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The map label for this gene is metF [H]

Identifier: 126695510

GI number: 126695510

Start: 161388

End: 162278

Strand: Reverse

Name: metF [H]

Synonym: P9301_01721

Alternate gene names: 126695510

Gene position: 162278-161388 (Counterclockwise)

Preceding gene: 126695512

Following gene: 126695504

Centisome position: 9.88

GC content: 36.25

Gene sequence:

>891_bases
TTGAAATCAAAACTTCAGCAGACCTTAGAAAAAAGATCTAAGGTAATAACGGCAGAGTTAATGCCGCCAAGAGGTGGAAG
CCCCATAAGATCTCTTAAGATAGCACAACTTTTGAAAGATAAGGTACACGCTGTTAACATTACTGATGGAAGCAGAGCTG
TAATGAGAATGTGCAGCTTGGCAATGTCTAAACTATTACTGGAAAATGGGATAGAACCAGTAATGCAAATTTCTTGCAGG
GATCGTAATAAAATTGCTTTACAATCAGACATTCTGGGAGCAAATGCTTTAGGAATTAGGAACATCTTGTGCATTACCGG
TGATTCAGTAAAAGCTGGGGATCAACATGACGCCAAAGCCGTACATGAGTTTGAGTCAGTCAGATTGCTTGAACAAATTC
AGGCTTTCAATCAAGGAATTGATCCTACTCTCGGAGAACTTTCGGATAAAAAAACATCTATTTTTGCAGGTGCTGCAGCT
GATCCTAGTTGCAAAAATAAAAGAAGTTTAGAAAATAGAATGCGAAAAAAAAAAGAGGCTGGAGCTGGATTTGTACAAAC
TCAAATGGTTATGGAAAGACAAAATTTGATAGATTTTTGTGAACAAATTAGCAATCCTCTTGAAATTCCTGTAATTGCCG
GTGTTTTCCTATTAAAGTCTTACAAAAACGCTCTCTTTATAAACAAATACGTTCCAGGCGCAAACATCCCTGAAAACATC
TTAAATCGTCTTAAAAATGCTAAAAACCCTTTACAAGAGGGTATTAAAATTGCAGCAGAACAAGCTCATGATTTTATTAA
TATCGCAGATGGTGTTCATATAATGGCCGTAAAAGCAGAGCATTTAATTCCTGATATTCTTGAAAAAGCTGATATTAGTC
TGGAATATTAA

Upstream 100 bases:

>100_bases
ACTTCTTCTTCAACCATTTGCATTTAAACAGTTCCTTTTTTATATTAATTAAGTTTAGCAATCTCAGTACACTTGTTAAC
CAACTAGGAAACAAAAGCAA

Downstream 100 bases:

>100_bases
TCAAATCAGTACCTAATAATTCTGCCATAGCTTTCTGCTGAGGCGATGGCTCAGTCAAATCAGATCTTCTTGAATCTGCA
ATTAACCAATCTAAAGATGC

Product: methylenetetrahydrofolate reductase

Products: NA

Alternate protein names: Homocysteine S-methyltransferase; S-methylmethionine:homocysteine methyltransferase; 5,10-methylenetetrahydrofolate reductase [H]

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MKSKLQQTLEKRSKVITAELMPPRGGSPIRSLKIAQLLKDKVHAVNITDGSRAVMRMCSLAMSKLLLENGIEPVMQISCR
DRNKIALQSDILGANALGIRNILCITGDSVKAGDQHDAKAVHEFESVRLLEQIQAFNQGIDPTLGELSDKKTSIFAGAAA
DPSCKNKRSLENRMRKKKEAGAGFVQTQMVMERQNLIDFCEQISNPLEIPVIAGVFLLKSYKNALFINKYVPGANIPENI
LNRLKNAKNPLQEGIKIAAEQAHDFINIADGVHIMAVKAEHLIPDILEKADISLEY

Sequences:

>Translated_296_residues
MKSKLQQTLEKRSKVITAELMPPRGGSPIRSLKIAQLLKDKVHAVNITDGSRAVMRMCSLAMSKLLLENGIEPVMQISCR
DRNKIALQSDILGANALGIRNILCITGDSVKAGDQHDAKAVHEFESVRLLEQIQAFNQGIDPTLGELSDKKTSIFAGAAA
DPSCKNKRSLENRMRKKKEAGAGFVQTQMVMERQNLIDFCEQISNPLEIPVIAGVFLLKSYKNALFINKYVPGANIPENI
LNRLKNAKNPLQEGIKIAAEQAHDFINIADGVHIMAVKAEHLIPDILEKADISLEY
>Mature_296_residues
MKSKLQQTLEKRSKVITAELMPPRGGSPIRSLKIAQLLKDKVHAVNITDGSRAVMRMCSLAMSKLLLENGIEPVMQISCR
DRNKIALQSDILGANALGIRNILCITGDSVKAGDQHDAKAVHEFESVRLLEQIQAFNQGIDPTLGELSDKKTSIFAGAAA
DPSCKNKRSLENRMRKKKEAGAGFVQTQMVMERQNLIDFCEQISNPLEIPVIAGVFLLKSYKNALFINKYVPGANIPENI
LNRLKNAKNPLQEGIKIAAEQAHDFINIADGVHIMAVKAEHLIPDILEKADISLEY

Specific function: Unknown

COG id: COG0685

COG function: function code E; 5,10-methylenetetrahydrofolate reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Hcy-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003171
- InterPro:   IPR003726 [H]

Pfam domain/function: PF02219 MTHFR; PF02574 S-methyl_trans [H]

EC number: =2.1.1.10; =1.5.1.20 [H]

Molecular weight: Translated: 32646; Mature: 32646

Theoretical pI: Translated: 9.22; Mature: 9.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSKLQQTLEKRSKVITAELMPPRGGSPIRSLKIAQLLKDKVHAVNITDGSRAVMRMCSL
CCHHHHHHHHHHHHEEEEEECCCCCCCHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHH
AMSKLLLENGIEPVMQISCRDRNKIALQSDILGANALGIRNILCITGDSVKAGDQHDAKA
HHHHHHHHHCCCHHHHHHCCCCCCEEHHHHCCCCCCHHHCEEEEEECCCCCCCCCHHHHH
VHEFESVRLLEQIQAFNQGIDPTLGELSDKKTSIFAGAAADPSCKNKRSLENRMRKKKEA
HHHHHHHHHHHHHHHHHCCCCCCHHHCCCCHHHEEECCCCCCCCCHHHHHHHHHHHHHHH
GAGFVQTQMVMERQNLIDFCEQISNPLEIPVIAGVFLLKSYKNALFINKYVPGANIPENI
CCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHH
LNRLKNAKNPLQEGIKIAAEQAHDFINIADGVHIMAVKAEHLIPDILEKADISLEY
HHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKSKLQQTLEKRSKVITAELMPPRGGSPIRSLKIAQLLKDKVHAVNITDGSRAVMRMCSL
CCHHHHHHHHHHHHEEEEEECCCCCCCHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHH
AMSKLLLENGIEPVMQISCRDRNKIALQSDILGANALGIRNILCITGDSVKAGDQHDAKA
HHHHHHHHHCCCHHHHHHCCCCCCEEHHHHCCCCCCHHHCEEEEEECCCCCCCCCHHHHH
VHEFESVRLLEQIQAFNQGIDPTLGELSDKKTSIFAGAAADPSCKNKRSLENRMRKKKEA
HHHHHHHHHHHHHHHHHCCCCCCHHHCCCCHHHEEECCCCCCCCCHHHHHHHHHHHHHHH
GAGFVQTQMVMERQNLIDFCEQISNPLEIPVIAGVFLLKSYKNALFINKYVPGANIPENI
CCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHH
LNRLKNAKNPLQEGIKIAAEQAHDFINIADGVHIMAVKAEHLIPDILEKADISLEY
HHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9353932; 9384377 [H]