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The map label for this gene is dxs

Identifier: 126696290

GI number: 126696290

Start: 820286

End: 822175

Strand: Direct

Name: dxs

Synonym: P9301_09521

Alternate gene names: 126696290

Gene position: 820286-822175 (Clockwise)

Preceding gene: 126696286

Following gene: 126696300

Centisome position: 49.96

GC content: 35.98

Gene sequence:

>1890_bases
ATGCTTTTAAGTGAGTTAAGTCATCCAAATCAACTTCATGGCTTAACAGTTTCACAATTAGAAGAAATTGCTTGTCAAAT
TAGAGAAAGACACCTTCAGGTAGTGTCTACTAGTGGAGGACATCTTGGTCCTGGATTAGGTGTAGTTGAGTTGACCTTGG
CTTTATATCAAACTCTTGATCTTGATTTTGACAAAGTTGTTTGGGATGTAGGACATCAAGGCTACCCTCATAAATTAATT
ACAGGACGTTTCAGTCAATTTGATTCTCTAAGGCAACAAAATGGAGTCGCTGGATATCTAAAAAGAAGTGAAAGTAAATT
TGATCATTTTGGTGCTGGACATGCAAGTACTTCTATTTCAGCTGCTTTAGGAATGGCAATAGCAAGAGATAGAAAAGGTG
ATAATTATAAATGTGTCGCTGTTATTGGAGATGGAGCACTAACTGGAGGAATGGCATTAGAAGCTATAAATCATGCAGGT
CACTTACCAAATACCCCTTTAGTAGTTGTATTGAACGATAATGATATGTCTATTTCACCTCCGGTTGGAGCCCTTTCATC
TTACTTAAATAAGGTAAGAGTAAGTCCACCATTACAATTTTTGTCCGATAGTGTTCAAGAAAGTGTAAAAAATATTCCCC
TAATTGGTAAAGATATCCCAGAAGAGCTCAAAAATATTAAAGGAAGCGTTAGACGACTATCTGTGCCAAAGGTTGGAGCT
GTTTTTGAAGAACTTGGATTTACATATATGGGTCCAATTGATGGTCATGATATTGGTAACTTAGTTAAGACCTTTAACGC
TGCCCATAAACTTAAGAGACCTGTACTTGTTCATGTTGTTACAACAAAAGGGAAGGGTTACCCATATGCAGAAGCCGATC
AGGTTGGATATCATGCACAGTCTGCATTTGATCTTACAACTGGGAAATCTATTCCATCAAAGAAACCTAAACCTGTTAGT
TATAGTAAAATATTTGGTCAAACCTTATTAAAAATATGTGAGCAAGATAGCAAAGTCGTTGGTATTACTGCTGCAATGGC
TACGGGTACTGGTTTAGATATTTTGCAAAAAAATATTCCTGATCAATATATCGATGTAGGAATAGCAGAACAACATGCAG
TTACTCTTGCGGCAGGAATGTCTTGCGATGGTCTTAAACCTGTTGTAGCTATTTATAGTACTTTTCTTCAACGTGCTTTC
GACCAATTAATTCATGATGTAGGGATACAAAATTTACCTGTATCATTCGTACTTGATAGAGCTGGTATAGTTGGAGCTGA
CGGTCCTACTCACCAAGGTCAGTACGACATCAGTTATATGAGATCTATACCTAATTTTGTATTGATGGCTCCAAAGGATG
AGTCTGAATTACAGAGAATGTTAATAACTTCAATAAACCATAATGGTCCTACAGCTCTAAGAATACCCAGAGGCTCTGGA
TTAGGAGTGGCTATAATGGATGAGGGTTGGGAACCTTTGAATATAGGCGAAGCTGAAATAATTGAAGGAGGAGAAGATAT
TTTAATTATTGCTTATGGTTCAATGGTTGCATCAGCAATCGAAACTGCAAAGATCTTAAAAAATATGAACATTAATGCAT
GCATTGTTAATGCAAGATTTGTTAAACCTCTCGATAAAAATCTTATTATGCCTTTAGCAAGTAGGATTCAAAAAGTTGTA
ACAATGGAAGAAGGAACCTTAATAGGTGGATTTGGTTCCGCAATAGTAGAATTATTTAACGATAATGAAATAAACATTCC
AGTATACAGAATAGGTATACCTGATGTTTTAGTTGATCATGCTTCACCTGATCAGAGTAAAGAAAAACTAGGACTTATGC
CTGATCAGATGGCAGATAACATTGTTAAGAAATTTAAGTTAGTTAATTAA

