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The map label for this gene is iscS1 [H]

Identifier: 126698333

GI number: 126698333

Start: 920745

End: 921896

Strand: Direct

Name: iscS1 [H]

Synonym: CD0753

Alternate gene names: 126698333

Gene position: 920745-921896 (Clockwise)

Preceding gene: 126698332

Following gene: 126698334

Centisome position: 21.46

GC content: 28.65

Gene sequence:

>1152_bases
TTGGAAATATACTTAGACAATAGCGCAACTACAAAACCTTATCAAGAAGTTATAGATAAAATGGTTTATGCACTTAATAC
GGAATATGGAAATCCTTCTTCTGTCCATAGAAAAGGTGTAGAAGTTGAAAAAGCTATAAAAGAAGTAAGACAAGATATAG
CTAAATCTCTAGGAGCGAAAGAAAAGGAGATTTATTTTACATCAGGTGGTACAGAGTGTAATAATACTATAATAAGAGGT
ATTACTAGTTTAAATAAAAAAAGAAAAAATCACATAATATCTACTAACATAGAACATCCTTCTGTTTTAAATACATTAAA
AGATTTAGAAGAAGATGGTTTTGAAGTAACTTATTTAGAGGTCGGAAAAGATGGGAAAATAAATATAGAGGATTTAAAAA
ATGCGATAAAGTCAACTACATGCTTAGTAAGCATGATGCATGTTAACAATGAAATAGGAACTATACAGCCAATAGGTGAA
GTTGGAAAGTATTTGAAGGGTTTAAAAGAAAAAATTTATTTCCATGTTGATGCTATTCAGTCATATGGAAAAATTAACTT
TAGACCATCTAAATACAATATAGATTTTATGAGTGTAAGTGCACATAAATTTCATGGTCCAAAGGGAATTGGATTTATGT
ATATAAAAGAAAATAATCGCCTTAAGCCTATGTTAACAGGTGGTGGTCAGGAAATTGGAATTAGGTCGGGAACAGAAAAT
GTACCTGGAATATATGGTCTTGGAGAAGCTGTTAGAATATTAAACAAAGATTTAGATGCTGTTATTTCGAAAGTAGATAA
CTTAAAAAATATATTAAAAAATGAAATAATTGATAATATAGAAGATATAAAAATCAATTCTCCAGAAGATGGAGTATGTC
ATATATTAAATGTATCATTTAGAGGGACAAAAGGAGAAGTTTTACTTCATTACTTAGAGCAAAAAGGTATTTATGTATCA
ACTGGCTCTGCATGTTCTTCTAAAAAGAAAGGTAGTTACGTATTAAATGCTATAGGTCTTACAAATGAAGAAATAAATGG
AACAATAAGATTTAGTTTATCTGATATGAATACAGAAGAAGAAATGTTAGAAGCTGTGAAAGTTTTGAAAGAATCAATTT
GTGACTTAAGGTCAATAATGAAAAGAAAATAA

Upstream 100 bases:

>100_bases
TTAAGATTGTCTTTTTAATAAAGATTAACAAAAAAAATACTATAATTAGTGGTATAATAGTTAGAGTTGAAGATTTTAAA
TAAAGGTAGGTGTAATTAAG

Downstream 100 bases:

>100_bases
AGAATACTGTATAAATAGTGATAATAAATTAGTTTAAGAGGTGAAATGGTGTATAATATATTAATAGTAAAGTATGGAGA
AATTGGAGTAAAAGGAAAGA

Product: cysteine desulfurase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 383; Mature: 383

Protein sequence:

>383_residues
MEIYLDNSATTKPYQEVIDKMVYALNTEYGNPSSVHRKGVEVEKAIKEVRQDIAKSLGAKEKEIYFTSGGTECNNTIIRG
ITSLNKKRKNHIISTNIEHPSVLNTLKDLEEDGFEVTYLEVGKDGKINIEDLKNAIKSTTCLVSMMHVNNEIGTIQPIGE
VGKYLKGLKEKIYFHVDAIQSYGKINFRPSKYNIDFMSVSAHKFHGPKGIGFMYIKENNRLKPMLTGGGQEIGIRSGTEN
VPGIYGLGEAVRILNKDLDAVISKVDNLKNILKNEIIDNIEDIKINSPEDGVCHILNVSFRGTKGEVLLHYLEQKGIYVS
TGSACSSKKKGSYVLNAIGLTNEEINGTIRFSLSDMNTEEEMLEAVKVLKESICDLRSIMKRK

Sequences:

>Translated_383_residues
MEIYLDNSATTKPYQEVIDKMVYALNTEYGNPSSVHRKGVEVEKAIKEVRQDIAKSLGAKEKEIYFTSGGTECNNTIIRG
ITSLNKKRKNHIISTNIEHPSVLNTLKDLEEDGFEVTYLEVGKDGKINIEDLKNAIKSTTCLVSMMHVNNEIGTIQPIGE
VGKYLKGLKEKIYFHVDAIQSYGKINFRPSKYNIDFMSVSAHKFHGPKGIGFMYIKENNRLKPMLTGGGQEIGIRSGTEN
VPGIYGLGEAVRILNKDLDAVISKVDNLKNILKNEIIDNIEDIKINSPEDGVCHILNVSFRGTKGEVLLHYLEQKGIYVS
TGSACSSKKKGSYVLNAIGLTNEEINGTIRFSLSDMNTEEEMLEAVKVLKESICDLRSIMKRK
>Mature_383_residues
MEIYLDNSATTKPYQEVIDKMVYALNTEYGNPSSVHRKGVEVEKAIKEVRQDIAKSLGAKEKEIYFTSGGTECNNTIIRG
ITSLNKKRKNHIISTNIEHPSVLNTLKDLEEDGFEVTYLEVGKDGKINIEDLKNAIKSTTCLVSMMHVNNEIGTIQPIGE
VGKYLKGLKEKIYFHVDAIQSYGKINFRPSKYNIDFMSVSAHKFHGPKGIGFMYIKENNRLKPMLTGGGQEIGIRSGTEN
VPGIYGLGEAVRILNKDLDAVISKVDNLKNILKNEIIDNIEDIKINSPEDGVCHILNVSFRGTKGEVLLHYLEQKGIYVS
TGSACSSKKKGSYVLNAIGLTNEEINGTIRFSLSDMNTEEEMLEAVKVLKESICDLRSIMKRK

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=381, Percent_Identity=40.6824146981627, Blast_Score=276, Evalue=3e-74,
Organism=Homo sapiens, GI156713448, Length=414, Percent_Identity=32.3671497584541, Blast_Score=199, Evalue=5e-51,
Organism=Escherichia coli, GI48994898, Length=386, Percent_Identity=42.4870466321244, Blast_Score=285, Evalue=2e-78,
Organism=Escherichia coli, GI1787970, Length=387, Percent_Identity=25.0645994832041, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1789175, Length=385, Percent_Identity=22.5974025974026, Blast_Score=75, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI25143064, Length=383, Percent_Identity=39.4255874673629, Blast_Score=265, Evalue=4e-71,
Organism=Caenorhabditis elegans, GI17533177, Length=311, Percent_Identity=35.3697749196142, Blast_Score=163, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6319831, Length=382, Percent_Identity=42.9319371727749, Blast_Score=291, Evalue=2e-79,
Organism=Drosophila melanogaster, GI20129463, Length=365, Percent_Identity=41.0958904109589, Blast_Score=268, Evalue=4e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR017772
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 42732; Mature: 42732

Theoretical pI: Translated: 7.91; Mature: 7.91

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIYLDNSATTKPYQEVIDKMVYALNTEYGNPSSVHRKGVEVEKAIKEVRQDIAKSLGAK
CEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHCCCC
EKEIYFTSGGTECNNTIIRGITSLNKKRKNHIISTNIEHPSVLNTLKDLEEDGFEVTYLE
CCEEEEECCCCCHHHHHHHHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHCCCEEEEEE
VGKDGKINIEDLKNAIKSTTCLVSMMHVNNEIGTIQPIGEVGKYLKGLKEKIYFHVDAIQ
ECCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHEEEHHHHH
SYGKINFRPSKYNIDFMSVSAHKFHGPKGIGFMYIKENNRLKPMLTGGGQEIGIRSGTEN
HCCCEEECCCCEEEEEEEECHHHCCCCCCCEEEEEECCCCCCEEECCCCCEECCCCCCCC
VPGIYGLGEAVRILNKDLDAVISKVDNLKNILKNEIIDNIEDIKINSPEDGVCHILNVSF
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCEEECCCCCCEEEEEEEEE
RGTKGEVLLHYLEQKGIYVSTGSACSSKKKGSYVLNAIGLTNEEINGTIRFSLSDMNTEE
CCCCHHHHHHHHHHCCEEEECCCCCCCCCCCCEEEEEECCCCCCCCEEEEEEECCCCCHH
EMLEAVKVLKESICDLRSIMKRK
HHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEIYLDNSATTKPYQEVIDKMVYALNTEYGNPSSVHRKGVEVEKAIKEVRQDIAKSLGAK
CEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHCCCC
EKEIYFTSGGTECNNTIIRGITSLNKKRKNHIISTNIEHPSVLNTLKDLEEDGFEVTYLE
CCEEEEECCCCCHHHHHHHHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHCCCEEEEEE
VGKDGKINIEDLKNAIKSTTCLVSMMHVNNEIGTIQPIGEVGKYLKGLKEKIYFHVDAIQ
ECCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHEEEHHHHH
SYGKINFRPSKYNIDFMSVSAHKFHGPKGIGFMYIKENNRLKPMLTGGGQEIGIRSGTEN
HCCCEEECCCCEEEEEEEECHHHCCCCCCCEEEEEECCCCCCEEECCCCCEECCCCCCCC
VPGIYGLGEAVRILNKDLDAVISKVDNLKNILKNEIIDNIEDIKINSPEDGVCHILNVSF
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCEEECCCCCCEEEEEEEEE
RGTKGEVLLHYLEQKGIYVSTGSACSSKKKGSYVLNAIGLTNEEINGTIRFSLSDMNTEE
CCCCHHHHHHHHHHCCEEEECCCCCCCCCCCCEEEEEECCCCCCCCEEEEEEECCCCCHH
EMLEAVKVLKESICDLRSIMKRK
HHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA