Click here to switch to the map view.

The map label for this gene is ptxD [H]

Identifier: 126696591

GI number: 126696591

Start: 1061914

End: 1062870

Strand: Direct

Name: ptxD [H]

Synonym: P9301_12531

Alternate gene names: 126696591

Gene position: 1061914-1062870 (Clockwise)

Preceding gene: 126696590

Following gene: 126696593

Centisome position: 64.68

GC content: 28.0

Gene sequence:

>957_bases
ATGAAGAAGGTTGTTATTTCCAATAAAGTTCATACTGAAGTTATTGAGTTATTAGAAAAAAATTTTGAAGTAATTAGTAA
CCAAAATGATAAACCTCTAACTTATGAAAAATTAAAGTTCTTATGTAAAGATGCACATGGTGTGATGGTATTCATGCCAG
ATAGAATTGATAAAAACTTTTTAGATAATTCAAAAAATTTAGAGATCATCTCTGGAGCACTAAGAGGATTTGACAATATT
GATTTGGAAGAGTGCATAAAAAGAAATATTAAATTTACAATGATCCCAGATTTACTTGCTTCGCCAACAGCAGAGTTAAC
TTTAGGACTTCTTATTGGTTTATCAAGAAATCTACTAATAGGTGATGAATATGTTAGATCTGAAAAGTTTAAAGGTTGGG
AACCAAAATTCTTCTCAAATGGGATTGAAGGGAAAAATGTTTGTCTTCTGGGTATGGGTAAATTAGGGGTTGAAGTAGCT
AGGAAGATTAAAGGTTTTAATGTAAAACTTTTTTATTATGATTTACAAAAATTAGATTCAATAGATGAACAACAACTAAA
CACCAAATATCTGGAATTAAATGATCTTTTTGAGAAGGCTGATTATTTGGTTATTCTTTTACCTTTGAAAAACGATACTT
ACCATTTTATTAACTTTGAAAATATTTTAAAAATAAAAAAAAATTGTTTAATTATTAATACTTCAAGAGGTTCTGTAGTA
GATGAGAGTGCAATTGCACAAGCAATTAATTCTGGGCACATAGGAGGATATGCTTCAGATGTCTTTGAATTTGAAGATTT
ATCGATAAAAGATCGACCAAAAAAAATTAATCAGGAATTATTAAATTTAAAAGATAAGACTTTTTTTACTCCTCATCTTG
GCTCGGCAGTTGATGAAGTTAGACTTTTTATTGAATTAGAAGCTGCTCAAAATATTATCAACTTTTTATATCATTAA

Upstream 100 bases:

>100_bases
CAAGTATCAGCTTTATTAATAGTAGTTTTAGTCGTAGTAACTGTATTAGATAGCATGAGTAACTATCTCAGGAAATCAGT
ATCTGAATAATTCTCATTAA

Downstream 100 bases:

>100_bases
TAGTTTTATACATTTTTATATAAGAGATATTTTCTTTTTTGAAATAATCACCTTCAGATAAAAAACCGAATTTTTCATAA
AACATTTGGGCTTTTTTTCT

Product: putative dehydrogenase

Products: NA

Alternate protein names: NAD-dependent phosphite dehydrogenase [H]

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MKKVVISNKVHTEVIELLEKNFEVISNQNDKPLTYEKLKFLCKDAHGVMVFMPDRIDKNFLDNSKNLEIISGALRGFDNI
DLEECIKRNIKFTMIPDLLASPTAELTLGLLIGLSRNLLIGDEYVRSEKFKGWEPKFFSNGIEGKNVCLLGMGKLGVEVA
RKIKGFNVKLFYYDLQKLDSIDEQQLNTKYLELNDLFEKADYLVILLPLKNDTYHFINFENILKIKKNCLIINTSRGSVV
DESAIAQAINSGHIGGYASDVFEFEDLSIKDRPKKINQELLNLKDKTFFTPHLGSAVDEVRLFIELEAAQNIINFLYH

Sequences:

>Translated_318_residues
MKKVVISNKVHTEVIELLEKNFEVISNQNDKPLTYEKLKFLCKDAHGVMVFMPDRIDKNFLDNSKNLEIISGALRGFDNI
DLEECIKRNIKFTMIPDLLASPTAELTLGLLIGLSRNLLIGDEYVRSEKFKGWEPKFFSNGIEGKNVCLLGMGKLGVEVA
RKIKGFNVKLFYYDLQKLDSIDEQQLNTKYLELNDLFEKADYLVILLPLKNDTYHFINFENILKIKKNCLIINTSRGSVV
DESAIAQAINSGHIGGYASDVFEFEDLSIKDRPKKINQELLNLKDKTFFTPHLGSAVDEVRLFIELEAAQNIINFLYH
>Mature_318_residues
MKKVVISNKVHTEVIELLEKNFEVISNQNDKPLTYEKLKFLCKDAHGVMVFMPDRIDKNFLDNSKNLEIISGALRGFDNI
DLEECIKRNIKFTMIPDLLASPTAELTLGLLIGLSRNLLIGDEYVRSEKFKGWEPKFFSNGIEGKNVCLLGMGKLGVEVA
RKIKGFNVKLFYYDLQKLDSIDEQQLNTKYLELNDLFEKADYLVILLPLKNDTYHFINFENILKIKKNCLIINTSRGSVV
DESAIAQAINSGHIGGYASDVFEFEDLSIKDRPKKINQELLNLKDKTFFTPHLGSAVDEVRLFIELEAAQNIINFLYH

Specific function: Catalyzes phosphite (phosphonate) oxidation [H]

