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The map label for this gene is yogA [H]

Identifier: 126454906

GI number: 126454906

Start: 3079786

End: 3081003

Strand: Direct

Name: yogA [H]

Synonym: BURPS1106A_3164

Alternate gene names: 126454906

Gene position: 3079786-3081003 (Clockwise)

Preceding gene: 126453810

Following gene: 126454982

Centisome position: 77.22

GC content: 68.47

Gene sequence:

>1218_bases
TTGTACGTTCTTGCGCCGAAAGAAGCAGGTGCGGACAATTCGCACATCCGCCATCGGCCGGGGCGGCCGAATGCGCGCCG
CATGCGCACGCGTGCGGCACGTACGGCGAACGGCACACGATACGCGCGCCGATCTCCCCGCCCGCCATTGCGGGCGCATC
GGCCGCACACCGAGCGATGCGCTCGCTCACCACTCACAGGAGTCGAATCGATGAAAGCCATCATGTTGCGTCAACCCGCC
GGCCTCGAGCATCTCGAACGCGTCACGCTCGCCGATCCCGGTGCACCGGCCGCCGGCGAAATCCGCGTGCGCATTCACGC
GAGTTCGCTCAACTATCACGATCTCGGCGTCGTCACCGGCAGGCTGAACCCCGCCGACAAGCGCATTCCAATGTCCGACG
GCGCAGGTGTCGTCGAAGCGATCGGCGAAGGCGTCACGGAGTTCGCGCCCGGCGACGCGGTCGTGTCGACCTTTTTTCCG
TACTGGCTCGACGGCGGGCCGACCGTCGCGGACTTCGCGACGGTCCCGGGCGACGGTGTCGACGGCTACGCGCGCGAGTC
GGTCGTGCGCCCCGCGCACTGGTTCACGCATGCGCCGCAGGGCTACACGCACGAGCAAGCCGCGACGCTGACGACGGCGG
GCCTCACCGCATGGCGCGCGCTCGTCGTCGACGGCGGCCTGAAGGCGGGCGACAGCGTGCTCGTGCTCGGCACGGGCGGC
GTATCGATCTTCGCGCTGCAGTTCGCGAAGCGAATGGGCGCGACCGTGATCGCCACGTCGTCGTCGGACGAAAAGCTGGA
ACGCGCACGCGCGCTCGGCGCCGATCACGTCGTCAACTATCGTCGCGACGCGAACTGGGCGGCGAAGGTGCTCGCGCTGA
CGAACGGGCGCGGCGTCGACCACGTGATCGAGGTCGGCGGCCCCGACACGCTCCCGCAATCGATCCAGGCATGCCGGATC
GGCGGCCATATCGCACTGATCGGCGTGCTGACGGGGATTGCCGGCCCGGTGCCGACCGTCGCGCTGATGGCGCGCCAGCA
GAACCTGCAAGGCCTGATCGTCGGCAGTCGCCGGCATCAGATCGACATGGTGCGCGCGATCGACGCAACCGGCATCAAGC
CGGTCGTCGATCGCACGTTCGCGCTCGACGACATCGCCGACGCGTTCGCCCATCAAGCGGCCGGCAAGCACTTCGGCAAG
ATCTGCCTGTCGATCTGA

Upstream 100 bases:

>100_bases
ATGACCGAAAGGGTCACCTCGACGGAACACCCGCTCTTGCTGTCGAAACGCTTCGGTCGCATCGTGCACGTACCTACAGA
ATTGATAGTACCTGCGTTAA

Downstream 100 bases:

>100_bases
GCGCGGCTTGCGCCGGCCGCCGCTCAGCCCATCGACCTGTGCCTCGTGTGAACGATCGGATTGTGCCGCGACGTGAAGCT
CATCGACGCGGCCAATCGCG

Product: zinc-binding dehydrogenase family oxidoreductase

Products: Glycerol; Nicotinamide adenine dinucleotide [C]

Alternate protein names: NA

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MYVLAPKEAGADNSHIRHRPGRPNARRMRTRAARTANGTRYARRSPRPPLRAHRPHTERCARSPLTGVESMKAIMLRQPA
GLEHLERVTLADPGAPAAGEIRVRIHASSLNYHDLGVVTGRLNPADKRIPMSDGAGVVEAIGEGVTEFAPGDAVVSTFFP
YWLDGGPTVADFATVPGDGVDGYARESVVRPAHWFTHAPQGYTHEQAATLTTAGLTAWRALVVDGGLKAGDSVLVLGTGG
VSIFALQFAKRMGATVIATSSSDEKLERARALGADHVVNYRRDANWAAKVLALTNGRGVDHVIEVGGPDTLPQSIQACRI
GGHIALIGVLTGIAGPVPTVALMARQQNLQGLIVGSRRHQIDMVRAIDATGIKPVVDRTFALDDIADAFAHQAAGKHFGK
ICLSI

Sequences:

>Translated_405_residues
MYVLAPKEAGADNSHIRHRPGRPNARRMRTRAARTANGTRYARRSPRPPLRAHRPHTERCARSPLTGVESMKAIMLRQPA
GLEHLERVTLADPGAPAAGEIRVRIHASSLNYHDLGVVTGRLNPADKRIPMSDGAGVVEAIGEGVTEFAPGDAVVSTFFP
YWLDGGPTVADFATVPGDGVDGYARESVVRPAHWFTHAPQGYTHEQAATLTTAGLTAWRALVVDGGLKAGDSVLVLGTGG
VSIFALQFAKRMGATVIATSSSDEKLERARALGADHVVNYRRDANWAAKVLALTNGRGVDHVIEVGGPDTLPQSIQACRI
GGHIALIGVLTGIAGPVPTVALMARQQNLQGLIVGSRRHQIDMVRAIDATGIKPVVDRTFALDDIADAFAHQAAGKHFGK
ICLSI
>Mature_405_residues
MYVLAPKEAGADNSHIRHRPGRPNARRMRTRAARTANGTRYARRSPRPPLRAHRPHTERCARSPLTGVESMKAIMLRQPA
GLEHLERVTLADPGAPAAGEIRVRIHASSLNYHDLGVVTGRLNPADKRIPMSDGAGVVEAIGEGVTEFAPGDAVVSTFFP
YWLDGGPTVADFATVPGDGVDGYARESVVRPAHWFTHAPQGYTHEQAATLTTAGLTAWRALVVDGGLKAGDSVLVLGTGG
VSIFALQFAKRMGATVIATSSSDEKLERARALGADHVVNYRRDANWAAKVLALTNGRGVDHVIEVGGPDTLPQSIQACRI
GGHIALIGVLTGIAGPVPTVALMARQQNLQGLIVGSRRHQIDMVRAIDATGIKPVVDRTFALDDIADAFAHQAAGKHFGK
ICLSI

Specific function: Preferred Specificity Is Towards 1-Propanol. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI22538446, Length=352, Percent_Identity=28.9772727272727, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI22538444, Length=352, Percent_Identity=28.9772727272727, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI47519420, Length=347, Percent_Identity=28.8184438040346, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI194239674, Length=334, Percent_Identity=27.2455089820359, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI13236495, Length=334, Percent_Identity=27.2455089820359, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI262073058, Length=295, Percent_Identity=27.1186440677966, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI71743840, Length=282, Percent_Identity=26.5957446808511, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI18379349, Length=332, Percent_Identity=25.3012048192771, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI28557745, Length=335, Percent_Identity=28.6567164179104, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI194239676, Length=253, Percent_Identity=29.2490118577075, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI41872631, Length=329, Percent_Identity=26.7477203647416, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI156627571, Length=327, Percent_Identity=26.9113149847095, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI87081918, Length=318, Percent_Identity=27.0440251572327, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1787863, Length=357, Percent_Identity=26.3305322128852, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1789651, Length=288, Percent_Identity=27.0833333333333, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1788073, Length=329, Percent_Identity=24.9240121580547, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17507255, Length=332, Percent_Identity=25, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6319520, Length=351, Percent_Identity=25.0712250712251, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323961, Length=314, Percent_Identity=26.1146496815287, Blast_Score=78, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6324486, Length=305, Percent_Identity=26.2295081967213, Blast_Score=74, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6323729, Length=352, Percent_Identity=23.8636363636364, Blast_Score=71, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6322619, Length=251, Percent_Identity=25.4980079681275, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6319955, Length=251, Percent_Identity=25.4980079681275, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6319621, Length=350, Percent_Identity=24.8571428571429, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24581345, Length=222, Percent_Identity=30.1801801801802, Blast_Score=82, Evalue=9e-16,
Organism=Drosophila melanogaster, GI19920632, Length=221, Percent_Identity=29.4117647058824, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI221330659, Length=221, Percent_Identity=29.4117647058824, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.1.1.1 [C]

Molecular weight: Translated: 43068; Mature: 43068

Theoretical pI: Translated: 10.20; Mature: 10.20

Prosite motif: PS00012 PHOSPHOPANTETHEINE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYVLAPKEAGADNSHIRHRPGRPNARRMRTRAARTANGTRYARRSPRPPLRAHRPHTERC
CEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCHHHH
ARSPLTGVESMKAIMLRQPAGLEHLERVTLADPGAPAAGEIRVRIHASSLNYHDLGVVTG
HCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCEEEEEEC
RLNPADKRIPMSDGAGVVEAIGEGVTEFAPGDAVVSTFFPYWLDGGPTVADFATVPGDGV
CCCCCCCCCCCCCCCHHHHHHHCCHHHCCCCHHHHHHHHHHHCCCCCCHHHEECCCCCCC
DGYARESVVRPAHWFTHAPQGYTHEQAATLTTAGLTAWRALVVDGGLKAGDSVLVLGTGG
CCHHHHHHCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHEECCCCCCCCEEEEECCC
VSIFALQFAKRMGATVIATSSSDEKLERARALGADHVVNYRRDANWAAKVLALTNGRGVD
HHHHHHHHHHHCCCEEEEECCCHHHHHHHHHCCHHHHHHCCCCCCHHEEEEEEECCCCCC
HVIEVGGPDTLPQSIQACRIGGHIALIGVLTGIAGPVPTVALMARQQNLQGLIVGSRRHQ
EEEECCCCCCCHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEECCCCH
IDMVRAIDATGIKPVVDRTFALDDIADAFAHQAAGKHFGKICLSI
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MYVLAPKEAGADNSHIRHRPGRPNARRMRTRAARTANGTRYARRSPRPPLRAHRPHTERC
CEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCHHHH
ARSPLTGVESMKAIMLRQPAGLEHLERVTLADPGAPAAGEIRVRIHASSLNYHDLGVVTG
HCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCEEEEEEC
RLNPADKRIPMSDGAGVVEAIGEGVTEFAPGDAVVSTFFPYWLDGGPTVADFATVPGDGV
CCCCCCCCCCCCCCCHHHHHHHCCHHHCCCCHHHHHHHHHHHCCCCCCHHHEECCCCCCC
DGYARESVVRPAHWFTHAPQGYTHEQAATLTTAGLTAWRALVVDGGLKAGDSVLVLGTGG
CCHHHHHHCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHEECCCCCCCCEEEEECCC
VSIFALQFAKRMGATVIATSSSDEKLERARALGADHVVNYRRDANWAAKVLALTNGRGVD
HHHHHHHHHHHCCCEEEEECCCHHHHHHHHHCCHHHHHHCCCCCCHHEEEEEEECCCCCC
HVIEVGGPDTLPQSIQACRIGGHIALIGVLTGIAGPVPTVALMARQQNLQGLIVGSRRHQ
EEEECCCCCCCHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEECCCCH
IDMVRAIDATGIKPVVDRTFALDDIADAFAHQAAGKHFGKICLSI
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NAD+; NADH [C]

Metal ions: Co2+ Zn2+-depleted [C]

Kcat value (1/min): 150 [C]

Specific activity: 19

Km value (mM): 0.2 {tryptophol}} 0.0074 {NAD+}} 0.0069 {NAD+}} 13 {ethylene} 6 {methanol}} 27 {pentanol}} 0.44 {1-butanol}} 120 {ethanol}} 0.91 {acetaldehyde}} 0.1 {acetaldehyde}} 0.005 {1-octanol}} 0.004 {benzyl} 0.005 {cyclohe

Substrates: D-Glyceraldehyde; H+; Nicotinamide adenine dinucleotide - reduced [C]

Specific reaction: D-Glyceraldehyde + H+ + Nicotinamide adenine dinucleotide - reduced <==> Glycerol + Nicotinamide adenine dinucleotide [C]

General reaction: Redox reaction [C]

Inhibitor: 2, 2'-Bipyridyl; 4-Methyl pyrazole acetaldehyde; 8-Amino-6-methoxyquinoline; 8-Hydroxy quinoline-5-sulfonic acid; Acetaldehyde; Dipicolinic acid; EDTA; Ethanol; GSH; Heptafluorbutanol; Imidazole; Iodoacetamide; Iodoacetate; Isobutyramide EDTA; NAD+; NADH;

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]