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The map label for this gene is thyX [H]

Identifier: 126695604

GI number: 126695604

Start: 247782

End: 248414

Strand: Reverse

Name: thyX [H]

Synonym: P9301_02661

Alternate gene names: 126695604

Gene position: 248414-247782 (Counterclockwise)

Preceding gene: 126695605

Following gene: 126695602

Centisome position: 15.13

GC content: 34.12

Gene sequence:

>633_bases
ATGAGTAAAGTTGAACTAATTTCGCTAACTCCTGATGCAGAAAAAACAATGGCTTACATTGCAAGAGTTAGTAACCCAAA
AAATCAGGAAAATGAGGACTACTCAAAATTATTGAGTTATTGCATTAAAAATGAACATTGGAGCGTTTTCGAACAGTCAT
TTATGACTTTACAAATAGAAACCAACAGAGGTATCGCTGCACAAATTTTAAGACATAGATCATTTACTTTCCAGGAATTT
TCACAGAGATATGCAGATAGTTCTCAATTGGGTAATATTCCCTTACCAGAACTAAGGCGTCAAGATTTCAAAAATAGGCA
AAATTCAATCCCCGATCTCCCTGATGAGTTAAAAAAAAGATTCAATGAAAAAATTGGTTTACATTTTCAGGCTGCATCAG
AATTATATGAAGATTTACTCGCTGAAGGCGTAGCAAAAGAATGTGCGAGATTTGTTTTACCATTAGCTACTCCAACAAGA
ATCTATATGTCTGGATCATGTAGATCGTGGATCCATTACATTCATTTAAGATCAGCTAACGGCACCCAAAAAGAACACAA
GTCTATCGCTCAGAATTGCAAGTCGATTTTTAAAAAAAGTTTTCCTATTGTATCAAAATCTTTAGGATGGTAA

Upstream 100 bases:

>100_bases
CTACTCTTTTTTGAAGGTGATCCATGCTCTACAACCTATGAAGATAGAAGAGGTAAATATCAAAACCAACCAGAAAAGGT
GACTCTAGCGAAAATCTAAA

Downstream 100 bases:

>100_bases
AAATTATCCATGACTACGAGGATTAACCTCATTTTTTTTATTTTCTTGAATTATTGAAAATTCAGCATTAACAATTTCCT
CATAGGGATTCTCTTCTTTT

Product: FAD-dependent thymidylate synthase

Products: NA

Alternate protein names: TS; TSase [H]

Number of amino acids: Translated: 210; Mature: 209

Protein sequence:

>210_residues
MSKVELISLTPDAEKTMAYIARVSNPKNQENEDYSKLLSYCIKNEHWSVFEQSFMTLQIETNRGIAAQILRHRSFTFQEF
SQRYADSSQLGNIPLPELRRQDFKNRQNSIPDLPDELKKRFNEKIGLHFQAASELYEDLLAEGVAKECARFVLPLATPTR
IYMSGSCRSWIHYIHLRSANGTQKEHKSIAQNCKSIFKKSFPIVSKSLGW

Sequences:

>Translated_210_residues
MSKVELISLTPDAEKTMAYIARVSNPKNQENEDYSKLLSYCIKNEHWSVFEQSFMTLQIETNRGIAAQILRHRSFTFQEF
SQRYADSSQLGNIPLPELRRQDFKNRQNSIPDLPDELKKRFNEKIGLHFQAASELYEDLLAEGVAKECARFVLPLATPTR
IYMSGSCRSWIHYIHLRSANGTQKEHKSIAQNCKSIFKKSFPIVSKSLGW
>Mature_209_residues
SKVELISLTPDAEKTMAYIARVSNPKNQENEDYSKLLSYCIKNEHWSVFEQSFMTLQIETNRGIAAQILRHRSFTFQEFS
QRYADSSQLGNIPLPELRRQDFKNRQNSIPDLPDELKKRFNEKIGLHFQAASELYEDLLAEGVAKECARFVLPLATPTRI
YMSGSCRSWIHYIHLRSANGTQKEHKSIAQNCKSIFKKSFPIVSKSLGW

Specific function: Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate [H]

COG id: COG1351

COG function: function code F; Predicted alternative thymidylate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thyX (flavin-dependent thymidylate synthase) domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003669 [H]

Pfam domain/function: PF02511 Thy1 [H]

EC number: =2.1.1.148 [H]

Molecular weight: Translated: 24279; Mature: 24148

Theoretical pI: Translated: 9.36; Mature: 9.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKVELISLTPDAEKTMAYIARVSNPKNQENEDYSKLLSYCIKNEHWSVFEQSFMTLQIE
CCCEEEEEECCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHCEEEEEEE
TNRGIAAQILRHRSFTFQEFSQRYADSSQLGNIPLPELRRQDFKNRQNSIPDLPDELKKR
CCCCHHHHHHHHCCCCHHHHHHHHCCHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHH
FNEKIGLHFQAASELYEDLLAEGVAKECARFVLPLATPTRIYMSGSCRSWIHYIHLRSAN
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHEECCC
GTQKEHKSIAQNCKSIFKKSFPIVSKSLGW
CCHHHHHHHHHHHHHHHHHCCCHHHHCCCC
>Mature Secondary Structure 
SKVELISLTPDAEKTMAYIARVSNPKNQENEDYSKLLSYCIKNEHWSVFEQSFMTLQIE
CCEEEEEECCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHCEEEEEEE
TNRGIAAQILRHRSFTFQEFSQRYADSSQLGNIPLPELRRQDFKNRQNSIPDLPDELKKR
CCCCHHHHHHHHCCCCHHHHHHHHCCHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHH
FNEKIGLHFQAASELYEDLLAEGVAKECARFVLPLATPTRIYMSGSCRSWIHYIHLRSAN
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHEECCC
GTQKEHKSIAQNCKSIFKKSFPIVSKSLGW
CCHHHHHHHHHHHHHHHHHCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]