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The map label for this gene is acrA [H]

Identifier: 126696666

GI number: 126696666

Start: 1107501

End: 1108562

Strand: Direct

Name: acrA [H]

Synonym: P9301_13281

Alternate gene names: 126696666

Gene position: 1107501-1108562 (Clockwise)

Preceding gene: 126696664

Following gene: 126696667

Centisome position: 67.45

GC content: 30.7

Gene sequence:

>1062_bases
ATGTTTGATTTAATAAAAAAAAATATAAATCTAAGAAGTGGAATTATATTGCTTTCTCTGGCTATATTTTTCGTTTTTAT
AACCAATTCCTTCAAGAAAAACAAGTCAAAAGATATTTCTGATTTTGTAGTTCAAGTGGAAAAAGGAATCCTGTCAGATT
CAATTAATACTAGTGGTGAAGTAAAAGCAAAAAAGACAAGCAATATTGGGCCTCGGAAGCAAGGCGTTATAAAAGAAATC
AAAGTAGATGAAGGCGATCTTGTAAAAAAAGATCAGGTTTTAGCTTCTCTTGATGATGAAGACTTTATCTATAAAATTGA
AGAACTTGAATTAAATGTAGAGAAACAAAAATCTGAATTTTTAAGAAGGGAATATTTATATCAAGAAGGTGCGGTAAGTA
AAGAAGACTATGAAAGTTATAAAAATAACTACGACATTAGTAGCGCCAAACTTAATGATGCAAAAGCTGAAAAAAGTTTC
TATCTAATTAAAGCTCCTTATGGAGGAAAGATAACTGCAAAATATGCTGAGATAGGATCTTATGTCACACCAAGTACAAA
CTTAAGTTCAGACTCTAAAACTAAAAACTTTATTTTTGAACTATCAGAGGGCCTAGAAATTGTTGCTAAAGTTCCTGAGA
GTGACATTGGCAGAATAAAAATAGGTCAAGAAGCCTCAGTAAGGATTGAGGCTTATCCCTCAAAAAAATATAGTGCCATA
GTTAAAAAAATAGCTGCGAGAGCTGTAAAAGATAATAATGTAACCTCATTCGAAGTAACTTTAAATTTTAAGGATATTTC
TGAAGAAATTAAAATTGGAATGACTGCAGATCTTGAATTTAGAGTCGAAGGTAATGAAGAAAAAATCTTAGTGCCAACAG
TTTCTATTGTCACTGAAAAAGGTGAAAAGGGAATTTTGAAAGTTGATAAAAACAATTCTCCCAAATTTGAAAAAATTGAA
ATTGGTATTAGTAGTGGAAATAAAACCTCAGTAATTGATGGATTAGAACCTGGAGAGCAAATCTTTATTAATATTCCACC
TTGGGCTAAGAAGAGAAAATGA

Upstream 100 bases:

>100_bases
AATATAGTATTTACTTAACCAATCTTGGATAAGTTAATTATAATCGTTTTGATTATTTATTTAGTTCCTAAATATTCTCT
ACTTCTGCTTTTAAAAAGAA

Downstream 100 bases:

>100_bases
GTTTAACATCTGAAAACTCTAAAAAACCAATTTTACTTTTAGTCGATGGTCATTCACTTGCTTTTAGAAGCTTCTATGCA
TTTAGCAAAGGGATTGATGG

Product: membrane fusion protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 353; Mature: 353

Protein sequence:

>353_residues
MFDLIKKNINLRSGIILLSLAIFFVFITNSFKKNKSKDISDFVVQVEKGILSDSINTSGEVKAKKTSNIGPRKQGVIKEI
KVDEGDLVKKDQVLASLDDEDFIYKIEELELNVEKQKSEFLRREYLYQEGAVSKEDYESYKNNYDISSAKLNDAKAEKSF
YLIKAPYGGKITAKYAEIGSYVTPSTNLSSDSKTKNFIFELSEGLEIVAKVPESDIGRIKIGQEASVRIEAYPSKKYSAI
VKKIAARAVKDNNVTSFEVTLNFKDISEEIKIGMTADLEFRVEGNEEKILVPTVSIVTEKGEKGILKVDKNNSPKFEKIE
IGISSGNKTSVIDGLEPGEQIFINIPPWAKKRK

Sequences:

>Translated_353_residues
MFDLIKKNINLRSGIILLSLAIFFVFITNSFKKNKSKDISDFVVQVEKGILSDSINTSGEVKAKKTSNIGPRKQGVIKEI
KVDEGDLVKKDQVLASLDDEDFIYKIEELELNVEKQKSEFLRREYLYQEGAVSKEDYESYKNNYDISSAKLNDAKAEKSF
YLIKAPYGGKITAKYAEIGSYVTPSTNLSSDSKTKNFIFELSEGLEIVAKVPESDIGRIKIGQEASVRIEAYPSKKYSAI
VKKIAARAVKDNNVTSFEVTLNFKDISEEIKIGMTADLEFRVEGNEEKILVPTVSIVTEKGEKGILKVDKNNSPKFEKIE
IGISSGNKTSVIDGLEPGEQIFINIPPWAKKRK
>Mature_353_residues
MFDLIKKNINLRSGIILLSLAIFFVFITNSFKKNKSKDISDFVVQVEKGILSDSINTSGEVKAKKTSNIGPRKQGVIKEI
KVDEGDLVKKDQVLASLDDEDFIYKIEELELNVEKQKSEFLRREYLYQEGAVSKEDYESYKNNYDISSAKLNDAKAEKSF
YLIKAPYGGKITAKYAEIGSYVTPSTNLSSDSKTKNFIFELSEGLEIVAKVPESDIGRIKIGQEASVRIEAYPSKKYSAI
VKKIAARAVKDNNVTSFEVTLNFKDISEEIKIGMTADLEFRVEGNEEKILVPTVSIVTEKGEKGILKVDKNNSPKFEKIE
IGISSGNKTSVIDGLEPGEQIFINIPPWAKKRK

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=329, Percent_Identity=22.1884498480243, Blast_Score=80, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 39540; Mature: 39540

Theoretical pI: Translated: 8.91; Mature: 8.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
0.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDLIKKNINLRSGIILLSLAIFFVFITNSFKKNKSKDISDFVVQVEKGILSDSINTSGE
CCCHHHCCCCCHHHHHHHHHHHHHHHHHCHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCC
VKAKKTSNIGPRKQGVIKEIKVDEGDLVKKDQVLASLDDEDFIYKIEELELNVEKQKSEF
EEEECCCCCCCCCCCCCEEEECCCCCCCCHHHHHHCCCCCHHEEEEEEEEECCHHHHHHH
LRREYLYQEGAVSKEDYESYKNNYDISSAKLNDAKAEKSFYLIKAPYGGKITAKYAEIGS
HHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCEEEEEHHHHCC
YVTPSTNLSSDSKTKNFIFELSEGLEIVAKVPESDIGRIKIGQEASVRIEAYPSKKYSAI
EECCCCCCCCCCCHHHHHEEHHCCCEEEEECCCCCCCEEEECCCCEEEEEECCCHHHHHH
VKKIAARAVKDNNVTSFEVTLNFKDISEEIKIGMTADLEFRVEGNEEKILVPTVSIVTEK
HHHHHHHHHCCCCCEEEEEEEEHHHCCCHHEECEEEEEEEEEECCCCEEEEEEEEEEECC
GEKGILKVDKNNSPKFEKIEIGISSGNKTSVIDGLEPGEQIFINIPPWAKKRK
CCCCEEEECCCCCCCEEEEEEEECCCCCEEEECCCCCCCEEEEECCCCCCCCC
>Mature Secondary Structure
MFDLIKKNINLRSGIILLSLAIFFVFITNSFKKNKSKDISDFVVQVEKGILSDSINTSGE
CCCHHHCCCCCHHHHHHHHHHHHHHHHHCHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCC
VKAKKTSNIGPRKQGVIKEIKVDEGDLVKKDQVLASLDDEDFIYKIEELELNVEKQKSEF
EEEECCCCCCCCCCCCCEEEECCCCCCCCHHHHHHCCCCCHHEEEEEEEEECCHHHHHHH
LRREYLYQEGAVSKEDYESYKNNYDISSAKLNDAKAEKSFYLIKAPYGGKITAKYAEIGS
HHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCEEEEEHHHHCC
YVTPSTNLSSDSKTKNFIFELSEGLEIVAKVPESDIGRIKIGQEASVRIEAYPSKKYSAI
EECCCCCCCCCCCHHHHHEEHHCCCEEEEECCCCCCCEEEECCCCEEEEEECCCHHHHHH
VKKIAARAVKDNNVTSFEVTLNFKDISEEIKIGMTADLEFRVEGNEEKILVPTVSIVTEK
HHHHHHHHHCCCCCEEEEEEEEHHHCCCHHEECEEEEEEEEEECCCCEEEEEEEEEEECC
GEKGILKVDKNNSPKFEKIEIGISSGNKTSVIDGLEPGEQIFINIPPWAKKRK
CCCCEEEECCCCCCCEEEEEEEECCCCCEEEECCCCCCCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]