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The map label for this gene is lytC [H]

Identifier: 126698424

GI number: 126698424

Start: 1020174

End: 1021115

Strand: Direct

Name: lytC [H]

Synonym: CD0844

Alternate gene names: 126698424

Gene position: 1020174-1021115 (Clockwise)

Preceding gene: 126698423

Following gene: 126698426

Centisome position: 23.78

GC content: 32.48

Gene sequence:

>942_bases
ATGAGGATTAGTAAAAAGGTATTGGCGTTAGGTATTTCAGCATTACTATTAAGTGTTAGTTTTCCAACATCAATAAACGC
ACTAGATAAGATTGAAAATATTCAAGGAGTAGATAAATATGAAACAGCTGGGCTTATTTCAGATAAGCAAGATTTTACAA
CAGCAGTTCTTATCAATGCAGACTCTACAATGGTAGATGGAATTGCTGCAAGTGGTCTTGCAGGAGTAAATAATGCAGCT
ATTTTATTAACTAATAAGGATGATATACCAGAAGCAACGCTTCAAAGACTGAATAGAGTTACTAAGATATATGTAATAGG
TGGAGAAAATTCTATAAGTAAAGATGTAGAAAAAATGTTACTTATGAGAAGAATGCAAGTTATAAGAATTGATGGTGTAG
ATAGAGTAGATACAAGTTATAAAATTGCAGGCGAAATAGAAAAAATTAAAAACAGTGATAAGATGTTTTTAGTAAATGGA
TTTAAGGATGAAGCTGATGCAGTAAGTGTTGCATCTGTTGCTTATAGAGATGGAGCTCCTATAATATTGACAAAAGATAT
ACCTTCAGCAGAAGAAGACACAGACTTAGACCCATGGTTTGGAGTTTCTCCTGTTCCAGTATATGCTATTGGAGGAGAGT
CTACATTAAGTGATTACATAGTGAGCAGATATAGAGCAACTAGAATTGGCGGTGTTGATAGATATCAAACTAATAAAAAT
GTTATTGAAAAGTTCTATAATGGAGCAAAAGAGTTCTATATAACAAGTGGAGACGATTTAGTTTATGCTTTAGTTGCATC
ACCACTTGCAAAAAATGCTCCTGTTGTTTTAGTTTCAAATAAAAGTGATAAGAGTATATTAAGTGGAGCTAGTAAAGTAA
CAGCAATAGGTATAAGTGATAAGAGTATTATAGAGCAATGTTTGGATGCTGTAAAGAAGTAA

Upstream 100 bases:

>100_bases
AATTATTTAAATTATAAAAAAGTGTAACTATTTTTACACTATTTTTAAATGATTTTATATTATACTAATACTAAATATAT
TTGTTTTAGGGAGGTAATTT

Downstream 100 bases:

>100_bases
TGGAGTGTTATTAGTAAAATGAATATATACATTGAAAATTAGTAGATTGTTCATTTTATAATGGTATAAAATATATGGGA
AGAGGCTATCAAATGGAGAT

Product: cell surface protein

Products: NA

Alternate protein names: Cell wall hydrolase; Cell wall-associated polypeptide CWBP49; CWBP49; Major autolysin [H]

Number of amino acids: Translated: 313; Mature: 313

Protein sequence:

>313_residues
MRISKKVLALGISALLLSVSFPTSINALDKIENIQGVDKYETAGLISDKQDFTTAVLINADSTMVDGIAASGLAGVNNAA
ILLTNKDDIPEATLQRLNRVTKIYVIGGENSISKDVEKMLLMRRMQVIRIDGVDRVDTSYKIAGEIEKIKNSDKMFLVNG
FKDEADAVSVASVAYRDGAPIILTKDIPSAEEDTDLDPWFGVSPVPVYAIGGESTLSDYIVSRYRATRIGGVDRYQTNKN
VIEKFYNGAKEFYITSGDDLVYALVASPLAKNAPVVLVSNKSDKSILSGASKVTAIGISDKSIIEQCLDAVKK

Sequences:

>Translated_313_residues
MRISKKVLALGISALLLSVSFPTSINALDKIENIQGVDKYETAGLISDKQDFTTAVLINADSTMVDGIAASGLAGVNNAA
ILLTNKDDIPEATLQRLNRVTKIYVIGGENSISKDVEKMLLMRRMQVIRIDGVDRVDTSYKIAGEIEKIKNSDKMFLVNG
FKDEADAVSVASVAYRDGAPIILTKDIPSAEEDTDLDPWFGVSPVPVYAIGGESTLSDYIVSRYRATRIGGVDRYQTNKN
VIEKFYNGAKEFYITSGDDLVYALVASPLAKNAPVVLVSNKSDKSILSGASKVTAIGISDKSIIEQCLDAVKK
>Mature_313_residues
MRISKKVLALGISALLLSVSFPTSINALDKIENIQGVDKYETAGLISDKQDFTTAVLINADSTMVDGIAASGLAGVNNAA
ILLTNKDDIPEATLQRLNRVTKIYVIGGENSISKDVEKMLLMRRMQVIRIDGVDRVDTSYKIAGEIEKIKNSDKMFLVNG
FKDEADAVSVASVAYRDGAPIILTKDIPSAEEDTDLDPWFGVSPVPVYAIGGESTLSDYIVSRYRATRIGGVDRYQTNKN
VIEKFYNGAKEFYITSGDDLVYALVASPLAKNAPVVLVSNKSDKSILSGASKVTAIGISDKSIIEQCLDAVKK

Specific function: Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation, formation of the flagella - in particular of its basal body - and sporulation. Has a high affinity for teich

COG id: COG2247

COG function: function code M; Putative cell wall-binding domain

Gene ontology:

Cell location: Secreted, cell wall [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007253
- InterPro:   IPR002508 [H]

Pfam domain/function: PF01520 Amidase_3; PF04122 CW_binding_2 [H]

EC number: =3.5.1.28 [H]

Molecular weight: Translated: 33795; Mature: 33795

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRISKKVLALGISALLLSVSFPTSINALDKIENIQGVDKYETAGLISDKQDFTTAVLINA
CCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCHHHCCCCCCCCCCEEEEEEEC
DSTMVDGIAASGLAGVNNAAILLTNKDDIPEATLQRLNRVTKIYVIGGENSISKDVEKML
CCHHHHHHHHCCCCCCCCCEEEEECCCCCCHHHHHHHHCEEEEEEECCCCCHHHHHHHHH
LMRRMQVIRIDGVDRVDTSYKIAGEIEKIKNSDKMFLVNGFKDEADAVSVASVAYRDGAP
HHHHHHEEEECCCCCCCCCEEEHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHCCCCCC
IILTKDIPSAEEDTDLDPWFGVSPVPVYAIGGESTLSDYIVSRYRATRIGGVDRYQTNKN
EEEECCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCHH
VIEKFYNGAKEFYITSGDDLVYALVASPLAKNAPVVLVSNKSDKSILSGASKVTAIGISD
HHHHHHCCCCEEEEECCCCEEHHHHHHHHCCCCCEEEEECCCCHHHHCCCCEEEEEECCC
KSIIEQCLDAVKK
HHHHHHHHHHHCC
>Mature Secondary Structure
MRISKKVLALGISALLLSVSFPTSINALDKIENIQGVDKYETAGLISDKQDFTTAVLINA
CCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCHHHCCCCCCCCCCEEEEEEEC
DSTMVDGIAASGLAGVNNAAILLTNKDDIPEATLQRLNRVTKIYVIGGENSISKDVEKML
CCHHHHHHHHCCCCCCCCCEEEEECCCCCCHHHHHHHHCEEEEEEECCCCCHHHHHHHHH
LMRRMQVIRIDGVDRVDTSYKIAGEIEKIKNSDKMFLVNGFKDEADAVSVASVAYRDGAP
HHHHHHEEEECCCCCCCCCEEEHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHCCCCCC
IILTKDIPSAEEDTDLDPWFGVSPVPVYAIGGESTLSDYIVSRYRATRIGGVDRYQTNKN
EEEECCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCHH
VIEKFYNGAKEFYITSGDDLVYALVASPLAKNAPVVLVSNKSDKSILSGASKVTAIGISD
HHHHHHCCCCEEEEECCCCEEHHHHHHHHCCCCCEEEEECCCCHHHHCCCCEEEEEECCC
KSIIEQCLDAVKK
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1357079; 1682302; 9384377 [H]