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The map label for this gene is moeA [H]

Identifier: 126698668

GI number: 126698668

Start: 1273574

End: 1274755

Strand: Direct

Name: moeA [H]

Synonym: CD1081

Alternate gene names: 126698668

Gene position: 1273574-1274755 (Clockwise)

Preceding gene: 126698667

Following gene: 126698669

Centisome position: 29.69

GC content: 28.51

Gene sequence:

>1182_bases
ATGATAGAATTAGAAGATGCCATAAAAATTATTGAAAAAAATGTTTTACCAATAAACAGGGTCAAGATAGTAAATCTTAT
AGATGCAGTAAATAAGGTAGTTGCAGAAGATATATATTCAACAATTGATAGTCCTCCATTTGATAGGTCACCCTATGATG
GTTATGCATATAATGCAAATTCTGAAAATAGAAATTTAAAGGTTATAGGGACTTTGTATGCAGGAGATGTATTTAATAGG
GTATTAAATAAAAATGAAGCAGTGAAGATAATGACTGGTGGAAAGATACCACAGGGTGCAAATTGTGTAATAAAAAAAGA
AGATGTAACAGTTATAGGTGATATGATAACCTTAAATATAAAATTAAAGGAATACGATAATTACATATTTAAGGGTGAGG
ATATAAAAAAGGGGCAATTGATTATTAATAAAAATCAGAATATAGGATATGATGGTATTGGAGTATTAGCAAGTCTTGGA
ATATCCAAAGTAACTGTTTATGATGATTTAAAAGTTGGAATTTTGAATACAGGTACAGAACTACAAGATATAAATGAGAC
TTTAGAGAATGGTAAAATATACGATAGTAATAGATATACCTTATATTCAAGATTATTAAAACTTGGAATACAAGCAGATA
CAATATGCAATTGTTCTGATGATATATTGGAGTTAGAAAAAAAGGTAAAGAATATGTTACAGAGTGTAGATTTTTTAATT
ACCACAGGTGGTGTTTCTGTTGGAGATAAAGATTTAATTCCAGATGTATTCAAAAAAATAGGGGCAACAGAATTATTTTG
GAAGATAAACATTAAACCTGGTGGAGCTTGTTATGTAGGTACATTGGGAGAAAAGCTATTATTTGGTCTTTCTGGTAATC
CACATGCAGCAATAGTGGTATTTGATAATGTGATAGTTCCTGTTATTGAGTATTTAACATATAAGAAGGGAACACATCAT
ATAAAAGCTATATTTAAAGGAGAATTTAATAAACTTTCAAATAAAGATAGATTTGTAAGTGGAAAACTATATACAAGTGA
AGGTAAATTGTATGTAGAGCTAAATGATAAGAAAGATGCAAAAGCTAGACTATCTGCAACTCTAAGAAGTAATTGTATGA
TTAAGATTAAAAAGAATGAGACAATAAAAGAAAATCAATTAGTGGATGTTGTTATTAGATAG

Upstream 100 bases:

>100_bases
TTATAATTAAATATAAGATAAAAGTATTTCCAACTTTTATAATCTATAATATATTACATAGAAATATCTTAAATAAAAAA
TATATTGGGGAGTATTTAAA

Downstream 100 bases:

>100_bases
TTTTATGAAAGGACACAATTTTATGTATAATATATTGTCAGTTGTCTCATATTCAGGAGTAGGTAAAACTACATTGATTG
AAGGCATAATAAAAGAATTA

Product: molybdopterin biosynthesis protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MIELEDAIKIIEKNVLPINRVKIVNLIDAVNKVVAEDIYSTIDSPPFDRSPYDGYAYNANSENRNLKVIGTLYAGDVFNR
VLNKNEAVKIMTGGKIPQGANCVIKKEDVTVIGDMITLNIKLKEYDNYIFKGEDIKKGQLIINKNQNIGYDGIGVLASLG
ISKVTVYDDLKVGILNTGTELQDINETLENGKIYDSNRYTLYSRLLKLGIQADTICNCSDDILELEKKVKNMLQSVDFLI
TTGGVSVGDKDLIPDVFKKIGATELFWKINIKPGGACYVGTLGEKLLFGLSGNPHAAIVVFDNVIVPVIEYLTYKKGTHH
IKAIFKGEFNKLSNKDRFVSGKLYTSEGKLYVELNDKKDAKARLSATLRSNCMIKIKKNETIKENQLVDVVIR

Sequences:

>Translated_393_residues
MIELEDAIKIIEKNVLPINRVKIVNLIDAVNKVVAEDIYSTIDSPPFDRSPYDGYAYNANSENRNLKVIGTLYAGDVFNR
VLNKNEAVKIMTGGKIPQGANCVIKKEDVTVIGDMITLNIKLKEYDNYIFKGEDIKKGQLIINKNQNIGYDGIGVLASLG
ISKVTVYDDLKVGILNTGTELQDINETLENGKIYDSNRYTLYSRLLKLGIQADTICNCSDDILELEKKVKNMLQSVDFLI
TTGGVSVGDKDLIPDVFKKIGATELFWKINIKPGGACYVGTLGEKLLFGLSGNPHAAIVVFDNVIVPVIEYLTYKKGTHH
IKAIFKGEFNKLSNKDRFVSGKLYTSEGKLYVELNDKKDAKARLSATLRSNCMIKIKKNETIKENQLVDVVIR
>Mature_393_residues
MIELEDAIKIIEKNVLPINRVKIVNLIDAVNKVVAEDIYSTIDSPPFDRSPYDGYAYNANSENRNLKVIGTLYAGDVFNR
VLNKNEAVKIMTGGKIPQGANCVIKKEDVTVIGDMITLNIKLKEYDNYIFKGEDIKKGQLIINKNQNIGYDGIGVLASLG
ISKVTVYDDLKVGILNTGTELQDINETLENGKIYDSNRYTLYSRLLKLGIQADTICNCSDDILELEKKVKNMLQSVDFLI
TTGGVSVGDKDLIPDVFKKIGATELFWKINIKPGGACYVGTLGEKLLFGLSGNPHAAIVVFDNVIVPVIEYLTYKKGTHH
IKAIFKGEFNKLSNKDRFVSGKLYTSEGKLYVELNDKKDAKARLSATLRSNCMIKIKKNETIKENQLVDVVIR

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=309, Percent_Identity=29.4498381877023, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI66932975, Length=309, Percent_Identity=29.4498381877023, Blast_Score=143, Evalue=3e-34,
Organism=Escherichia coli, GI1787049, Length=315, Percent_Identity=28.8888888888889, Blast_Score=165, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI25147659, Length=356, Percent_Identity=29.2134831460674, Blast_Score=134, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI17562606, Length=367, Percent_Identity=24.7956403269755, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17136978, Length=397, Percent_Identity=27.455919395466, Blast_Score=131, Evalue=6e-31,
Organism=Drosophila melanogaster, GI24638841, Length=397, Percent_Identity=27.455919395466, Blast_Score=131, Evalue=6e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 43742; Mature: 43742

Theoretical pI: Translated: 8.59; Mature: 8.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIELEDAIKIIEKNVLPINRVKIVNLIDAVNKVVAEDIYSTIDSPPFDRSPYDGYAYNAN
CCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCC
SENRNLKVIGTLYAGDVFNRVLNKNEAVKIMTGGKIPQGANCVIKKEDVTVIGDMITLNI
CCCCEEEEEEEEHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEECCEEEEEEEEEEEE
KLKEYDNYIFKGEDIKKGQLIINKNQNIGYDGIGVLASLGISKVTVYDDLKVGILNTGTE
EEEECCCEEECCCCCCCCEEEEECCCCCCCCHHHHHHHCCCCEEEEECCEEEEEEECCCH
LQDINETLENGKIYDSNRYTLYSRLLKLGIQADTICNCSDDILELEKKVKNMLQSVDFLI
HHHHHHHHHCCEEEECCCHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHHHHHCCEEE
TTGGVSVGDKDLIPDVFKKIGATELFWKINIKPGGACYVGTLGEKLLFGLSGNPHAAIVV
EECCCCCCCCCCCHHHHHHCCCEEEEEEEEECCCCEEEEECCCCEEEEECCCCCCEEEEE
FDNVIVPVIEYLTYKKGTHHIKAIFKGEFNKLSNKDRFVSGKLYTSEGKLYVELNDKKDA
ECCHHHHHHHHHHCCCCCCEEEEEEECCCHHCCCCCCEEECEEEECCCEEEEEECCCCCH
KARLSATLRSNCMIKIKKNETIKENQLVDVVIR
HHHHHHHHCCCEEEEEECCCCCCCCCEEEEEEC
>Mature Secondary Structure
MIELEDAIKIIEKNVLPINRVKIVNLIDAVNKVVAEDIYSTIDSPPFDRSPYDGYAYNAN
CCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCC
SENRNLKVIGTLYAGDVFNRVLNKNEAVKIMTGGKIPQGANCVIKKEDVTVIGDMITLNI
CCCCEEEEEEEEHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEECCEEEEEEEEEEEE
KLKEYDNYIFKGEDIKKGQLIINKNQNIGYDGIGVLASLGISKVTVYDDLKVGILNTGTE
EEEECCCEEECCCCCCCCEEEEECCCCCCCCHHHHHHHCCCCEEEEECCEEEEEEECCCH
LQDINETLENGKIYDSNRYTLYSRLLKLGIQADTICNCSDDILELEKKVKNMLQSVDFLI
HHHHHHHHHCCEEEECCCHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHHHHHCCEEE
TTGGVSVGDKDLIPDVFKKIGATELFWKINIKPGGACYVGTLGEKLLFGLSGNPHAAIVV
EECCCCCCCCCCCHHHHHHCCCEEEEEEEEECCCCEEEEECCCCEEEEECCCCCCEEEEE
FDNVIVPVIEYLTYKKGTHHIKAIFKGEFNKLSNKDRFVSGKLYTSEGKLYVELNDKKDA
ECCHHHHHHHHHHCCCCCCEEEEEEECCCHHCCCCCCEEECEEEECCCEEEEEECCCCCH
KARLSATLRSNCMIKIKKNETIKENQLVDVVIR
HHHHHHHHCCCEEEEEECCCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA