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The map label for this gene is rnc [H]

Identifier: 126698844

GI number: 126698844

Start: 1448918

End: 1449628

Strand: Direct

Name: rnc [H]

Synonym: CD1248

Alternate gene names: 126698844

Gene position: 1448918-1449628 (Clockwise)

Preceding gene: 126698843

Following gene: 126698845

Centisome position: 33.77

GC content: 28.97

Gene sequence:

>711_bases
ATGAAAATAAGTAAAAAATTACTAGATAATATACAAAGATTTGAAAATGTTATAAATTATAAATTTAAAAATAAAGAATA
TATACTAGAAGCTCTTACTCATAGTTCATATTCTAATGAAAATAAAAAATATAATTTTAACGAAAGATTGGAATTTTTAG
GGGATTCGGTTTTAGGCATAGTGATAAGTGATTATTTATTTAATGAAGAAGCTAATCTGCCCGAAGGGGAACTAACTAAA
CTTAGAGCAAATATAGTTTGTGAAGATTCATTAAGTGAAGTAGCTAATGATATAAATTTAGGTATTCACATGTTATTAGG
TAGAGGAGAAGAAGCAACAGGAGGAAGACATAGGACTTCAATTTTAGCAGACGCATTTGAAGCTGTAATAGCTGCTATAT
ATCTTGATGGAGGTTTTGAAAGTGCAAGACAGTTTATACTTCATCATATGGAAAATATAATTTATGATTCAAGAAAAGGA
AATATATTTAGAGACTACAAAACGCATCTTCAAGAGGTGTTACAAGGGAATGGAGAAAATAATATCTGGTACAGGCTTAT
AGAAGAAAAAGGACCAGACCATAATAAAAGATTTGTAATGGAAGTTGGAATTAATGACGATGTACTTGGTATAGGAGAAG
GCAAGAGTAAAAAAGAAGCTGAACAGTTAGCTGCTAAAATAGCTTTAAAGAAAAAATTATGGGAAAAATAA

Upstream 100 bases:

>100_bases
TATTTTTATGAGGAAGGGTATTATGTATTTTGGTTTTGCAATACTTGGACAAAAATAGTACACTAGAATTTATAGAATAG
GATTTTGGAGGGATGTAAAT

Downstream 100 bases:

>100_bases
ATATAATATGTAAAAATATAAAAAGAAATATTTATATTAGAAGGATGTTGTAGATGAAAAAGAGAATTATACCTATATTT
GTTCCTCACAAAGGATGTCC

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 236; Mature: 236

Protein sequence:

>236_residues
MKISKKLLDNIQRFENVINYKFKNKEYILEALTHSSYSNENKKYNFNERLEFLGDSVLGIVISDYLFNEEANLPEGELTK
LRANIVCEDSLSEVANDINLGIHMLLGRGEEATGGRHRTSILADAFEAVIAAIYLDGGFESARQFILHHMENIIYDSRKG
NIFRDYKTHLQEVLQGNGENNIWYRLIEEKGPDHNKRFVMEVGINDDVLGIGEGKSKKEAEQLAAKIALKKKLWEK

Sequences:

>Translated_236_residues
MKISKKLLDNIQRFENVINYKFKNKEYILEALTHSSYSNENKKYNFNERLEFLGDSVLGIVISDYLFNEEANLPEGELTK
LRANIVCEDSLSEVANDINLGIHMLLGRGEEATGGRHRTSILADAFEAVIAAIYLDGGFESARQFILHHMENIIYDSRKG
NIFRDYKTHLQEVLQGNGENNIWYRLIEEKGPDHNKRFVMEVGINDDVLGIGEGKSKKEAEQLAAKIALKKKLWEK
>Mature_236_residues
MKISKKLLDNIQRFENVINYKFKNKEYILEALTHSSYSNENKKYNFNERLEFLGDSVLGIVISDYLFNEEANLPEGELTK
LRANIVCEDSLSEVANDINLGIHMLLGRGEEATGGRHRTSILADAFEAVIAAIYLDGGFESARQFILHHMENIIYDSRKG
NIFRDYKTHLQEVLQGNGENNIWYRLIEEKGPDHNKRFVMEVGINDDVLGIGEGKSKKEAEQLAAKIALKKKLWEK

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030234, Length=238, Percent_Identity=26.890756302521, Blast_Score=88, Evalue=7e-18,
Organism=Homo sapiens, GI155030236, Length=238, Percent_Identity=26.890756302521, Blast_Score=88, Evalue=8e-18,
Organism=Homo sapiens, GI29294649, Length=263, Percent_Identity=26.9961977186312, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI29294651, Length=263, Percent_Identity=26.9961977186312, Blast_Score=70, Evalue=1e-12,
Organism=Escherichia coli, GI1788920, Length=210, Percent_Identity=34.7619047619048, Blast_Score=132, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI193202651, Length=238, Percent_Identity=27.7310924369748, Blast_Score=78, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17506883, Length=238, Percent_Identity=27.7310924369748, Blast_Score=78, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17552834, Length=256, Percent_Identity=27.734375, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17137682, Length=237, Percent_Identity=27.8481012658228, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17738129, Length=98, Percent_Identity=35.7142857142857, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 27024; Mature: 27024

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKISKKLLDNIQRFENVINYKFKNKEYILEALTHSSYSNENKKYNFNERLEFLGDSVLGI
CCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHH
VISDYLFNEEANLPEGELTKLRANIVCEDSLSEVANDINLGIHMLLGRGEEATGGRHRTS
HHHHHHHCCCCCCCCCHHHHHHHHEEEHHHHHHHHHHHHHHHHEEECCCCCCCCCHHHHH
ILADAFEAVIAAIYLDGGFESARQFILHHMENIIYDSRKGNIFRDYKTHLQEVLQGNGEN
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCC
NIWYRLIEEKGPDHNKRFVMEVGINDDVLGIGEGKSKKEAEQLAAKIALKKKLWEK
CCEEEEECCCCCCCCCEEEEEECCCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKISKKLLDNIQRFENVINYKFKNKEYILEALTHSSYSNENKKYNFNERLEFLGDSVLGI
CCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHH
VISDYLFNEEANLPEGELTKLRANIVCEDSLSEVANDINLGIHMLLGRGEEATGGRHRTS
HHHHHHHCCCCCCCCCHHHHHHHHEEEHHHHHHHHHHHHHHHHEEECCCCCCCCCHHHHH
ILADAFEAVIAAIYLDGGFESARQFILHHMENIIYDSRKGNIFRDYKTHLQEVLQGNGEN
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCC
NIWYRLIEEKGPDHNKRFVMEVGINDDVLGIGEGKSKKEAEQLAAKIALKKKLWEK
CCEEEEECCCCCCCCCEEEEEECCCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]