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The map label for this gene is gyrA [H]

Identifier: 126696507

GI number: 126696507

Start: 978806

End: 981403

Strand: Direct

Name: gyrA [H]

Synonym: P9301_11691

Alternate gene names: 126696507

Gene position: 978806-981403 (Clockwise)

Preceding gene: 126696502

Following gene: 126696508

Centisome position: 59.61

GC content: 35.95

Gene sequence:

>2598_bases
ATGTCTGATATTTTAGATTCCGATAATTCAGGATTAAGCGAAGATAATGACCGAATTATTCAGACTGACCTAAGAAATGA
GATGTCTCGTTCATACCTTGAGTATGCAATGAGCGTTATAGTTGGTCGCGCTCTTCCAGATGCAAGAGATGGATTAAAAC
CTGTTCACAGAAGAATTCTTTATGCAATGTATGAACTTGGTTTGACTAGCGGTAGACCATATAGAAAATGTGCAAGAGTT
GTTGGAGAAGTACTTGGTAAATACCACCCTCATGGCGATACTGCTGTTTATGATGCTTTGGTTAGGATGGCCCAGGATTT
CTCTATGAGGATGCCACTCATAGATGGCCATGGGAACTTTGGTTCTGTTGATAACGACCCTCCAGCAGCAATGAGATATA
CAGAATCTCGTTTACAGTCTCTTACGGATGAAAGTTTATTAGAGGATATTGAATCTGAAACTGTGGATTTCGCTGATAAT
TTTGACGGTTCACAGCAAGAGCCAACAGTTTTACCTGCTAGGATCCCTCAACTACTTCTAAATGGATCATCAGGAATAGC
AGTAGGAATGGCAACTAATATTCCACCTCATAACTTAGGGGAATTAATTAATGGCCTTAAATCAATAATCAATAACCCTT
CAATTGAAGATAGAGAACTTTTTGAAATAATTAAGGGCCCTGATTTTCCGACAGGTGGTCAAATCTTAGGCAGAGACGGT
ATTAGAGAAACTTTCAAAACAGGAAGGGGGTCAATAACCATGAGAGGAGTAGCAAATATTGAGCAAATTAAATCCATTGG
AAGAGCAGAGAAAGATGCAGTAATAATTACCGAGTTGCCATTTCAAACCAATAAAGCAGCATTGATAGAAAGAATTGCTG
ACTTAGTTAATGAAAAAAAATTAGAAGGTATTTCTGACATTAGAGATGAAAGTGATCGAGATGGGATGAGGATAGTTATT
GAACTAAAAAGAGATGCCTACCCACAAGTAGTTTTAAATAATTTATTTAAGTTAACACCTCTTCAAAATAACTTTAGTGC
AAATATCCTTGCTTTAGTAAAAGGAGAGCCCACAACACTTTCACTCAGAAAAATGTTAGATGTATTTTTAGATTTTAGGG
TTGAGACAATAAGGCGGAGAACAGCATTTTTATTAAAAAAGGCAGAAGAAAGAGATCATATTGTAAAGGGTCTTTTATTG
GCATTAGATGCTATGGATGAAATTATAAATCTAATAAGATCTGCGAAAGATTCAATTTCAGCCCGTGAAAAATTACAAAA
CGACCATAAATTATCTTCTATACAGGCAGATGCTATTCTACAAATGCAGTTAAGAAGATTAACAGCACTAGAAGCAGATA
AAATAAAGGGTGAACATAATGATTTAACCCAAAAAATCAACCTATATCAGCAAATATTAAATAGTAAAGAAAGAATTTTT
GAAATTATTCTTGAAGAACTTAATAAAATCGATGAAAGATTCTCTTCTCCAAGGAAAACAGAAATATTAGATTTAGGCGG
CGGACTAGATGATATTGATCTCATAGCTAATGAAAGATCTGTAGTGCTATTAACTGAAGCAGGTTATTTAAAAAGAATGC
CTGTTAATGATTTTGAATCTACCAGTCGTGGTTCGAGGGGTAAAGCTGGCACAAAAACCAAAGAAGATGATGATGTGAAA
TTATTTATAAGCTGTAACGATCATGATACTCTTTTGCTTTTCAGTGATAAAGGAGTAGCTTATGCTCTCCCTGCATATCG
GGTTCCTATGAGTAGCAGAACAGCAAAAGGGACTCCATCGGTTCAACTTCTCCCAATTCCAAGAGAAGAGAAAATAACCT
CAATCGTTGCTGTGGATTCTTTTGTTGACGATAGTTATTTATTAATGCTAACCAAAGCTGGCTTTATAAAAAGAACTGCA
CTTTCTGCTTTCTCAAAAATTCGTTCAAATGGACTAATAGCAATTAATCTTGAGGATGGAGATGCCCTAACCTGGGTCAG
ACTATCAAAAGAAGGTGATAGTGTTTTAATTGGATCAAAAACAGGAATGGCAATTCATTTCAGACTAGATATCAATGAAT
TAAGACCACTTGGTAGAACAGCAAGAGGGGTAAAATCAATGAACTTGAGAGAGGGAGACAATCTAGTTTCTATGGATGTT
TTAACATCTAATTTGGCTGATCAATTGGCTAAAATTGAGTATCCGAAAGAAGATCTTGATGATAATGTTGAGGAAAACTC
TTCAGATGGTCCATGGGTATTAATAGCCAGTGCATTTGGACTAGGAAAGAGAGTACCTGTAGCTCAGTTTAGATTACAAA
AAAGAGCAGGCATGGGTTTGAGAGCAATAAAATTTAGAATTAAATATGATCAGCTGGTTAGTTTGAAGGTCCTTGGAGAG
GGAGAAGAATTACTACTTGTGACCGAAAAAGGCGTAATAGTAAGAACAAATGCAGATCAAATCTCTCAGCAATCCAGAGC
AGCTACAGGAGTAAAATTACAAAGATTAGATGATGGTGATCATTTATCTGAAGTAGTATTGGTACCTCGTGAACAAATAG
AGGAAGAAGACCAACCTAGCTCAGTTGAACAAAATTAA

Upstream 100 bases:

>100_bases
TTTTGATTTGTGTGTAAATGTGAGTATTTGGGAATTAAATAAATCTTTTTTTTTATTCATTATGACAATCAGCGATTATT
ATTAAAGAAAGGTTTTTTGT

Downstream 100 bases:

>100_bases
AAGCCTTATGGTTAGCTAAATAATATGGAAATACTTGATATTTTAATTTTAGGTTCAGGTCCTGCAGCATTATGTTTAGC
CTCAGAATTAGCAAAGCAGG

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 865; Mature: 864

Protein sequence:

>865_residues
MSDILDSDNSGLSEDNDRIIQTDLRNEMSRSYLEYAMSVIVGRALPDARDGLKPVHRRILYAMYELGLTSGRPYRKCARV
VGEVLGKYHPHGDTAVYDALVRMAQDFSMRMPLIDGHGNFGSVDNDPPAAMRYTESRLQSLTDESLLEDIESETVDFADN
FDGSQQEPTVLPARIPQLLLNGSSGIAVGMATNIPPHNLGELINGLKSIINNPSIEDRELFEIIKGPDFPTGGQILGRDG
IRETFKTGRGSITMRGVANIEQIKSIGRAEKDAVIITELPFQTNKAALIERIADLVNEKKLEGISDIRDESDRDGMRIVI
ELKRDAYPQVVLNNLFKLTPLQNNFSANILALVKGEPTTLSLRKMLDVFLDFRVETIRRRTAFLLKKAEERDHIVKGLLL
ALDAMDEIINLIRSAKDSISAREKLQNDHKLSSIQADAILQMQLRRLTALEADKIKGEHNDLTQKINLYQQILNSKERIF
EIILEELNKIDERFSSPRKTEILDLGGGLDDIDLIANERSVVLLTEAGYLKRMPVNDFESTSRGSRGKAGTKTKEDDDVK
LFISCNDHDTLLLFSDKGVAYALPAYRVPMSSRTAKGTPSVQLLPIPREEKITSIVAVDSFVDDSYLLMLTKAGFIKRTA
LSAFSKIRSNGLIAINLEDGDALTWVRLSKEGDSVLIGSKTGMAIHFRLDINELRPLGRTARGVKSMNLREGDNLVSMDV
LTSNLADQLAKIEYPKEDLDDNVEENSSDGPWVLIASAFGLGKRVPVAQFRLQKRAGMGLRAIKFRIKYDQLVSLKVLGE
GEELLLVTEKGVIVRTNADQISQQSRAATGVKLQRLDDGDHLSEVVLVPREQIEEEDQPSSVEQN

Sequences:

>Translated_865_residues
MSDILDSDNSGLSEDNDRIIQTDLRNEMSRSYLEYAMSVIVGRALPDARDGLKPVHRRILYAMYELGLTSGRPYRKCARV
VGEVLGKYHPHGDTAVYDALVRMAQDFSMRMPLIDGHGNFGSVDNDPPAAMRYTESRLQSLTDESLLEDIESETVDFADN
FDGSQQEPTVLPARIPQLLLNGSSGIAVGMATNIPPHNLGELINGLKSIINNPSIEDRELFEIIKGPDFPTGGQILGRDG
IRETFKTGRGSITMRGVANIEQIKSIGRAEKDAVIITELPFQTNKAALIERIADLVNEKKLEGISDIRDESDRDGMRIVI
ELKRDAYPQVVLNNLFKLTPLQNNFSANILALVKGEPTTLSLRKMLDVFLDFRVETIRRRTAFLLKKAEERDHIVKGLLL
ALDAMDEIINLIRSAKDSISAREKLQNDHKLSSIQADAILQMQLRRLTALEADKIKGEHNDLTQKINLYQQILNSKERIF
EIILEELNKIDERFSSPRKTEILDLGGGLDDIDLIANERSVVLLTEAGYLKRMPVNDFESTSRGSRGKAGTKTKEDDDVK
LFISCNDHDTLLLFSDKGVAYALPAYRVPMSSRTAKGTPSVQLLPIPREEKITSIVAVDSFVDDSYLLMLTKAGFIKRTA
LSAFSKIRSNGLIAINLEDGDALTWVRLSKEGDSVLIGSKTGMAIHFRLDINELRPLGRTARGVKSMNLREGDNLVSMDV
LTSNLADQLAKIEYPKEDLDDNVEENSSDGPWVLIASAFGLGKRVPVAQFRLQKRAGMGLRAIKFRIKYDQLVSLKVLGE
GEELLLVTEKGVIVRTNADQISQQSRAATGVKLQRLDDGDHLSEVVLVPREQIEEEDQPSSVEQN
>Mature_864_residues
SDILDSDNSGLSEDNDRIIQTDLRNEMSRSYLEYAMSVIVGRALPDARDGLKPVHRRILYAMYELGLTSGRPYRKCARVV
GEVLGKYHPHGDTAVYDALVRMAQDFSMRMPLIDGHGNFGSVDNDPPAAMRYTESRLQSLTDESLLEDIESETVDFADNF
DGSQQEPTVLPARIPQLLLNGSSGIAVGMATNIPPHNLGELINGLKSIINNPSIEDRELFEIIKGPDFPTGGQILGRDGI
RETFKTGRGSITMRGVANIEQIKSIGRAEKDAVIITELPFQTNKAALIERIADLVNEKKLEGISDIRDESDRDGMRIVIE
LKRDAYPQVVLNNLFKLTPLQNNFSANILALVKGEPTTLSLRKMLDVFLDFRVETIRRRTAFLLKKAEERDHIVKGLLLA
LDAMDEIINLIRSAKDSISAREKLQNDHKLSSIQADAILQMQLRRLTALEADKIKGEHNDLTQKINLYQQILNSKERIFE
IILEELNKIDERFSSPRKTEILDLGGGLDDIDLIANERSVVLLTEAGYLKRMPVNDFESTSRGSRGKAGTKTKEDDDVKL
FISCNDHDTLLLFSDKGVAYALPAYRVPMSSRTAKGTPSVQLLPIPREEKITSIVAVDSFVDDSYLLMLTKAGFIKRTAL
SAFSKIRSNGLIAINLEDGDALTWVRLSKEGDSVLIGSKTGMAIHFRLDINELRPLGRTARGVKSMNLREGDNLVSMDVL
TSNLADQLAKIEYPKEDLDDNVEENSSDGPWVLIASAFGLGKRVPVAQFRLQKRAGMGLRAIKFRIKYDQLVSLKVLGEG
EELLLVTEKGVIVRTNADQISQQSRAATGVKLQRLDDGDHLSEVVLVPREQIEEEDQPSSVEQN

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=525, Percent_Identity=22.4761904761905, Blast_Score=84, Evalue=9e-16,
Organism=Homo sapiens, GI19913406, Length=356, Percent_Identity=23.314606741573, Blast_Score=74, Evalue=7e-13,
Organism=Escherichia coli, GI1788562, Length=873, Percent_Identity=42.2680412371134, Blast_Score=666, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=613, Percent_Identity=37.8466557911909, Blast_Score=388, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI17535065, Length=357, Percent_Identity=24.0896358543417, Blast_Score=76, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI212645845, Length=227, Percent_Identity=28.1938325991189, Blast_Score=70, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=293, Percent_Identity=27.6450511945392, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI17136538, Length=364, Percent_Identity=25.5494505494505, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 96302; Mature: 96171

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDILDSDNSGLSEDNDRIIQTDLRNEMSRSYLEYAMSVIVGRALPDARDGLKPVHRRIL
CCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHH
YAMYELGLTSGRPYRKCARVVGEVLGKYHPHGDTAVYDALVRMAQDFSMRMPLIDGHGNF
HHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCCCC
GSVDNDPPAAMRYTESRLQSLTDESLLEDIESETVDFADNFDGSQQEPTVLPARIPQLLL
CCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHCCCCCCCCCCCCCHHHHHHHHH
NGSSGIAVGMATNIPPHNLGELINGLKSIINNPSIEDRELFEIIKGPDFPTGGQILGRDG
CCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCEECCHH
IRETFKTGRGSITMRGVANIEQIKSIGRAEKDAVIITELPFQTNKAALIERIADLVNEKK
HHHHHHCCCCCEEECCCCCHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHH
LEGISDIRDESDRDGMRIVIELKRDAYPQVVLNNLFKLTPLQNNFSANILALVKGEPTTL
HCCHHHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHEECCCCCCCCCCEEEEECCCCCHH
SLRKMLDVFLDFRVETIRRRTAFLLKKAEERDHIVKGLLLALDAMDEIINLIRSAKDSIS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AREKLQNDHKLSSIQADAILQMQLRRLTALEADKIKGEHNDLTQKINLYQQILNSKERIF
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
EIILEELNKIDERFSSPRKTEILDLGGGLDDIDLIANERSVVLLTEAGYLKRMPVNDFES
HHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHEECCCCEEEEECCCCEECCCCCCCHH
TSRGSRGKAGTKTKEDDDVKLFISCNDHDTLLLFSDKGVAYALPAYRVPMSSRTAKGTPS
CCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEECCCCEEECCCEECCCCCCCCCCCCC
VQLLPIPREEKITSIVAVDSFVDDSYLLMLTKAGFIKRTALSAFSKIRSNGLIAINLEDG
