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The map label for this gene is hhoB [H]

Identifier: 126696600

GI number: 126696600

Start: 1071397

End: 1072776

Strand: Reverse

Name: hhoB [H]

Synonym: P9301_12621

Alternate gene names: 126696600

Gene position: 1072776-1071397 (Counterclockwise)

Preceding gene: 126696603

Following gene: 126696595

Centisome position: 65.34

GC content: 32.61

Gene sequence:

>1380_bases
ATGAGAAAATTAATACTTTTAGTAATTGTTTTGGGGTTTGGCTCTTTTTTTAATGCTCAAGAATTATTAGCCGTAAAGAT
TAATTGTGATTCACCTGTTCACAAAAATAAAAAAAGATGTAGTGAGAAATACCTGCGAAATGTAGTTATTGATGAAGATA
CAGGTTTAGAAGTTATTGAATATGAAAAAGATGTCGATTGGAAAAAGAAAAATCCTAAGATTGCTTGGTCCAAAATCATA
AAATACAAATCATCTCTTAGAAATTCATATGAATTAACAATTTTTGATAGGGATTATGTTTCTGATTTTAGTACCGGAGC
AGTTAAAAGTTATGTCACGAAATGGAATACCAACAAATTAGAAGGAAGAATATTAACTTGGGGTGGTTGTGGTTTTTGGA
CATGTACTTATGAAAGTGCTAGATATTACGATTTTCCTGGTTTTATTGAGATATTTGTTGGAGACAAGAGGTTTAGATTA
AGAGGTAGTAGAGGTGAATTTCAATTCCCTTATGGATTTGCAAAAAGAATAAAGAATATAGGTGAGAATGAATCTATTAA
TTTACAAATTAAAGCTATCCCAAATAGTGGTTTAGCAGATAAATTTATCCCTATAGGTGATGAAACAATAAAAAATTTAA
AACTATTATTCCAAAAGGATACAAAAGAGTGGAACAAACCTAAATATGAAATAGCTCGAGCCTCAATTAGTTCAAAAAAA
CTTGATATAGAGGAAATAGCATCTATAACTCTTCCATCAGTAGTCAAATTAGAGGGAGATTCTGGATTAGGAAGTGGCTT
TTTTATAAATAATACAGGACTTATTGTTACTAATATGCACGTAGTTGCCGGTGGAGATAAAGAATTCACTATCTCTGGAG
ATAATGGGTTAAAAGATCAAGGTGAAGTTATTTATGTAGACTCAAAGCTTGATTTCGCATTAATACAATCAAATAACACT
AAGAATTCAAAAGCTCTTCCTCTTTGTTTTAGTAAATATCCAAGACCTGGTCAAAATGTAATTGCTCTTGGATCTCCTTT
AGGTTTAGCGGGAACAGTGACTAGAGGGATTGTAAGTGCAGTGAGACAACCATCAAGTGATTTAGAAGACGTAGTCCCAT
ATTATGTGACTCTTATACAAACAGATGCAGCTATAAGTCCTGGTAATAGCGGAGGCCCTTTGGTAAATAGCAATGGTGAG
GTAGTTGGAGTGAATACCTGGAGTTTACCTGGAGACGAGGGTAGAGCTCAGAATTTAAATTTTGCCATCTCAATCGTAGA
TATTTTAAGGTCGTTAAATAGTGAAATTCCAGTTGAAGCTGAAAATACTAATAGTTGCGGGAATTTTGTAGAGAAAGAGA
GCATATTTAAATTTTGGTAA

Upstream 100 bases:

>100_bases
CTGATTTTTAAATTGACTTTTTGTTTGCTTAAGCTGCTCTTAACAAAAGAGGGACAATTAAATTAAATACAGATAATATC
AATAAAAGAAAATCTATTTG

Downstream 100 bases:

>100_bases
AAAAATAGCAGAAAATTACAATTAATTAGAGAAAAATCTCATAAGTGTTATCCTCATTGGGTAATAGCTATTAAGTATTG
AAGGAATTTTTACAGGAGAT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MRKLILLVIVLGFGSFFNAQELLAVKINCDSPVHKNKKRCSEKYLRNVVIDEDTGLEVIEYEKDVDWKKKNPKIAWSKII
KYKSSLRNSYELTIFDRDYVSDFSTGAVKSYVTKWNTNKLEGRILTWGGCGFWTCTYESARYYDFPGFIEIFVGDKRFRL
RGSRGEFQFPYGFAKRIKNIGENESINLQIKAIPNSGLADKFIPIGDETIKNLKLLFQKDTKEWNKPKYEIARASISSKK
LDIEEIASITLPSVVKLEGDSGLGSGFFINNTGLIVTNMHVVAGGDKEFTISGDNGLKDQGEVIYVDSKLDFALIQSNNT
KNSKALPLCFSKYPRPGQNVIALGSPLGLAGTVTRGIVSAVRQPSSDLEDVVPYYVTLIQTDAAISPGNSGGPLVNSNGE
VVGVNTWSLPGDEGRAQNLNFAISIVDILRSLNSEIPVEAENTNSCGNFVEKESIFKFW

Sequences:

>Translated_459_residues
MRKLILLVIVLGFGSFFNAQELLAVKINCDSPVHKNKKRCSEKYLRNVVIDEDTGLEVIEYEKDVDWKKKNPKIAWSKII
KYKSSLRNSYELTIFDRDYVSDFSTGAVKSYVTKWNTNKLEGRILTWGGCGFWTCTYESARYYDFPGFIEIFVGDKRFRL
RGSRGEFQFPYGFAKRIKNIGENESINLQIKAIPNSGLADKFIPIGDETIKNLKLLFQKDTKEWNKPKYEIARASISSKK
LDIEEIASITLPSVVKLEGDSGLGSGFFINNTGLIVTNMHVVAGGDKEFTISGDNGLKDQGEVIYVDSKLDFALIQSNNT
KNSKALPLCFSKYPRPGQNVIALGSPLGLAGTVTRGIVSAVRQPSSDLEDVVPYYVTLIQTDAAISPGNSGGPLVNSNGE
VVGVNTWSLPGDEGRAQNLNFAISIVDILRSLNSEIPVEAENTNSCGNFVEKESIFKFW
>Mature_459_residues
MRKLILLVIVLGFGSFFNAQELLAVKINCDSPVHKNKKRCSEKYLRNVVIDEDTGLEVIEYEKDVDWKKKNPKIAWSKII
KYKSSLRNSYELTIFDRDYVSDFSTGAVKSYVTKWNTNKLEGRILTWGGCGFWTCTYESARYYDFPGFIEIFVGDKRFRL
RGSRGEFQFPYGFAKRIKNIGENESINLQIKAIPNSGLADKFIPIGDETIKNLKLLFQKDTKEWNKPKYEIARASISSKK
LDIEEIASITLPSVVKLEGDSGLGSGFFINNTGLIVTNMHVVAGGDKEFTISGDNGLKDQGEVIYVDSKLDFALIQSNNT
KNSKALPLCFSKYPRPGQNVIALGSPLGLAGTVTRGIVSAVRQPSSDLEDVVPYYVTLIQTDAAISPGNSGGPLVNSNGE
VVGVNTWSLPGDEGRAQNLNFAISIVDILRSLNSEIPVEAENTNSCGNFVEKESIFKFW

Specific function: A putative protease, its function overlaps that of the related putative proteases HtrA and HhoA [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI22129776, Length=175, Percent_Identity=39.4285714285714, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI4506141, Length=146, Percent_Identity=43.1506849315069, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI7019477, Length=145, Percent_Identity=46.2068965517241, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI24308541, Length=162, Percent_Identity=39.5061728395062, Blast_Score=87, Evalue=3e-17,
Organism=Escherichia coli, GI1786356, Length=175, Percent_Identity=40.5714285714286, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1789629, Length=177, Percent_Identity=37.8531073446328, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1789630, Length=150, Percent_Identity=35.3333333333333, Blast_Score=84, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24646839, Length=165, Percent_Identity=39.3939393939394, Blast_Score=90, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 51049; Mature: 51049

Theoretical pI: Translated: 8.30; Mature: 8.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKLILLVIVLGFGSFFNAQELLAVKINCDSPVHKNKKRCSEKYLRNVVIDEDTGLEVIE
CHHHEEEHHHHHCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHEEEECCCCCEEEE
YEKDVDWKKKNPKIAWSKIIKYKSSLRNSYELTIFDRDYVSDFSTGAVKSYVTKWNTNKL
ECCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECHHHCCCCCHHHHHHHHHCCCCCC
EGRILTWGGCGFWTCTYESARYYDFPGFIEIFVGDKRFRLRGSRGEFQFPYGFAKRIKNI
CCEEEEEECCCEEEEEECCCEEECCCCEEEEEECCCEEEEECCCCCEECCHHHHHHHHHC
GENESINLQIKAIPNSGLADKFIPIGDETIKNLKLLFQKDTKEWNKPKYEIARASISSKK
CCCCEEEEEEEECCCCCCCCCEECCCHHHHHHHHHHHHHCCHHHCCCHHHHHHHHCCCCC
LDIEEIASITLPSVVKLEGDSGLGSGFFINNTGLIVTNMHVVAGGDKEFTISGDNGLKDQ
CCHHHHHHCCCCEEEEEECCCCCCCCEEEECCCEEEEEEEEEECCCEEEEEECCCCCCCC
GEVIYVDSKLDFALIQSNNTKNSKALPLCFSKYPRPGQNVIALGSPLGLAGTVTRGIVSA
CCEEEEECCCCEEEEECCCCCCCCCCEEHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHH
VRQPSSDLEDVVPYYVTLIQTDAAISPGNSGGPLVNSNGEVVGVNTWSLPGDEGRAQNLN
HHCCCCCHHHHHHHEEEEEEECCEECCCCCCCCEECCCCCEEEEEEECCCCCCCCCCCCE
FAISIVDILRSLNSEIPVEAENTNSCGNFVEKESIFKFW
EEEEHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MRKLILLVIVLGFGSFFNAQELLAVKINCDSPVHKNKKRCSEKYLRNVVIDEDTGLEVIE
CHHHEEEHHHHHCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHEEEECCCCCEEEE
YEKDVDWKKKNPKIAWSKIIKYKSSLRNSYELTIFDRDYVSDFSTGAVKSYVTKWNTNKL
ECCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECHHHCCCCCHHHHHHHHHCCCCCC
EGRILTWGGCGFWTCTYESARYYDFPGFIEIFVGDKRFRLRGSRGEFQFPYGFAKRIKNI
CCEEEEEECCCEEEEEECCCEEECCCCEEEEEECCCEEEEECCCCCEECCHHHHHHHHHC
GENESINLQIKAIPNSGLADKFIPIGDETIKNLKLLFQKDTKEWNKPKYEIARASISSKK
CCCCEEEEEEEECCCCCCCCCEECCCHHHHHHHHHHHHHCCHHHCCCHHHHHHHHCCCCC
LDIEEIASITLPSVVKLEGDSGLGSGFFINNTGLIVTNMHVVAGGDKEFTISGDNGLKDQ
CCHHHHHHCCCCEEEEEECCCCCCCCEEEECCCEEEEEEEEEECCCEEEEEECCCCCCCC
GEVIYVDSKLDFALIQSNNTKNSKALPLCFSKYPRPGQNVIALGSPLGLAGTVTRGIVSA
CCEEEEECCCCEEEEECCCCCCCCCCEEHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHH
VRQPSSDLEDVVPYYVTLIQTDAAISPGNSGGPLVNSNGEVVGVNTWSLPGDEGRAQNLN
HHCCCCCHHHHHHHEEEEEEECCEECCCCCCCCEECCCCCEEEEEEECCCCCCCCCCCCE
FAISIVDILRSLNSEIPVEAENTNSCGNFVEKESIFKFW
EEEEHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]