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The map label for this gene is clpP1 [H]

Identifier: 126696140

GI number: 126696140

Start: 690492

End: 691079

Strand: Direct

Name: clpP1 [H]

Synonym: P9301_08021

Alternate gene names: 126696140

Gene position: 690492-691079 (Clockwise)

Preceding gene: 126696138

Following gene: 126696142

Centisome position: 42.05

GC content: 36.39

Gene sequence:

>588_bases
ATGATCCCTTTAGTATTAGAAGAATCTGGCGGAAGCGAAAGAGTCTTTGATATTTATTCGAGACTATTAAGAGAGAGAAT
AATCTTTTTGGGAGAACAAGTTACTAGTGAAACTGCTAATAGAATTGTTGCTCAATTATTGTTTCTTGAAGCAGAGGATC
CAGAAAAGGACATTTATATGTACATAAATTCTCCAGGCGGGTCAGTCTATGATGGATTGGGTATCTTTGACACAATGCAA
CATGTTAAGCCTGATATACATACGGTTTGTGTAGGATTAGCAGCTAGTATGGGTGCATTTTTGCTTGCGGCAGGTACTCA
AGGTAAAAGAAGCAGCCTTAGACATTCAAGAATAATGATTCATCAACCACTTGGAGGTGCTAGAGGTCAGGCCAGTGATA
TAAGAATTCAAGCGGATGAAATTCTGTTTTTAAAAGAGCGTCTTAATACTGAATTATCAGAGAGAACTGGAAAAGATTAT
GACACAATCAAAGAAGATACTGATAGAGATTTTTATATGTCACCAAACGAAGCTGTTGAGTACGGTTTAATTGATTTGGT
TCTAGATAAGAAACCTATTAAGGTCTAA

Upstream 100 bases:

>100_bases
ACAGTCAATTTTTCTTTCAATTTTTTATATGTAAACCTTAATAAGGTTAGCGTATGTTGACTCAATATCGTTAATATCTA
ATAAACAAATAAATATTATT

Downstream 100 bases:

>100_bases
GTTAATAATTGAGGTGTTCTCTCTTTCTTTGGGATTTTAGTGAACTTGGAAAGAATGTTTACAAATTCTTCACCATCTAA
TGTTTCTTTTTCGATTAATA

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 1 [H]

Number of amino acids: Translated: 195; Mature: 195

Protein sequence:

>195_residues
MIPLVLEESGGSERVFDIYSRLLRERIIFLGEQVTSETANRIVAQLLFLEAEDPEKDIYMYINSPGGSVYDGLGIFDTMQ
HVKPDIHTVCVGLAASMGAFLLAAGTQGKRSSLRHSRIMIHQPLGGARGQASDIRIQADEILFLKERLNTELSERTGKDY
DTIKEDTDRDFYMSPNEAVEYGLIDLVLDKKPIKV

Sequences:

>Translated_195_residues
MIPLVLEESGGSERVFDIYSRLLRERIIFLGEQVTSETANRIVAQLLFLEAEDPEKDIYMYINSPGGSVYDGLGIFDTMQ
HVKPDIHTVCVGLAASMGAFLLAAGTQGKRSSLRHSRIMIHQPLGGARGQASDIRIQADEILFLKERLNTELSERTGKDY
DTIKEDTDRDFYMSPNEAVEYGLIDLVLDKKPIKV
>Mature_195_residues
MIPLVLEESGGSERVFDIYSRLLRERIIFLGEQVTSETANRIVAQLLFLEAEDPEKDIYMYINSPGGSVYDGLGIFDTMQ
HVKPDIHTVCVGLAASMGAFLLAAGTQGKRSSLRHSRIMIHQPLGGARGQASDIRIQADEILFLKERLNTELSERTGKDY
DTIKEDTDRDFYMSPNEAVEYGLIDLVLDKKPIKV

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=192, Percent_Identity=54.6875, Blast_Score=211, Evalue=4e-55,
Organism=Escherichia coli, GI1786641, Length=191, Percent_Identity=58.6387434554974, Blast_Score=239, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=51.6129032258064, Blast_Score=194, Evalue=3e-50,
Organism=Drosophila melanogaster, GI20129427, Length=192, Percent_Identity=51.5625, Blast_Score=204, Evalue=3e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 21837; Mature: 21837

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS00381 CLP_PROTEASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPLVLEESGGSERVFDIYSRLLRERIIFLGEQVTSETANRIVAQLLFLEAEDPEKDIYM
CCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
YINSPGGSVYDGLGIFDTMQHVKPDIHTVCVGLAASMGAFLLAAGTQGKRSSLRHSRIMI
EEECCCCCHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHCEEEE
HQPLGGARGQASDIRIQADEILFLKERLNTELSERTGKDYDTIKEDTDRDFYMSPNEAVE
ECCCCCCCCCCCCEEEEHHHHHHHHHHHCCHHHHHCCCCCHHHHCCCCCCEEECCCHHHH
YGLIDLVLDKKPIKV
HHHEEEEECCCCCCC
>Mature Secondary Structure
MIPLVLEESGGSERVFDIYSRLLRERIIFLGEQVTSETANRIVAQLLFLEAEDPEKDIYM
CCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
YINSPGGSVYDGLGIFDTMQHVKPDIHTVCVGLAASMGAFLLAAGTQGKRSSLRHSRIMI
EEECCCCCHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHCEEEE
HQPLGGARGQASDIRIQADEILFLKERLNTELSERTGKDYDTIKEDTDRDFYMSPNEAVE
ECCCCCCCCCCCCEEEEHHHHHHHHHHHCCHHHHHCCCCCHHHHCCCCCCEEECCCHHHH
YGLIDLVLDKKPIKV
HHHEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12917642 [H]