| Definition | Clostridium difficile 630 chromosome, complete genome. |
|---|---|
| Accession | NC_009089 |
| Length | 4,290,252 |
Click here to switch to the map view.
The map label for this gene is ucpA [C]
Identifier: 126697632
GI number: 126697632
Start: 88901
End: 89689
Strand: Direct
Name: ucpA [C]
Synonym: CD0065
Alternate gene names: 126697632
Gene position: 88901-89689 (Clockwise)
Preceding gene: 126697631
Following gene: 126697633
Centisome position: 2.07
GC content: 33.21
Gene sequence:
>789_bases ATGGAAAAATTACAAGGAAAAATTGCAGTAGTTACTGCAGCAACAAAAGGTATTGGATTAGCATCAGCAGAGATATTAGC AAAAAATGGAGCAACTGTGTACTTAGCAGCTCGTTCAGAAGAATTAGCTCATGAAGTTATAAATAAAATAAGTGCAGAAG GTGGTTGTGCTAAGTTTGTTTACTTTAATGCTCGTGAAGAAGAGACCTTTACCTCAATGATAGAAGAGGTAGTTAAAAAA GAAGGTAAGATAGATATACTTGTAAACAATTTTGGTTCAACAAACCCTTCTCTTGACAAAGACCTTGTAACTGGGGATAC AGATAATTTCTTTGACACAGTAAATACTAATTTAAAAAGTGTGTATTTACCATGTAAAGCAGCAATTCCTCATATGATAA AGAATGGAAAAGGAAGTATAGTAAATATATCAAGTATAGGTTCAGTATTACCTGATTTATCTAGAATAGCTTACTGTGTA TCAAAAGCAGCAATCAACTCATTAACTCAAAACATAGCTACACAATATGCTAAAGACAATGTTAGATGTAATGCTGTACT TCCAGGGCTTATTGCAACTAAAGCAGCATTAGACAATATGTCTCCAGAGTTCATAAAAGAATTTTTAAAGCATGTTCCTT TAAATCGTATAGGGGAACCAGATGATATAGCAAAAGCTGTTCTATTCTATGCTAGTGATGACTCATCATTTATAACAGGG GATTTACTTGAAGTTGCAGGAGGATTTGGTTTACCTACTCCACAATTTGCAGATAATATATTAGGATAA
Upstream 100 bases:
>100_bases TAAATAATTAATTAACAAATATAAATTTTAAAATAAGTTAGATATTTAGAAAAATCGAAATTTGTAGGATTTAAAGGACA TATTCAAGGAGGAGTTAATA
Downstream 100 bases:
>100_bases TTAAATTACTAATATGCAATGAAAGCTTATGCATTAGTTATAGTAGAAATGATATTTTTATAAAGGCCATAGATATAATT TATATTGGAAAGGTTTGAGG
Product: NADP-dependent 7-alpha-hydroxysteroid dehydrogenase
Products: NA
Alternate protein names: 7-alpha-HSDH; Bile acid 7-dehydroxylase [H]
Number of amino acids: Translated: 262; Mature: 262
Protein sequence:
>262_residues MEKLQGKIAVVTAATKGIGLASAEILAKNGATVYLAARSEELAHEVINKISAEGGCAKFVYFNAREEETFTSMIEEVVKK EGKIDILVNNFGSTNPSLDKDLVTGDTDNFFDTVNTNLKSVYLPCKAAIPHMIKNGKGSIVNISSIGSVLPDLSRIAYCV SKAAINSLTQNIATQYAKDNVRCNAVLPGLIATKAALDNMSPEFIKEFLKHVPLNRIGEPDDIAKAVLFYASDDSSFITG DLLEVAGGFGLPTPQFADNILG
Sequences:
>Translated_262_residues MEKLQGKIAVVTAATKGIGLASAEILAKNGATVYLAARSEELAHEVINKISAEGGCAKFVYFNAREEETFTSMIEEVVKK EGKIDILVNNFGSTNPSLDKDLVTGDTDNFFDTVNTNLKSVYLPCKAAIPHMIKNGKGSIVNISSIGSVLPDLSRIAYCV SKAAINSLTQNIATQYAKDNVRCNAVLPGLIATKAALDNMSPEFIKEFLKHVPLNRIGEPDDIAKAVLFYASDDSSFITG DLLEVAGGFGLPTPQFADNILG >Mature_262_residues MEKLQGKIAVVTAATKGIGLASAEILAKNGATVYLAARSEELAHEVINKISAEGGCAKFVYFNAREEETFTSMIEEVVKK EGKIDILVNNFGSTNPSLDKDLVTGDTDNFFDTVNTNLKSVYLPCKAAIPHMIKNGKGSIVNISSIGSVLPDLSRIAYCV SKAAINSLTQNIATQYAKDNVRCNAVLPGLIATKAALDNMSPEFIKEFLKHVPLNRIGEPDDIAKAVLFYASDDSSFITG DLLEVAGGFGLPTPQFADNILG
Specific function: Unknown
COG id: NA
COG function: NA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Unknown [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI32483357, Length=252, Percent_Identity=35.7142857142857, Blast_Score=137, Evalue=1e-32, Organism=Homo sapiens, GI5031737, Length=246, Percent_Identity=31.7073170731707, Blast_Score=120, Evalue=2e-27, Organism=Homo sapiens, GI15277342, Length=256, Percent_Identity=31.25, Blast_Score=119, Evalue=4e-27, Organism=Homo sapiens, GI126723750, Length=250, Percent_Identity=30.4, Blast_Score=112, Evalue=3e-25, Organism=Homo sapiens, GI40254992, Length=246, Percent_Identity=31.7073170731707, Blast_Score=111, Evalue=5e-25, Organism=Homo sapiens, GI19923817, Length=265, Percent_Identity=29.4339622641509, Blast_Score=111, Evalue=6e-25, Organism=Homo sapiens, GI66933014, Length=258, Percent_Identity=29.4573643410853, Blast_Score=95, Evalue=6e-20, Organism=Homo sapiens, GI33667109, Length=191, Percent_Identity=30.8900523560209, Blast_Score=92, Evalue=6e-19, Organism=Homo sapiens, GI59889578, Length=197, Percent_Identity=28.9340101522843, Blast_Score=90, Evalue=2e-18, Organism=Homo sapiens, GI7705925, Length=249, Percent_Identity=28.5140562248996, Blast_Score=90, Evalue=2e-18, Organism=Homo sapiens, GI209862901, Length=205, Percent_Identity=30.2439024390244, Blast_Score=87, Evalue=2e-17, Organism=Homo sapiens, GI19923983, Length=205, Percent_Identity=30.2439024390244, Blast_Score=87, Evalue=2e-17, Organism=Homo sapiens, GI126723191, Length=186, Percent_Identity=32.7956989247312, Blast_Score=86, Evalue=3e-17, Organism=Homo sapiens, GI7705855, Length=222, Percent_Identity=32.4324324324324, Blast_Score=86, Evalue=5e-17, Organism=Homo sapiens, GI10190704, Length=263, Percent_Identity=25.8555133079848, Blast_Score=86, Evalue=5e-17, Organism=Homo sapiens, GI109715829, Length=254, Percent_Identity=27.9527559055118, Blast_Score=84, Evalue=2e-16, Organism=Homo sapiens, GI32455239, Length=206, Percent_Identity=33.495145631068, Blast_Score=79, Evalue=3e-15, Organism=Homo sapiens, GI5031765, Length=206, Percent_Identity=33.495145631068, Blast_Score=79, Evalue=3e-15, Organism=Homo sapiens, GI40254986, Length=207, Percent_Identity=29.4685990338164, Blast_Score=79, Evalue=4e-15, Organism=Homo sapiens, GI4503301, Length=255, Percent_Identity=25.8823529411765, Blast_Score=79, Evalue=4e-15, Organism=Homo sapiens, GI31542939, Length=248, Percent_Identity=28.6290322580645, Blast_Score=78, Evalue=8e-15, Organism=Homo sapiens, GI226371731, Length=202, Percent_Identity=28.7128712871287, Blast_Score=77, Evalue=1e-14, Organism=Homo sapiens, GI4504505, Length=256, Percent_Identity=25, Blast_Score=72, Evalue=6e-13, Organism=Homo sapiens, GI4758504, Length=257, Percent_Identity=26.0700389105058, Blast_Score=69, Evalue=3e-12, Organism=Homo sapiens, GI224922801, Length=173, Percent_Identity=30.0578034682081, Blast_Score=66, Evalue=3e-11, Organism=Homo sapiens, GI20149619, Length=206, Percent_Identity=26.6990291262136, Blast_Score=65, Evalue=4e-11, Organism=Homo sapiens, GI7706318, Length=212, Percent_Identity=26.4150943396226, Blast_Score=65, Evalue=7e-11, Organism=Escherichia coli, GI87082100, Length=260, Percent_Identity=34.6153846153846, Blast_Score=138, Evalue=4e-34, Organism=Escherichia coli, GI1787335, Length=246, Percent_Identity=34.5528455284553, Blast_Score=132, Evalue=2e-32, Organism=Escherichia coli, GI1787905, Length=246, Percent_Identity=33.739837398374, Blast_Score=127, Evalue=5e-31, Organism=Escherichia coli, GI2367175, Length=246, Percent_Identity=31.3008130081301, Blast_Score=120, Evalue=6e-29, Organism=Escherichia coli, GI1790717, Length=247, Percent_Identity=29.5546558704453, Blast_Score=110, Evalue=7e-26, Organism=Escherichia coli, GI1788459, Length=257, Percent_Identity=31.1284046692607, Blast_Score=110, Evalue=1e-25, Organism=Escherichia coli, GI1789208, Length=250, Percent_Identity=31.6, Blast_Score=110, Evalue=1e-25, Organism=Escherichia coli, GI87082160, Length=247, Percent_Identity=31.5789473684211, Blast_Score=107, Evalue=7e-25, Organism=Escherichia coli, GI1789378, Length=251, Percent_Identity=30.2788844621514, Blast_Score=95, Evalue=4e-21, Organism=Escherichia coli, GI2367365, Length=253, Percent_Identity=27.2727272727273, Blast_Score=77, Evalue=1e-15, Organism=Escherichia coli, GI1786812, Length=257, Percent_Identity=27.2373540856031, Blast_Score=75, Evalue=3e-15, Organism=Escherichia coli, GI1789057, Length=256, Percent_Identity=24.21875, Blast_Score=71, Evalue=8e-14, Organism=Caenorhabditis elegans, GI17561402, Length=258, Percent_Identity=36.046511627907, Blast_Score=136, Evalue=9e-33, Organism=Caenorhabditis elegans, GI71994604, Length=258, Percent_Identity=34.1085271317829, Blast_Score=132, Evalue=1e-31, Organism=Caenorhabditis elegans, GI17560676, Length=247, Percent_Identity=31.9838056680162, Blast_Score=125, Evalue=2e-29, Organism=Caenorhabditis elegans, GI17559104, Length=281, Percent_Identity=34.8754448398576, Blast_Score=125, Evalue=3e-29, Organism=Caenorhabditis elegans, GI71994600, Length=259, Percent_Identity=32.8185328185328, Blast_Score=124, Evalue=7e-29, Organism=Caenorhabditis elegans, GI17562910, Length=278, Percent_Identity=32.3741007194245, Blast_Score=120, Evalue=1e-27, Organism=Caenorhabditis elegans, GI25147288, Length=250, Percent_Identity=34.8, Blast_Score=120, Evalue=1e-27, Organism=Caenorhabditis elegans, GI17555706, Length=250, Percent_Identity=33.2, Blast_Score=119, Evalue=2e-27, Organism=Caenorhabditis elegans, GI17560332, Length=266, Percent_Identity=31.9548872180451, Blast_Score=112, Evalue=2e-25, Organism=Caenorhabditis elegans, GI17531453, Length=267, Percent_Identity=33.3333333333333, Blast_Score=109, Evalue=1e-24, Organism=Caenorhabditis elegans, GI17544670, Length=263, Percent_Identity=30.7984790874525, Blast_Score=109, Evalue=2e-24, Organism=Caenorhabditis elegans, GI193204405, Length=267, Percent_Identity=32.2097378277154, Blast_Score=108, Evalue=3e-24, Organism=Caenorhabditis elegans, GI17562904, Length=279, Percent_Identity=31.1827956989247, Blast_Score=106, Evalue=1e-23, Organism=Caenorhabditis elegans, GI17562906, Length=278, Percent_Identity=29.8561151079137, Blast_Score=105, Evalue=2e-23, Organism=Caenorhabditis elegans, GI17560220, Length=280, Percent_Identity=29.6428571428571, Blast_Score=101, Evalue=4e-22, Organism=Caenorhabditis elegans, GI17551412, Length=266, Percent_Identity=29.3233082706767, Blast_Score=101, Evalue=4e-22, Organism=Caenorhabditis elegans, GI17563726, Length=274, Percent_Identity=31.021897810219, Blast_Score=100, Evalue=8e-22, Organism=Caenorhabditis elegans, GI17562908, Length=277, Percent_Identity=29.6028880866426, Blast_Score=100, Evalue=1e-21, Organism=Caenorhabditis elegans, GI115534694, Length=247, Percent_Identity=33.6032388663968, Blast_Score=98, Evalue=4e-21, Organism=Caenorhabditis elegans, GI17538480, Length=265, Percent_Identity=30.188679245283, Blast_Score=96, Evalue=2e-20, Organism=Caenorhabditis elegans, GI17565030, Length=266, Percent_Identity=29.6992481203008, Blast_Score=96, Evalue=2e-20, Organism=Caenorhabditis elegans, GI17560150, Length=269, Percent_Identity=31.2267657992565, Blast_Score=92, Evalue=3e-19, Organism=Caenorhabditis elegans, GI17538486, Length=268, Percent_Identity=30.5970149253731, Blast_Score=89, Evalue=2e-18, Organism=Caenorhabditis elegans, GI17536651, Length=257, Percent_Identity=29.5719844357977, Blast_Score=88, Evalue=4e-18, Organism=Caenorhabditis elegans, GI72000259, Length=276, Percent_Identity=28.9855072463768, Blast_Score=88, Evalue=5e-18, Organism=Caenorhabditis elegans, GI17562990, Length=269, Percent_Identity=31.2267657992565, Blast_Score=87, Evalue=9e-18, Organism=Caenorhabditis elegans, GI17536025, Length=257, Percent_Identity=30.3501945525292, Blast_Score=84, Evalue=7e-17, Organism=Caenorhabditis elegans, GI17555612, Length=208, Percent_Identity=33.6538461538462, Blast_Score=84, Evalue=9e-17, Organism=Caenorhabditis elegans, GI71997099, Length=209, Percent_Identity=30.1435406698565, Blast_Score=81, Evalue=6e-16, Organism=Caenorhabditis elegans, GI17508651, Length=248, Percent_Identity=30.241935483871, Blast_Score=78, Evalue=6e-15, Organism=Caenorhabditis elegans, GI17561272, Length=252, Percent_Identity=27.7777777777778, Blast_Score=74, Evalue=5e-14, Organism=Caenorhabditis elegans, GI17538182, Length=264, Percent_Identity=26.1363636363636, Blast_Score=74, Evalue=9e-14, Organism=Caenorhabditis elegans, GI86565303, Length=212, Percent_Identity=30.188679245283, Blast_Score=71, Evalue=5e-13, Organism=Caenorhabditis elegans, GI17568967, Length=256, Percent_Identity=26.953125, Blast_Score=70, Evalue=1e-12, Organism=Caenorhabditis elegans, GI193203117, Length=215, Percent_Identity=28.3720930232558, Blast_Score=66, Evalue=2e-11, Organism=Caenorhabditis elegans, GI17560176, Length=203, Percent_Identity=28.0788177339901, Blast_Score=65, Evalue=4e-11, Organism=Caenorhabditis elegans, GI193203115, Length=214, Percent_Identity=28.0373831775701, Blast_Score=65, Evalue=5e-11, Organism=Caenorhabditis elegans, GI71982365, Length=214, Percent_Identity=25.7009345794392, Blast_Score=64, Evalue=8e-11, Organism=Saccharomyces cerevisiae, GI6322227, Length=227, Percent_Identity=29.0748898678414, Blast_Score=78, Evalue=2e-15, Organism=Saccharomyces cerevisiae, GI6322861, Length=255, Percent_Identity=25.4901960784314, Blast_Score=75, Evalue=7e-15, Organism=Saccharomyces cerevisiae, GI6324126, Length=259, Percent_Identity=25.8687258687259, Blast_Score=75, Evalue=1e-14, Organism=Saccharomyces cerevisiae, GI6323882, Length=254, Percent_Identity=30.3149606299213, Blast_Score=67, Evalue=3e-12, Organism=Drosophila melanogaster, GI23397609, Length=257, Percent_Identity=34.6303501945525, Blast_Score=137, Evalue=5e-33, Organism=Drosophila melanogaster, GI28571526, Length=262, Percent_Identity=35.1145038167939, Blast_Score=126, Evalue=1e-29, Organism=Drosophila melanogaster, GI21357041, Length=265, Percent_Identity=34.3396226415094, Blast_Score=124, Evalue=8e-29, Organism=Drosophila melanogaster, GI21355319, Length=254, Percent_Identity=34.251968503937, Blast_Score=120, Evalue=7e-28, Organism=Drosophila melanogaster, GI24639444, Length=249, Percent_Identity=32.5301204819277, Blast_Score=120, Evalue=7e-28, Organism=Drosophila melanogaster, GI24644339, Length=262, Percent_Identity=33.206106870229, Blast_Score=118, Evalue=5e-27, Organism=Drosophila melanogaster, GI24643142, Length=248, Percent_Identity=32.6612903225806, Blast_Score=104, Evalue=6e-23, Organism=Drosophila melanogaster, GI24644337, Length=264, Percent_Identity=32.5757575757576, Blast_Score=93, Evalue=1e-19, Organism=Drosophila melanogaster, GI161076933, Length=192, Percent_Identity=31.7708333333333, Blast_Score=86, Evalue=3e-17, Organism=Drosophila melanogaster, GI24584748, Length=192, Percent_Identity=31.7708333333333, Blast_Score=86, Evalue=3e-17, Organism=Drosophila melanogaster, GI17737361, Length=266, Percent_Identity=27.0676691729323, Blast_Score=79, Evalue=3e-15, Organism=Drosophila melanogaster, GI18859837, Length=256, Percent_Identity=27.34375, Blast_Score=79, Evalue=4e-15, Organism=Drosophila melanogaster, GI24641232, Length=242, Percent_Identity=28.5123966942149, Blast_Score=78, Evalue=6e-15, Organism=Drosophila melanogaster, GI24584744, Length=194, Percent_Identity=29.8969072164948, Blast_Score=76, Evalue=2e-14, Organism=Drosophila melanogaster, GI28574402, Length=194, Percent_Identity=29.8969072164948, Blast_Score=76, Evalue=2e-14, Organism=Drosophila melanogaster, GI24640442, Length=219, Percent_Identity=30.1369863013699, Blast_Score=76, Evalue=2e-14, Organism=Drosophila melanogaster, GI21357673, Length=260, Percent_Identity=27.6923076923077, Blast_Score=76, Evalue=2e-14, Organism=Drosophila melanogaster, GI21358495, Length=254, Percent_Identity=24.8031496062992, Blast_Score=71, Evalue=9e-13, Organism=Drosophila melanogaster, GI24640492, Length=200, Percent_Identity=26, Blast_Score=70, Evalue=1e-12, Organism=Drosophila melanogaster, GI281364494, Length=243, Percent_Identity=28.3950617283951, Blast_Score=69, Evalue=3e-12,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: 1.-.-.- [C]
Molecular weight: Translated: 27991; Mature: 27991
Theoretical pI: Translated: 4.97; Mature: 4.97
Prosite motif: PS00061 ADH_SHORT
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.5 %Cys (Translated Protein) 1.5 %Met (Translated Protein) 3.1 %Cys+Met (Translated Protein) 1.5 %Cys (Mature Protein) 1.5 %Met (Mature Protein) 3.1 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MEKLQGKIAVVTAATKGIGLASAEILAKNGATVYLAARSEELAHEVINKISAEGGCAKFV CCCCCCCEEEEEECCCCCCCHHHHHHCCCCCEEEEEECCHHHHHHHHHHHCCCCCEEEEE YFNAREEETFTSMIEEVVKKEGKIDILVNNFGSTNPSLDKDLVTGDTDNFFDTVNTNLKS EEECCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHCCCCCHHHHHHCCCCCE VYLPCKAAIPHMIKNGKGSIVNISSIGSVLPDLSRIAYCVSKAAINSLTQNIATQYAKDN EECCHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC VRCNAVLPGLIATKAALDNMSPEFIKEFLKHVPLNRIGEPDDIAKAVLFYASDDSSFITG CEEEEECCHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHEEEEEECCCCCCHHH DLLEVAGGFGLPTPQFADNILG HHHHHHCCCCCCCHHHHHHCCC >Mature Secondary Structure MEKLQGKIAVVTAATKGIGLASAEILAKNGATVYLAARSEELAHEVINKISAEGGCAKFV CCCCCCCEEEEEECCCCCCCHHHHHHCCCCCEEEEEECCHHHHHHHHHHHCCCCCEEEEE YFNAREEETFTSMIEEVVKKEGKIDILVNNFGSTNPSLDKDLVTGDTDNFFDTVNTNLKS EEECCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHCCCCCHHHHHHCCCCCE VYLPCKAAIPHMIKNGKGSIVNISSIGSVLPDLSRIAYCVSKAAINSLTQNIATQYAKDN EECCHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC VRCNAVLPGLIATKAALDNMSPEFIKEFLKHVPLNRIGEPDDIAKAVLFYASDDSSFITG CEEEEECCHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHEEEEEECCCCCCHHH DLLEVAGGFGLPTPQFADNILG HHHHHHCCCCCCCHHHHHHCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 8050999 [H]