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The map label for this gene is elaC

Identifier: 126696873

GI number: 126696873

Start: 1302358

End: 1303296

Strand: Direct

Name: elaC

Synonym: P9301_15351

Alternate gene names: 126696873

Gene position: 1302358-1303296 (Clockwise)

Preceding gene: 126696871

Following gene: 126696874

Centisome position: 79.32

GC content: 33.44

Gene sequence:

>939_bases
GTGAATATCACCTTCTTAGGAACAAGCTCAGGTGTCCCATCCTTAACGAGAAATGTTTCTTCCCTAGCACTTAAATTATC
ACAGTCATCAGAAGTTTGGCTTTTTGATTGCGGAGAAGGAACGCAACATCAAATAATGAAAAGCAATATTAAATCTTCAC
AAATCAAGAAAATATTTATTACTCATATGCATGGCGATCATATTTATGGTTTGCCTGGACTTTTAGCTACCTTAGGTTTA
TCAGGAAATAGTGAGGGTATTCAAATTTACGGTCCCTCAGGGTTGCGAAGTTTTATAAATTCATCACTTAAAAGTAGTTT
TTGCAAATTGTCTTTTCCATTAAATTTTGTGGAAGTTGAAAATTTTGCATCAGAAAATAAAATCCTATTTGAAAACAACA
AAATAAAAGTAAATTGTGCCTGCCTTAAACATAAAATACCTGCTTATGGTTATAGGGTGAGTGAAAAAGATAAACCAGGT
ATATTTGATATCAAAAAAGCAGAGTCTCTAAAAATAGCACCTGGACCAATTTATTCAGAACTGCAACAAGGTAAAAAAGT
CGTATTAGCGGATGGTAGGACATTCGATGGGAAAGAATTCTGTGGACCTCCTAGAAAAGGTGAAAGTTTTGTTTATTGCA
CAGATACAGTGTTTAGCGAATCAGCTGTTTCACTATCAAAAAATGCCGATTTACTCGTACATGAATCGACTTTTTCAGTG
GAGGATGAAAGTATGGCATACGAAAAATTACATTCCACAACAATCATGGCTGCCAAAACAGCATTATTATCTAACACAAA
AAAATTAATTATTACTCATTTAAGTCCAAGATATACTAATAAAAACGCAATTACACCAAGCGATTTGCTTAAAGAGGCTC
AAAAAGTTTTTCCAAATACTTACCTTGCCAAAGATTTTCTAACGGCAGAAATAAAATAA

Upstream 100 bases:

>100_bases
TTTAAGTATCACTTTGTTTAAAAACAAATGCTTAATTTGCCTAAGTTTGACTAAAAGTCTAAATTTAATCCAGATATAAC
AATAAAAATATCATAAATAA

Downstream 100 bases:

>100_bases
ACTGCAACAGTTCGTTAGCAGGAGCGTTGTAAATGACCAACCCATGAAATAATAGTCTTAGGTTTTTCTATTTGATGTCG
ATCGAAATGGTCTCTATTTT

Product: metallo-beta-lactamase superfamily protein

Products: NA

Alternate protein names: RNase Z; tRNA 3 endonuclease; tRNase Z

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MNITFLGTSSGVPSLTRNVSSLALKLSQSSEVWLFDCGEGTQHQIMKSNIKSSQIKKIFITHMHGDHIYGLPGLLATLGL
SGNSEGIQIYGPSGLRSFINSSLKSSFCKLSFPLNFVEVENFASENKILFENNKIKVNCACLKHKIPAYGYRVSEKDKPG
IFDIKKAESLKIAPGPIYSELQQGKKVVLADGRTFDGKEFCGPPRKGESFVYCTDTVFSESAVSLSKNADLLVHESTFSV
EDESMAYEKLHSTTIMAAKTALLSNTKKLIITHLSPRYTNKNAITPSDLLKEAQKVFPNTYLAKDFLTAEIK

Sequences:

>Translated_312_residues
MNITFLGTSSGVPSLTRNVSSLALKLSQSSEVWLFDCGEGTQHQIMKSNIKSSQIKKIFITHMHGDHIYGLPGLLATLGL
SGNSEGIQIYGPSGLRSFINSSLKSSFCKLSFPLNFVEVENFASENKILFENNKIKVNCACLKHKIPAYGYRVSEKDKPG
IFDIKKAESLKIAPGPIYSELQQGKKVVLADGRTFDGKEFCGPPRKGESFVYCTDTVFSESAVSLSKNADLLVHESTFSV
EDESMAYEKLHSTTIMAAKTALLSNTKKLIITHLSPRYTNKNAITPSDLLKEAQKVFPNTYLAKDFLTAEIK
>Mature_312_residues
MNITFLGTSSGVPSLTRNVSSLALKLSQSSEVWLFDCGEGTQHQIMKSNIKSSQIKKIFITHMHGDHIYGLPGLLATLGL
SGNSEGIQIYGPSGLRSFINSSLKSSFCKLSFPLNFVEVENFASENKILFENNKIKVNCACLKHKIPAYGYRVSEKDKPG
IFDIKKAESLKIAPGPIYSELQQGKKVVLADGRTFDGKEFCGPPRKGESFVYCTDTVFSESAVSLSKNADLLVHESTFSV
EDESMAYEKLHSTTIMAAKTALLSNTKKLIITHLSPRYTNKNAITPSDLLKEAQKVFPNTYLAKDFLTAEIK

Specific function: Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA

COG id: COG1234

COG function: function code R; Metal-dependent hydrolases of the beta-lactamase superfamily III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNase Z family

Homologues:

Organism=Homo sapiens, GI8922122, Length=363, Percent_Identity=36.3636363636364, Blast_Score=210, Evalue=1e-54,
Organism=Escherichia coli, GI87082078, Length=308, Percent_Identity=40.2597402597403, Blast_Score=256, Evalue=2e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNZ_PROM0 (A3PEI3)

Other databases:

- EMBL:   CP000576
- RefSeq:   YP_001091759.1
- ProteinModelPortal:   A3PEI3
- SMR:   A3PEI3
- STRING:   A3PEI3
- GeneID:   4912422
- GenomeReviews:   CP000576_GR
- KEGG:   pmg:P9301_15351
- eggNOG:   COG1234
- HOGENOM:   HBG648406
- OMA:   HSTSTMA
- ProtClustDB:   CLSK922157
- BioCyc:   PMAR167546:P9301ORF_1564-MONOMER
- HAMAP:   MF_01818
- InterPro:   IPR001279
- InterPro:   IPR013471
- TIGRFAMs:   TIGR02651

Pfam domain/function: PF00753 Lactamase_B

EC number: =3.1.26.11

Molecular weight: Translated: 34364; Mature: 34364

Theoretical pI: Translated: 9.11; Mature: 9.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNITFLGTSSGVPSLTRNVSSLALKLSQSSEVWLFDCGEGTQHQIMKSNIKSSQIKKIFI
CEEEEEECCCCCCHHHHHHHHHEEEECCCCCEEEEECCCCCHHHHHHHCCCHHHEEEEEE
THMHGDHIYGLPGLLATLGLSGNSEGIQIYGPSGLRSFINSSLKSSFCKLSFPLNFVEVE
EEECCCEEECCHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHEEEECCCCEEEHH
NFASENKILFENNKIKVNCACLKHKIPAYGYRVSEKDKPGIFDIKKAESLKIAPGPIYSE
CCCCCCEEEEECCEEEEEEEEEECCCCCCCEEECCCCCCCEEEECCCCCEEECCCHHHHH
LQQGKKVVLADGRTFDGKEFCGPPRKGESFVYCTDTVFSESAVSLSKNADLLVHESTFSV
HHCCCEEEEECCCCCCCHHHCCCCCCCCEEEEEECCHHCCCHHHHCCCCCEEEECCCCCC
EDESMAYEKLHSTTIMAAKTALLSNTKKLIITHLSPRYTNKNAITPSDLLKEAQKVFPNT
CHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCC
YLAKDFLTAEIK
HHHHHHEEEECC
>Mature Secondary Structure
MNITFLGTSSGVPSLTRNVSSLALKLSQSSEVWLFDCGEGTQHQIMKSNIKSSQIKKIFI
CEEEEEECCCCCCHHHHHHHHHEEEECCCCCEEEEECCCCCHHHHHHHCCCHHHEEEEEE
THMHGDHIYGLPGLLATLGLSGNSEGIQIYGPSGLRSFINSSLKSSFCKLSFPLNFVEVE
EEECCCEEECCHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHEEEECCCCEEEHH
NFASENKILFENNKIKVNCACLKHKIPAYGYRVSEKDKPGIFDIKKAESLKIAPGPIYSE
CCCCCCEEEEECCEEEEEEEEEECCCCCCCEEECCCCCCCEEEECCCCCEEECCCHHHHH
LQQGKKVVLADGRTFDGKEFCGPPRKGESFVYCTDTVFSESAVSLSKNADLLVHESTFSV
HHCCCEEEEECCCCCCCHHHCCCCCCCCEEEEEECCHHCCCHHHHCCCCCEEEECCCCCC
EDESMAYEKLHSTTIMAAKTALLSNTKKLIITHLSPRYTNKNAITPSDLLKEAQKVFPNT
CHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCC
YLAKDFLTAEIK
HHHHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA