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The map label for this gene is mleN [H]

Identifier: 126698023

GI number: 126698023

Start: 534026

End: 535447

Strand: Direct

Name: mleN [H]

Synonym: CD0449

Alternate gene names: 126698023

Gene position: 534026-535447 (Clockwise)

Preceding gene: 126698022

Following gene: 126698024

Centisome position: 12.45

GC content: 32.63

Gene sequence:

>1422_bases
ATGAAAGAGCGAGAATGTAGAAAAGCAAGTCTGTTTGATGCAATGATACCAATTACTTGTTTGATATTATTTTTAAGTCT
AGGAGTATTAGTGTATGGTTCATCACCTCATGTACCACTAATAGGAGCAGCAGCAGTAGCAGGACTTGTGGCTGTATATA
GACTTGGATTTAAATGGAAAGAGTTAGAATTAAGTATGTTTAATAGTATAAAGATGGCAATGCAAGCAATCTTAATCATA
ATTATAATAGGCGTACTTATAGGAACTTGGATAGTAAGTGGAGTAGTTCCATGTATGATTTACTGGGGACTAAAAATTTT
ATCACCAAATATTTTTTTAGTAGCATCAACATTAGTCTGTGCAATAGTATCTCTTGCGACAGGTTCATCTTGGAGCACAA
TGGGTACAGTAGGAGTAGCTCTTTTAGGAATTGGTCAAAGTTTAGGTATGCCAATTGGATTAATCGTAGGTTCTATAATA
TCTGGAGCTTACTTTGGAGATAAACTATCACCTTTATCTGAAACGACTAACTTAGCTCCAGCAATGGCAGGAACAGATTT
GTTTACACATATAAAATATATGCTATATTCGACTATACCATCATTATTAATTTGTTTAGTAATTTATGGTGTAATTGGAA
TGAAGTATTCAGGTCAAGCACTAGATATAAAACAAATAGAATTAATTAGGTCTACATTAGATTCTACATTTAATACTTTA
TCACCAGTATTATTATTAGCTCCAGCAATAGTAATTGGATTAGTTGTATTTAAAGTTCCTGCTATACCAGGGCTTATAGT
AGGTGCTGTATTGGGAGTATTGTTTGCAGTAGTTTTTCAAGGAGAATCTATGAATACGATATTAGATGCAGCACAAAATG
GATATGTTTCGTCAACACAAATACAAGAGGTAGATGCTTTATTATCTAAAGGTGGGATTATGAATATGATGTCCACTGTA
TCCTTAACAATATGCGCTTTATCTCTTGGAGGTATTTTAGAAAAAACAGGTATGCTTGAAGTAGTAGCGTCTTCTTTACT
AAGATTAGCAAAGGGTGTATTTGGAACAGTATTATGTACTATGGTAACTTGTACAATTACCAATATAATAGCAGGTGAAC
AATATCTATCTATAGTTATACCAGGAAGAATGTATAATAAGGAATATAAAAAGAGAGGTATACATCCTAAGATGTTGTCG
AGAGCTTTAGAAGATAGTGGAACTTTAACTTCTCCATTAGTACCATGGAATACATGCGGGGCGTATATAACAGCAACATT
AGGTGTATCTGCACTAACATATGGTCCATACGCTTTATTAAATATTATAAATCCAATAGTATCTTTAGTATTAATTGCAT
GTAAGTTTAAAATAGCAAGAATAGAAGATGAACCTGAAACTTGTTTAAATTTTGATGTTTGA

Upstream 100 bases:

>100_bases
TTTTATTAACTTATGGGGGTATCATGTCATCTAGTACGAGCAAATATGTTGCAAAAAAAATTATAGTGTAGTGTTTAAAT
AATTAGGAGGAAACTATTTT

Downstream 100 bases:

>100_bases
TATTTTAATTGTTTGTATAAATTTTTTATAGAAAAAGATTTCTTTTAGACTTGCCTAAAAATTAGGCAAGTCTTTTAAGT
ATGTTCTGATTATAAGAGCA

Product: Na+/H+ antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 473; Mature: 473

Protein sequence:

>473_residues
MKERECRKASLFDAMIPITCLILFLSLGVLVYGSSPHVPLIGAAAVAGLVAVYRLGFKWKELELSMFNSIKMAMQAILII
IIIGVLIGTWIVSGVVPCMIYWGLKILSPNIFLVASTLVCAIVSLATGSSWSTMGTVGVALLGIGQSLGMPIGLIVGSII
SGAYFGDKLSPLSETTNLAPAMAGTDLFTHIKYMLYSTIPSLLICLVIYGVIGMKYSGQALDIKQIELIRSTLDSTFNTL
SPVLLLAPAIVIGLVVFKVPAIPGLIVGAVLGVLFAVVFQGESMNTILDAAQNGYVSSTQIQEVDALLSKGGIMNMMSTV
SLTICALSLGGILEKTGMLEVVASSLLRLAKGVFGTVLCTMVTCTITNIIAGEQYLSIVIPGRMYNKEYKKRGIHPKMLS
RALEDSGTLTSPLVPWNTCGAYITATLGVSALTYGPYALLNIINPIVSLVLIACKFKIARIEDEPETCLNFDV

Sequences:

>Translated_473_residues
MKERECRKASLFDAMIPITCLILFLSLGVLVYGSSPHVPLIGAAAVAGLVAVYRLGFKWKELELSMFNSIKMAMQAILII
IIIGVLIGTWIVSGVVPCMIYWGLKILSPNIFLVASTLVCAIVSLATGSSWSTMGTVGVALLGIGQSLGMPIGLIVGSII
SGAYFGDKLSPLSETTNLAPAMAGTDLFTHIKYMLYSTIPSLLICLVIYGVIGMKYSGQALDIKQIELIRSTLDSTFNTL
SPVLLLAPAIVIGLVVFKVPAIPGLIVGAVLGVLFAVVFQGESMNTILDAAQNGYVSSTQIQEVDALLSKGGIMNMMSTV
SLTICALSLGGILEKTGMLEVVASSLLRLAKGVFGTVLCTMVTCTITNIIAGEQYLSIVIPGRMYNKEYKKRGIHPKMLS
RALEDSGTLTSPLVPWNTCGAYITATLGVSALTYGPYALLNIINPIVSLVLIACKFKIARIEDEPETCLNFDV
>Mature_473_residues
MKERECRKASLFDAMIPITCLILFLSLGVLVYGSSPHVPLIGAAAVAGLVAVYRLGFKWKELELSMFNSIKMAMQAILII
IIIGVLIGTWIVSGVVPCMIYWGLKILSPNIFLVASTLVCAIVSLATGSSWSTMGTVGVALLGIGQSLGMPIGLIVGSII
SGAYFGDKLSPLSETTNLAPAMAGTDLFTHIKYMLYSTIPSLLICLVIYGVIGMKYSGQALDIKQIELIRSTLDSTFNTL
SPVLLLAPAIVIGLVVFKVPAIPGLIVGAVLGVLFAVVFQGESMNTILDAAQNGYVSSTQIQEVDALLSKGGIMNMMSTV
SLTICALSLGGILEKTGMLEVVASSLLRLAKGVFGTVLCTMVTCTITNIIAGEQYLSIVIPGRMYNKEYKKRGIHPKMLS
RALEDSGTLTSPLVPWNTCGAYITATLGVSALTYGPYALLNIINPIVSLVLIACKFKIARIEDEPETCLNFDV

Specific function: Couples proton uptake and Na(+) efflux to the substrate- product malate/lactate antiport, in an electroneutral malate- 2H(+)/Na(+)-lactate exchange. Plays a role in supporting growth to high density on malate at reduced protonmotive force [H]

COG id: COG1757

COG function: function code C; Na+/H+ antiporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaC Na(+)/H(+) antiporter family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004770
- InterPro:   IPR018461 [H]

Pfam domain/function: PF03553 Na_H_antiporter [H]

EC number: NA

Molecular weight: Translated: 50278; Mature: 50278

Theoretical pI: Translated: 8.02; Mature: 8.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKERECRKASLFDAMIPITCLILFLSLGVLVYGSSPHVPLIGAAAVAGLVAVYRLGFKWK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHCCCHH
ELELSMFNSIKMAMQAILIIIIIGVLIGTWIVSGVVPCMIYWGLKILSPNIFLVASTLVC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
AIVSLATGSSWSTMGTVGVALLGIGQSLGMPIGLIVGSIISGAYFGDKLSPLSETTNLAP
HHHHHHCCCCCHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHHCCCH
AMAGTDLFTHIKYMLYSTIPSLLICLVIYGVIGMKYSGQALDIKQIELIRSTLDSTFNTL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHH
SPVLLLAPAIVIGLVVFKVPAIPGLIVGAVLGVLFAVVFQGESMNTILDAAQNGYVSSTQ
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHH
IQEVDALLSKGGIMNMMSTVSLTICALSLGGILEKTGMLEVVASSLLRLAKGVFGTVLCT
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MVTCTITNIIAGEQYLSIVIPGRMYNKEYKKRGIHPKMLSRALEDSGTLTSPLVPWNTCG
HHHHHHHHHHCCCCEEEEEECCHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCHHHH
AYITATLGVSALTYGPYALLNIINPIVSLVLIACKFKIARIEDEPETCLNFDV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHCCCCC
>Mature Secondary Structure
MKERECRKASLFDAMIPITCLILFLSLGVLVYGSSPHVPLIGAAAVAGLVAVYRLGFKWK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHCCCHH
ELELSMFNSIKMAMQAILIIIIIGVLIGTWIVSGVVPCMIYWGLKILSPNIFLVASTLVC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
AIVSLATGSSWSTMGTVGVALLGIGQSLGMPIGLIVGSIISGAYFGDKLSPLSETTNLAP
HHHHHHCCCCCHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHHCCCH
AMAGTDLFTHIKYMLYSTIPSLLICLVIYGVIGMKYSGQALDIKQIELIRSTLDSTFNTL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHH
SPVLLLAPAIVIGLVVFKVPAIPGLIVGAVLGVLFAVVFQGESMNTILDAAQNGYVSSTQ
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHH
IQEVDALLSKGGIMNMMSTVSLTICALSLGGILEKTGMLEVVASSLLRLAKGVFGTVLCT
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MVTCTITNIIAGEQYLSIVIPGRMYNKEYKKRGIHPKMLSRALEDSGTLTSPLVPWNTCG
HHHHHHHHHHCCCCEEEEEECCHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCHHHH
AYITATLGVSALTYGPYALLNIINPIVSLVLIACKFKIARIEDEPETCLNFDV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377; 10903309 [H]