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The map label for this gene is disA

Identifier: 126697594

GI number: 126697594

Start: 46917

End: 47987

Strand: Direct

Name: disA

Synonym: CD0028

Alternate gene names: 126697594

Gene position: 46917-47987 (Clockwise)

Preceding gene: 126697593

Following gene: 126697595

Centisome position: 1.09

GC content: 28.94

Gene sequence:

>1071_bases
ATGGAGAATTTTCTAGATAATAAAAATATGCTATATGCATTAAAAATGATATCTCCTGGAACTCCACTTAGATTAGGTCT
AAACAATGTACTAAGAGCTAAGACTGGTGGATTAATTGTAATTGCAACAAACGAAGATGTAATGAAAATAGTAGATGGAG
GATTTGCTATAAATGCAGAATATTCACCATCATATCTATATGAATTAGCTAAAATGGATGGAGCTATAGTTTTAAGTGGT
GATGTAAAGAAAATATTATTTGCTAATGCACAACTTATACCTGACTATTTTATAGAAACATCAGAGACAGGAACAAGACA
TAGAACAGCAGAAAGAGTAGCAAAACAAACTGGTGCTATAGTCATAGGAATTTCACAAAGAAGAAATGTTATAACAGTTT
ATAGAGGAAATGAGAAGTATGTAGTCGAAGATATATCTAAGATATTTACTAAGGCAAATCAGGCTATACAAACTCTGGAA
AAATATAAGACAGTATTGGACCAAGCTGTAACAAATTTAAATGCCTTAGAGTTTAATGATTTGGTAACTATTTATGATGT
TGCATTAGTCATGCAAAAGATGGAAATGGTAATGAGAGTTACAAGTATAATTGAAAAATATGTGATAGAATTGGGTGATG
AAGGAACTTTAGTAAGTATGCAATTAGAAGAATTAATGGGTACAACCAGAATAGACCAGAAATTAATATTCAAAGATTAT
AATAAAGAAAACACAGAAATAAAAGAACTTATGAAAAAGGTCAAAAATTTAAATTCAGAAGAACTAATAGAATTGGTTAA
TATGGCAAAACTATTAGGGTATAGTGGTTTTTCAGAAAGTATGGATATGCCTATAAAAACAAGAGGTTATAGGATTCTTA
GCAAAATACATAGACTACCAACAGCAATAATAGAAAACTTAGTAAATTATTTTGAAAACTTTCAACAAATTTTAGATGCA
TCTATTGAAGAATTAGATGAGGTTGAAGGAATAGGTGAAATAAGAGCAACATATATAAAAAATGGACTCATAAAAATGAA
ACAATTAGTCTTATTAGATAGACACATATGA

Upstream 100 bases:

>100_bases
GTAATTATGATGTTGTAAAAGAGACCAAAGGCATAGAAATATGGCCAGTAGATAACTTAAGACAAGCTATAAATATAGTA
CTTGGGAGGAATCAATAAAT

Downstream 100 bases:

>100_bases
TGAATTTTAAATGAATTTTACTACTTTTTTCTTGAATATAATATACACTTTGGTCTATAATAGATAAGTATAACTAGGGG
GTGAAGCATTGATAAGGAAA

Product: DNA integrity scanning protein DisA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MENFLDNKNMLYALKMISPGTPLRLGLNNVLRAKTGGLIVIATNEDVMKIVDGGFAINAEYSPSYLYELAKMDGAIVLSG
DVKKILFANAQLIPDYFIETSETGTRHRTAERVAKQTGAIVIGISQRRNVITVYRGNEKYVVEDISKIFTKANQAIQTLE
KYKTVLDQAVTNLNALEFNDLVTIYDVALVMQKMEMVMRVTSIIEKYVIELGDEGTLVSMQLEELMGTTRIDQKLIFKDY
NKENTEIKELMKKVKNLNSEELIELVNMAKLLGYSGFSESMDMPIKTRGYRILSKIHRLPTAIIENLVNYFENFQQILDA
SIEELDEVEGIGEIRATYIKNGLIKMKQLVLLDRHI

Sequences:

>Translated_356_residues
MENFLDNKNMLYALKMISPGTPLRLGLNNVLRAKTGGLIVIATNEDVMKIVDGGFAINAEYSPSYLYELAKMDGAIVLSG
DVKKILFANAQLIPDYFIETSETGTRHRTAERVAKQTGAIVIGISQRRNVITVYRGNEKYVVEDISKIFTKANQAIQTLE
KYKTVLDQAVTNLNALEFNDLVTIYDVALVMQKMEMVMRVTSIIEKYVIELGDEGTLVSMQLEELMGTTRIDQKLIFKDY
NKENTEIKELMKKVKNLNSEELIELVNMAKLLGYSGFSESMDMPIKTRGYRILSKIHRLPTAIIENLVNYFENFQQILDA
SIEELDEVEGIGEIRATYIKNGLIKMKQLVLLDRHI
>Mature_356_residues
MENFLDNKNMLYALKMISPGTPLRLGLNNVLRAKTGGLIVIATNEDVMKIVDGGFAINAEYSPSYLYELAKMDGAIVLSG
DVKKILFANAQLIPDYFIETSETGTRHRTAERVAKQTGAIVIGISQRRNVITVYRGNEKYVVEDISKIFTKANQAIQTLE
KYKTVLDQAVTNLNALEFNDLVTIYDVALVMQKMEMVMRVTSIIEKYVIELGDEGTLVSMQLEELMGTTRIDQKLIFKDY
NKENTEIKELMKKVKNLNSEELIELVNMAKLLGYSGFSESMDMPIKTRGYRILSKIHRLPTAIIENLVNYFENFQQILDA
SIEELDEVEGIGEIRATYIKNGLIKMKQLVLLDRHI

Specific function: Participates in a DNA-damage check-point that is active prior to asymmetric division when DNA is damaged. DisA forms globular foci that rapidly scan along the chromosomes during sporulation, searching for lesions. When a lesion is present, disA pauses at

COG id: COG1623

COG function: function code R; Predicted nucleic-acid-binding protein (contains the HHH domain)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the disA family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DISA_CLOD6 (Q18CB2)

Other databases:

- EMBL:   AM180355
- RefSeq:   YP_001086491.1
- ProteinModelPortal:   Q18CB2
- SMR:   Q18CB2
- STRING:   Q18CB2
- GeneID:   4916497
- GenomeReviews:   AM180355_GR
- KEGG:   cdf:CD0028
- NMPDR:   fig|1496.1.peg.121
- eggNOG:   COG1623
- HOGENOM:   HBG292471
- OMA:   ISVSQSM
- ProtClustDB:   PRK13482
- HAMAP:   MF_01438
- InterPro:   IPR018906
- InterPro:   IPR003390
- InterPro:   IPR010994

Pfam domain/function: PF10635 DisA-linker; PF02457 DisA_N; SSF47781 RuvA_2_like

EC number: NA

Molecular weight: Translated: 40370; Mature: 40370

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENFLDNKNMLYALKMISPGTPLRLGLNNVLRAKTGGLIVIATNEDVMKIVDGGFAINAE
CCCCCCCCCEEEEEEECCCCCCEECCHHHHHHHCCCCEEEEECCCHHHHHHCCCEEEECC
YSPSYLYELAKMDGAIVLSGDVKKILFANAQLIPDYFIETSETGTRHRTAERVAKQTGAI
CCHHHHHHHHHCCCEEEEECCHHHHHHHCCHHCHHHHHCCCCCCCHHHHHHHHHHHCCCE
VIGISQRRNVITVYRGNEKYVVEDISKIFTKANQAIQTLEKYKTVLDQAVTNLNALEFND
EEEECCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
LVTIYDVALVMQKMEMVMRVTSIIEKYVIELGDEGTLVSMQLEELMGTTRIDQKLIFKDY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHCHHHHHHHHHHHCC
NKENTEIKELMKKVKNLNSEELIELVNMAKLLGYSGFSESMDMPIKTRGYRILSKIHRLP
CCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHH
TAIIENLVNYFENFQQILDASIEELDEVEGIGEIRATYIKNGLIKMKQLVLLDRHI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MENFLDNKNMLYALKMISPGTPLRLGLNNVLRAKTGGLIVIATNEDVMKIVDGGFAINAE
CCCCCCCCCEEEEEEECCCCCCEECCHHHHHHHCCCCEEEEECCCHHHHHHCCCEEEECC
YSPSYLYELAKMDGAIVLSGDVKKILFANAQLIPDYFIETSETGTRHRTAERVAKQTGAI
CCHHHHHHHHHCCCEEEEECCHHHHHHHCCHHCHHHHHCCCCCCCHHHHHHHHHHHCCCE
VIGISQRRNVITVYRGNEKYVVEDISKIFTKANQAIQTLEKYKTVLDQAVTNLNALEFND
EEEECCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
LVTIYDVALVMQKMEMVMRVTSIIEKYVIELGDEGTLVSMQLEELMGTTRIDQKLIFKDY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHCHHHHHHHHHHHCC
NKENTEIKELMKKVKNLNSEELIELVNMAKLLGYSGFSESMDMPIKTRGYRILSKIHRLP
CCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHH
TAIIENLVNYFENFQQILDASIEELDEVEGIGEIRATYIKNGLIKMKQLVLLDRHI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA