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The map label for this gene is leuE [H]

Identifier: 126455433

GI number: 126455433

Start: 3091324

End: 3091947

Strand: Direct

Name: leuE [H]

Synonym: BURPS1106A_3176

Alternate gene names: 126455433

Gene position: 3091324-3091947 (Clockwise)

Preceding gene: 126454116

Following gene: 126451691

Centisome position: 77.51

GC content: 68.11

Gene sequence:

>624_bases
ATGACGGTCAACCCCACTCTCGCCTTCATCGCGACGTGCATCGGCTTCGGCTTCATTCCGGGCCCGGCGCTGCTGCAAAC
CGTTTCGCTGACGTTGCAGCACGGCCGGCGCGCGGGCGTGCTTTCGGCGCTCGGCATCCACCTCGGCGCGTTCTTCCAGA
TCTGCGCGGTCGCGATCGGCGCGGTGGTCGTGCTCGACACGTCGCCGTGGCTCTATCACGCGCTGCGCATCGCGGGCGGC
GGGTATCTGATCTGGCTCGGCATCCAACGCATCCGCACGCGCGAGGCGAACGACGGCGGCGACGGCGCGCCGTCGACGGT
GCCGAAGAACGTGATCTCGTCGAGCGCGCTCATCGAGGCGTCGAATCCGAAATCGGCACTGTTCTATCTGTCGTTCCTGC
TGCAGTTCGTCGATCCGTCCGCTTCGCTCGATGTCGGCTGGCAGCTCTTCCTGCTCGGCGCGGGTGCAAACCTGCTGTTC
TCGCTCGCCGATCTGACCTGCATCGCGCTCGCGCATCCGCTGCGCAAGCGCGCGGCGCCGGGCGGCGCGGCGATGATCAT
TGGGCGCTATCTCGCGGGCGGGCTGTTCATCGCGCTCGGCGTCGCCGCGATCGTCGAGCGCTGA

Upstream 100 bases:

>100_bases
CCGCTGGCGTCGACGCATCACCGCCGACGCGAGCCAATGCCGTTTCCGGCCATCGCTCAGCGACGGCGGCCGGCCGCGTT
TCCTCGACGAGCGATTCCCC

Downstream 100 bases:

>100_bases
CGCGCGGCCCGGCGGGCGATCAGGCCGCGCCGAGCACCTCGCGGCCGACGTCGCGGCGCTGCCGCGCCGGTCGGCATGCT
TCGCACGTCCGCTTGCGGAC

Product: LysE family translocator protein

Products: homoserine lactone [Periplasm]; Proton [Cytoplasm]; homoserine [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 207; Mature: 206

Protein sequence:

>207_residues
MTVNPTLAFIATCIGFGFIPGPALLQTVSLTLQHGRRAGVLSALGIHLGAFFQICAVAIGAVVVLDTSPWLYHALRIAGG
GYLIWLGIQRIRTREANDGGDGAPSTVPKNVISSSALIEASNPKSALFYLSFLLQFVDPSASLDVGWQLFLLGAGANLLF
SLADLTCIALAHPLRKRAAPGGAAMIIGRYLAGGLFIALGVAAIVER

Sequences:

>Translated_207_residues
MTVNPTLAFIATCIGFGFIPGPALLQTVSLTLQHGRRAGVLSALGIHLGAFFQICAVAIGAVVVLDTSPWLYHALRIAGG
GYLIWLGIQRIRTREANDGGDGAPSTVPKNVISSSALIEASNPKSALFYLSFLLQFVDPSASLDVGWQLFLLGAGANLLF
SLADLTCIALAHPLRKRAAPGGAAMIIGRYLAGGLFIALGVAAIVER
>Mature_206_residues
TVNPTLAFIATCIGFGFIPGPALLQTVSLTLQHGRRAGVLSALGIHLGAFFQICAVAIGAVVVLDTSPWLYHALRIAGGG
YLIWLGIQRIRTREANDGGDGAPSTVPKNVISSSALIEASNPKSALFYLSFLLQFVDPSASLDVGWQLFLLGAGANLLFS
LADLTCIALAHPLRKRAAPGGAAMIIGRYLAGGLFIALGVAAIVER

Specific function: Exporter of leucine [H]

COG id: COG1280

COG function: function code E; Putative threonine efflux protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the rht family [H]

Homologues:

Organism=Escherichia coli, GI48994979, Length=140, Percent_Identity=30.7142857142857, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1788099, Length=143, Percent_Identity=28.6713286713287, Blast_Score=65, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001123 [H]

Pfam domain/function: PF01810 LysE [H]

EC number: NA

Molecular weight: Translated: 21568; Mature: 21436

Theoretical pI: Translated: 9.27; Mature: 9.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVNPTLAFIATCIGFGFIPGPALLQTVSLTLQHGRRAGVLSALGIHLGAFFQICAVAIG
CCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
AVVVLDTSPWLYHALRIAGGGYLIWLGIQRIRTREANDGGDGAPSTVPKNVISSSALIEA
HEEEEECCHHHHHHHHHCCCCEEEEEEHHHHHHCCCCCCCCCCCCCCHHHHHCCHHEEEC
SNPKSALFYLSFLLQFVDPSASLDVGWQLFLLGAGANLLFSLADLTCIALAHPLRKRAAP
CCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCC
GGAAMIIGRYLAGGLFIALGVAAIVER
CCHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TVNPTLAFIATCIGFGFIPGPALLQTVSLTLQHGRRAGVLSALGIHLGAFFQICAVAIG
CCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
AVVVLDTSPWLYHALRIAGGGYLIWLGIQRIRTREANDGGDGAPSTVPKNVISSSALIEA
HEEEEECCHHHHHHHHHCCCCEEEEEEHHHHHHCCCCCCCCCCCCCCHHHHHCCHHEEEC
SNPKSALFYLSFLLQFVDPSASLDVGWQLFLLGAGANLLFSLADLTCIALAHPLRKRAAP
CCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCC
GGAAMIIGRYLAGGLFIALGVAAIVER
CCHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; homoserine [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + homoserine lactone [Cytoplasm] = Proton [Cytoplasm] + homoserine lactone [Periplasm] Proton [Periplasm] + homoserine [Cytoplasm] = Proton [Cytoplasm] + homoserine [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA