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The map label for this gene is htpG [H]

Identifier: 126696296

GI number: 126696296

Start: 823972

End: 825876

Strand: Reverse

Name: htpG [H]

Synonym: P9301_09581

Alternate gene names: 126696296

Gene position: 825876-823972 (Counterclockwise)

Preceding gene: 126696297

Following gene: 126696295

Centisome position: 50.3

GC content: 30.76

Gene sequence:

>1905_bases
ATGGAAAAAGGCGAAATTCGTATTAATACTGAAAATATTTTCCCAATTATTAAGAAGGCAGTATATTCTGACCATGAAAT
CTTTTTAAGAGAACTTGTTAGTAATGGTGTTGACGCAATTAGTAAAAGAAGAATGGCCTCTATGGCAGGCGATTGCGAAA
ATACTGAGGAGGCACAAGTAAAAATAACAATTAACCGTGAAAAAAATACGTTAACAATTTCCGATAATGGAATTGGAATG
AATGATGAAGAAATTAAGAAGTACATAAATCAAGTTGCATTTTCTAGTGCTGAAGAATTTCTAACAAAATACAAAAAAGA
TAATGATGAATTCATAGGTCATTTTGGACTAGGTTTTTATTCAAGTTTCATGGTTGCAGATAAAGTTGATATTTTAACTA
AGTCGGCAATTGGGGAATCAAAAGCTTTCAAATGGTCTTGTGATGGATCGCCAAATTTCACGTTAGAGGAATCAGAAAGA
GAGACAATTGGTACAGATGTAATTCTTCACCTACTTGAAGAAGAGAAAGAGTTTATTGAGCCTGAAAGGATTAAATCACT
CATTAAAAAATATTGTGATTTTATGCCAATAGATGTCTTACTAGAAGGAGAGACAATTAATAAGAAAAATCCTCCCTGGA
GAAAACAACCTAGTGAATTAAAAGATGAAGATTATATTGAGTTATATAAATACCTTTATCCTTTCCAGGGAGATCCACTA
TTATGGATCCATCTAAATACAGATTATCCATATGACATACAAGGGATATTGTATTTTCCAAAGTTGTCAGGTAGAGCTGA
TTGGGAAAAGGGAGAAATAAAACTATTTTGCAATCAAGTATTCGTAAGCGATTCAATTAAGGAGATAGTACCAAAATACC
TTTTACCTCTAAGAGGAGTTATTGACTCTACAGATATACCCCTAAATGTTAGTAGAAGTGCATTACAAACAGATAGAAAA
GTAAGATCTATATCATCATTTATCTCAAAAAAAATCGCTAATAAACTGAAGGATTTAATAAAAAATTCTCCAGAATTTTA
TGCAGAAATTTGGGATTCAATCTCTGCATTTATTAAGATTGGTGCTATCGAAGATGAAAAATTTGCTGAATTAGTAAATA
ACAGTATAATTTTTGAAACAATAATAAATTCAGAGAAAAACGTAACCAAAAATATTGAAAATAAATCCCTCATCAAATCC
AATGATAAATATTTCACAACTCTCGCAAATTACAAAGAGCGAAATAAATTAACTGATTCAAAAAAAATAATTTACTGTTC
AGATTTGATTGCGCAGTCTAGTGCATTAAAAATCTGTTTATCTGATAATAAAGAAGTGATTAAATCAGATCCCTTAATTG
ACGCACAATTTCTTCCATGGTTGGAAAGTAAAAATGAAGATTTTCAATTCCAAAGGGTAGATTCAGAGATAAATGAAATA
GAAGATAAAGAATCAAAAGAAATTGTAGATAAGGATGGCAAATCAAATACAGATAATCTTAGAGATACGATAGTTAAGGC
CCTTAACAATGAGAAAGTAACAGTTAAAGTACAGTCACTTTCAAGTAAAGATGCTCCACCAGCGATGATATTGCTTCCAG
AACAAATGAGAAGAATTAATGATATGGGAGCTTACATGGAACAAAAGATGCCTGGCTTACCTGAATATCATGTGCTCTTA
ATTAATAAAGAACATCCACTTATTGTTGGTCTTAATAAAATTACAGGCAACAAAATAATTATTGATGAGAAAGACCCTAC
TGAGAATCCATTGGCATCTAAAATTGCAAATCATGTTTACGATATGGCTAAGCTTTCAGTTGGTGGATTAGATCAAGAAC
AGATCATTAATTTACAAAATAATAATGCCGAATTAATTTCAGAATTACTTAATTCAACAAATTGA

Upstream 100 bases:

>100_bases
TTTAACTTTTAAATTCATATATTGTTCGGACAATACTCCTAATTAAACTTGATTAACTAGTTTTTACGAAATAAGATTTA
ATATGTTTGATTTTTTTTAA

Downstream 100 bases:

>100_bases
GCCATGTGTTAGAATTTTTAAAGATATAACTCAATAAATATGTCAAGAGTTTGCGAACTGACAGGTGCAAAAGCTAATAA
CGGGATGGCAGTGAGTCACT

Product: heat shock protein 90

Products: NA

Alternate protein names: Heat shock protein htpG; High temperature protein G [H]

Number of amino acids: Translated: 634; Mature: 634

Protein sequence:

>634_residues
MEKGEIRINTENIFPIIKKAVYSDHEIFLRELVSNGVDAISKRRMASMAGDCENTEEAQVKITINREKNTLTISDNGIGM
NDEEIKKYINQVAFSSAEEFLTKYKKDNDEFIGHFGLGFYSSFMVADKVDILTKSAIGESKAFKWSCDGSPNFTLEESER
ETIGTDVILHLLEEEKEFIEPERIKSLIKKYCDFMPIDVLLEGETINKKNPPWRKQPSELKDEDYIELYKYLYPFQGDPL
LWIHLNTDYPYDIQGILYFPKLSGRADWEKGEIKLFCNQVFVSDSIKEIVPKYLLPLRGVIDSTDIPLNVSRSALQTDRK
VRSISSFISKKIANKLKDLIKNSPEFYAEIWDSISAFIKIGAIEDEKFAELVNNSIIFETIINSEKNVTKNIENKSLIKS
NDKYFTTLANYKERNKLTDSKKIIYCSDLIAQSSALKICLSDNKEVIKSDPLIDAQFLPWLESKNEDFQFQRVDSEINEI
EDKESKEIVDKDGKSNTDNLRDTIVKALNNEKVTVKVQSLSSKDAPPAMILLPEQMRRINDMGAYMEQKMPGLPEYHVLL
INKEHPLIVGLNKITGNKIIIDEKDPTENPLASKIANHVYDMAKLSVGGLDQEQIINLQNNNAELISELLNSTN

Sequences:

>Translated_634_residues
MEKGEIRINTENIFPIIKKAVYSDHEIFLRELVSNGVDAISKRRMASMAGDCENTEEAQVKITINREKNTLTISDNGIGM
NDEEIKKYINQVAFSSAEEFLTKYKKDNDEFIGHFGLGFYSSFMVADKVDILTKSAIGESKAFKWSCDGSPNFTLEESER
ETIGTDVILHLLEEEKEFIEPERIKSLIKKYCDFMPIDVLLEGETINKKNPPWRKQPSELKDEDYIELYKYLYPFQGDPL
LWIHLNTDYPYDIQGILYFPKLSGRADWEKGEIKLFCNQVFVSDSIKEIVPKYLLPLRGVIDSTDIPLNVSRSALQTDRK
VRSISSFISKKIANKLKDLIKNSPEFYAEIWDSISAFIKIGAIEDEKFAELVNNSIIFETIINSEKNVTKNIENKSLIKS
NDKYFTTLANYKERNKLTDSKKIIYCSDLIAQSSALKICLSDNKEVIKSDPLIDAQFLPWLESKNEDFQFQRVDSEINEI
EDKESKEIVDKDGKSNTDNLRDTIVKALNNEKVTVKVQSLSSKDAPPAMILLPEQMRRINDMGAYMEQKMPGLPEYHVLL
INKEHPLIVGLNKITGNKIIIDEKDPTENPLASKIANHVYDMAKLSVGGLDQEQIINLQNNNAELISELLNSTN
>Mature_634_residues
MEKGEIRINTENIFPIIKKAVYSDHEIFLRELVSNGVDAISKRRMASMAGDCENTEEAQVKITINREKNTLTISDNGIGM
NDEEIKKYINQVAFSSAEEFLTKYKKDNDEFIGHFGLGFYSSFMVADKVDILTKSAIGESKAFKWSCDGSPNFTLEESER
ETIGTDVILHLLEEEKEFIEPERIKSLIKKYCDFMPIDVLLEGETINKKNPPWRKQPSELKDEDYIELYKYLYPFQGDPL
LWIHLNTDYPYDIQGILYFPKLSGRADWEKGEIKLFCNQVFVSDSIKEIVPKYLLPLRGVIDSTDIPLNVSRSALQTDRK
VRSISSFISKKIANKLKDLIKNSPEFYAEIWDSISAFIKIGAIEDEKFAELVNNSIIFETIINSEKNVTKNIENKSLIKS
NDKYFTTLANYKERNKLTDSKKIIYCSDLIAQSSALKICLSDNKEVIKSDPLIDAQFLPWLESKNEDFQFQRVDSEINEI
EDKESKEIVDKDGKSNTDNLRDTIVKALNNEKVTVKVQSLSSKDAPPAMILLPEQMRRINDMGAYMEQKMPGLPEYHVLL
INKEHPLIVGLNKITGNKIIIDEKDPTENPLASKIANHVYDMAKLSVGGLDQEQIINLQNNNAELISELLNSTN

Specific function: Molecular chaperone. Has ATPase activity [H]

COG id: COG0326

COG function: function code O; Molecular chaperone, HSP90 family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heat shock protein 90 family [H]

Homologues:

Organism=Homo sapiens, GI155722983, Length=635, Percent_Identity=26.9291338582677, Blast_Score=242, Evalue=7e-64,
Organism=Homo sapiens, GI4507677, Length=697, Percent_Identity=28.4074605451937, Blast_Score=189, Evalue=6e-48,
Organism=Homo sapiens, GI153792590, Length=198, Percent_Identity=36.3636363636364, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI154146191, Length=198, Percent_Identity=36.3636363636364, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI20149594, Length=200, Percent_Identity=37.5, Blast_Score=122, Evalue=1e-27,
Organism=Escherichia coli, GI1786679, Length=587, Percent_Identity=30.1533219761499, Blast_Score=237, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI115535205, Length=647, Percent_Identity=28.7480680061824, Blast_Score=246, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI115535167, Length=431, Percent_Identity=32.2505800464037, Blast_Score=233, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI17542208, Length=690, Percent_Identity=28.2608695652174, Blast_Score=220, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI17559162, Length=414, Percent_Identity=28.0193236714976, Blast_Score=174, Evalue=9e-44,
Organism=Saccharomyces cerevisiae, GI6323840, Length=605, Percent_Identity=27.7685950413223, Blast_Score=180, Evalue=7e-46,
Organism=Saccharomyces cerevisiae, GI6325016, Length=209, Percent_Identity=35.4066985645933, Blast_Score=114, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24586016, Length=667, Percent_Identity=29.0854572713643, Blast_Score=253, Evalue=2e-67,
Organism=Drosophila melanogaster, GI21357739, Length=689, Percent_Identity=26.8505079825835, Blast_Score=200, Evalue=2e-51,
Organism=Drosophila melanogaster, GI17647529, Length=197, Percent_Identity=34.010152284264, Blast_Score=114, Evalue=1e-25,

Paralogues:

None

Copy number: 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 2419 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR001404
- InterPro:   IPR020575
- InterPro:   IPR020568 [H]

Pfam domain/function: PF02518 HATPase_c; PF00183 HSP90 [H]

EC number: NA

Molecular weight: Translated: 72445; Mature: 72445

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKGEIRINTENIFPIIKKAVYSDHEIFLRELVSNGVDAISKRRMASMAGDCENTEEAQV
CCCCCEEEECHHHHHHHHHHHHCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCEEE
KITINREKNTLTISDNGIGMNDEEIKKYINQVAFSSAEEFLTKYKKDNDEFIGHFGLGFY
EEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEEHHHHHHH
SSFMVADKVDILTKSAIGESKAFKWSCDGSPNFTLEESERETIGTDVILHLLEEEKEFIE
HHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCEECCCCHHHHHHHHHHHHHHHHHHCCC
PERIKSLIKKYCDFMPIDVLLEGETINKKNPPWRKQPSELKDEDYIELYKYLYPFQGDPL
HHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCE
LWIHLNTDYPYDIQGILYFPKLSGRADWEKGEIKLFCNQVFVSDSIKEIVPKYLLPLRGV
EEEEECCCCCCCCCEEEEECCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHC
IDSTDIPLNVSRSALQTDRKVRSISSFISKKIANKLKDLIKNSPEFYAEIWDSISAFIKI
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEE
GAIEDEKFAELVNNSIIFETIINSEKNVTKNIENKSLIKSNDKYFTTLANYKERNKLTDS
CCCCHHHHHHHHCCCEEEEHHHCCCCHHHHCCCCCHHHCCCCCEEEHHHHHHHHHCCCCC
KKIIYCSDLIAQSSALKICLSDNKEVIKSDPLIDAQFLPWLESKNEDFQFQRVDSEINEI
CEEEEEHHHHHCCCCEEEEECCCCHHHHCCCCCCHHHCCHHCCCCCCCCHHHHHHHHHHH
EDKESKEIVDKDGKSNTDNLRDTIVKALNNEKVTVKVQSLSSKDAPPAMILLPEQMRRIN
CCHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEEEEEEECCCCCCCCEEEECHHHHHHHH
DMGAYMEQKMPGLPEYHVLLINKEHPLIVGLNKITGNKIIIDEKDPTENPLASKIANHVY
HHHHHHHHHCCCCCCEEEEEEECCCCEEEEEEECCCCEEEEECCCCCCCHHHHHHHHHHH
DMAKLSVGGLDQEQIINLQNNNAELISELLNSTN
HHHHHCCCCCCHHHEEEECCCCHHHHHHHHHCCC
>Mature Secondary Structure
MEKGEIRINTENIFPIIKKAVYSDHEIFLRELVSNGVDAISKRRMASMAGDCENTEEAQV
CCCCCEEEECHHHHHHHHHHHHCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCEEE
KITINREKNTLTISDNGIGMNDEEIKKYINQVAFSSAEEFLTKYKKDNDEFIGHFGLGFY
EEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEEHHHHHHH
SSFMVADKVDILTKSAIGESKAFKWSCDGSPNFTLEESERETIGTDVILHLLEEEKEFIE
HHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCEECCCCHHHHHHHHHHHHHHHHHHCCC
PERIKSLIKKYCDFMPIDVLLEGETINKKNPPWRKQPSELKDEDYIELYKYLYPFQGDPL
HHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCE
LWIHLNTDYPYDIQGILYFPKLSGRADWEKGEIKLFCNQVFVSDSIKEIVPKYLLPLRGV
EEEEECCCCCCCCCEEEEECCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHC
IDSTDIPLNVSRSALQTDRKVRSISSFISKKIANKLKDLIKNSPEFYAEIWDSISAFIKI
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEE
GAIEDEKFAELVNNSIIFETIINSEKNVTKNIENKSLIKSNDKYFTTLANYKERNKLTDS
CCCCHHHHHHHHCCCEEEEHHHCCCCHHHHCCCCCHHHCCCCCEEEHHHHHHHHHCCCCC
KKIIYCSDLIAQSSALKICLSDNKEVIKSDPLIDAQFLPWLESKNEDFQFQRVDSEINEI
CEEEEEHHHHHCCCCEEEEECCCCHHHHCCCCCCHHHCCHHCCCCCCCCHHHHHHHHHHH
EDKESKEIVDKDGKSNTDNLRDTIVKALNNEKVTVKVQSLSSKDAPPAMILLPEQMRRIN
CCHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEEEEEEECCCCCCCCEEEECHHHHHHHH
DMGAYMEQKMPGLPEYHVLLINKEHPLIVGLNKITGNKIIIDEKDPTENPLASKIANHVY
HHHHHHHHHCCCCCCEEEEEEECCCCEEEEEEECCCCEEEEECCCCCCCHHHHHHHHHHH
DMAKLSVGGLDQEQIINLQNNNAELISELLNSTN
HHHHHCCCCCCHHHEEEECCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10722592 [H]