Upstream 100 bases:

>100_bases
TTAATTATTAATCTAATAAAACATTACATGATCTATTTCAAAAAAAATACTCATTTTGCACCTCGGCGTTTTAGATTATA
TAGATACCAAATTTTGTTAA

Downstream 100 bases:

>100_bases
AAATTTAATAAATAAATATTTATAAAACACCTCTTGAGGCTAATCCTAAGATTGCTCCAATACCAAAAATATGACCTAGG
CAATTAGCACCTACAACTGA

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 629; Mature: 629

Protein sequence:

>629_residues
MLLSELSHPNQLHGLTVSQLEEIACQIRERHLQVVSTSGGHLGPGLGVVELTLALYQTLDLDFDKVVWDVGHQGYPHKLI
TGRFSQFDSLRQQNGVAGYLKRSESKFDHFGAGHASTSISAALGMAIARDRKGDNYKCVAVIGDGALTGGMALEAINHAG
HLPNTPLVVVLNDNDMSISPPVGALSSYLNKVRVSPPLQFLSDSVQESVKNIPLIGKDIPEELKNIKGSVRRLSVPKVGA
VFEELGFTYMGPIDGHDIGNLVKTFNAAHKLKRPVLVHVVTTKGKGYPYAEADQVGYHAQSAFDLTTGKSIPSKKPKPVS
YSKIFGQTLLKICEQDSKVVGITAAMATGTGLDILQKNIPDQYIDVGIAEQHAVTLAAGMSCDGLKPVVAIYSTFLQRAF
DQLIHDVGIQNLPVSFVLDRAGIVGADGPTHQGQYDISYMRSIPNFVLMAPKDESELQRMLITSINHNGPTALRIPRGSG
LGVAIMDEGWEPLNIGEAEIIEGGEDILIIAYGSMVASAIETAKILKNMNINACIVNARFVKPLDKNLIMPLASRIQKVV
TMEEGTLIGGFGSAIVELFNDNEINIPVYRIGIPDVLVDHASPDQSKEKLGLMPDQMADNIVKKFKLVN

Sequences:

>Translated_629_residues
MLLSELSHPNQLHGLTVSQLEEIACQIRERHLQVVSTSGGHLGPGLGVVELTLALYQTLDLDFDKVVWDVGHQGYPHKLI
TGRFSQFDSLRQQNGVAGYLKRSESKFDHFGAGHASTSISAALGMAIARDRKGDNYKCVAVIGDGALTGGMALEAINHAG
HLPNTPLVVVLNDNDMSISPPVGALSSYLNKVRVSPPLQFLSDSVQESVKNIPLIGKDIPEELKNIKGSVRRLSVPKVGA
VFEELGFTYMGPIDGHDIGNLVKTFNAAHKLKRPVLVHVVTTKGKGYPYAEADQVGYHAQSAFDLTTGKSIPSKKPKPVS
YSKIFGQTLLKICEQDSKVVGITAAMATGTGLDILQKNIPDQYIDVGIAEQHAVTLAAGMSCDGLKPVVAIYSTFLQRAF
DQLIHDVGIQNLPVSFVLDRAGIVGADGPTHQGQYDISYMRSIPNFVLMAPKDESELQRMLITSINHNGPTALRIPRGSG
LGVAIMDEGWEPLNIGEAEIIEGGEDILIIAYGSMVASAIETAKILKNMNINACIVNARFVKPLDKNLIMPLASRIQKVV
TMEEGTLIGGFGSAIVELFNDNEINIPVYRIGIPDVLVDHASPDQSKEKLGLMPDQMADNIVKKFKLVN
>Mature_629_residues
MLLSELSHPNQLHGLTVSQLEEIACQIRERHLQVVSTSGGHLGPGLGVVELTLALYQTLDLDFDKVVWDVGHQGYPHKLI
TGRFSQFDSLRQQNGVAGYLKRSESKFDHFGAGHASTSISAALGMAIARDRKGDNYKCVAVIGDGALTGGMALEAINHAG
HLPNTPLVVVLNDNDMSISPPVGALSSYLNKVRVSPPLQFLSDSVQESVKNIPLIGKDIPEELKNIKGSVRRLSVPKVGA
VFEELGFTYMGPIDGHDIGNLVKTFNAAHKLKRPVLVHVVTTKGKGYPYAEADQVGYHAQSAFDLTTGKSIPSKKPKPVS
YSKIFGQTLLKICEQDSKVVGITAAMATGTGLDILQKNIPDQYIDVGIAEQHAVTLAAGMSCDGLKPVVAIYSTFLQRAF
DQLIHDVGIQNLPVSFVLDRAGIVGADGPTHQGQYDISYMRSIPNFVLMAPKDESELQRMLITSINHNGPTALRIPRGSG
LGVAIMDEGWEPLNIGEAEIIEGGEDILIIAYGSMVASAIETAKILKNMNINACIVNARFVKPLDKNLIMPLASRIQKVV
TMEEGTLIGGFGSAIVELFNDNEINIPVYRIGIPDVLVDHASPDQSKEKLGLMPDQMADNIVKKFKLVN

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=511, Percent_Identity=23.2876712328767, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI4507521, Length=511, Percent_Identity=23.2876712328767, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI133778974, Length=640, Percent_Identity=21.5625, Blast_Score=98, Evalue=3e-20,
Organism=Homo sapiens, GI225637459, Length=377, Percent_Identity=24.6684350132626, Blast_Score=94, Evalue=6e-19,
Organism=Homo sapiens, GI225637461, Length=377, Percent_Identity=24.6684350132626, Blast_Score=93, Evalue=7e-19,
Organism=Homo sapiens, GI225637463, Length=377, Percent_Identity=24.1379310344828, Blast_Score=93, Evalue=7e-19,
Organism=Escherichia coli, GI1786622, Length=604, Percent_Identity=43.7086092715232, Blast_Score=513, Evalue=1e-146,
Organism=Caenorhabditis elegans, GI17539652, Length=408, Percent_Identity=26.7156862745098, Blast_Score=119, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6319698, Length=317, Percent_Identity=24.9211356466877, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI45551847, Length=651, Percent_Identity=23.3486943164363, Blast_Score=128, Evalue=1e-29,
Organism=Drosophila melanogaster, GI45550715, Length=651, Percent_Identity=23.3486943164363, Blast_Score=128, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24645119, Length=607, Percent_Identity=23.7232289950577, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24666278, Length=654, Percent_Identity=23.8532110091743, Blast_Score=117, Evalue=3e-26,
Organism=Drosophila melanogaster, GI21358145, Length=332, Percent_Identity=23.7951807228916, Blast_Score=73, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24650940, Length=332, Percent_Identity=23.7951807228916, Blast_Score=73, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_PROM0 (A3PCV0)

Other databases:

- EMBL:   CP000576
- RefSeq:   YP_001091176.1
- STRING:   A3PCV0
- GeneID:   4911752
- GenomeReviews:   CP000576_GR
- KEGG:   pmg:P9301_09521
- eggNOG:   COG1154
- HOGENOM:   HBG571647
- OMA:   QRFPDRY
- ProtClustDB:   PRK05444
- BioCyc:   PMAR167546:P9301ORF_0969-MONOMER
- HAMAP:   MF_00315
- InterPro:   IPR001017
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF00676 E1_dh; PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 67912; Mature: 67912

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLSELSHPNQLHGLTVSQLEEIACQIRERHLQVVSTSGGHLGPGLGVVELTLALYQTLD
CCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHEEEECCCCCCCCCCHHHHHHHHHHHHHC
LDFDKVVWDVGHQGYPHKLITGRFSQFDSLRQQNGVAGYLKRSESKFDHFGAGHASTSIS
CCHHHHHHHCCCCCCCCHHHHCCHHHHHHHHHHCCCHHHHHHCCCCHHHCCCCCCCHHHH
AALGMAIARDRKGDNYKCVAVIGDGALTGGMALEAINHAGHLPNTPLVVVLNDNDMSISP
HHHHHHHHHCCCCCCEEEEEEEECCCCCCCHHHHHHHHCCCCCCCCEEEEECCCCCCCCC
PVGALSSYLNKVRVSPPLQFLSDSVQESVKNIPLIGKDIPEELKNIKGSVRRLSVPKVGA
CHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHEECCCHHHH
VFEELGFTYMGPIDGHDIGNLVKTFNAAHKLKRPVLVHVVTTKGKGYPYAEADQVGYHAQ
HHHHCCCEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCHHHCCCCCC
SAFDLTTGKSIPSKKPKPVSYSKIFGQTLLKICEQDSKVVGITAAMATGTGLDILQKNIP
CCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEHHCCCCHHHHHHCCC
DQYIDVGIAEQHAVTLAAGMSCDGLKPVVAIYSTFLQRAFDQLIHDVGIQNLPVSFVLDR
HHHHCCCCCCHHEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHEEEC
AGIVGADGPTHQGQYDISYMRSIPNFVLMAPKDESELQRMLITSINHNGPTALRIPRGSG
CCEECCCCCCCCCCCHHHHHHCCCCEEEECCCCHHHHHHHHHHHCCCCCCEEEEEECCCC
LGVAIMDEGWEPLNIGEAEIIEGGEDILIIAYGSMVASAIETAKILKNMNINACIVNARF
CEEEEECCCCCCCCCCCHHEECCCCCEEEEEEHHHHHHHHHHHHHHHCCCCCEEEEEEHH
VKPLDKNLIMPLASRIQKVVTMEEGTLIGGFGSAIVELFNDNEINIPVYRIGIPDVLVDH
HCCCCHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHCCCCCCEEEEEECCCHHHCCC
ASPDQSKEKLGLMPDQMADNIVKKFKLVN
CCCCCHHHHCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLLSELSHPNQLHGLTVSQLEEIACQIRERHLQVVSTSGGHLGPGLGVVELTLALYQTLD
CCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHEEEECCCCCCCCCCHHHHHHHHHHHHHC
LDFDKVVWDVGHQGYPHKLITGRFSQFDSLRQQNGVAGYLKRSESKFDHFGAGHASTSIS
CCHHHHHHHCCCCCCCCHHHHCCHHHHHHHHHHCCCHHHHHHCCCCHHHCCCCCCCHHHH
AALGMAIARDRKGDNYKCVAVIGDGALTGGMALEAINHAGHLPNTPLVVVLNDNDMSISP
HHHHHHHHHCCCCCCEEEEEEEECCCCCCCHHHHHHHHCCCCCCCCEEEEECCCCCCCCC
PVGALSSYLNKVRVSPPLQFLSDSVQESVKNIPLIGKDIPEELKNIKGSVRRLSVPKVGA
CHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHEECCCHHHH
VFEELGFTYMGPIDGHDIGNLVKTFNAAHKLKRPVLVHVVTTKGKGYPYAEADQVGYHAQ
HHHHCCCEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCHHHCCCCCC
SAFDLTTGKSIPSKKPKPVSYSKIFGQTLLKICEQDSKVVGITAAMATGTGLDILQKNIP
CCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEHHCCCCHHHHHHCCC
DQYIDVGIAEQHAVTLAAGMSCDGLKPVVAIYSTFLQRAFDQLIHDVGIQNLPVSFVLDR
HHHHCCCCCCHHEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHEEEC
AGIVGADGPTHQGQYDISYMRSIPNFVLMAPKDESELQRMLITSINHNGPTALRIPRGSG
CCEECCCCCCCCCCCHHHHHHCCCCEEEECCCCHHHHHHHHHHHCCCCCCEEEEEECCCC
LGVAIMDEGWEPLNIGEAEIIEGGEDILIIAYGSMVASAIETAKILKNMNINACIVNARF
CEEEEECCCCCCCCCCCHHEECCCCCEEEEEEHHHHHHHHHHHHHHHCCCCCEEEEEEHH
VKPLDKNLIMPLASRIQKVVTMEEGTLIGGFGSAIVELFNDNEINIPVYRIGIPDVLVDH
HCCCCHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHCCCCCCEEEEEECCCHHHCCC
ASPDQSKEKLGLMPDQMADNIVKKFKLVN
CCCCCHHHHCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA