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The map label for this gene is gyrB [H]

Identifier: 126697571

GI number: 126697571

Start: 4145

End: 6046

Strand: Direct

Name: gyrB [H]

Synonym: CD0005

Alternate gene names: 126697571

Gene position: 4145-6046 (Clockwise)

Preceding gene: 126700594

Following gene: 126697572

Centisome position: 0.1

GC content: 32.39

Gene sequence:

>1902_bases
ATGAAACAAGAATACGGTGCAAGTCAGATACAAGTATTAGAGGGATTAGAAGCCGTTAGAAAAAGACCAGGTATGTATAT
TGGTAGTACAAGCCCTAGAGGTTTACATCACTTAGTTTATGAAGTTGTAGATAATAGTATAGATGAGGCTTTACAAGGAT
ATTGTTCAGACATATATGTATCTATTAATGAAGATGGCAGTGTTTTAGTAAAAGATAACGGAAGAGGTATACCTGTTGAA
ATACATCCTAAAACTGGTAAATCAACTTTAGAAACAGTATTAACTAATCTTCATGCAGGAGGAAAGTTTGGAGGCGGAGG
ATATAAAGTATCTGGAGGTCTTCATGGAGTTGGTGTTTCTGTAGTTAATGCATTGTCAAAATGGATGGTAGCAGAGGTTT
ATTTAAACGGAAAGATATATAAGCAGACATATGAGAAAGGATTACCAACATCTAAGCTTGAAGTAGTTGGAGAATCTCAA
GATAAAGGAACAATGATTCAATTTATGCCAGATGAGACAATATTTGATGAAATAGAGTTTAAATATGAAACATTGGAGTA
TAGGCTTAGAGAACTTTCTTTCTTGAATAAAGGAATAAAAATAGTATTTGAAGATAAAAGAGAAGGACAAGAAAAAAGAA
AAGAATTTCACTATACAGGTGGTTTGGTAGAATATATTAAGTATTTAAATAAATCTAGAACTGGTATACATGATGACATA
GTTTATATAGATAAAAAGGTTGATGATTGTTTTGTTGAACTAGCTATGCAATATACAGATGGTTATACAGAGAACATATA
TTCTTTTGCAAACAATATAAATACACACGAAGGTGGTTCTCATTTAAGTGGATTTAAAGCAGCTCTTACTAAAACTGTAA
ATGATTATGCTAAGAGAAATAAATTTTTAAAGGAAAATGATGTTAACCTACTTGGTGAAGACATAAGAGAAGGTCTTACA
GCAGTAGTATCAGTTAAATTACCAGAACCTCAATTTGAAGGTCAAACTAAAACAAAGCTAGGTAATAGCTTTATGAGAGG
TATAGTTGATAGTGTAACAGTTGATGAACTGGGGTCTTTCCTAGAAGAAAACCCATCAACAGCAAGAATCATAGTTGATA
AAGCTTTAAGAGCACAAAGAGCTAGAGAAGCTGCAAAAAAAGCAAGAGAATTAACAAGGAGAAAAAGTGTATTAGAAAGT
ACATCTTTACCTGGAAAACTTGCAGATTGTGCAGAAAAAGATCCATCTAAAAGTGAAATATTCTTAGTCGAAGGGGATTC
AGCGGGAGGTTCAGCTAAACAAGGTAGAGATAGAAATAGTCAAGCTATACTTCCATTAAGAGGGAAAATACTTAATGTTG
AGAAATCAAGACTAGATAGGATACTATCTTCAGATGAAATAAAAAATATGATAACAGCTTATGGTTGTGGTATTGGAGAA
GATTTTGATATAGATAAAGCTAGGTATCATAAAATTATAATTATGACCGATGCTGATGTAGATGGAGCCCATATAAGAAC
TTTATTATTAACATTCTTCTTTAGATATATGAGACCTCTTATAGATGAGGGGTATGTTTATGCAGCACAGCCACCTTTAT
ATAAAGTGACAAAGCAAAAGAAGGAACATTATGTTTACTCAGATAAAGAGTTAAATATCTTATTAGATGAAATTGGAAGA
AATGGTGTTGAACTTCAAAGGTACAAAGGTCTTGGAGAGATGAATGCAGAGCAATTATGGGAAACAACTATGAATCCTGA
GACAAGAACTTTATTACAAGTTACTGTAGAAGATGCTGCAATTGCAGATGAAGTATTTTCAATGCTTATGGGTGATAAGG
TTGCTCCAAGAAAAGAATTTATAGAAGAAAATGCAAGATTTGTTAGAAACTTAGATATATAG

Upstream 100 bases:

>100_bases
TGCTGAAGTTTCACATAAAAAAATATTTGATGAAAAAAATGTTACAATATTTAATATTGAAAATGGCGATGTTATTAGCA
TAGAGAATGGAGGAAATTAA

Downstream 100 bases:

>100_bases
AGAGAGGGGATTAGTATACATGGAAGAAAATAACAAAATACTCCCTATTGAAATAGCGGAAGAAATGAAAAAATCGTATA
TTGATTATTCAATGAGTGTT

Product: DNA gyrase subunit B

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 633; Mature: 633

Protein sequence:

>633_residues
MKQEYGASQIQVLEGLEAVRKRPGMYIGSTSPRGLHHLVYEVVDNSIDEALQGYCSDIYVSINEDGSVLVKDNGRGIPVE
IHPKTGKSTLETVLTNLHAGGKFGGGGYKVSGGLHGVGVSVVNALSKWMVAEVYLNGKIYKQTYEKGLPTSKLEVVGESQ
DKGTMIQFMPDETIFDEIEFKYETLEYRLRELSFLNKGIKIVFEDKREGQEKRKEFHYTGGLVEYIKYLNKSRTGIHDDI
VYIDKKVDDCFVELAMQYTDGYTENIYSFANNINTHEGGSHLSGFKAALTKTVNDYAKRNKFLKENDVNLLGEDIREGLT
AVVSVKLPEPQFEGQTKTKLGNSFMRGIVDSVTVDELGSFLEENPSTARIIVDKALRAQRAREAAKKARELTRRKSVLES
TSLPGKLADCAEKDPSKSEIFLVEGDSAGGSAKQGRDRNSQAILPLRGKILNVEKSRLDRILSSDEIKNMITAYGCGIGE
DFDIDKARYHKIIIMTDADVDGAHIRTLLLTFFFRYMRPLIDEGYVYAAQPPLYKVTKQKKEHYVYSDKELNILLDEIGR
NGVELQRYKGLGEMNAEQLWETTMNPETRTLLQVTVEDAAIADEVFSMLMGDKVAPRKEFIEENARFVRNLDI

Sequences:

>Translated_633_residues
MKQEYGASQIQVLEGLEAVRKRPGMYIGSTSPRGLHHLVYEVVDNSIDEALQGYCSDIYVSINEDGSVLVKDNGRGIPVE
IHPKTGKSTLETVLTNLHAGGKFGGGGYKVSGGLHGVGVSVVNALSKWMVAEVYLNGKIYKQTYEKGLPTSKLEVVGESQ
DKGTMIQFMPDETIFDEIEFKYETLEYRLRELSFLNKGIKIVFEDKREGQEKRKEFHYTGGLVEYIKYLNKSRTGIHDDI
VYIDKKVDDCFVELAMQYTDGYTENIYSFANNINTHEGGSHLSGFKAALTKTVNDYAKRNKFLKENDVNLLGEDIREGLT
AVVSVKLPEPQFEGQTKTKLGNSFMRGIVDSVTVDELGSFLEENPSTARIIVDKALRAQRAREAAKKARELTRRKSVLES
TSLPGKLADCAEKDPSKSEIFLVEGDSAGGSAKQGRDRNSQAILPLRGKILNVEKSRLDRILSSDEIKNMITAYGCGIGE
DFDIDKARYHKIIIMTDADVDGAHIRTLLLTFFFRYMRPLIDEGYVYAAQPPLYKVTKQKKEHYVYSDKELNILLDEIGR
NGVELQRYKGLGEMNAEQLWETTMNPETRTLLQVTVEDAAIADEVFSMLMGDKVAPRKEFIEENARFVRNLDI
>Mature_633_residues
MKQEYGASQIQVLEGLEAVRKRPGMYIGSTSPRGLHHLVYEVVDNSIDEALQGYCSDIYVSINEDGSVLVKDNGRGIPVE
IHPKTGKSTLETVLTNLHAGGKFGGGGYKVSGGLHGVGVSVVNALSKWMVAEVYLNGKIYKQTYEKGLPTSKLEVVGESQ
DKGTMIQFMPDETIFDEIEFKYETLEYRLRELSFLNKGIKIVFEDKREGQEKRKEFHYTGGLVEYIKYLNKSRTGIHDDI
VYIDKKVDDCFVELAMQYTDGYTENIYSFANNINTHEGGSHLSGFKAALTKTVNDYAKRNKFLKENDVNLLGEDIREGLT
AVVSVKLPEPQFEGQTKTKLGNSFMRGIVDSVTVDELGSFLEENPSTARIIVDKALRAQRAREAAKKARELTRRKSVLES
TSLPGKLADCAEKDPSKSEIFLVEGDSAGGSAKQGRDRNSQAILPLRGKILNVEKSRLDRILSSDEIKNMITAYGCGIGE
DFDIDKARYHKIIIMTDADVDGAHIRTLLLTFFFRYMRPLIDEGYVYAAQPPLYKVTKQKKEHYVYSDKELNILLDEIGR
NGVELQRYKGLGEMNAEQLWETTMNPETRTLLQVTVEDAAIADEVFSMLMGDKVAPRKEFIEENARFVRNLDI

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Toprim domain [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=677, Percent_Identity=24.519940915805, Blast_Score=129, Evalue=1e-29,
Organism=Homo sapiens, GI19913406, Length=621, Percent_Identity=23.1884057971014, Blast_Score=116, Evalue=5e-26,
Organism=Escherichia coli, GI48994957, Length=582, Percent_Identity=54.8109965635739, Blast_Score=620, Evalue=1e-179,
Organism=Escherichia coli, GI1789408, Length=632, Percent_Identity=40.1898734177215, Blast_Score=438, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI212645845, Length=603, Percent_Identity=24.0464344941957, Blast_Score=121, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17535065, Length=608, Percent_Identity=25, Blast_Score=121, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI212645657, Length=178, Percent_Identity=28.6516853932584, Blast_Score=74, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=678, Percent_Identity=26.401179941003, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI17136538, Length=608, Percent_Identity=25, Blast_Score=122, Evalue=6e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011557
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR006171 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c; PF01751 Toprim [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 71117; Mature: 71117

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQEYGASQIQVLEGLEAVRKRPGMYIGSTSPRGLHHLVYEVVDNSIDEALQGYCSDIYV
CCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEE
SINEDGSVLVKDNGRGIPVEIHPKTGKSTLETVLTNLHAGGKFGGGGYKVSGGLHGVGVS
EECCCCCEEEECCCCCCCEEECCCCCHHHHHHHHHHHCCCCCCCCCCEEECCCCCHHHHH
VVNALSKWMVAEVYLNGKIYKQTYEKGLPTSKLEVVGESQDKGTMIQFMPDETIFDEIEF
HHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHEEECCCCCCCCEEEECCCCHHHHHHHH
KYETLEYRLRELSFLNKGIKIVFEDKREGQEKRKEFHYTGGLVEYIKYLNKSRTGIHDDI
HHHHHHHHHHHHHHHCCCCEEEECCHHCCHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCE
VYIDKKVDDCFVELAMQYTDGYTENIYSFANNINTHEGGSHLSGFKAALTKTVNDYAKRN
EEEECHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHC
KFLKENDVNLLGEDIREGLTAVVSVKLPEPQFEGQTKTKLGNSFMRGIVDSVTVDELGSF
CCCCCCCCHHHHHHHHCCHHEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHH
LEENPSTARIIVDKALRAQRAREAAKKARELTRRKSVLESTSLPGKLADCAEKDPSKSEI
HHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCEE
FLVEGDSAGGSAKQGRDRNSQAILPLRGKILNVEKSRLDRILSSDEIKNMITAYGCGIGE
EEEECCCCCCCCCCCCCCCCCEEEECCCEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCC
DFDIDKARYHKIIIMTDADVDGAHIRTLLLTFFFRYMRPLIDEGYVYAAQPPLYKVTKQK
CCCCCCHHEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHH
KEHYVYSDKELNILLDEIGRNGVELQRYKGLGEMNAEQLWETTMNPETRTLLQVTVEDAA
HHCCEECCCCHHHHHHHHCCCCCEEHHHCCCCCCCHHHHHHHCCCCCCEEEEEEEHHHHH
IADEVFSMLMGDKVAPRKEFIEENARFVRNLDI
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKQEYGASQIQVLEGLEAVRKRPGMYIGSTSPRGLHHLVYEVVDNSIDEALQGYCSDIYV
CCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEE
SINEDGSVLVKDNGRGIPVEIHPKTGKSTLETVLTNLHAGGKFGGGGYKVSGGLHGVGVS
EECCCCCEEEECCCCCCCEEECCCCCHHHHHHHHHHHCCCCCCCCCCEEECCCCCHHHHH
VVNALSKWMVAEVYLNGKIYKQTYEKGLPTSKLEVVGESQDKGTMIQFMPDETIFDEIEF
HHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHEEECCCCCCCCEEEECCCCHHHHHHHH
KYETLEYRLRELSFLNKGIKIVFEDKREGQEKRKEFHYTGGLVEYIKYLNKSRTGIHDDI
HHHHHHHHHHHHHHHCCCCEEEECCHHCCHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCE
VYIDKKVDDCFVELAMQYTDGYTENIYSFANNINTHEGGSHLSGFKAALTKTVNDYAKRN
EEEECHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHC
KFLKENDVNLLGEDIREGLTAVVSVKLPEPQFEGQTKTKLGNSFMRGIVDSVTVDELGSF
CCCCCCCCHHHHHHHHCCHHEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHH
LEENPSTARIIVDKALRAQRAREAAKKARELTRRKSVLESTSLPGKLADCAEKDPSKSEI
HHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCEE
FLVEGDSAGGSAKQGRDRNSQAILPLRGKILNVEKSRLDRILSSDEIKNMITAYGCGIGE
EEEECCCCCCCCCCCCCCCCCEEEECCCEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCC
DFDIDKARYHKIIIMTDADVDGAHIRTLLLTFFFRYMRPLIDEGYVYAAQPPLYKVTKQK
CCCCCCHHEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHH
KEHYVYSDKELNILLDEIGRNGVELQRYKGLGEMNAEQLWETTMNPETRTLLQVTVEDAA
HHCCEECCCCHHHHHHHHCCCCCEEHHHCCCCCCCHHHHHHHCCCCCCEEEEEEEHHHHH
IADEVFSMLMGDKVAPRKEFIEENARFVRNLDI
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]