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The map label for this gene is livM [H]

Identifier: 126454800

GI number: 126454800

Start: 3968564

End: 3969538

Strand: Reverse

Name: livM [H]

Synonym: BURPS1106A_4062

Alternate gene names: 126454800

Gene position: 3969538-3968564 (Counterclockwise)

Preceding gene: 126452969

Following gene: 126453644

Centisome position: 99.53

GC content: 66.56

Gene sequence:

>975_bases
ATGCAGAGAAAAGCGCTCTACGGCCTGCTGCTGCTCGGCCTGCTCGTCGCGCCGTTCGTCGGCGCGTATCCGGTGTTCGT
GATGAAGGTGCTGTGTTTCGCGTTGTTCGCGGCGGCGTTCAATCTGCTGATCGGCTTCACGGGGTTGCTGTCGTTCGGCC
ACGCGATGTTTCTCGCGACTGCGGGCTACGTGACGGGTTACGCGATGCAGTCGCTCGGCACGGCGCCCGAGCTCGGCGTG
CTGGCCGGCACCGCCGCCGCGACGCTGCTCGGCCTCGTCGTCGGCCTGTTCGCGATCCGGCGGCAGGGCATCTATTTCGC
GATGATCACGCTCGCGTTCGCGCAGATGGTGTATTTCATCTATCTGCAAGCGCCGTTCACGCACGGCGAGGACGGCCTGC
AGGGCGTGCCGCGCGGGCGGCTGTTCGGGCTCGTCGATCTGTCGTCCGATCTCGCGCTCTACTATGTGGTGCTCGTCGTG
ATCGCGTGCGCGTGCTTCTTCATCGTGCGCATCGTGCATTCGCCGTTCGGGCAGGTGCTTGTCGCGATCAAGGAGAACGA
GCCTCGCGCGATATCGCTCGGCTACGATACCGATCGCTTCAAGCTGCTTGCGTTCATCCTGTCGGCCGCGCTCGCGGGGC
TTGCCGGCGCGCTGAAAGTGGTCGTGCTCGGCTTCGAGACGCTGAGCGATGCGTACTGGACGATGTCGGGCCTCGTCGTG
CTGATGACGCTCGTGGGCGGCATGGGCACGCTGTTCGGCCCGCTCGTCGGCGCGGCGCTGATCGTCGCGCTCGAGGATCG
GCTGGGCGACATCGGCGGCTGGCTCGCGTCGGTCACGCACATCGACTGGTTCCGCTCGCTCGGCGAATCCGCGACGATCG
TCACCGGCCTTATCTTCATCGTGTGCGTGCTCGCGTTCAGGCGCGGCATCGTCGGCGAGGTGATCGCCCGGGTGCGGCCG
CTGCGCGCGTCGTGA

Upstream 100 bases:

>100_bases
CGCGCGTGTTCTATCCGGAAGCATCGGCGACGGTCGTCTTCGTGATCATGGCGATCGTGCTGTTGATTCGTCCGGCAGGT
TTGTTCGGCAAGGAAAGATG

Downstream 100 bases:

>100_bases
ATGGCGAGGACGCGCGATCGTGCGGTGCGCAATGATCGGCGGCCATCCGGTGCGATGCGCGCCGCGAACGGCCGGCCCGG
TTCGGCCGGACATGGCCGCC

Product: putative amino acid uptake ABC transporter, permease protein

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein M [H]

Number of amino acids: Translated: 324; Mature: 324

Protein sequence:

>324_residues
MQRKALYGLLLLGLLVAPFVGAYPVFVMKVLCFALFAAAFNLLIGFTGLLSFGHAMFLATAGYVTGYAMQSLGTAPELGV
LAGTAAATLLGLVVGLFAIRRQGIYFAMITLAFAQMVYFIYLQAPFTHGEDGLQGVPRGRLFGLVDLSSDLALYYVVLVV
IACACFFIVRIVHSPFGQVLVAIKENEPRAISLGYDTDRFKLLAFILSAALAGLAGALKVVVLGFETLSDAYWTMSGLVV
LMTLVGGMGTLFGPLVGAALIVALEDRLGDIGGWLASVTHIDWFRSLGESATIVTGLIFIVCVLAFRRGIVGEVIARVRP
LRAS

Sequences:

>Translated_324_residues
MQRKALYGLLLLGLLVAPFVGAYPVFVMKVLCFALFAAAFNLLIGFTGLLSFGHAMFLATAGYVTGYAMQSLGTAPELGV
LAGTAAATLLGLVVGLFAIRRQGIYFAMITLAFAQMVYFIYLQAPFTHGEDGLQGVPRGRLFGLVDLSSDLALYYVVLVV
IACACFFIVRIVHSPFGQVLVAIKENEPRAISLGYDTDRFKLLAFILSAALAGLAGALKVVVLGFETLSDAYWTMSGLVV
LMTLVGGMGTLFGPLVGAALIVALEDRLGDIGGWLASVTHIDWFRSLGESATIVTGLIFIVCVLAFRRGIVGEVIARVRP
LRAS
>Mature_324_residues
MQRKALYGLLLLGLLVAPFVGAYPVFVMKVLCFALFAAAFNLLIGFTGLLSFGHAMFLATAGYVTGYAMQSLGTAPELGV
LAGTAAATLLGLVVGLFAIRRQGIYFAMITLAFAQMVYFIYLQAPFTHGEDGLQGVPRGRLFGLVDLSSDLALYYVVLVV
IACACFFIVRIVHSPFGQVLVAIKENEPRAISLGYDTDRFKLLAFILSAALAGLAGALKVVVLGFETLSDAYWTMSGLVV
LMTLVGGMGTLFGPLVGAALIVALEDRLGDIGGWLASVTHIDWFRSLGESATIVTGLIFIVCVLAFRRGIVGEVIARVRP
LRAS

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG4177

COG function: function code E; ABC-type branched-chain amino acid transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789865, Length=258, Percent_Identity=29.0697674418605, Blast_Score=80, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851
- InterPro:   IPR021807 [H]

Pfam domain/function: PF02653 BPD_transp_2; PF11862 DUF3382 [H]

EC number: NA

Molecular weight: Translated: 34490; Mature: 34490

Theoretical pI: Translated: 8.58; Mature: 8.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRKALYGLLLLGLLVAPFVGAYPVFVMKVLCFALFAAAFNLLIGFTGLLSFGHAMFLAT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGYVTGYAMQSLGTAPELGVLAGTAAATLLGLVVGLFAIRRQGIYFAMITLAFAQMVYFI
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
YLQAPFTHGEDGLQGVPRGRLFGLVDLSSDLALYYVVLVVIACACFFIVRIVHSPFGQVL
HHCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEE
VAIKENEPRAISLGYDTDRFKLLAFILSAALAGLAGALKVVVLGFETLSDAYWTMSGLVV
EEEECCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMTLVGGMGTLFGPLVGAALIVALEDRLGDIGGWLASVTHIDWFRSLGESATIVTGLIFI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
VCVLAFRRGIVGEVIARVRPLRAS
HHHHHHHCCHHHHHHHHHCCCCCC
>Mature Secondary Structure
MQRKALYGLLLLGLLVAPFVGAYPVFVMKVLCFALFAAAFNLLIGFTGLLSFGHAMFLAT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGYVTGYAMQSLGTAPELGVLAGTAAATLLGLVVGLFAIRRQGIYFAMITLAFAQMVYFI
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
YLQAPFTHGEDGLQGVPRGRLFGLVDLSSDLALYYVVLVVIACACFFIVRIVHSPFGQVL
HHCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEE
VAIKENEPRAISLGYDTDRFKLLAFILSAALAGLAGALKVVVLGFETLSDAYWTMSGLVV
EEEECCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMTLVGGMGTLFGPLVGAALIVALEDRLGDIGGWLASVTHIDWFRSLGESATIVTGLIFI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
VCVLAFRRGIVGEVIARVRPLRAS
HHHHHHHCCHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2195019; 8041620; 9278503 [H]