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=320, Percent_Identity=29.6875, Blast_Score=150, Evalue=1e-36,
Organism=Homo sapiens, GI23308577, Length=303, Percent_Identity=27.0627062706271, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI61743967, Length=290, Percent_Identity=26.551724137931, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI4557497, Length=290, Percent_Identity=26.551724137931, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI145580578, Length=290, Percent_Identity=26.8965517241379, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI4557499, Length=290, Percent_Identity=26.8965517241379, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI145580575, Length=290, Percent_Identity=26.8965517241379, Blast_Score=96, Evalue=6e-20,
Organism=Escherichia coli, GI87082289, Length=316, Percent_Identity=26.8987341772152, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1787645, Length=290, Percent_Identity=27.5862068965517, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1789279, Length=316, Percent_Identity=25.9493670886076, Blast_Score=91, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17532191, Length=317, Percent_Identity=28.7066246056782, Blast_Score=134, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI25147481, Length=225, Percent_Identity=23.1111111111111, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324055, Length=245, Percent_Identity=33.469387755102, Blast_Score=133, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6320925, Length=329, Percent_Identity=24.9240121580547, Blast_Score=106, Evalue=6e-24,
Organism=Saccharomyces cerevisiae, GI6322116, Length=287, Percent_Identity=24.7386759581882, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6324964, Length=322, Percent_Identity=25.1552795031056, Blast_Score=94, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6324980, Length=202, Percent_Identity=26.7326732673267, Blast_Score=70, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6325144, Length=177, Percent_Identity=30.5084745762712, Blast_Score=70, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6321253, Length=270, Percent_Identity=24.8148148148148, Blast_Score=62, Evalue=1e-10,
Organism=Drosophila melanogaster, GI28571528, Length=304, Percent_Identity=31.5789473684211, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI28574286, Length=321, Percent_Identity=28.3489096573209, Blast_Score=124, Evalue=7e-29,
Organism=Drosophila melanogaster, GI19921140, Length=325, Percent_Identity=26.7692307692308, Blast_Score=124, Evalue=8e-29,
Organism=Drosophila melanogaster, GI45552429, Length=318, Percent_Identity=27.6729559748428, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24585514, Length=318, Percent_Identity=27.6729559748428, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI28574282, Length=318, Percent_Identity=27.6729559748428, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI45551003, Length=318, Percent_Identity=27.6729559748428, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI28574284, Length=318, Percent_Identity=27.6729559748428, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24646446, Length=280, Percent_Identity=27.5, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24646448, Length=280, Percent_Identity=27.5, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24646452, Length=280, Percent_Identity=27.5, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24646450, Length=280, Percent_Identity=27.5, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24585516, Length=323, Percent_Identity=24.7678018575851, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI62472511, Length=280, Percent_Identity=27.5, Blast_Score=92, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.20.1.1 [H]

Molecular weight: Translated: 36361; Mature: 36361

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKVVISNKVHTEVIELLEKNFEVISNQNDKPLTYEKLKFLCKDAHGVMVFMPDRIDKNF
CCCEEECCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCHHH
LDNSKNLEIISGALRGFDNIDLEECIKRNIKFTMIPDLLASPTAELTLGLLIGLSRNLLI
HCCCCCHHHHHHHHCCCCCCCHHHHHHCCCEEEECCHHHCCCHHHHHHHHHHHCCCCEEE
GDEYVRSEKFKGWEPKFFSNGIEGKNVCLLGMGKLGVEVARKIKGFNVKLFYYDLQKLDS
CHHHHHHCCCCCCCCHHHCCCCCCCCEEEEECCHHHHHHHHHHCCCEEEEEEEEHHHHCC
IDEQQLNTKYLELNDLFEKADYLVILLPLKNDTYHFINFENILKIKKNCLIINTSRGSVV
CCHHHHCCCEEHHHHHHHCCCEEEEEEECCCCCEEEEEHHHHHHCCCCEEEEECCCCCCC
DESAIAQAINSGHIGGYASDVFEFEDLSIKDRPKKINQELLNLKDKTFFTPHLGSAVDEV
CHHHHHHHHCCCCCCCCHHHHEECCCCCCCCCHHHHHHHHHCCCCCEEECCCCCHHHHHH
RLFIELEAAQNIINFLYH
EEEEEHHHHHHHHHHHCC
>Mature Secondary Structure
MKKVVISNKVHTEVIELLEKNFEVISNQNDKPLTYEKLKFLCKDAHGVMVFMPDRIDKNF
CCCEEECCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCHHH
LDNSKNLEIISGALRGFDNIDLEECIKRNIKFTMIPDLLASPTAELTLGLLIGLSRNLLI
HCCCCCHHHHHHHHCCCCCCCHHHHHHCCCEEEECCHHHCCCHHHHHHHHHHHCCCCEEE
GDEYVRSEKFKGWEPKFFSNGIEGKNVCLLGMGKLGVEVARKIKGFNVKLFYYDLQKLDS
CHHHHHHCCCCCCCCHHHCCCCCCCCEEEEECCHHHHHHHHHHCCCEEEEEEEEHHHHCC
IDEQQLNTKYLELNDLFEKADYLVILLPLKNDTYHFINFENILKIKKNCLIINTSRGSVV
CCHHHHCCCEEHHHHHHHCCCEEEEEEECCCCCEEEEEHHHHHHCCCCEEEEECCCCCCC
DESAIAQAINSGHIGGYASDVFEFEDLSIKDRPKKINQELLNLKDKTFFTPHLGSAVDEV
CHHHHHHHHCCCCCCCCHHHHEECCCCCCCCCHHHHHHHHHCCCCCEEECCCCCHHHHHH
RLFIELEAAQNIINFLYH
EEEEEHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9791102; 11278981 [H]