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The map label for this gene is deoD [H]

Identifier: 126698820

GI number: 126698820

Start: 1421866

End: 1422678

Strand: Direct

Name: deoD [H]

Synonym: CD1224

Alternate gene names: 126698820

Gene position: 1421866-1422678 (Clockwise)

Preceding gene: 126698819

Following gene: 126698821

Centisome position: 33.14

GC content: 32.47

Gene sequence:

>813_bases
ATGTTTGAAAAGATAGCACAAAGTAGTAAATTTATAAATTCTAAAAGTAATATAAAACCTAAGATTGGTTTGATATTAGG
TTCTGGACTAGGTGATTTAGCAAATGATATAGAAGACCCTGTCACAATTAAATATAGTGAAATTCCAAACTTCCCTGTAT
CAACAGTAGCAGGACATGCTGGACAACTTGTAATTGGAAAACTTGAAGGAAAAGAAGTTATTGCTATGCAAGGTAGATTT
CATTACTATGAAGGATATTCTCAGAAAGAAGCTACTTTTCCAGTAAGGGTTATGAAAGAATTAGGAGTCGAGATTCTTAT
AGTAACTAACGCTGCTGGAGGCGTAAATAAAGAATTTAAAGCAGGAGATTTGATGCTTATAAGAGACCATATAAACTTTA
GTGGAAGTAATCCATTAGTAGGAAAAAATGATGACAGATTTGGTGCTAGATTTCCAGATATGTCAGATGCATATTCTTCT
AAATATGTAGATGTAGTTAAAAACTGCGCTAAAGAATGTAATATAGATGTCAAAGAAGGCGTTTATATGTTTTTTAGTGG
TCCAAACTATGAAACATCAGCAGAAGTGAGAATGGCACAAATTTTGGGAGCTGATGCTGTAGGTATGTCTACTGTTCCAG
AAGTCATAGTGGCTTCTCACTCTAATATAGGAGTTATTGGTATATCTTGTATAACAAATATGGCTGCTGGCATCTTAAAT
CAACCACTAAGTCATGAGGAAGTAATAGAAACTACTCAAAAAGTTAAATCAGAATTTATGAATTTAGTTAAAACAACGGT
TAAAAATTTATAA

Upstream 100 bases:

>100_bases
CTAAATGTAAAGTTGCCTAAACATGGGTCAAGCTTTAAAGGAGATTTATTTTAAATTATAAAATGATAAAAACTTAGCTT
AATAGGATGGAGAGATTGGA

Downstream 100 bases:

>100_bases
GTTAAAGCTTATTATAGATTTTTTGAGGAAGTTTATAATAAAATAGTTAATGTTTAATTTGAAAAGAATTAATAAAAAGC
TGTCTTGATATAGAAAGTTA

Product: purine nucleoside phosphorylase

Products: NA

Alternate protein names: Inosine phosphorylase; Purine nucleoside phosphorylase I; PNP I; PU-NPase I [H]

Number of amino acids: Translated: 270; Mature: 270

Protein sequence:

>270_residues
MFEKIAQSSKFINSKSNIKPKIGLILGSGLGDLANDIEDPVTIKYSEIPNFPVSTVAGHAGQLVIGKLEGKEVIAMQGRF
HYYEGYSQKEATFPVRVMKELGVEILIVTNAAGGVNKEFKAGDLMLIRDHINFSGSNPLVGKNDDRFGARFPDMSDAYSS
KYVDVVKNCAKECNIDVKEGVYMFFSGPNYETSAEVRMAQILGADAVGMSTVPEVIVASHSNIGVIGISCITNMAAGILN
QPLSHEEVIETTQKVKSEFMNLVKTTVKNL

Sequences:

>Translated_270_residues
MFEKIAQSSKFINSKSNIKPKIGLILGSGLGDLANDIEDPVTIKYSEIPNFPVSTVAGHAGQLVIGKLEGKEVIAMQGRF
HYYEGYSQKEATFPVRVMKELGVEILIVTNAAGGVNKEFKAGDLMLIRDHINFSGSNPLVGKNDDRFGARFPDMSDAYSS
KYVDVVKNCAKECNIDVKEGVYMFFSGPNYETSAEVRMAQILGADAVGMSTVPEVIVASHSNIGVIGISCITNMAAGILN
QPLSHEEVIETTQKVKSEFMNLVKTTVKNL
>Mature_270_residues
MFEKIAQSSKFINSKSNIKPKIGLILGSGLGDLANDIEDPVTIKYSEIPNFPVSTVAGHAGQLVIGKLEGKEVIAMQGRF
HYYEGYSQKEATFPVRVMKELGVEILIVTNAAGGVNKEFKAGDLMLIRDHINFSGSNPLVGKNDDRFGARFPDMSDAYSS
KYVDVVKNCAKECNIDVKEGVYMFFSGPNYETSAEVRMAQILGADAVGMSTVPEVIVASHSNIGVIGISCITNMAAGILN
QPLSHEEVIETTQKVKSEFMNLVKTTVKNL

Specific function: Cleavage of guanosine or inosine to respective bases and sugar-1-phosphate molecules [H]

COG id: COG0005

COG function: function code F; Purine nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/MTAP phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI157168362, Length=271, Percent_Identity=47.9704797047971, Blast_Score=253, Evalue=1e-67,
Organism=Homo sapiens, GI47132622, Length=257, Percent_Identity=26.0700389105058, Blast_Score=75, Evalue=8e-14,
Organism=Escherichia coli, GI1788746, Length=249, Percent_Identity=47.7911646586345, Blast_Score=251, Evalue=4e-68,
Organism=Caenorhabditis elegans, GI17541190, Length=242, Percent_Identity=45.4545454545455, Blast_Score=216, Evalue=7e-57,
Organism=Saccharomyces cerevisiae, GI6323238, Length=283, Percent_Identity=43.1095406360424, Blast_Score=206, Evalue=2e-54,
Organism=Drosophila melanogaster, GI45552887, Length=280, Percent_Identity=47.5, Blast_Score=256, Evalue=8e-69,
Organism=Drosophila melanogaster, GI45552885, Length=280, Percent_Identity=47.5, Blast_Score=256, Evalue=9e-69,
Organism=Drosophila melanogaster, GI24656093, Length=280, Percent_Identity=47.5, Blast_Score=256, Evalue=1e-68,
Organism=Drosophila melanogaster, GI24656090, Length=280, Percent_Identity=47.5, Blast_Score=256, Evalue=1e-68,
Organism=Drosophila melanogaster, GI24762376, Length=240, Percent_Identity=37.9166666666667, Blast_Score=157, Evalue=7e-39,
Organism=Drosophila melanogaster, GI221459247, Length=264, Percent_Identity=24.2424242424242, Blast_Score=64, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011268
- InterPro:   IPR000845
- InterPro:   IPR011270
- InterPro:   IPR001369
- InterPro:   IPR018099 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: =2.4.2.1 [H]

Molecular weight: Translated: 29319; Mature: 29319

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFEKIAQSSKFINSKSNIKPKIGLILGSGLGDLANDIEDPVTIKYSEIPNFPVSTVAGHA
CCHHHHHHHHHCCCCCCCCCEEEEEEECCCHHHHHHCCCCEEEEECCCCCCCHHHHCCCC
GQLVIGKLEGKEVIAMQGRFHYYEGYSQKEATFPVRVMKELGVEILIVTNAAGGVNKEFK
CCEEEEECCCCEEEEECCCEEEECCCCCCCCCCHHHHHHHCCCEEEEEECCCCCCCCCCC
AGDLMLIRDHINFSGSNPLVGKNDDRFGARFPDMSDAYSSKYVDVVKNCAKECNIDVKEG
CCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHC
VYMFFSGPNYETSAEVRMAQILGADAVGMSTVPEVIVASHSNIGVIGISCITNMAAGILN
EEEEECCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHC
QPLSHEEVIETTQKVKSEFMNLVKTTVKNL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFEKIAQSSKFINSKSNIKPKIGLILGSGLGDLANDIEDPVTIKYSEIPNFPVSTVAGHA
CCHHHHHHHHHCCCCCCCCCEEEEEEECCCHHHHHHCCCCEEEEECCCCCCCHHHHCCCC
GQLVIGKLEGKEVIAMQGRFHYYEGYSQKEATFPVRVMKELGVEILIVTNAAGGVNKEFK
CCEEEEECCCCEEEEECCCEEEECCCCCCCCCCHHHHHHHCCCEEEEEECCCCCCCCCCC
AGDLMLIRDHINFSGSNPLVGKNDDRFGARFPDMSDAYSSKYVDVVKNCAKECNIDVKEG
CCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHC
VYMFFSGPNYETSAEVRMAQILGADAVGMSTVPEVIVASHSNIGVIGISCITNMAAGILN
EEEEECCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHC
QPLSHEEVIETTQKVKSEFMNLVKTTVKNL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10537218; 8969508; 9384377; 1629150 [H]