EEEEECCCHHHHHHEEEEHHHCCCCEEEEEECCCHHHHHHHHHHHHHHCCCEEEEEECCC
DALTWVRLSKEGDSVLIGSKTGMAIHFRLDINELRPLGRTARGVKSMNLREGDNLVSMDV
CEEEEEEEECCCCEEEEECCCCEEEEEEEEHHHCCCCCHHHHCHHCCCCCCCCCEEEHHH
LTSNLADQLAKIEYPKEDLDDNVEENSSDGPWVLIASAFGLGKRVPVAQFRLQKRAGMGL
HHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCE
RAIKFRIKYDQLVSLKVLGEGEELLLVTEKGVIVRTNADQISQQSRAATGVKLQRLDDGD
EEEEEEEEHHHEEEEEEECCCCEEEEEECCCEEEECCHHHHHHHHHHHCCCEEEECCCCC
HLSEVVLVPREQIEEEDQPSSVEQN
CCHHHEECCHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
SDILDSDNSGLSEDNDRIIQTDLRNEMSRSYLEYAMSVIVGRALPDARDGLKPVHRRIL
CCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHH
YAMYELGLTSGRPYRKCARVVGEVLGKYHPHGDTAVYDALVRMAQDFSMRMPLIDGHGNF
HHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCCCC
GSVDNDPPAAMRYTESRLQSLTDESLLEDIESETVDFADNFDGSQQEPTVLPARIPQLLL
CCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHCCCCCCCCCCCCCHHHHHHHHH
NGSSGIAVGMATNIPPHNLGELINGLKSIINNPSIEDRELFEIIKGPDFPTGGQILGRDG
CCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCEECCHH
IRETFKTGRGSITMRGVANIEQIKSIGRAEKDAVIITELPFQTNKAALIERIADLVNEKK
HHHHHHCCCCCEEECCCCCHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHH
LEGISDIRDESDRDGMRIVIELKRDAYPQVVLNNLFKLTPLQNNFSANILALVKGEPTTL
HCCHHHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHEECCCCCCCCCCEEEEECCCCCHH
SLRKMLDVFLDFRVETIRRRTAFLLKKAEERDHIVKGLLLALDAMDEIINLIRSAKDSIS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AREKLQNDHKLSSIQADAILQMQLRRLTALEADKIKGEHNDLTQKINLYQQILNSKERIF
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
EIILEELNKIDERFSSPRKTEILDLGGGLDDIDLIANERSVVLLTEAGYLKRMPVNDFES
HHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHEECCCCEEEEECCCCEECCCCCCCHH
TSRGSRGKAGTKTKEDDDVKLFISCNDHDTLLLFSDKGVAYALPAYRVPMSSRTAKGTPS
CCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEECCCCEEECCCEECCCCCCCCCCCCC
VQLLPIPREEKITSIVAVDSFVDDSYLLMLTKAGFIKRTALSAFSKIRSNGLIAINLEDG
EEEEECCCHHHHHHEEEEHHHCCCCEEEEEECCCHHHHHHHHHHHHHHCCCEEEEEECCC
DALTWVRLSKEGDSVLIGSKTGMAIHFRLDINELRPLGRTARGVKSMNLREGDNLVSMDV
CEEEEEEEECCCCEEEEECCCCEEEEEEEEHHHCCCCCHHHHCHHCCCCCCCCCEEEHHH
LTSNLADQLAKIEYPKEDLDDNVEENSSDGPWVLIASAFGLGKRVPVAQFRLQKRAGMGL
HHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCE
RAIKFRIKYDQLVSLKVLGEGEELLLVTEKGVIVRTNADQISQQSRAATGVKLQRLDDGD
EEEEEEEEHHHEEEEEEECCCCEEEEEECCCEEEECCHHHHHHHHHHHCCCEEEECCCCC
HLSEVVLVPREQIEEEDQPSSVEQN
CCHHHEECCHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]