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The map label for this gene is yrkA [H]

Identifier: 126695636

GI number: 126695636

Start: 272771

End: 274039

Strand: Reverse

Name: yrkA [H]

Synonym: P9301_02981

Alternate gene names: 126695636

Gene position: 274039-272771 (Counterclockwise)

Preceding gene: 126695639

Following gene: 126695634

Centisome position: 16.69

GC content: 30.58

Gene sequence:

>1269_bases
ATGAAAATAACTCTACTTTTATTTCTTTTATTTCTACCAGCTTTTTTCGCAGCGAGTGAACTCTCTTTTTTATTAATAAG
GCCAAGTAAAGTTTTAAGGTTAATAGAAGAAAAAAAGAAAGGGGCATTTTCAATTTTAAAAATTCAAAAACGTTTTAGAT
CTTCACTAATTGCTTCTCAATTTGGAGTAACAATTTCATTAATTGCAATTGGATGGCTCAGCAATAACCTGGCTAATGAT
TATTGGAAAAGTAATATTTTATCAAATAGATTTTATGATCTTCTATTATTTTTATTTGTTGTTTTAGTTGTTACTCTTGT
TTCTGGACTCATTCCAAAAGCTTTAGTAATTAACAATCCAGAATCTGCTGCATTAAGGTTAACTACAATATTCGATGCCG
TGAGAAAAGCTATGAATCCTATAGTGAAAATAATAGAATTCTTTGCTAGCGCCTGTTTAGGCTTGTTCAATTTAAATAAC
AAATGGGATTCTTTAAACTCTGGTTTATCTGCTGGAGAATTAGAAACTCTTATAGAAACAGATAACGTAACAGGTTTAAA
ACCAGATGAGAAGAATATTCTTGAGGGAGTCTTTGCTTTAAAAGATACACAGGTTAAAGAAGTTATGATTCCAAGATCTG
AAATGGTAACTTTGCCAAAAAATATAACCTTTTCAGAACTAATGAAACAAGTAGATAAAACTCGACATGCTCGCTTCTTT
GTCATTGGTGAGTCTTTAGATGATGTATTAGGTGTATTAGATTTACGTTATCTAGCTAAGCCAATTTCAAAAGGTGAAAT
GGAAGCAGATACATTATTAGAGCCATTCCTTTTACCAGTAACAAAAATAATAGAAACATGTTCACTAGCAGAAATATTTC
CAATAGTTAGAGACTACAATCCGTTCTTACTAGTAGTTGATGAACATGGTGGAACAGAAGGACTTATAACTGCAGCTGAT
CTAAATGGCGAAATAGTTGGAGAGGAAATGCTCAATAATAGAATTTATTCAGATATGAGAATGTTAGATAATTTCTCTAA
AAAATGGTCAATAGCTGGAAAATCAGAAATTGTTGAAATCAATAAAAAGATAGGATGTTCAATTCCAGAAGGTACTGATT
ATCATACTCTTGCTGGATTTATGTTAGAAAAATTTCAAATGGTTCCAAAAATTGGCGACGTTTTAGATTTTAATAACATT
AAATTCGAAGTTATTTCTATGTCAGGTCCAAAAATTGATCGTGTTAAAATAATTCTTCCCAAAAGCTAA

Upstream 100 bases:

>100_bases
AATTTCTTTGGGGGTGTAGCAATCTGGTGAATGCACCAAACTCATAATTTGGCTAAGGCGAGTTCGATCCTCGCCACCCC
CATTCTTCATTTGTCATTGA

Downstream 100 bases:

>100_bases
ATATGACTCCCCATAGAGGATAATGATAATTAATATATGGATTTGAAATTATGCAACCAACCTCATCACCCGTAAAGGTT
GGAGTCATAGGTATAGGAAA

Product: hemolysin-like protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MKITLLLFLLFLPAFFAASELSFLLIRPSKVLRLIEEKKKGAFSILKIQKRFRSSLIASQFGVTISLIAIGWLSNNLAND
YWKSNILSNRFYDLLLFLFVVLVVTLVSGLIPKALVINNPESAALRLTTIFDAVRKAMNPIVKIIEFFASACLGLFNLNN
KWDSLNSGLSAGELETLIETDNVTGLKPDEKNILEGVFALKDTQVKEVMIPRSEMVTLPKNITFSELMKQVDKTRHARFF
VIGESLDDVLGVLDLRYLAKPISKGEMEADTLLEPFLLPVTKIIETCSLAEIFPIVRDYNPFLLVVDEHGGTEGLITAAD
LNGEIVGEEMLNNRIYSDMRMLDNFSKKWSIAGKSEIVEINKKIGCSIPEGTDYHTLAGFMLEKFQMVPKIGDVLDFNNI
KFEVISMSGPKIDRVKIILPKS

Sequences:

