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The map label for this gene is fabF [H]

Identifier: 126698780

GI number: 126698780

Start: 1383344

End: 1384582

Strand: Direct

Name: fabF [H]

Synonym: CD1184

Alternate gene names: 126698780

Gene position: 1383344-1384582 (Clockwise)

Preceding gene: 126698779

Following gene: 126698781

Centisome position: 32.24

GC content: 34.3

Gene sequence:

>1239_bases
ATGAATAAAAGAGTAGTAATAACAGGACTTGGATGTGTTACGCCGTTGGGAACAGGAAAAGAAGAGTTCTGGAGTAATAT
AAAATCTGGAGTATCTGGTATAGATAAAATAACTAATTTTGATGCTAGCACATATCAAACTCAGATAGCAGGAGAAGTTA
AGAATTTTCATCCAGAAGAATATATAAGTAAAAAAGAATTGAAGAGATTAGATAAATTTGCTCAATTTGCAATAGTATCT
GCTAAATTAGCAGTTGAAGATGCAAATCTTGATTTAGATAAAGTTGATAGAGAACGTTTTGGTGTTATAATAGGTTCTGG
AATAGGTGGAGTTGAAGCTATAGAAACTCAACATAAAATTCTTTTGGAAAAAGGAAATAAAAGAGTAAGTTCACTTTTTG
TACCTATGATGATAGGAAATATGGCAGCTGGTCAAGTTTCAATATTTTTAGGAGCAAAAGGGCCTAACACTAATGTATGT
ACAGCTTGTGCATCAGGAACTCATTCAATAGGTGATGCTTTTAAGGTAATTCAAAGAGGTGATGCAGACATCATGGTAGC
AGGGGGCTCTGAAGCTGCTGTAACAGGTCTTGCTTTTGCTGGATTCTGTAACATGAAGGCTATGTCAACTAGAAATGATG
ACCCTAAAACTGCATCAAGACCATTTGATAAAGACAGAGATGGTTTTGTAATGGGAGAAGGAGCAGGTATTGTTATCTTA
GAAGACTTAGAACATGCTTTAGCAAGAGGCGCTAAAATATATGCAGAAGTAGTTGGATATGGTTTAACTGCTGATGCATA
CCATATGACAACTCCAGCTGAAAATGGAGAGGGAGCAGCTAGGTCTATGAATATGGCTTTGAAAGATGGAAATGTTCCAT
TAGAAGAAGTAGATTATATAAATGCTCATGGAACTTCAACTTATTACAATGATTTATATGAAACTATGGCTATAAAAACT
GTATTTGGAGAAAAGGCATATGACTTATGTGTGTCATCAACAAAATCTATGACTGGTCACTTATTAGGAGCATCAGGTGC
TATAGAGGCTGTTGTTTGTGCTATGAGTATAGAAGATAGTTTTGTGCCTCCAACTATAAACATACAAGAAGTTGGTGAAG
ATTTGGATTTAGATTATGTTCCAAATCAAGGTAAAGAAAAAAATATTAGATATGCACTATCAAATTCTTTAGGATTTGGT
GGGCATAATGCTACAATAGTACTAAAAAAATATGTATAA

Upstream 100 bases:

>100_bases
ATACCAGATACAGAAGCAGAAAACTTCAAATCTATAGGAGATATAGTTAAGTATATAGAAGCTAATAAATAGTCGAGCTT
TAAAAAAGTGGAGGTATCCG

Downstream 100 bases:

>100_bases
ATAAATATTAAATATAAAACTAAAAAACAAGCACTTGTTTTAACTGTATAAATTTATATTAGCTTAAATTTAAAGTCTCC
TAAATTATTTTAGGAGACTT

Product: 3-oxoacyl-[acyl-carrier-protein] synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 412; Mature: 412

Protein sequence:

