BacMap

Definition	Clostridium difficile 630 chromosome, complete genome.
Accession	NC_009089
Length	4,290,252

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The map label for this gene is bcrA [H]

Identifier: 126698231

GI number: 126698231

Start: 778334

End: 779191

Strand: Direct

Name: bcrA [H]

Synonym: CD0653

Alternate gene names: 126698231

Gene position: 778334-779191 (Clockwise)

Preceding gene: 126698230

Following gene: 126698232

Centisome position: 18.14

GC content: 29.49

Gene sequence:

>858_bases
ATGGAAAATATTTTAGAAGTTTATAACTTAAATAAGACTTATACCGATTTTTCATTATCTAATATAAGCTTTGCATTACC
AGAAGATTGTATAACTGGATTTATAGGTGTTAATGGAGCAGGAAAAACAACAACAATCCGTTCAATATTGGATGTCATAA
AGCGTGATAGTGGAAAAATAAAAATCTTTGGTAAAGATTTCGATGGAAATGAGAAGGAATTAAAAAATCGAATTGGAGTT
GTATTTGATGATTCATATTTCTATGAGGAGTTGTCAATGGCAGAAATGAAAAGTATTATTGCACCTTCATATGATAATTG
GTGTGAAGAAGATTATCAACAAAATATGAAGCGTTTTAATCTTAACCCAAAACAAAAGATTGATACACTTTCAAAAGGAA
TGAAAATGAAATTTGCTTTAGCATTAGCATTATCGCATAAAGCTGAGTTTTTAATTATGGATGAGCCTACAAGTGGCTTA
GACCCACTAATCCGTAGTCAGATACTTGACATACTAACAGAATATATGAAGAAATGTGGTCGTGGTGTTTTCTTTTCCAC
TCATATAACATCTGATTTAGACAAAATAGCAGATATGATTGTTATGATTGACAATGGACGTATTATATTAGAGCGTGAAA
AAGATACTCTATTGGACGAACATAGAAAAGTAAAAGGGGATATTCAATTTCTAAATGATGAAATCAAAAAATTATTTTTA
AATTTAGAAATTACAGGTTATGGTTTTATAGGGATTACCTCAAAAATTAATGAAGTGCAAAAAAATATGCCAGATATTTT
AATAGAGCGTCCTACAATTGAAGATATTATGCTTGCATATATTGAAAGGAGAGAGTAA

Upstream 100 bases:

>100_bases
GAACAAAAAATGGCAGATATGATTAAGGATGCAAAAGCACTAGGAATTACACAGATAGAGTTACAAGAAATGATGGATAT
TCTATATCAGGAGGATTAAT

Downstream 100 bases:

>100_bases
TTATGTTGATTCATTTAGTTAAAAAAGATATTCTGATTGTAAAAAAATATGTATTGTTGATATTGTTTATTGCAATAGGA
ATCCCATTATTTATATTGTG

Product: ABC transporter ATP-binding protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MENILEVYNLNKTYTDFSLSNISFALPEDCITGFIGVNGAGKTTTIRSILDVIKRDSGKIKIFGKDFDGNEKELKNRIGV
VFDDSYFYEELSMAEMKSIIAPSYDNWCEEDYQQNMKRFNLNPKQKIDTLSKGMKMKFALALALSHKAEFLIMDEPTSGL
DPLIRSQILDILTEYMKKCGRGVFFSTHITSDLDKIADMIVMIDNGRIILEREKDTLLDEHRKVKGDIQFLNDEIKKLFL
NLEITGYGFIGITSKINEVQKNMPDILIERPTIEDIMLAYIERRE

Sequences:

>Translated_285_residues
MENILEVYNLNKTYTDFSLSNISFALPEDCITGFIGVNGAGKTTTIRSILDVIKRDSGKIKIFGKDFDGNEKELKNRIGV
VFDDSYFYEELSMAEMKSIIAPSYDNWCEEDYQQNMKRFNLNPKQKIDTLSKGMKMKFALALALSHKAEFLIMDEPTSGL
DPLIRSQILDILTEYMKKCGRGVFFSTHITSDLDKIADMIVMIDNGRIILEREKDTLLDEHRKVKGDIQFLNDEIKKLFL
NLEITGYGFIGITSKINEVQKNMPDILIERPTIEDIMLAYIERRE
>Mature_285_residues
MENILEVYNLNKTYTDFSLSNISFALPEDCITGFIGVNGAGKTTTIRSILDVIKRDSGKIKIFGKDFDGNEKELKNRIGV
VFDDSYFYEELSMAEMKSIIAPSYDNWCEEDYQQNMKRFNLNPKQKIDTLSKGMKMKFALALALSHKAEFLIMDEPTSGL
DPLIRSQILDILTEYMKKCGRGVFFSTHITSDLDKIADMIVMIDNGRIILEREKDTLLDEHRKVKGDIQFLNDEIKKLFL
NLEITGYGFIGITSKINEVQKNMPDILIERPTIEDIMLAYIERRE

Specific function: Part of the binding-protein-dependent transport system for bacitracin that confer resistance to this antibiotic. Probably responsible for energy coupling to the transport system [H]

COG id: COG1131

COG function: function code V; ABC-type multidrug transport system, ATPase component

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI45446740, Length=224, Percent_Identity=33.4821428571429, Blast_Score=104, Evalue=8e-23,
Organism=Homo sapiens, GI47078218, Length=224, Percent_Identity=33.4821428571429, Blast_Score=104, Evalue=8e-23,
Organism=Homo sapiens, GI105990541, Length=194, Percent_Identity=32.4742268041237, Blast_Score=98, Evalue=8e-21,
Organism=Homo sapiens, GI21536376, Length=214, Percent_Identity=30.3738317757009, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI27881501, Length=213, Percent_Identity=27.2300469483568, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI30795238, Length=213, Percent_Identity=27.2300469483568, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI31657092, Length=197, Percent_Identity=29.9492385786802, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI116734710, Length=196, Percent_Identity=28.0612244897959, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI150417984, Length=204, Percent_Identity=26.9607843137255, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI153792144, Length=239, Percent_Identity=25.9414225941423, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI27436953, Length=237, Percent_Identity=25.7383966244726, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI27262624, Length=202, Percent_Identity=28.2178217821782, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI27262626, Length=202, Percent_Identity=28.2178217821782, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI27477115, Length=220, Percent_Identity=26.3636363636364, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI171184400, Length=237, Percent_Identity=28.2700421940928, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI48994943, Length=214, Percent_Identity=26.1682242990654, Blast_Score=98, Evalue=6e-22,
Organism=Escherichia coli, GI87081782, Length=222, Percent_Identity=27.4774774774775, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1786398, Length=228, Percent_Identity=28.9473684210526, Blast_Score=84, Evalue=8e-18,
Organism=Escherichia coli, GI1786319, Length=212, Percent_Identity=28.3018867924528, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788450, Length=292, Percent_Identity=22.6027397260274, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788472, Length=225, Percent_Identity=25.7777777777778, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI1789032, Length=256, Percent_Identity=26.171875, Blast_Score=78, Evalue=5e-16,
Organism=Escherichia coli, GI1786803, Length=214, Percent_Identity=22.4299065420561, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1787029, Length=216, Percent_Identity=25.9259259259259, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1788506, Length=210, Percent_Identity=28.5714285714286, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI87081709, Length=215, Percent_Identity=25.5813953488372, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI1787759, Length=241, Percent_Identity=22.4066390041494, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI1790190, Length=232, Percent_Identity=24.1379310344828, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1789672, Length=238, Percent_Identity=24.3697478991597, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788897, Length=230, Percent_Identity=26.0869565217391, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI87082268, Length=213, Percent_Identity=26.2910798122066, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1786872, Length=238, Percent_Identity=25.6302521008403, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1790467, Length=210, Percent_Identity=26.1904761904762, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1787712, Length=216, Percent_Identity=25.462962962963, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1788540, Length=188, Percent_Identity=26.5957446808511, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1789593, Length=231, Percent_Identity=25.5411255411255, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI48995001, Length=268, Percent_Identity=24.2537313432836, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1787089, Length=207, Percent_Identity=27.536231884058, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1788225, Length=223, Percent_Identity=24.6636771300448, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1786563, Length=249, Percent_Identity=25.3012048192771, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1790739, Length=219, Percent_Identity=24.6575342465753, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI87081791, Length=235, Percent_Identity=20.8510638297872, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1788165, Length=195, Percent_Identity=27.6923076923077, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1787370, Length=226, Percent_Identity=27.4336283185841, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1788210, Length=221, Percent_Identity=23.9819004524887, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1789962, Length=218, Percent_Identity=23.8532110091743, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71983523, Length=182, Percent_Identity=28.5714285714286, Blast_Score=95, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71983510, Length=182, Percent_Identity=28.5714285714286, Blast_Score=95, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI71983516, Length=182, Percent_Identity=28.5714285714286, Blast_Score=95, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI115533608, Length=212, Percent_Identity=28.3018867924528, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17510237, Length=221, Percent_Identity=25.3393665158371, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17565586, Length=225, Percent_Identity=26.2222222222222, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI193208177, Length=218, Percent_Identity=28.4403669724771, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI85725262, Length=231, Percent_Identity=28.5714285714286, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI221512771, Length=214, Percent_Identity=28.5046728971963, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24643674, Length=214, Percent_Identity=28.5046728971963, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI221500365, Length=220, Percent_Identity=27.2727272727273, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI116007184, Length=220, Percent_Identity=27.2727272727273, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24650855, Length=223, Percent_Identity=29.1479820627803, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24650853, Length=223, Percent_Identity=29.1479820627803, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24666092, Length=210, Percent_Identity=27.6190476190476, Blast_Score=85, Evalue=6e-17,
Organism=Drosophila melanogaster, GI281362751, Length=223, Percent_Identity=29.1479820627803, Blast_Score=85, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24582014, Length=209, Percent_Identity=27.2727272727273, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24582012, Length=209, Percent_Identity=27.2727272727273, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI28574150, Length=219, Percent_Identity=28.310502283105, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI116007328, Length=219, Percent_Identity=28.310502283105, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24648314, Length=214, Percent_Identity=28.0373831775701, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28573571, Length=214, Percent_Identity=22.8971962616822, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI28573573, Length=210, Percent_Identity=22.8571428571429, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI45550390, Length=210, Percent_Identity=25.7142857142857, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 32774; Mature: 32774

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENILEVYNLNKTYTDFSLSNISFALPEDCITGFIGVNGAGKTTTIRSILDVIKRDSGKI
CCCHHHHHCCCCCCCCCEECCCEEECCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEE
KIFGKDFDGNEKELKNRIGVVFDDSYFYEELSMAEMKSIIAPSYDNWCEEDYQQNMKRFN
EEEECCCCCCHHHHHHHCCEEECCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCC
LNPKQKIDTLSKGMKMKFALALALSHKAEFLIMDEPTSGLDPLIRSQILDILTEYMKKCG
CCHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHC
RGVFFSTHITSDLDKIADMIVMIDNGRIILEREKDTLLDEHRKVKGDIQFLNDEIKKLFL
CCEEEEHHHHHHHHHHHHEEEEEECCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHH
NLEITGYGFIGITSKINEVQKNMPDILIERPTIEDIMLAYIERRE
EEEEEEEEEEEHHHHHHHHHHCCCHHEECCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MENILEVYNLNKTYTDFSLSNISFALPEDCITGFIGVNGAGKTTTIRSILDVIKRDSGKI
CCCHHHHHCCCCCCCCCEECCCEEECCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEE
KIFGKDFDGNEKELKNRIGVVFDDSYFYEELSMAEMKSIIAPSYDNWCEEDYQQNMKRFN
EEEECCCCCCHHHHHHHCCEEECCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCC
LNPKQKIDTLSKGMKMKFALALALSHKAEFLIMDEPTSGLDPLIRSQILDILTEYMKKCG
CCHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHC
RGVFFSTHITSDLDKIADMIVMIDNGRIILEREKDTLLDEHRKVKGDIQFLNDEIKKLFL
CCEEEEHHHHHHHHHHHHEEEEEECCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHH
NLEITGYGFIGITSKINEVQKNMPDILIERPTIEDIMLAYIERRE
EEEEEEEEEEEHHHHHHHHHHCCCHHEECCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7476193 [H]