>Translated_422_residues
MKITLLLFLLFLPAFFAASELSFLLIRPSKVLRLIEEKKKGAFSILKIQKRFRSSLIASQFGVTISLIAIGWLSNNLAND
YWKSNILSNRFYDLLLFLFVVLVVTLVSGLIPKALVINNPESAALRLTTIFDAVRKAMNPIVKIIEFFASACLGLFNLNN
KWDSLNSGLSAGELETLIETDNVTGLKPDEKNILEGVFALKDTQVKEVMIPRSEMVTLPKNITFSELMKQVDKTRHARFF
VIGESLDDVLGVLDLRYLAKPISKGEMEADTLLEPFLLPVTKIIETCSLAEIFPIVRDYNPFLLVVDEHGGTEGLITAAD
LNGEIVGEEMLNNRIYSDMRMLDNFSKKWSIAGKSEIVEINKKIGCSIPEGTDYHTLAGFMLEKFQMVPKIGDVLDFNNI
KFEVISMSGPKIDRVKIILPKS
>Mature_422_residues
MKITLLLFLLFLPAFFAASELSFLLIRPSKVLRLIEEKKKGAFSILKIQKRFRSSLIASQFGVTISLIAIGWLSNNLAND
YWKSNILSNRFYDLLLFLFVVLVVTLVSGLIPKALVINNPESAALRLTTIFDAVRKAMNPIVKIIEFFASACLGLFNLNN
KWDSLNSGLSAGELETLIETDNVTGLKPDEKNILEGVFALKDTQVKEVMIPRSEMVTLPKNITFSELMKQVDKTRHARFF
VIGESLDDVLGVLDLRYLAKPISKGEMEADTLLEPFLLPVTKIIETCSLAEIFPIVRDYNPFLLVVDEHGGTEGLITAAD
LNGEIVGEEMLNNRIYSDMRMLDNFSKKWSIAGKSEIVEINKKIGCSIPEGTDYHTLAGFMLEKFQMVPKIGDVLDFNNI
KFEVISMSGPKIDRVKIILPKS

Specific function: Unknown

COG id: COG1253

COG function: function code R; Hemolysins and related proteins containing CBS domains

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI310128564, Length=385, Percent_Identity=21.8181818181818, Blast_Score=100, Evalue=4e-21,
Organism=Escherichia coli, GI1790664, Length=437, Percent_Identity=24.0274599542334, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI145693175, Length=419, Percent_Identity=25.0596658711217, Blast_Score=95, Evalue=7e-21,
Organism=Escherichia coli, GI1786879, Length=239, Percent_Identity=27.1966527196653, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI87082033, Length=259, Percent_Identity=25.0965250965251, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1788119, Length=235, Percent_Identity=22.1276595744681, Blast_Score=70, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016169
- InterPro:   IPR000644
- InterPro:   IPR002550
- InterPro:   IPR005170 [H]

Pfam domain/function: PF00571 CBS; PF03471 CorC_HlyC; PF01595 DUF21 [H]

EC number: NA

Molecular weight: Translated: 47290; Mature: 47290

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKITLLLFLLFLPAFFAASELSFLLIRPSKVLRLIEEKKKGAFSILKIQKRFRSSLIASQ
CHHHHHHHHHHHHHHHHHHCCEEEEECHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
FGVTISLIAIGWLSNNLANDYWKSNILSNRFYDLLLFLFVVLVVTLVSGLIPKALVINNP
HCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
ESAALRLTTIFDAVRKAMNPIVKIIEFFASACLGLFNLNNKWDSLNSGLSAGELETLIET
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCHHHHHHCC
DNVTGLKPDEKNILEGVFALKDTQVKEVMIPRSEMVTLPKNITFSELMKQVDKTRHARFF
CCCCCCCCCHHHHHHHHHHHCCCHHHHHHCCCHHHEECCCCCCHHHHHHHHHHHHCCEEE
VIGESLDDVLGVLDLRYLAKPISKGEMEADTLLEPFLLPVTKIIETCSLAEIFPIVRDYN
EECCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PFLLVVDEHGGTEGLITAADLNGEIVGEEMLNNRIYSDMRMLDNFSKKWSIAGKSEIVEI
CEEEEEECCCCCCCEEEEECCCCCEECHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHEE
NKKIGCSIPEGTDYHTLAGFMLEKFQMVPKIGDVLDFNNIKFEVISMSGPKIDRVKIILP
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCEEEEEEC
KS
CC
>Mature Secondary Structure
MKITLLLFLLFLPAFFAASELSFLLIRPSKVLRLIEEKKKGAFSILKIQKRFRSSLIASQ
CHHHHHHHHHHHHHHHHHHCCEEEEECHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
FGVTISLIAIGWLSNNLANDYWKSNILSNRFYDLLLFLFVVLVVTLVSGLIPKALVINNP
HCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
ESAALRLTTIFDAVRKAMNPIVKIIEFFASACLGLFNLNNKWDSLNSGLSAGELETLIET
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCHHHHHHCC
DNVTGLKPDEKNILEGVFALKDTQVKEVMIPRSEMVTLPKNITFSELMKQVDKTRHARFF
CCCCCCCCCHHHHHHHHHHHCCCHHHHHHCCCHHHEECCCCCCHHHHHHHHHHHHCCEEE
VIGESLDDVLGVLDLRYLAKPISKGEMEADTLLEPFLLPVTKIIETCSLAEIFPIVRDYN
EECCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PFLLVVDEHGGTEGLITAADLNGEIVGEEMLNNRIYSDMRMLDNFSKKWSIAGKSEIVEI
CEEEEEECCCCCCCEEEEECCCCCEECHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHEE
NKKIGCSIPEGTDYHTLAGFMLEKFQMVPKIGDVLDFNNIKFEVISMSGPKIDRVKIILP
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCEEEEEEC
KS
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 8969508; 7608059 [H]