>412_residues
MNKRVVITGLGCVTPLGTGKEEFWSNIKSGVSGIDKITNFDASTYQTQIAGEVKNFHPEEYISKKELKRLDKFAQFAIVS
AKLAVEDANLDLDKVDRERFGVIIGSGIGGVEAIETQHKILLEKGNKRVSSLFVPMMIGNMAAGQVSIFLGAKGPNTNVC
TACASGTHSIGDAFKVIQRGDADIMVAGGSEAAVTGLAFAGFCNMKAMSTRNDDPKTASRPFDKDRDGFVMGEGAGIVIL
EDLEHALARGAKIYAEVVGYGLTADAYHMTTPAENGEGAARSMNMALKDGNVPLEEVDYINAHGTSTYYNDLYETMAIKT
VFGEKAYDLCVSSTKSMTGHLLGASGAIEAVVCAMSIEDSFVPPTINIQEVGEDLDLDYVPNQGKEKNIRYALSNSLGFG
GHNATIVLKKYV

Sequences:

>Translated_412_residues
MNKRVVITGLGCVTPLGTGKEEFWSNIKSGVSGIDKITNFDASTYQTQIAGEVKNFHPEEYISKKELKRLDKFAQFAIVS
AKLAVEDANLDLDKVDRERFGVIIGSGIGGVEAIETQHKILLEKGNKRVSSLFVPMMIGNMAAGQVSIFLGAKGPNTNVC
TACASGTHSIGDAFKVIQRGDADIMVAGGSEAAVTGLAFAGFCNMKAMSTRNDDPKTASRPFDKDRDGFVMGEGAGIVIL
EDLEHALARGAKIYAEVVGYGLTADAYHMTTPAENGEGAARSMNMALKDGNVPLEEVDYINAHGTSTYYNDLYETMAIKT
VFGEKAYDLCVSSTKSMTGHLLGASGAIEAVVCAMSIEDSFVPPTINIQEVGEDLDLDYVPNQGKEKNIRYALSNSLGFG
GHNATIVLKKYV
>Mature_412_residues
MNKRVVITGLGCVTPLGTGKEEFWSNIKSGVSGIDKITNFDASTYQTQIAGEVKNFHPEEYISKKELKRLDKFAQFAIVS
AKLAVEDANLDLDKVDRERFGVIIGSGIGGVEAIETQHKILLEKGNKRVSSLFVPMMIGNMAAGQVSIFLGAKGPNTNVC
TACASGTHSIGDAFKVIQRGDADIMVAGGSEAAVTGLAFAGFCNMKAMSTRNDDPKTASRPFDKDRDGFVMGEGAGIVIL
EDLEHALARGAKIYAEVVGYGLTADAYHMTTPAENGEGAARSMNMALKDGNVPLEEVDYINAHGTSTYYNDLYETMAIKT
VFGEKAYDLCVSSTKSMTGHLLGASGAIEAVVCAMSIEDSFVPPTINIQEVGEDLDLDYVPNQGKEKNIRYALSNSLGFG
GHNATIVLKKYV

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=418, Percent_Identity=45.2153110047847, Blast_Score=350, Evalue=1e-96,
Organism=Homo sapiens, GI223972627, Length=176, Percent_Identity=44.3181818181818, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI41872631, Length=434, Percent_Identity=25.1152073732719, Blast_Score=98, Evalue=2e-20,
Organism=Escherichia coli, GI1787337, Length=409, Percent_Identity=49.8777506112469, Blast_Score=392, Evalue=1e-110,
Organism=Escherichia coli, GI1788663, Length=412, Percent_Identity=38.3495145631068, Blast_Score=255, Evalue=4e-69,
Organism=Caenorhabditis elegans, GI71983541, Length=416, Percent_Identity=37.2596153846154, Blast_Score=261, Evalue=4e-70,
Organism=Caenorhabditis elegans, GI71983535, Length=264, Percent_Identity=42.0454545454545, Blast_Score=210, Evalue=9e-55,
Organism=Caenorhabditis elegans, GI17550940, Length=283, Percent_Identity=27.5618374558304, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI212642053, Length=362, Percent_Identity=24.585635359116, Blast_Score=98, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6320904, Length=445, Percent_Identity=39.3258426966292, Blast_Score=295, Evalue=9e-81,
Organism=Saccharomyces cerevisiae, GI6325025, Length=175, Percent_Identity=29.7142857142857, Blast_Score=63, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24644341, Length=420, Percent_Identity=42.1428571428571, Blast_Score=346, Evalue=2e-95,
Organism=Drosophila melanogaster, GI221330659, Length=433, Percent_Identity=23.5565819861432, Blast_Score=95, Evalue=9e-20,
Organism=Drosophila melanogaster, GI19920632, Length=433, Percent_Identity=23.5565819861432, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24581345, Length=433, Percent_Identity=23.3256351039261, Blast_Score=82, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 44045; Mature: 44045

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS00606 B_KETOACYL_SYNTHASE ; PS00107 PROTEIN_KINASE_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKRVVITGLGCVTPLGTGKEEFWSNIKSGVSGIDKITNFDASTYQTQIAGEVKNFHPEE
CCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHH
YISKKELKRLDKFAQFAIVSAKLAVEDANLDLDKVDRERFGVIIGSGIGGVEAIETQHKI
HHHHHHHHHHHHHHHHHHEEEEEEEECCCCCHHHHCHHHCCEEEECCCCCHHHHHHHHHH
LLEKGNKRVSSLFVPMMIGNMAAGQVSIFLGAKGPNTNVCTACASGTHSIGDAFKVIQRG
HHHCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCEEEEECCCCCHHHHHHHHHHCC
DADIMVAGGSEAAVTGLAFAGFCNMKAMSTRNDDPKTASRPFDKDRDGFVMGEGAGIVIL
CCCEEEECCCCHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCEEEECCCCEEEE
EDLEHALARGAKIYAEVVGYGLTADAYHMTTPAENGEGAARSMNMALKDGNVPLEEVDYI
HHHHHHHHCCHHHHHHHHCCCCCCCCEEEECCCCCCCCCHHHEEEEEECCCCCHHHHCEE
NAHGTSTYYNDLYETMAIKTVFGEKAYDLCVSSTKSMTGHLLGASGAIEAVVCAMSIEDS
CCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHCEEECCCCCHHHEEEEEECCCC
FVPPTINIQEVGEDLDLDYVPNQGKEKNIRYALSNSLGFGGHNATIVLKKYV
CCCCCCCHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEEECC
>Mature Secondary Structure
MNKRVVITGLGCVTPLGTGKEEFWSNIKSGVSGIDKITNFDASTYQTQIAGEVKNFHPEE
CCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHH
YISKKELKRLDKFAQFAIVSAKLAVEDANLDLDKVDRERFGVIIGSGIGGVEAIETQHKI
HHHHHHHHHHHHHHHHHHEEEEEEEECCCCCHHHHCHHHCCEEEECCCCCHHHHHHHHHH
LLEKGNKRVSSLFVPMMIGNMAAGQVSIFLGAKGPNTNVCTACASGTHSIGDAFKVIQRG
HHHCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCEEEEECCCCCHHHHHHHHHHCC
DADIMVAGGSEAAVTGLAFAGFCNMKAMSTRNDDPKTASRPFDKDRDGFVMGEGAGIVIL
CCCEEEECCCCHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCEEEECCCCEEEE
EDLEHALARGAKIYAEVVGYGLTADAYHMTTPAENGEGAARSMNMALKDGNVPLEEVDYI
HHHHHHHHCCHHHHHHHHCCCCCCCCEEEECCCCCCCCCHHHEEEEEECCCCCHHHHCEE
NAHGTSTYYNDLYETMAIKTVFGEKAYDLCVSSTKSMTGHLLGASGAIEAVVCAMSIEDS
CCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHCEEECCCCCHHHEEEEEECCCC
FVPPTINIQEVGEDLDLDYVPNQGKEKNIRYALSNSLGFGGHNATIVLKKYV
CCCCCCCHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]