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The map label for this gene is lpxC [H]

Identifier: 126696861

GI number: 126696861

Start: 1289311

End: 1290147

Strand: Reverse

Name: lpxC [H]

Synonym: P9301_15231

Alternate gene names: 126696861

Gene position: 1290147-1289311 (Counterclockwise)

Preceding gene: 126696862

Following gene: 126696860

Centisome position: 78.58

GC content: 34.41

Gene sequence:

>837_bases
GTGTTTTCTTGGCCTGCTAATTATGATTTCTGCTATACCCTTGCTGGAGTTATCTCTAGAGAAGGTATAGGTCTTCATAG
TGGAGAAAAAACAAGAGTTATAATTTCTCCTTACGACAAAGAGGGGTATTATGTTTCTTTTAAGGAAAAACCTGGTGAGA
TTTTCAAGCTTACTCAAGATTTAATTGGAAGTACTATGCTTTGTACGGCGGTTAAATTAGGGGGTAGAAATTTGTATACT
ATAGAGCATTTATTATCTTCACTTGCCGGTTGTGGCTTGAGTTATATACACATTGAGGTTGATGGGAAAGAGATTCCTCT
TTTAGATGGATCGGCAATCCAGTGGGTTAGAGATTTTGAAGAAGTAGGGATAAAAAAGGCACCTAGACCAGATAATTTCT
TTCAAGAAATTAATAAATCAATAATTTTAAATAAAGAAGGCTCAGTCATAGCAGCAACTCCTTCTGAAAAAATTACAATT
ATATCCACTATAAGTTTTGCCTATAAAGCAATTGGAAATCAAACTTTTGTGATTGATTTAAATCCAAAAAGTTTTGTTGA
AATGATCGCTCCTGCGAGAACATTTGGTTTTAAAGATCAATTTCAAGAGTTAAGTGAACTTGGATTAATAAAAGGCGGAA
GTTTGGACAATGCCCTTGTATGTGACGATGAAAAATGGGTTAATCCACCATTAAGATTTGATGATGAACCAATAAGACAT
AAAATTTTGGACCTCATTGGAGACTTGGCTTTGGTAGGGTTACCTAAGGCTCAAATTTTAGTCTATAAAGGATCACATTC
TTTAAACGCTTTGTTGGCCTCATCGCTAAAAAATTAA

Upstream 100 bases:

>100_bases
TGGGATTAAAACGCCAATTGGTCCATTAAGGTTAGATATTGCCAGCAAGGACCTAAGTGGAGATACGAGATATACACTTG
GAGTAGGATGGAAGTTTTAA

Downstream 100 bases:

>100_bases
CTTTATTTTTAATTGTTTTGGAAAAGAAATTATCCAGTGAAAAAAATCAACTTTCCTCTGAGCACATACTAGGTTTATTA
CCTCACAGATATCCTTTTGC

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase [H]

Number of amino acids: Translated: 278; Mature: 278

Protein sequence:

>278_residues
MFSWPANYDFCYTLAGVISREGIGLHSGEKTRVIISPYDKEGYYVSFKEKPGEIFKLTQDLIGSTMLCTAVKLGGRNLYT
IEHLLSSLAGCGLSYIHIEVDGKEIPLLDGSAIQWVRDFEEVGIKKAPRPDNFFQEINKSIILNKEGSVIAATPSEKITI
ISTISFAYKAIGNQTFVIDLNPKSFVEMIAPARTFGFKDQFQELSELGLIKGGSLDNALVCDDEKWVNPPLRFDDEPIRH
KILDLIGDLALVGLPKAQILVYKGSHSLNALLASSLKN

Sequences:

>Translated_278_residues
MFSWPANYDFCYTLAGVISREGIGLHSGEKTRVIISPYDKEGYYVSFKEKPGEIFKLTQDLIGSTMLCTAVKLGGRNLYT
IEHLLSSLAGCGLSYIHIEVDGKEIPLLDGSAIQWVRDFEEVGIKKAPRPDNFFQEINKSIILNKEGSVIAATPSEKITI
ISTISFAYKAIGNQTFVIDLNPKSFVEMIAPARTFGFKDQFQELSELGLIKGGSLDNALVCDDEKWVNPPLRFDDEPIRH
KILDLIGDLALVGLPKAQILVYKGSHSLNALLASSLKN
>Mature_278_residues
MFSWPANYDFCYTLAGVISREGIGLHSGEKTRVIISPYDKEGYYVSFKEKPGEIFKLTQDLIGSTMLCTAVKLGGRNLYT
IEHLLSSLAGCGLSYIHIEVDGKEIPLLDGSAIQWVRDFEEVGIKKAPRPDNFFQEINKSIILNKEGSVIAATPSEKITI
ISTISFAYKAIGNQTFVIDLNPKSFVEMIAPARTFGFKDQFQELSELGLIKGGSLDNALVCDDEKWVNPPLRFDDEPIRH
KILDLIGDLALVGLPKAQILVYKGSHSLNALLASSLKN

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family [H]

Homologues:

Organism=Escherichia coli, GI1786285, Length=271, Percent_Identity=33.5793357933579, Blast_Score=133, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870 [H]

Pfam domain/function: PF03331 LpxC [H]

EC number: 3.5.1.-

Molecular weight: Translated: 30732; Mature: 30732

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSWPANYDFCYTLAGVISREGIGLHSGEKTRVIISPYDKEGYYVSFKEKPGEIFKLTQD
CCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCEEEEEECCCCHHHHHHHH
LIGSTMLCTAVKLGGRNLYTIEHLLSSLAGCGLSYIHIEVDGKEIPLLDGSAIQWVRDFE
HHCCHHHHHHHHHCCCCEEHHHHHHHHHHCCCEEEEEEEECCCEECEECCHHHHHHHHHH
EVGIKKAPRPDNFFQEINKSIILNKEGSVIAATPSEKITIISTISFAYKAIGNQTFVIDL
HCCCCCCCCCCHHHHHCCCEEEEECCCCEEEECCCCCEEEEEHHHHHHHHHCCEEEEEEC
NPKSFVEMIAPARTFGFKDQFQELSELGLIKGGSLDNALVCDDEKWVNPPLRFDDEPIRH
CHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCEEECCHHHCCCCCCCCCCHHHH
KILDLIGDLALVGLPKAQILVYKGSHSLNALLASSLKN
HHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHCC
>Mature Secondary Structure
MFSWPANYDFCYTLAGVISREGIGLHSGEKTRVIISPYDKEGYYVSFKEKPGEIFKLTQD
CCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCEEEEEECCCCHHHHHHHH
LIGSTMLCTAVKLGGRNLYTIEHLLSSLAGCGLSYIHIEVDGKEIPLLDGSAIQWVRDFE
HHCCHHHHHHHHHCCCCEEHHHHHHHHHHCCCEEEEEEEECCCEECEECCHHHHHHHHHH
EVGIKKAPRPDNFFQEINKSIILNKEGSVIAATPSEKITIISTISFAYKAIGNQTFVIDL
HCCCCCCCCCCHHHHHCCCEEEEECCCCEEEECCCCCEEEEEHHHHHHHHHCCEEEEEEC
NPKSFVEMIAPARTFGFKDQFQELSELGLIKGGSLDNALVCDDEKWVNPPLRFDDEPIRH
CHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCEEECCHHHCCCCCCCCCCHHHH
KILDLIGDLALVGLPKAQILVYKGSHSLNALLASSLKN
HHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA