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The map label for this gene is yngG [H]

Identifier: 126698377

GI number: 126698377

Start: 968115

End: 969011

Strand: Direct

Name: yngG [H]

Synonym: CD0797

Alternate gene names: 126698377

Gene position: 968115-969011 (Clockwise)

Preceding gene: 126698375

Following gene: 126698378

Centisome position: 22.57

GC content: 33.78

Gene sequence:

>897_bases
ATGAGTAAGGTAAATATATTTGAAGTTGGTCCTAGAGATGGATTTCAAAACCTGAAAGAGTTTTTAGAAACTGATAAAAA
GCTTAAGATTATTGATGGTCTTATTGCTTCAGGGATTAAACAACTTGAAATTAGTTCATTTGTAAGCCCAAAAGCAATAC
CTCAGATGAAAGATGCAAAAGAAGTAGCAACTTATTGTGTAGAAAAATATCCTGATGTGAAACTTTATGCATTAGTTCCA
AATTTATACGGTGCTAAAGTTGCATGGGAGTGTGGTATAAGAGATATATCCTATGTTATATCTTTGAGTGAAACTCATAA
TAAAAAAAATATAAATCGTACCCATGAAGAGTCTATTGATGAGCTTAAAAAAATAATGAATACTTATCCAGACATGAATA
TATGTATTGGAATGGCTACTGTATTTGGATGTCCTTTTGAAGGTTTACCAAAAATTGAAGATGCCATAAGATTTGCTAAA
CGCCTTTGGGAAAACGGTATCAGGGAGATGAATCTAGCAGATACAATAGGGATTGCTGACCCTAAGCAAGTAAGAGAAAC
TATTAGTGCATTAGTTGAAGCTTTACCAGAGTGCAGATGGCAGGTACATATTCATGATACTAGAAATATGGGAATGGTTA
ATACTCTTGTGGCTATTGAATCTGGAATTACAACTGTTCAGTCTACACTTGGAGGATTAGGAGGATGCCCATTTGCTCCT
GGAGCATCTGGCAATACTGCAACTGAAGATTTAGTATATATGCTTGAACGTATGGGGTATGATACAGGAGTTGATTTTGT
TAAACTTCTTGAATTATCAAAGTATCAGAAGAGTTTTGTAAATGGAGTATATAGTGGTCATCATGTAAATATAAAGTCTG
ATAGTTGTAATTGTTAG

Upstream 100 bases:

>100_bases
ATAATATGCTTAAATAAGCTTATGATTAACTTAAATTAAGCAAAGTTAAGCATGAACATGCAATGCTAGCTTGCAATATG
ACTGTAAAGGGGGAAAAGGT

Downstream 100 bases:

>100_bases
TTCTATTGATTAATTGATTAAAAAAATATGTTGATTAAAAAAATATGCTGATTGGTAAAATAGATTTATTGATAAAAAAT
ATAAATTATAAAATACATTA

Product: hydroxymethylglutaryl-CoA lyase

Products: NA

Alternate protein names: HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase [H]

Number of amino acids: Translated: 298; Mature: 297

Protein sequence:

>298_residues
MSKVNIFEVGPRDGFQNLKEFLETDKKLKIIDGLIASGIKQLEISSFVSPKAIPQMKDAKEVATYCVEKYPDVKLYALVP
NLYGAKVAWECGIRDISYVISLSETHNKKNINRTHEESIDELKKIMNTYPDMNICIGMATVFGCPFEGLPKIEDAIRFAK
RLWENGIREMNLADTIGIADPKQVRETISALVEALPECRWQVHIHDTRNMGMVNTLVAIESGITTVQSTLGGLGGCPFAP
GASGNTATEDLVYMLERMGYDTGVDFVKLLELSKYQKSFVNGVYSGHHVNIKSDSCNC

Sequences:

>Translated_298_residues
MSKVNIFEVGPRDGFQNLKEFLETDKKLKIIDGLIASGIKQLEISSFVSPKAIPQMKDAKEVATYCVEKYPDVKLYALVP
NLYGAKVAWECGIRDISYVISLSETHNKKNINRTHEESIDELKKIMNTYPDMNICIGMATVFGCPFEGLPKIEDAIRFAK
RLWENGIREMNLADTIGIADPKQVRETISALVEALPECRWQVHIHDTRNMGMVNTLVAIESGITTVQSTLGGLGGCPFAP
GASGNTATEDLVYMLERMGYDTGVDFVKLLELSKYQKSFVNGVYSGHHVNIKSDSCNC
>Mature_297_residues
SKVNIFEVGPRDGFQNLKEFLETDKKLKIIDGLIASGIKQLEISSFVSPKAIPQMKDAKEVATYCVEKYPDVKLYALVPN
LYGAKVAWECGIRDISYVISLSETHNKKNINRTHEESIDELKKIMNTYPDMNICIGMATVFGCPFEGLPKIEDAIRFAKR
LWENGIREMNLADTIGIADPKQVRETISALVEALPECRWQVHIHDTRNMGMVNTLVAIESGITTVQSTLGGLGGCPFAPG
ASGNTATEDLVYMLERMGYDTGVDFVKLLELSKYQKSFVNGVYSGHHVNIKSDSCNC

Specific function: Involved in the catabolism of branched amino acids such as leucine (Probable) [H]

COG id: COG0119

COG function: function code E; Isopropylmalate/homocitrate/citramalate synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA lyase family [H]

Homologues:

Organism=Homo sapiens, GI62198232, Length=275, Percent_Identity=41.0909090909091, Blast_Score=219, Evalue=2e-57,
Organism=Homo sapiens, GI109150422, Length=280, Percent_Identity=39.6428571428571, Blast_Score=211, Evalue=7e-55,
Organism=Homo sapiens, GI109150427, Length=280, Percent_Identity=39.6428571428571, Blast_Score=211, Evalue=8e-55,
Organism=Homo sapiens, GI260654708, Length=116, Percent_Identity=46.551724137931, Blast_Score=119, Evalue=3e-27,
Organism=Escherichia coli, GI1786261, Length=270, Percent_Identity=26.6666666666667, Blast_Score=65, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17510563, Length=278, Percent_Identity=36.6906474820144, Blast_Score=195, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6320019, Length=241, Percent_Identity=24.0663900414938, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24582381, Length=301, Percent_Identity=35.8803986710963, Blast_Score=203, Evalue=1e-52,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000891 [H]

Pfam domain/function: PF00682 HMGL-like [H]

EC number: =4.1.3.4 [H]

Molecular weight: Translated: 33110; Mature: 32978

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS50991 PYR_CT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKVNIFEVGPRDGFQNLKEFLETDKKLKIIDGLIASGIKQLEISSFVSPKAIPQMKDAK
CCCCEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
EVATYCVEKYPDVKLYALVPNLYGAKVAWECGIRDISYVISLSETHNKKNINRTHEESID
HHHHHHHHHCCCEEEEEECCCCCCCCEEHHCCCHHHHHHEEHHHHCCCCCCCHHHHHHHH
ELKKIMNTYPDMNICIGMATVFGCPFEGLPKIEDAIRFAKRLWENGIREMNLADTIGIAD
HHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHCCCCC
PKQVRETISALVEALPECRWQVHIHDTRNMGMVNTLVAIESGITTVQSTLGGLGGCPFAP
HHHHHHHHHHHHHHHHHCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GASGNTATEDLVYMLERMGYDTGVDFVKLLELSKYQKSFVNGVYSGHHVNIKSDSCNC
CCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCC
>Mature Secondary Structure 
SKVNIFEVGPRDGFQNLKEFLETDKKLKIIDGLIASGIKQLEISSFVSPKAIPQMKDAK
CCCEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
EVATYCVEKYPDVKLYALVPNLYGAKVAWECGIRDISYVISLSETHNKKNINRTHEESID
HHHHHHHHHCCCEEEEEECCCCCCCCEEHHCCCHHHHHHEEHHHHCCCCCCCHHHHHHHH
ELKKIMNTYPDMNICIGMATVFGCPFEGLPKIEDAIRFAKRLWENGIREMNLADTIGIAD
HHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHCCCCC
PKQVRETISALVEALPECRWQVHIHDTRNMGMVNTLVAIESGITTVQSTLGGLGGCPFAP
HHHHHHHHHHHHHHHHHCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GASGNTATEDLVYMLERMGYDTGVDFVKLLELSKYQKSFVNGVYSGHHVNIKSDSCNC
CCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]