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The map label for this gene is met3 [H]

Identifier: 126695587

GI number: 126695587

Start: 232658

End: 233833

Strand: Reverse

Name: met3 [H]

Synonym: P9301_02491

Alternate gene names: 126695587

Gene position: 233833-232658 (Counterclockwise)

Preceding gene: 126695588

Following gene: 126695586

Centisome position: 14.24

GC content: 34.01

Gene sequence:

>1176_bases
ATGGAATTACAACAAAAAACAAAAACTGACCCTAATGGACTAATACCGCCTTATGGAGGGGAACTAAAAAATTTAATAAT
TAAAGATAATAGCTTTAAAAATGACCTTATCTCCAAAGCTACTTATGAATTTGAATGTAGCGAGAGAAATGCATGTGATG
TAGAACTTTTGATGGTTGGTGCTTTTTCTCCTTTGGAAGGTTTTATGGATGAAAATAACTACAAATCGGTTATCGAAAAT
AACAGAGATACAAGCGGTTTGCTTTTTGGCTTACCTATTGTCTTTGATTCAAATAATGATGAAGTAAAAGCTGGAGAAAC
AATCTTGCTTACCTACAAAAACCAAAAAATTGCAATTTTAGAAGTAAGTTCTATTTGGGAGCCTGATAAATCTTTAGAAG
CCGAATTTTGTTATGGTACTAATTCTTTAGATCATCCTGCTGTTAAGATGATTTTTAATGAAAGGGGAAGATTCTATATA
GGAGGGAAAGTTTATGGTTTCGAACTACCAGTTAGAGAATTTCCCTGCAAAACCCCTGAAGAAGTTAGATCTTCACTGCC
ATCAAATTATGATGTAGTTGCATTTCAATGCAGAAATCCAATTCATAGAGCACATTATGAGTTATTTACTAATGCCCTAC
TCTCAGATAATGTCTCTTCTAACTCAGTGGTTTTGGTACATCCAACTTGTGGGCCAACTCAACAAGACGATATACCTGGA
AAAGTTAGATATTTGACCTATAAAGAATTAGAAGAGGAAATATCTGATGAAAGAATAAAATGGGCTTTTTTACCTTATTC
AATGCATATGGCAGGGCCAAGGGAAGCTCTTCAACACATGATAATCAGAAGAAATTATGGCTGCACCCACTTTATTATTG
GTAGAGATATGGCTGGTTGTAAGTCATCATCAACTGGTGAAGATTTTTATGGCCCATATGACGCCCAGAATTTTGCTAAT
AAGTGTGCAGATGAATTAATGATGCAGACTGTTCCTTCAAAAAATTTAGTTTATACGAAGGAAAAAGGATATATAACAGC
TGAAGAAGCTAAAGAATTTAATTATGAAATTATGAAACTTAGTGGTACTGAATTTAGAAAGAAATTGAGGAATGGCGAAC
CAATTCCTGAATGGTTTGCATTCAAAAGTGTAGTAGATGTTCTAAGACGCTCTTAA

Upstream 100 bases:

>100_bases
GGAGAGCTTTACGGAAGAAAGGCATAAATCCTAATTAATAAATAAAAGGGGGTTCCACCCCTCTTTTTTTTTTCAAAATT
TTTATTTATCAATTCAAAAA

Downstream 100 bases:

>100_bases
TATTGTTTTATTATTAGTATTATAGATTTATTAAAGTTTTTTATTGTGAACAAACGTTGGAGAAACTTAGGACTTTATGT
TCTAGCTGTGATTACTGTAA

Product: ATP-sulfurylase

Products: NA

Alternate protein names: Sulfate adenylyltransferase; ATP-sulfurylase; Sulfate adenylate transferase; SAT; Adenylyl-sulfate kinase; APS kinase; ATP adenosine-5'-phosphosulfate 3'-phosphotransferase; Adenosine-5'-phosphosulfate kinase [H]

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MELQQKTKTDPNGLIPPYGGELKNLIIKDNSFKNDLISKATYEFECSERNACDVELLMVGAFSPLEGFMDENNYKSVIEN
NRDTSGLLFGLPIVFDSNNDEVKAGETILLTYKNQKIAILEVSSIWEPDKSLEAEFCYGTNSLDHPAVKMIFNERGRFYI
GGKVYGFELPVREFPCKTPEEVRSSLPSNYDVVAFQCRNPIHRAHYELFTNALLSDNVSSNSVVLVHPTCGPTQQDDIPG
KVRYLTYKELEEEISDERIKWAFLPYSMHMAGPREALQHMIIRRNYGCTHFIIGRDMAGCKSSSTGEDFYGPYDAQNFAN
KCADELMMQTVPSKNLVYTKEKGYITAEEAKEFNYEIMKLSGTEFRKKLRNGEPIPEWFAFKSVVDVLRRS

Sequences:

>Translated_391_residues
MELQQKTKTDPNGLIPPYGGELKNLIIKDNSFKNDLISKATYEFECSERNACDVELLMVGAFSPLEGFMDENNYKSVIEN
NRDTSGLLFGLPIVFDSNNDEVKAGETILLTYKNQKIAILEVSSIWEPDKSLEAEFCYGTNSLDHPAVKMIFNERGRFYI
GGKVYGFELPVREFPCKTPEEVRSSLPSNYDVVAFQCRNPIHRAHYELFTNALLSDNVSSNSVVLVHPTCGPTQQDDIPG
KVRYLTYKELEEEISDERIKWAFLPYSMHMAGPREALQHMIIRRNYGCTHFIIGRDMAGCKSSSTGEDFYGPYDAQNFAN
KCADELMMQTVPSKNLVYTKEKGYITAEEAKEFNYEIMKLSGTEFRKKLRNGEPIPEWFAFKSVVDVLRRS
>Mature_391_residues
MELQQKTKTDPNGLIPPYGGELKNLIIKDNSFKNDLISKATYEFECSERNACDVELLMVGAFSPLEGFMDENNYKSVIEN
NRDTSGLLFGLPIVFDSNNDEVKAGETILLTYKNQKIAILEVSSIWEPDKSLEAEFCYGTNSLDHPAVKMIFNERGRFYI
GGKVYGFELPVREFPCKTPEEVRSSLPSNYDVVAFQCRNPIHRAHYELFTNALLSDNVSSNSVVLVHPTCGPTQQDDIPG
KVRYLTYKELEEEISDERIKWAFLPYSMHMAGPREALQHMIIRRNYGCTHFIIGRDMAGCKSSSTGEDFYGPYDAQNFAN
KCADELMMQTVPSKNLVYTKEKGYITAEEAKEFNYEIMKLSGTEFRKKLRNGEPIPEWFAFKSVVDVLRRS

Specific function: Unknown

COG id: COG2046

COG function: function code P; ATP sulfurylase (sulfate adenylyltransferase)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the APS kinase family [H]

Homologues:

Organism=Homo sapiens, GI46094058, Length=355, Percent_Identity=29.8591549295775, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI34447231, Length=356, Percent_Identity=29.2134831460674, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI62912492, Length=361, Percent_Identity=28.808864265928, Blast_Score=118, Evalue=9e-27,
Organism=Caenorhabditis elegans, GI17542422, Length=425, Percent_Identity=27.7647058823529, Blast_Score=116, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6322469, Length=389, Percent_Identity=39.0745501285347, Blast_Score=273, Evalue=2e-74,
Organism=Drosophila melanogaster, GI116007838, Length=349, Percent_Identity=29.512893982808, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24667044, Length=349, Percent_Identity=29.512893982808, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24667032, Length=349, Percent_Identity=29.512893982808, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24667028, Length=349, Percent_Identity=29.512893982808, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24667036, Length=349, Percent_Identity=29.512893982808, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24667040, Length=349, Percent_Identity=29.512893982808, Blast_Score=109, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002891
- InterPro:   IPR015947
- InterPro:   IPR014729
- InterPro:   IPR020792
- InterPro:   IPR002650 [H]

Pfam domain/function: PF01583 APS_kinase; PF01747 ATP-sulfurylase [H]

EC number: =2.7.7.4; =2.7.1.25 [H]

Molecular weight: Translated: 44586; Mature: 44586

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELQQKTKTDPNGLIPPYGGELKNLIIKDNSFKNDLISKATYEFECSERNACDVELLMVG
CCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHCEEEEECCCCCCCCEEEEEEE
AFSPLEGFMDENNYKSVIENNRDTSGLLFGLPIVFDSNNDEVKAGETILLTYKNQKIAIL
CCCHHHHHHCCCCCHHHHCCCCCCCCEEEEEEEEECCCCCCEECCCEEEEEECCCEEEEE
EVSSIWEPDKSLEAEFCYGTNSLDHPAVKMIFNERGRFYIGGKVYGFELPVREFPCKTPE
EECCCCCCCCCCCEEEEECCCCCCCHHHHHHCCCCCCEEECCEEEEEECCHHHCCCCCHH
EVRSSLPSNYDVVAFQCRNPIHRAHYELFTNALLSDNVSSNSVVLVHPTCGPTQQDDIPG
HHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCC
KVRYLTYKELEEEISDERIKWAFLPYSMHMAGPREALQHMIIRRNYGCTHFIIGRDMAGC
EEEEEEHHHHHHHHCCCCEEEEEECEEEECCCHHHHHHHHHHHCCCCCEEEEECCCCCCC
KSSSTGEDFYGPYDAQNFANKCADELMMQTVPSKNLVYTKEKGYITAEEAKEFNYEIMKL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCEEEHHHHHCCCEEEEEE
SGTEFRKKLRNGEPIPEWFAFKSVVDVLRRS
CCHHHHHHHHCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MELQQKTKTDPNGLIPPYGGELKNLIIKDNSFKNDLISKATYEFECSERNACDVELLMVG
CCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHCEEEEECCCCCCCCEEEEEEE
AFSPLEGFMDENNYKSVIENNRDTSGLLFGLPIVFDSNNDEVKAGETILLTYKNQKIAIL
CCCHHHHHHCCCCCHHHHCCCCCCCCEEEEEEEEECCCCCCEECCCEEEEEECCCEEEEE
EVSSIWEPDKSLEAEFCYGTNSLDHPAVKMIFNERGRFYIGGKVYGFELPVREFPCKTPE
EECCCCCCCCCCCEEEEECCCCCCCHHHHHHCCCCCCEEECCEEEEEECCHHHCCCCCHH
EVRSSLPSNYDVVAFQCRNPIHRAHYELFTNALLSDNVSSNSVVLVHPTCGPTQQDDIPG
HHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCC
KVRYLTYKELEEEISDERIKWAFLPYSMHMAGPREALQHMIIRRNYGCTHFIIGRDMAGC
EEEEEEHHHHHHHHCCCCEEEEEECEEEECCCHHHHHHHHHHHCCCCCEEEEECCCCCCC
KSSSTGEDFYGPYDAQNFANKCADELMMQTVPSKNLVYTKEKGYITAEEAKEFNYEIMKL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCEEEHHHHHCCCEEEEEE
SGTEFRKKLRNGEPIPEWFAFKSVVDVLRRS
CCHHHHHHHHCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]