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The map label for this gene is clpP4 [H]

Identifier: 126697184

GI number: 126697184

Start: 1571500

End: 1572144

Strand: Direct

Name: clpP4 [H]

Synonym: P9301_18461

Alternate gene names: 126697184

Gene position: 1571500-1572144 (Clockwise)

Preceding gene: 126697183

Following gene: 126697185

Centisome position: 95.71

GC content: 34.26

Gene sequence:

>645_bases
GTGAACTCAGAAAAAAAACATTTAATCCAAAGCTCAATAAGTTCTTACGAAAGTAATAATAAAACTATTGCTGCTGTTCC
TACTGTTATAGAACAATCAGGTAGAGGAGAAAGAGCTTTTGATATATATTCAAGATTATTGAGGGAGAGAATAATTTTTT
TAGGTACTGGAATAAATGATCAAGTTTCTGACTCACTTGTTGCACAATTATTATTTCTTGAAGCTGAAGATCCTGAAAAA
GACATACAAATATATATCAATTCTCCTGGAGGCTCAGTAACCGCAGGAATGGCCATTTACGATACTATGCAACAAATATC
TCCAGATGTAGTGACAATATGCTTTGGAGTAGCTGCAAGTATGGGGGCATTTCTACTTTCTGGAGGAGCAAAGGGGAAAA
GATTGGCTTTACCTAATTCTAGAATTATGATTCATCAGCCTCTTGGAGGTGCACAAGGTCAAGCAGTAGAGATAGAAATA
CAAGCTAAAGAGATACTTTTTCTAAAGAAAACATTAAATTCGCTTTTAGCCGAACATACCGGTCAACCTTTAGAAAAAAT
TAATGAAGATACAGAAAGAGATTACTTTTTATCTCCCTCAGAAGCAGTCGAATATGGATTAATTGATAAAGTTATCAAAA
AGTGA

Upstream 100 bases:

>100_bases
CTACAAAAACTCAAAATAAAAAAGAAAAAAAATAATTTATGAAATTTCCTACTAATTAAACAAAAACCCCTTAAATTATC
TATAAGGCGAAAACTAATTT

Downstream 100 bases:

>100_bases
CAAGGAATACTGATTTTTTAAGAATATGATGACGAATTGATATTTATAAGCAATCCTAGTGAATAGGGAATATTAAACAC
CTTACACTTTAAAAACTTAT

Product: Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 4 [H]

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MNSEKKHLIQSSISSYESNNKTIAAVPTVIEQSGRGERAFDIYSRLLRERIIFLGTGINDQVSDSLVAQLLFLEAEDPEK
DIQIYINSPGGSVTAGMAIYDTMQQISPDVVTICFGVAASMGAFLLSGGAKGKRLALPNSRIMIHQPLGGAQGQAVEIEI
QAKEILFLKKTLNSLLAEHTGQPLEKINEDTERDYFLSPSEAVEYGLIDKVIKK

Sequences:

>Translated_214_residues
MNSEKKHLIQSSISSYESNNKTIAAVPTVIEQSGRGERAFDIYSRLLRERIIFLGTGINDQVSDSLVAQLLFLEAEDPEK
DIQIYINSPGGSVTAGMAIYDTMQQISPDVVTICFGVAASMGAFLLSGGAKGKRLALPNSRIMIHQPLGGAQGQAVEIEI
QAKEILFLKKTLNSLLAEHTGQPLEKINEDTERDYFLSPSEAVEYGLIDKVIKK
>Mature_214_residues
MNSEKKHLIQSSISSYESNNKTIAAVPTVIEQSGRGERAFDIYSRLLRERIIFLGTGINDQVSDSLVAQLLFLEAEDPEK
DIQIYINSPGGSVTAGMAIYDTMQQISPDVVTICFGVAASMGAFLLSGGAKGKRLALPNSRIMIHQPLGGAQGQAVEIEI
QAKEILFLKKTLNSLLAEHTGQPLEKINEDTERDYFLSPSEAVEYGLIDKVIKK

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=197, Percent_Identity=55.8375634517767, Blast_Score=230, Evalue=6e-61,
Organism=Escherichia coli, GI1786641, Length=190, Percent_Identity=68.4210526315789, Blast_Score=277, Evalue=3e-76,
Organism=Caenorhabditis elegans, GI17538017, Length=187, Percent_Identity=54.0106951871658, Blast_Score=214, Evalue=3e-56,
Organism=Drosophila melanogaster, GI20129427, Length=193, Percent_Identity=53.8860103626943, Blast_Score=224, Evalue=3e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 23386; Mature: 23386

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSEKKHLIQSSISSYESNNKTIAAVPTVIEQSGRGERAFDIYSRLLRERIIFLGTGIND
CCCHHHHHHHHHHHHHHCCCCEEEEEHHHHHCCCCCCHHHHHHHHHHHHHHEEEECCCCH
QVSDSLVAQLLFLEAEDPEKDIQIYINSPGGSVTAGMAIYDTMQQISPDVVTICFGVAAS
HHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHH
MGAFLLSGGAKGKRLALPNSRIMIHQPLGGAQGQAVEIEIQAKEILFLKKTLNSLLAEHT
HHHHHHCCCCCCCEEECCCCEEEEECCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHC
GQPLEKINEDTERDYFLSPSEAVEYGLIDKVIKK
CCHHHHHCCCCCCCEEECHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNSEKKHLIQSSISSYESNNKTIAAVPTVIEQSGRGERAFDIYSRLLRERIIFLGTGIND
CCCHHHHHHHHHHHHHHCCCCEEEEEHHHHHCCCCCCHHHHHHHHHHHHHHEEEECCCCH
QVSDSLVAQLLFLEAEDPEKDIQIYINSPGGSVTAGMAIYDTMQQISPDVVTICFGVAAS
HHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHH
MGAFLLSGGAKGKRLALPNSRIMIHQPLGGAQGQAVEIEIQAKEILFLKKTLNSLLAEHT
HHHHHHCCCCCCCEEECCCCEEEEECCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHC
GQPLEKINEDTERDYFLSPSEAVEYGLIDKVIKK
CCHHHHHCCCCCCCEEECHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA