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The map label for this gene is clcA [H]

Identifier: 126698184

GI number: 126698184

Start: 727281

End: 727943

Strand: Direct

Name: clcA [H]

Synonym: CD0606

Alternate gene names: 126698184

Gene position: 727281-727943 (Clockwise)

Preceding gene: 126698183

Following gene: 126698185

Centisome position: 16.95

GC content: 41.18

Gene sequence:

>2357_bases
ATGAAAAAGGATACATCTCATATTATCAAACGGGCAGAGCACTTTCAGGTAATTTTGATTGGTGAAGGACTTATGGTTGG
GGCTGTGGCTGGTTTGATTGTGCTTTTATACAGGATACTTTTAGGGCAGGCTGGTACTTGGCTTAGCCAAATTTTAAAAT
TTGTAGAAGGTTCTACAATAAAAATAATAGCTTGGTTTGCAGTACTTGCAGTACTTGCGTGGATTGTATCAAAGTTGGTG
GACTGGGAGCCAATGATTTCTGGAAGTGGTATCCCTCAGCTTGAGGGGGAAATGACAGGGAAAATAAAACAAGTATGGTG
GCGAGTGTTGCCAACAAAATTTATTGGAGGATTCTTATCACTTATGGGTGGTCTTGCTTTGGGAAGGGAAGGTCCTTCCA
TTCAGCTTGGTGCTATGGCAGGTAAAGGTATTTCTAGAGCTCTTGACCGAGGGAAGACAGAGGAAAAATTCCTGTTAACC
TGTGGGGCAAGTGCTGGATTATCAGCAGCCTTTCATGCACCACTAGCAGGTGTTATGTTTTCACTTGAAGAAGTCCATAA
AAACTTTTCAGTATCTGTTTTAATTTCTGTGATGACAGCATCTTTGACAGCAGACTATATTTCAGCCAATTTCCTAGGAA
TGGAGTCTGTATTCCAGTTTGATTAAAAAATAGCTACGAACACTTGTGACTTTAGTCATGAGTTAGTAGCTAAAATAGTC
AGCATATAGGGAAACCTATATGTAGAGATAGGATAGAACCTATCCAATACTACTTGAATTGCTGGAAACCCCTAAAGCTA
ACCAAACTAAAACATAAGGATGAAATAAACCTAAGTGTGAAAGTTACGAAAGTAGAAAAAATTGGTTAGATGGTATAAGG
TTAAATCCTAAGTACTTTAAAATGGGCAATCAGCAGGTAAGCTCCGAATAGGAGAAACTTCAACGACTATTCCTCTTGAG
GGAAGTACACTACAAGTTATTGGTAGTGGAAGTGGGTAGACCTTAACGGATAATGCCGAAGGATAAGATATAGTCTGTGC
TTGCATGAAAGTGTAAGAAGTTCATAAGAGAACTGCATAGGTAGTAGCGAACTTATGTGAACGACAACCTCAAAAATGAT
AAAAGTTAAGACTTACGGTTCTTAAATATGTTATTTAAAATTAAATATAAAACCTTCTAAATAATTGTTTTAAATAATTA
CATTTGTTAACATTATTATAAGAGAATGGATTTGTCCTAGTTGTAATGAAACTCACGATAGAGATATAAATGCAAGTATA
AATATATTAAAAGAAGGATTAAGACTAATAACAATTCAAAATAAATAACTTATGTAAGAACCGTAGGAACTACGGGGATA
GCCTGTGGAGAATTAGTAAGACATATTTTAGTATGCAAAATTCTATGAAGCAGGAACCCTGTGACTTTAGTCATGGGAGG
TTCAGATTGGAAATGTGTTGCCACAAGATTATTATGGATTAATAGTGATTTTAGGTGTTATTCTTGGAGTTATGGGGGCA
TTTTACAACTGGTTTACTCTATATGTGCAGTCTTTATACAAGAAGATTCCTAAAATTGGTACCTTTGGAAAACTGTTGAT
TCCATTTATAATGGCTGGTATTCTTGGGATTGTTATGCCTGATGTTCTGGGGAGTGGACACAATTTAGTTGAAGAACTTA
CAAGTCATGAATATATTTTTGGAATGGTTGTTTTGATTTTTGTTATACGTTTTATATTTTCGGCTGTTAGTTTTGGGTCA
GGTGCACCAGGGGGAATATTTTTTCCATTGCTTGTTTTAGGAGCATTTATAGGTGGAATATTTGGTATGGTAGGTGTTAA
AGTTTTTGGAATGAATCCCGATTATGTAAATAACTTTGTGCTTTTGGCTATGGCAGGATATTTTACAGCTATTGTGCGTG
CCCCTTTGACTGGTATCATATTAATTTTTGAAATGACAGGTTCTGTTAGTCAAATGCTTTCACTATCAGTAATTTCAATT
GTGGCATATATTGTGGCTACACTTATGAAGTCTAAACCTATTTATGAAAGTCTTCTTGAGAGGTTACTTGAAAAAAATGG
AGAACCTGTACATAAGGAGAGGGGCGAAAAGATACTAGACCAGTTCTCTGTTATGTTTGGCTCTCCTGTTGCGAACAAGG
CAATTCAGGATGTACAGTGGCCTGAAAATTGTCTTTTGGTAGCAATTCAAAGAGGTGGAGAAGAAATTATTCCTAGAGGT
AAGACAATTCTTAGACCAAGTGATGTAATTGTGACTATGACAGATGAGAGAGATAGTGGTGCTGTGTATGATAAAATGGA
AAATTTGTGTAAAGAACATACGGCACATATTTTTTAG

Upstream 100 bases:

>100_bases
AAAATCTATTTTTGTTGATTAAAAAATATCTGTACACACTCATGACTTTAGTCATTGGAGATTCAGATTGTGTAGAATTA
TTGGATGAAGGAGGAACAGT

Downstream 100 bases:

>100_bases
GGATAATGATGAATGTTTAATAATGATAGAATATTTAATGAAGATTTGATTAAAAATTGGTAATTTGAAAGAGAGTTAAG
GAATTAATATAAGAAAATGA

Product: chloride ion channel protein

Products: Cl Ion [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 221; Mature: 221

Protein sequence:

>524_residues
MKKDTSHIIKRAEHFQVILIGEGLMVGAVAGLIVLLYRILLGQAGTWLSQILKFVEGSTIKIIAWFAVLAVLAWIVSKLV
DWEPMISGSGIPQLEGEMTGKIKQVWWRVLPTKFIGGFLSLMGGLALGREGPSIQLGAMAGKGISRALDRGKTEEKFLLT
CGASAGLSAAFHAPLAGVMFSLEEVHKNFSVSVLISVMTASLTADYISANFLGMESVFQFDIGNVLPQDYYGLIVILGVI
LGVMGAFYNWFTLYVQSLYKKIPKIGTFGKLLIPFIMAGILGIVMPDVLGSGHNLVEELTSHEYIFGMVVLIFVIRFIFS
AVSFGSGAPGGIFFPLLVLGAFIGGIFGMVGVKVFGMNPDYVNNFVLLAMAGYFTAIVRAPLTGIILIFEMTGSVSQMLS
LSVISIVAYIVATLMKSKPIYESLLERLLEKNGEPVHKERGEKILDQFSVMFGSPVANKAIQDVQWPENCLLVAIQRGGE
EIIPRGKTILRPSDVIVTMTDERDSGAVYDKMENLCKEHTAHIF

Sequences:

>Translated_221_residues
MKKDTSHIIKRAEHFQVILIGEGLMVGAVAGLIVLLYRILLGQAGTWLSQILKFVEGSTIKIIAWFAVLAVLAWIVSKLV
DWEPMISGSGIPQLEGEMTGKIKQVWWRVLPTKFIGGFLSLMGGLALGREGPSIQLGAMAGKGISRALDRGKTEEKFLLT
CGASAGLSAAFHAPLAGVMFSLEEVHKNFSVSVLISVMTASLTADYISANFLGMESVFQFD
>Mature_221_residues
MKKDTSHIIKRAEHFQVILIGEGLMVGAVAGLIVLLYRILLGQAGTWLSQILKFVEGSTIKIIAWFAVLAVLAWIVSKLV
DWEPMISGSGIPQLEGEMTGKIKQVWWRVLPTKFIGGFLSLMGGLALGREGPSIQLGAMAGKGISRALDRGKTEEKFLLT
CGASAGLSAAFHAPLAGVMFSLEEVHKNFSVSVLISVMTASLTADYISANFLGMESVFQFD

Specific function: Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786350, Length=184, Percent_Identity=38.0434782608696, Blast_Score=70, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17559050, Length=238, Percent_Identity=31.9327731092437, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71980828, Length=139, Percent_Identity=28.7769784172662, Blast_Score=64, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI71980824, Length=139, Percent_Identity=28.7769784172662, Blast_Score=64, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI71980820, Length=139, Percent_Identity=28.7769784172662, Blast_Score=64, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 23800; Mature: 23800

Theoretical pI: Translated: 9.11; Mature: 9.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKDTSHIIKRAEHFQVILIGEGLMVGAVAGLIVLLYRILLGQAGTWLSQILKFVEGSTI
CCCCHHHHHHHHHCEEEEEEECCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHH
KIIAWFAVLAVLAWIVSKLVDWEPMISGSGIPQLEGEMTGKIKQVWWRVLPTKFIGGFLS
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LMGGLALGREGPSIQLGAMAGKGISRALDRGKTEEKFLLTCGASAGLSAAFHAPLAGVMF
HHHHHHCCCCCCCEEEECHHCCHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHH
SLEEVHKNFSVSVLISVMTASLTADYISANFLGMESVFQFD
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKKDTSHIIKRAEHFQVILIGEGLMVGAVAGLIVLLYRILLGQAGTWLSQILKFVEGSTI
CCCCHHHHHHHHHCEEEEEEECCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHH
KIIAWFAVLAVLAWIVSKLVDWEPMISGSGIPQLEGEMTGKIKQVWWRVLPTKFIGGFLS
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LMGGLALGREGPSIQLGAMAGKGISRALDRGKTEEKFLLTCGASAGLSAAFHAPLAGVMF
HHHHHHCCCCCCCEEEECHHCCHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHH
SLEEVHKNFSVSVLISVMTASLTADYISANFLGMESVFQFD
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Cl Ion [Periplasm] [C]

Specific reaction: Cl Ion [Periplasm] = Cl Ion [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA