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The map label for this gene is adk

Identifier: 126697068

GI number: 126697068

Start: 1461613

End: 1462161

Strand: Reverse

Name: adk

Synonym: P9301_17301

Alternate gene names: 126697068

Gene position: 1462161-1461613 (Counterclockwise)

Preceding gene: 126697069

Following gene: 126697067

Centisome position: 89.05

GC content: 30.78

Gene sequence:

>549_bases
ATGAAGAAACATATACTATTTTTAGGAGCCCCTGGAGCAGGGAAAGGGACTCAAGCAGAATTGATAAGTCAAAGTAATTC
TTATTTACACCTCTCTACGGGTGAATTATTAAGAAAAGAAATCGAAATGAATACTGCCCTTGGTATTCAGGTAAAAGATA
TTATGAATCGAGGGGAACTCGTTAGCGATGAACTCGTATTAAAGATAGTAAGACAAAATTTAGTCAAGGATAATAAAGGT
TGGATTCTAGATGGTTACCCAAGAAATTTATCTCAAGCAAATTCATTGAATGAAGTCTTGAATGAAATAAATCAACCTTT
GGAATTAGTTTTTTATCTAGATATTCCAGAAGAAGTACTAATTAAGCGTTTGCTTTTAAGAGGTAGAAAAGATGATACTG
AAGAGACAATTAGAACAAGAGTTGATATTTATAAAAAAACTACAGAACCATTAATTCAATATTTTAAGGATCTCTCATTG
ATAGAATATATTGATGCTGATAGAGATTTAAAAACTATTTCATCTGATATCAAACAAAAAATGGCTTGA

Upstream 100 bases:

>100_bases
CAACTTCATTACTTATTCTTGTGGGTGTTGCTATAGATACTGCTAAGCAAATTCAAACTTATGTTATTTCACAAAGGTAT
GAGGGATTAATTAACAATTA

Downstream 100 bases:

>100_bases
TGATGATGTAGAATGTAATATTAACGTTATATTTGTTAAACCCCTATGAAGGTCCGATCTTCAGTCAAAAAAATTAGTCC
TGACGATCAGATCGTGAGGA

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 182; Mature: 182

Protein sequence:

>182_residues
MKKHILFLGAPGAGKGTQAELISQSNSYLHLSTGELLRKEIEMNTALGIQVKDIMNRGELVSDELVLKIVRQNLVKDNKG
WILDGYPRNLSQANSLNEVLNEINQPLELVFYLDIPEEVLIKRLLLRGRKDDTEETIRTRVDIYKKTTEPLIQYFKDLSL
IEYIDADRDLKTISSDIKQKMA

Sequences:

>Translated_182_residues
MKKHILFLGAPGAGKGTQAELISQSNSYLHLSTGELLRKEIEMNTALGIQVKDIMNRGELVSDELVLKIVRQNLVKDNKG
WILDGYPRNLSQANSLNEVLNEINQPLELVFYLDIPEEVLIKRLLLRGRKDDTEETIRTRVDIYKKTTEPLIQYFKDLSL
IEYIDADRDLKTISSDIKQKMA
>Mature_182_residues
MKKHILFLGAPGAGKGTQAELISQSNSYLHLSTGELLRKEIEMNTALGIQVKDIMNRGELVSDELVLKIVRQNLVKDNKG
WILDGYPRNLSQANSLNEVLNEINQPLELVFYLDIPEEVLIKRLLLRGRKDDTEETIRTRVDIYKKTTEPLIQYFKDLSL
IEYIDADRDLKTISSDIKQKMA

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI4502011, Length=182, Percent_Identity=39.5604395604396, Blast_Score=135, Evalue=3e-32,
Organism=Homo sapiens, GI28144899, Length=172, Percent_Identity=36.046511627907, Blast_Score=113, Evalue=1e-25,
Organism=Homo sapiens, GI28144897, Length=172, Percent_Identity=36.046511627907, Blast_Score=113, Evalue=1e-25,
Organism=Homo sapiens, GI4502013, Length=205, Percent_Identity=30.2439024390244, Blast_Score=112, Evalue=2e-25,
Organism=Homo sapiens, GI7524346, Length=205, Percent_Identity=30.2439024390244, Blast_Score=112, Evalue=2e-25,
Organism=Homo sapiens, GI7706497, Length=192, Percent_Identity=29.6875, Blast_Score=97, Evalue=8e-21,
Organism=Homo sapiens, GI19923437, Length=189, Percent_Identity=27.5132275132275, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI310110345, Length=189, Percent_Identity=29.1005291005291, Blast_Score=85, Evalue=3e-17,
Organism=Homo sapiens, GI53832003, Length=189, Percent_Identity=29.1005291005291, Blast_Score=85, Evalue=3e-17,
Organism=Homo sapiens, GI8051579, Length=189, Percent_Identity=29.1005291005291, Blast_Score=85, Evalue=3e-17,
Organism=Homo sapiens, GI53832001, Length=189, Percent_Identity=29.1005291005291, Blast_Score=85, Evalue=3e-17,
Organism=Homo sapiens, GI22749187, Length=126, Percent_Identity=33.3333333333333, Blast_Score=78, Evalue=4e-15,
Organism=Escherichia coli, GI1786680, Length=184, Percent_Identity=35.8695652173913, Blast_Score=120, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI17552384, Length=210, Percent_Identity=33.8095238095238, Blast_Score=127, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17567503, Length=178, Percent_Identity=35.9550561797753, Blast_Score=117, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17550688, Length=188, Percent_Identity=30.3191489361702, Blast_Score=107, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17533833, Length=184, Percent_Identity=29.8913043478261, Blast_Score=105, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17537943, Length=186, Percent_Identity=27.9569892473118, Blast_Score=78, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI25147457, Length=185, Percent_Identity=29.7297297297297, Blast_Score=77, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6320432, Length=212, Percent_Identity=30.188679245283, Blast_Score=119, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6322828, Length=183, Percent_Identity=34.9726775956284, Blast_Score=117, Evalue=7e-28,
Organism=Saccharomyces cerevisiae, GI6321018, Length=185, Percent_Identity=32.4324324324324, Blast_Score=100, Evalue=1e-22,
Organism=Drosophila melanogaster, GI22026816, Length=205, Percent_Identity=32.1951219512195, Blast_Score=111, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24663208, Length=186, Percent_Identity=31.7204301075269, Blast_Score=107, Evalue=6e-24,
Organism=Drosophila melanogaster, GI17647141, Length=186, Percent_Identity=31.7204301075269, Blast_Score=107, Evalue=6e-24,
Organism=Drosophila melanogaster, GI221459597, Length=184, Percent_Identity=29.3478260869565, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI21356893, Length=184, Percent_Identity=29.3478260869565, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI17737899, Length=188, Percent_Identity=29.7872340425532, Blast_Score=98, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24645822, Length=188, Percent_Identity=29.7872340425532, Blast_Score=98, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24582962, Length=182, Percent_Identity=26.9230769230769, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_PROM0 (A3PF28)

Other databases:

- EMBL:   CP000576
- RefSeq:   YP_001091954.1
- ProteinModelPortal:   A3PF28
- SMR:   A3PF28
- STRING:   A3PF28
- GeneID:   4912132
- GenomeReviews:   CP000576_GR
- KEGG:   pmg:P9301_17301
- eggNOG:   COG0563
- HOGENOM:   HBG630208
- OMA:   EINQPLE
- ProtClustDB:   CLSK922216
- BioCyc:   PMAR167546:P9301ORF_1763-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK

EC number: =2.7.4.3

Molecular weight: Translated: 20841; Mature: 20841

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKHILFLGAPGAGKGTQAELISQSNSYLHLSTGELLRKEIEMNTALGIQVKDIMNRGEL
CCCEEEEEECCCCCCCCHHHHHHCCCCEEEECHHHHHHHHHHHHHHCCEEHHHHHCCCCC
VSDELVLKIVRQNLVKDNKGWILDGYPRNLSQANSLNEVLNEINQPLELVFYLDIPEEVL
HHHHHHHHHHHHHHHCCCCCCEECCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCHHHH
IKRLLLRGRKDDTEETIRTRVDIYKKTTEPLIQYFKDLSLIEYIDADRDLKTISSDIKQK
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
MA
CC
>Mature Secondary Structure
MKKHILFLGAPGAGKGTQAELISQSNSYLHLSTGELLRKEIEMNTALGIQVKDIMNRGEL
CCCEEEEEECCCCCCCCHHHHHHCCCCEEEECHHHHHHHHHHHHHHCCEEHHHHHCCCCC
VSDELVLKIVRQNLVKDNKGWILDGYPRNLSQANSLNEVLNEINQPLELVFYLDIPEEVL
HHHHHHHHHHHHHHHCCCCCCEECCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCHHHH
IKRLLLRGRKDDTEETIRTRVDIYKKTTEPLIQYFKDLSLIEYIDADRDLKTISSDIKQK
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
MA
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA