Click here to switch to the map view.

The map label for this gene is sugE [H]

Identifier: 126454766

GI number: 126454766

Start: 1233537

End: 1233857

Strand: Direct

Name: sugE [H]

Synonym: BURPS1106A_1257

Alternate gene names: 126454766

Gene position: 1233537-1233857 (Clockwise)

Preceding gene: 126453138

Following gene: 126451843

Centisome position: 30.93

GC content: 68.54

Gene sequence:

>321_bases
ATGCCTTGGCTGTGGCTTCTCGTCGCCGGTTTGCTCGAAGTTGCGTGGGCGGCCGGTCTCAAATCGTCCGAGGGCTTCAC
GCGTCTCGGCCCGTCCGTCTTCACGATCGTCACCGCGCTCGGCAGCTTCGGCCTGCTCGCCGTCGCGATGCGCGAATTGC
CGCTCGGCACCGCGTACGCGGTCTGGACGGGCATCGGCGCGGTCGGCGCGTTCATTTTCGGGATCGTGATGCTCGGCGAA
GCGGTGACGCTCGCCCGGATCGCGAGTGCGTCGCTGATCGTCGCCGGGCTCGTCGGCCTGAAGCTGTCGTCGGCCGGCTG
A

Upstream 100 bases:

>100_bases
AGGCTGTAAGCCTGTTGTTATACTTTCGCTGCCCGGGGACGACCCCGGGCCGTCGATGTTCAACGGGGACGACCCCAATT
GATTCATGGAGAGTCTCCCC

Downstream 100 bases:

>100_bases
GCGCAGGGTTTGCCCCTGCGTCGGCGCTACGGCGGTTGTGCGCGGCGCGCGTCTATAATGAAGCGCAATCCATCTGACAA
TGTCCCGCCGCCGCGCGTGA

Product: SMR family multidrug efflux pump

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 106; Mature: 105

Protein sequence:

>106_residues
MPWLWLLVAGLLEVAWAAGLKSSEGFTRLGPSVFTIVTALGSFGLLAVAMRELPLGTAYAVWTGIGAVGAFIFGIVMLGE
AVTLARIASASLIVAGLVGLKLSSAG

Sequences:

>Translated_106_residues
MPWLWLLVAGLLEVAWAAGLKSSEGFTRLGPSVFTIVTALGSFGLLAVAMRELPLGTAYAVWTGIGAVGAFIFGIVMLGE
AVTLARIASASLIVAGLVGLKLSSAG
>Mature_105_residues
PWLWLLVAGLLEVAWAAGLKSSEGFTRLGPSVFTIVTALGSFGLLAVAMRELPLGTAYAVWTGIGAVGAFIFGIVMLGEA
VTLARIASASLIVAGLVGLKLSSAG

Specific function: Quaternary ammonium compound efflux pump. Confers resistance to cetylpyridinium, cetyldimethylethyl ammonium and cetrimide cations [H]

COG id: COG2076

COG function: function code P; Membrane transporters of cations and cationic drugs

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the small multidrug resistance (SMR) protein family. SugE (TC 2.A.7.1.4) subfamily [H]

Homologues:

Organism=Escherichia coli, GI87082378, Length=104, Percent_Identity=61.5384615384615, Blast_Score=119, Evalue=3e-29,
Organism=Escherichia coli, GI1786755, Length=103, Percent_Identity=40.7766990291262, Blast_Score=61, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000390 [H]

Pfam domain/function: PF00893 Multi_Drug_Res [H]

EC number: NA

Molecular weight: Translated: 10762; Mature: 10631

Theoretical pI: Translated: 9.25; Mature: 9.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPWLWLLVAGLLEVAWAAGLKSSEGFTRLGPSVFTIVTALGSFGLLAVAMRELPLGTAYA
CCHHHHHHHHHHHHHHHHCCCCCCCCHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
VWTGIGAVGAFIFGIVMLGEAVTLARIASASLIVAGLVGLKLSSAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
PWLWLLVAGLLEVAWAAGLKSSEGFTRLGPSVFTIVTALGSFGLLAVAMRELPLGTAYA
CHHHHHHHHHHHHHHHHCCCCCCCCHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
VWTGIGAVGAFIFGIVMLGEAVTLARIASASLIVAGLVGLKLSSAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]