEKAKELEQKIKKQELDFEDFLQQMEQIQNMGPLDKILGMIPGMGNVK
HHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCHH
DQLGDVDLNGKEMKRTKAIIQSMTTYERRNPGVLNASRKKRIAKGSGTSVQDVNRLIKQL
HHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHH
NEMKKMMKMFAGSQKSMKKRGGLGGLPFFK
HHHHHHHHHHCCCHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MIFEGLSDKLQGAFSKLKSKGKLTEVDVKNAMREVKLALLEADVNFKVVKDFIKKVQERC
CCCCCHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
VGQEVMQSLTPAQHVIKIVNEELTSLMGDVQSKVMISSKPPTILMMVGLQGAGKTTTAGK
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEEEECCCCCCCCCCHH
LGGYFKKQGKKPLLVACDIYRPAAIKQLQVVGEKLDIPVFNMGDKENPVNIAKAGLNHAI
HCCHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHHHH
KNANDLVIIDTAGRLHIDEVLMDELKSIKSEVKPHEILLVVDSMTGQDAVNVAESFNEAL
CCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHH
GVDGVVLTKLDGDTRGGAALSIRAVTQKPIKFMGMGEKLDDIEPFHPDRMASRILGMGDV
CCCCEEEEEECCCCCCCCEEEEEHHHHCCHHHHCCCCCCCCCCCCCHHHHHHHHHCHHHH
LSLIEKAQENIDLEKAKELEQKIKKQELDFEDFLQQMEQIQNMGPLDKILGMIPGMGNVK
HHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCHH
DQLGDVDLNGKEMKRTKAIIQSMTTYERRNPGVLNASRKKRIAKGSGTSVQDVNRLIKQL
HHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHH
NEMKKMMKMFAGSQKSMKKRGGLGGLPFFK
HHHHHHHHHHCCCHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8335643; 9384377; 7511896 [H]