Click here to switch to the map view.

The map label for this gene is hppD [H]

Identifier: 126455066

GI number: 126455066

Start: 3744627

End: 3745724

Strand: Direct

Name: hppD [H]

Synonym: BURPS1106A_3845

Alternate gene names: 126455066

Gene position: 3744627-3745724 (Clockwise)

Preceding gene: 126453419

Following gene: 126453324

Centisome position: 93.89

GC content: 63.21

Gene sequence:

>1098_bases
ATGCAAATCCCCACCTGGGACAATCCCGTCGGCACCGACGGCTTCGAATTCATCGAATACACCGCCCCCGATCCGAAGGC
GCTCGGCCAACTGTTCGAGCGAATGGGCTTCACCGCGGTCGCCCGCCATCGCCACAAGGACGTGACGCTGTACCGCCAGG
GCGACATCAACTTCATCATCAACGCGGAACCCGATTCGTTCGCGCAACGCTTCGCGCGGCTGCACGGGCCGTCGATCTGC
GCGATCGCATTCCGCGTGCAGGACGCCGCGAAAGCGTACAGGCATGCGCTCGAGCTCGGCGCATGGGGCTTCGACAACAA
GACGGGCCCGATGGAGCTGAACATCCCGGCGATCAAGGGCATCGGCGATTCGCTGATCTACTTCGTCGACCGCTGGCGCG
GCAAGAACGGCGCGAAGCCGGGCGCGATCGGCGATATCAGCATCTACGACGTCGATTTCGAGCCGATTCCGGGCGCCGAT
CCGAACCCGGCCGGCCACGGCCTCACGTACATCGATCACCTCACGCACAACGTGCACCGCGGCCGCATGCAGGAATGGGC
GGAGTTCTACGAGCGCCTGTTCAACTTCCGCGAGGTTCGCTACTTCGACATCGAAGGCAAGGTGACGGGCGTGAAATCGA
AGGCGATGACGTCGCCGTGCGGCAAGATCCGGATTCCGATCAACGAGGAAGGCTCGGACACGGCCGGCCAGATCCAGGAA
TATCTGGACGCGTATCGCGGCGAAGGCATCCAGCACATCGCGCTCGGCGCGGCCGACATCTATCGGGCGGTCGACGGCCT
GCGCGCGAAGGGCGTGACGCTGCTCGACACGATCGACACGTACTACGAGCTCGTCGATCGCCGCGTGCCGAACCACGGCG
AGCCGCTCGACGAGCTCAGAAAGCGCAAGATCCTGATCGACGGCGCGCACGACGATCTGCTGCTGCAGATCTTCACCGAG
AACCAGATCGGGCCGATCTTCTTCGAGATTATTCAGCGCAAGGGTAATCAGGGTTTCGGCGAGGGCAACTTCAAGGCGCT
GTTCGAATCGATCGAACTCGACCAGATCCGCCGCGGCGTCGTGCAGGACAAGGCGTAA

Upstream 100 bases:

>100_bases
TTGCGCGACCAAGTTCGCAAGTTTCCACTCGGCTCTCCCCGCTACACTTTGCCGCAGACATTCACCAAGACGCGTGCCCC
GCCGAGGGCTAGGAGACGCC

Downstream 100 bases:

>100_bases
GCGCGCCCGCGCGGCGCGTTGCGGCGCCCGCCGCGCGGGATGCCGCGAACGGCCTGACAGTTGGGCGCCGGCAAGCGGGC
CTGAAGATGAGCCTGCAGGT

Product: 4-hydroxyphenylpyruvate dioxygenase

Products: NA

Alternate protein names: 4HPPD; HPD; HPPDase [H]

Number of amino acids: Translated: 365; Mature: 365

Protein sequence:

>365_residues
MQIPTWDNPVGTDGFEFIEYTAPDPKALGQLFERMGFTAVARHRHKDVTLYRQGDINFIINAEPDSFAQRFARLHGPSIC
AIAFRVQDAAKAYRHALELGAWGFDNKTGPMELNIPAIKGIGDSLIYFVDRWRGKNGAKPGAIGDISIYDVDFEPIPGAD
PNPAGHGLTYIDHLTHNVHRGRMQEWAEFYERLFNFREVRYFDIEGKVTGVKSKAMTSPCGKIRIPINEEGSDTAGQIQE
YLDAYRGEGIQHIALGAADIYRAVDGLRAKGVTLLDTIDTYYELVDRRVPNHGEPLDELRKRKILIDGAHDDLLLQIFTE
NQIGPIFFEIIQRKGNQGFGEGNFKALFESIELDQIRRGVVQDKA

Sequences:

>Translated_365_residues
MQIPTWDNPVGTDGFEFIEYTAPDPKALGQLFERMGFTAVARHRHKDVTLYRQGDINFIINAEPDSFAQRFARLHGPSIC
AIAFRVQDAAKAYRHALELGAWGFDNKTGPMELNIPAIKGIGDSLIYFVDRWRGKNGAKPGAIGDISIYDVDFEPIPGAD
PNPAGHGLTYIDHLTHNVHRGRMQEWAEFYERLFNFREVRYFDIEGKVTGVKSKAMTSPCGKIRIPINEEGSDTAGQIQE
YLDAYRGEGIQHIALGAADIYRAVDGLRAKGVTLLDTIDTYYELVDRRVPNHGEPLDELRKRKILIDGAHDDLLLQIFTE
NQIGPIFFEIIQRKGNQGFGEGNFKALFESIELDQIRRGVVQDKA
>Mature_365_residues
MQIPTWDNPVGTDGFEFIEYTAPDPKALGQLFERMGFTAVARHRHKDVTLYRQGDINFIINAEPDSFAQRFARLHGPSIC
AIAFRVQDAAKAYRHALELGAWGFDNKTGPMELNIPAIKGIGDSLIYFVDRWRGKNGAKPGAIGDISIYDVDFEPIPGAD
PNPAGHGLTYIDHLTHNVHRGRMQEWAEFYERLFNFREVRYFDIEGKVTGVKSKAMTSPCGKIRIPINEEGSDTAGQIQE
YLDAYRGEGIQHIALGAADIYRAVDGLRAKGVTLLDTIDTYYELVDRRVPNHGEPLDELRKRKILIDGAHDDLLLQIFTE
NQIGPIFFEIIQRKGNQGFGEGNFKALFESIELDQIRRGVVQDKA

Specific function: Unknown

COG id: COG3185

COG function: function code ER; 4-hydroxyphenylpyruvate dioxygenase and related hemolysins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4HPPD family [H]

Homologues:

Organism=Homo sapiens, GI285002264, Length=327, Percent_Identity=29.6636085626911, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI4504477, Length=351, Percent_Identity=29.0598290598291, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI14249394, Length=378, Percent_Identity=24.6031746031746, Blast_Score=83, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17555220, Length=308, Percent_Identity=32.1428571428571, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17550752, Length=223, Percent_Identity=31.390134529148, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI21356105, Length=301, Percent_Identity=33.8870431893688, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24667510, Length=301, Percent_Identity=33.8870431893688, Blast_Score=140, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005956
- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: =1.13.11.27 [H]

Molecular weight: Translated: 41080; Mature: 41080

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIPTWDNPVGTDGFEFIEYTAPDPKALGQLFERMGFTAVARHRHKDVTLYRQGDINFII
CCCCCCCCCCCCCCHHEEEECCCCHHHHHHHHHHHCHHHHHHHCCCCEEEEEECCEEEEE
NAEPDSFAQRFARLHGPSICAIAFRVQDAAKAYRHALELGAWGFDNKTGPMELNIPAIKG
ECCCHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCHHHC
IGDSLIYFVDRWRGKNGAKPGAIGDISIYDVDFEPIPGADPNPAGHGLTYIDHLTHNVHR
CCHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHH
GRMQEWAEFYERLFNFREVRYFDIEGKVTGVKSKAMTSPCGKIRIPINEEGSDTAGQIQE
HHHHHHHHHHHHHHCHHHEEEEEECCEEECCCHHHHCCCCCEEEEECCCCCCCHHHHHHH
YLDAYRGEGIQHIALGAADIYRAVDGLRAKGVTLLDTIDTYYELVDRRVPNHGEPLDELR
HHHHHHCCCEEEEEHHHHHHHHHHHHHHHCCEEHHHHHHHHHHHHHHCCCCCCCCHHHHH
KRKILIDGAHDDLLLQIFTENQIGPIFFEIIQRKGNQGFGEGNFKALFESIELDQIRRGV
HCEEEEECCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHCHHHHHHHH
VQDKA
HCCCC
>Mature Secondary Structure
MQIPTWDNPVGTDGFEFIEYTAPDPKALGQLFERMGFTAVARHRHKDVTLYRQGDINFII
CCCCCCCCCCCCCCHHEEEECCCCHHHHHHHHHHHCHHHHHHHCCCCEEEEEECCEEEEE
NAEPDSFAQRFARLHGPSICAIAFRVQDAAKAYRHALELGAWGFDNKTGPMELNIPAIKG
ECCCHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCHHHC
IGDSLIYFVDRWRGKNGAKPGAIGDISIYDVDFEPIPGADPNPAGHGLTYIDHLTHNVHR
CCHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHH
GRMQEWAEFYERLFNFREVRYFDIEGKVTGVKSKAMTSPCGKIRIPINEEGSDTAGQIQE
HHHHHHHHHHHHHHCHHHEEEEEECCEEECCCHHHHCCCCCEEEEECCCCCCCHHHHHHH
YLDAYRGEGIQHIALGAADIYRAVDGLRAKGVTLLDTIDTYYELVDRRVPNHGEPLDELR
HHHHHHCCCEEEEEHHHHHHHHHHHHHHHCCEEHHHHHHHHHHHHHHCCCCCCCCHHHHH
KRKILIDGAHDDLLLQIFTENQIGPIFFEIIQRKGNQGFGEGNFKALFESIELDQIRRGV
HCEEEEECCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHCHHHHHHHH
VQDKA
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]