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The map label for this gene is argE [H]

Identifier: 126697875

GI number: 126697875

Start: 364777

End: 366039

Strand: Direct

Name: argE [H]

Synonym: CD0303

Alternate gene names: 126697875

Gene position: 364777-366039 (Clockwise)

Preceding gene: 126697874

Following gene: 126697876

Centisome position: 8.5

GC content: 31.2

Gene sequence:

>1263_bases
ATGAAAAAAATTCTCTTAGATACATTAAATAGTAAAAAACAAGAATACATAGATTATTTAAAAGAACTTGTAAGTATAAA
GACTGAAGATGTTGGTCATGGAATACTAGGTGGACTTGAAAAAGAAGGACAGGAATATATTGAAAAACTTGCAAATTACA
TAGGCTTTAGTGTAGATAGACAAGAAATGAGCGAAGAATTAATTAAAAAAGCAAAAAATATATATAAAGAAGGAAATCTA
GGTCACAATTATCAAGATAGATATAATTTAATTTGTAAGTATAGTGATGATTTACCTGGTAAGACAATTGTATTTAATGG
TCATGTAGACACTATGCCACCGGGTGATATAAGTAAGTGGAAATATAATCCATATCGTGCTACAGAAGATAATGGAAAAC
TTTATGGACTTGGAACTGCTGATATGAAATCTGGACTTATAGCATCAATATTAGCTGTAAAGCTTATAAAAGATAGTGGT
CTAAATGTACCTGGTAATGTAAAAATAATGTCAGTAGTAGATGAAGAAGGTGGCGGAAATGGTACCATAAATGCAGTTAT
GAATGGTATTGATGGAGATTGTTGCATAATTTGTGAACCATCAGAACAAAACTTAATAGTTGCACATATGGGATTTGTAT
TCTTTGAAGTTGAGGTTAAAGGTGTGTCTCTTCACTGTGGTAGTAAGTGGGAGGGTGTAAATGCAATTGAGAAGGCTATG
TTGTTGCTTCAAGATATAAAAGAGTTGGAACATAACTGGCTTATGATATATAAGCATCCACTATTACCTTCACCTACAAT
AAATTTAGGTGTAATAAATGGTGGAACAGCAGGTTCTACTGTGCCAGATAAGTGTGTATTTAATTTATGTGTACACTTCT
TGCCAAATATAATGAGTTATGAACAAGTTGTAAATGATGTAACAAATGTCATAATGACAAGGGCTAATGGAGATTTATGG
CTTAAAGATAATAAACCAAATATAAACATATATCAATCAGGGTTAGGTTTTGAGATGGACAAGGATTCTGATTTTGTAGT
GAATGCACATAAAATACTAGAAGAAACTCTAGGGAAAAAATTAGAGATAAAAGGTTCAACAGCTGGCAATGATGCGAGAG
TAATGAAAAATTTAGCTGAAATACCAACACTTATATTAGGGCCAGGTTCAATAGAACAATGTCATTCAATTGATGAATAT
GTTGAAATTAAGGAGTATTTAGATAGTATACTTATGTATGCAAGTCTAATATTAAACTTATAA

Upstream 100 bases:

>100_bases
CATTGAATGGGAATATGCTAAGTGAAAAAGTTTACTATGGCTTAAATAGATGAGATTAGACTTGAAATTTTAAATGTAAA
AATAAATCTTAGGAGGAAAT

Downstream 100 bases:

>100_bases
AAGTAGGAGGAATATATAAATGAAAAAAGTATTAATAGTAGGGGAATCTTGGGTAAAAAATATAACTCATATAAAAGGAT
TTGATACGTTTGTTACAACT

Product: acetylornithine deacetylase

Products: acetate; L-ornithine

Alternate protein names: NA

Number of amino acids: Translated: 420; Mature: 420

Protein sequence:

>420_residues
MKKILLDTLNSKKQEYIDYLKELVSIKTEDVGHGILGGLEKEGQEYIEKLANYIGFSVDRQEMSEELIKKAKNIYKEGNL
GHNYQDRYNLICKYSDDLPGKTIVFNGHVDTMPPGDISKWKYNPYRATEDNGKLYGLGTADMKSGLIASILAVKLIKDSG
LNVPGNVKIMSVVDEEGGGNGTINAVMNGIDGDCCIICEPSEQNLIVAHMGFVFFEVEVKGVSLHCGSKWEGVNAIEKAM
LLLQDIKELEHNWLMIYKHPLLPSPTINLGVINGGTAGSTVPDKCVFNLCVHFLPNIMSYEQVVNDVTNVIMTRANGDLW
LKDNKPNINIYQSGLGFEMDKDSDFVVNAHKILEETLGKKLEIKGSTAGNDARVMKNLAEIPTLILGPGSIEQCHSIDEY
VEIKEYLDSILMYASLILNL

Sequences:

>Translated_420_residues
MKKILLDTLNSKKQEYIDYLKELVSIKTEDVGHGILGGLEKEGQEYIEKLANYIGFSVDRQEMSEELIKKAKNIYKEGNL
GHNYQDRYNLICKYSDDLPGKTIVFNGHVDTMPPGDISKWKYNPYRATEDNGKLYGLGTADMKSGLIASILAVKLIKDSG
LNVPGNVKIMSVVDEEGGGNGTINAVMNGIDGDCCIICEPSEQNLIVAHMGFVFFEVEVKGVSLHCGSKWEGVNAIEKAM
LLLQDIKELEHNWLMIYKHPLLPSPTINLGVINGGTAGSTVPDKCVFNLCVHFLPNIMSYEQVVNDVTNVIMTRANGDLW
LKDNKPNINIYQSGLGFEMDKDSDFVVNAHKILEETLGKKLEIKGSTAGNDARVMKNLAEIPTLILGPGSIEQCHSIDEY
VEIKEYLDSILMYASLILNL
>Mature_420_residues
MKKILLDTLNSKKQEYIDYLKELVSIKTEDVGHGILGGLEKEGQEYIEKLANYIGFSVDRQEMSEELIKKAKNIYKEGNL
GHNYQDRYNLICKYSDDLPGKTIVFNGHVDTMPPGDISKWKYNPYRATEDNGKLYGLGTADMKSGLIASILAVKLIKDSG
LNVPGNVKIMSVVDEEGGGNGTINAVMNGIDGDCCIICEPSEQNLIVAHMGFVFFEVEVKGVSLHCGSKWEGVNAIEKAM
LLLQDIKELEHNWLMIYKHPLLPSPTINLGVINGGTAGSTVPDKCVFNLCVHFLPNIMSYEQVVNDVTNVIMTRANGDLW
LKDNKPNINIYQSGLGFEMDKDSDFVVNAHKILEETLGKKLEIKGSTAGNDARVMKNLAEIPTLILGPGSIEQCHSIDEY
VEIKEYLDSILMYASLILNL

Specific function: Displays A Broad Specificity And Can Also Deacylate Substrates Such As Acetylarginine, Acetylhistidine Or Acetylglutamate Semialdehyde. [C]

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20A family [H]

Homologues:

Organism=Escherichia coli, GI1790395, Length=326, Percent_Identity=32.2085889570552, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI1788816, Length=192, Percent_Identity=26.5625, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1789236, Length=334, Percent_Identity=22.7544910179641, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17551016, Length=247, Percent_Identity=27.1255060728745, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI193211059, Length=196, Percent_Identity=23.9795918367347, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24649210, Length=355, Percent_Identity=24.7887323943662, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010182
- InterPro:   IPR002933
- InterPro:   IPR011650 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: 3.5.1.16

Molecular weight: Translated: 46571; Mature: 46571

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKILLDTLNSKKQEYIDYLKELVSIKTEDVGHGILGGLEKEGQEYIEKLANYIGFSVDR
CCCHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCHHHCCHHHHHHHHHHHHHHHHCCCCCH
QEMSEELIKKAKNIYKEGNLGHNYQDRYNLICKYSDDLPGKTIVFNGHVDTMPPGDISKW
HHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCEEEECCCCCCCCCCCCCCC
KYNPYRATEDNGKLYGLGTADMKSGLIASILAVKLIKDSGLNVPGNVKIMSVVDEEGGGN
CCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCC
GTINAVMNGIDGDCCIICEPSEQNLIVAHMGFVFFEVEVKGVSLHCGSKWEGVNAIEKAM
CEEHHEECCCCCCEEEEECCCCCCEEEEEECEEEEEEEEEEEEEECCCCCCCHHHHHHHH
LLLQDIKELEHNWLMIYKHPLLPSPTINLGVINGGTAGSTVPDKCVFNLCVHFLPNIMSY
HHHHHHHHHCCCEEEEEECCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHH
EQVVNDVTNVIMTRANGDLWLKDNKPNINIYQSGLGFEMDKDSDFVVNAHKILEETLGKK
HHHHHHHHHHEEEECCCCEEEECCCCCEEEEECCCCCEECCCCCEEEHHHHHHHHHCCCE
LEIKGSTAGNDARVMKNLAEIPTLILGPGSIEQCHSIDEYVEIKEYLDSILMYASLILNL
EEEECCCCCCHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKKILLDTLNSKKQEYIDYLKELVSIKTEDVGHGILGGLEKEGQEYIEKLANYIGFSVDR
CCCHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCHHHCCHHHHHHHHHHHHHHHHCCCCCH
QEMSEELIKKAKNIYKEGNLGHNYQDRYNLICKYSDDLPGKTIVFNGHVDTMPPGDISKW
HHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCEEEECCCCCCCCCCCCCCC
KYNPYRATEDNGKLYGLGTADMKSGLIASILAVKLIKDSGLNVPGNVKIMSVVDEEGGGN
CCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCC
GTINAVMNGIDGDCCIICEPSEQNLIVAHMGFVFFEVEVKGVSLHCGSKWEGVNAIEKAM
CEEHHEECCCCCCEEEEECCCCCCEEEEEECEEEEEEEEEEEEEECCCCCCCHHHHHHHH
LLLQDIKELEHNWLMIYKHPLLPSPTINLGVINGGTAGSTVPDKCVFNLCVHFLPNIMSY
HHHHHHHHHCCCEEEEEECCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHH
EQVVNDVTNVIMTRANGDLWLKDNKPNINIYQSGLGFEMDKDSDFVVNAHKILEETLGKK
HHHHHHHHHHEEEECCCCEEEECCCCCEEEEECCCCCEECCCCCEEEHHHHHHHHHCCCE
LEIKGSTAGNDARVMKNLAEIPTLILGPGSIEQCHSIDEYVEIKEYLDSILMYASLILNL
EEEECCCCCCHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Glutathione. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N2-acetyl-L-ornithine; H2O

Specific reaction: N2-acetyl-L-ornithine + H2O = acetate + L-ornithine

General reaction: Carboxylic acid amide hydrolysis [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9734814; 9384377 [H]