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The map label for this gene is relA [H]

Identifier: 126454760

GI number: 126454760

Start: 1691666

End: 1693903

Strand: Direct

Name: relA [H]

Synonym: BURPS1106A_1733

Alternate gene names: 126454760

Gene position: 1691666-1693903 (Clockwise)

Preceding gene: 126455137

Following gene: 126453502

Centisome position: 42.41

GC content: 68.68

Gene sequence:

>2238_bases
ATGACAGCCGATTCCGCTTCCACCGCTGCGGCGCCGTCGCTCGACGACGTGCTCGCGTTCGTGCGCGAGCACGCGGGCGA
CGCGCGCTTGTCGTCGGGAGAGCGGCTCGCCGATCATGCGGCGGGCACGTCGACGATCATGCAGCGGCTGAACGTCGATC
CGCCCGCGACGCAGGCGGCCGCGCTGTTCGCGCTCGCGCCGTATCTGAGCGATCCTGACAAGCAGATCGCCGAGCACTTC
GGCGACGAGGTCGCGCACCTCGTCGCCGACGTGCGCAAGCTGCTGCGCCTCGGTACCGTGAGCCTGCGCGCTGCGCAGAG
CGCGCCTGTCGATGCGGGCCGCGACGCACAGGCGGAGCGCCGCGCGCAGATCGAAGCGCTGCGCAAGATGCTGCTCGCGT
TCGCGCAGGACATCCGCGTCGTGCTGATCCGGCTCGCGTCGCGGCTGCAATCGTTGCGCTACTATGCGGCCGCGAAAATC
GAGCCGCCGCCCGACGTCGCGCGCGAGACGCTCGAAATCTACGCGCCGCTCGCGAACCGGCTCGGCATCTGGCAACTGAA
GTGGGAGCTCGAGGATCTCGCGTTCCGCTTCGAGGATCCCGTCACCTACAAGCGCATCGCGAAGCTGCTCGACGAGAAGC
GCGTCGAGCGCGAGGCGTACGTCGCCGGCGCGATCGAGCGGTTGCAGCACGAACTGGCGGCCGCGCACATCCAGGCCGAA
GTGAGCGGCCGGCCGAAGCACATCTACAGCATCTGGCGCAAGATGCGCGGCAAGGAGCTCGACTTCTCCGAGCTCTACGA
CGTGCGCGCGTTTCGCGTCATCGTGCCGGACATCAAGGATTGCTACACGGTGCTCGGCATCGTCCACCACCTGTGGCAGC
CGGTGCCGAAGGAATTCGACGATTACATCTCGCGGCCGAAGCCGAACGGCTACAAATCGCTGCATACGGTCGTGATCGGC
GACGACGGTCGCGCGTTCGAAGTGCAGATCCGCACGCAGGAGATGCACCGCTTCGCCGAGTACGGCGTCGCCGCGCACTG
GCGGTACAAGGAGGCGGGCGCGCGCGGCTACGGCGGCCAGTTCTCCGCGAGCGAGAAATACGACGAGAAGATCGCGTGGC
TGCGCCAACTGCTCGCGTGGAAGGACGAGATCGCGGACGGCGGCGGCGCGGAGGTGAGCGGTCAGCAGGCATGGGCGCAA
CTGCGCGAGGCGACGCTCGACGACGACCACATTTACGTGCTGACGCCGCAGGCGCGCGTGATCGCGCTGCCGCAGGGCGC
GACGCCCGTCGATTTCGCTTACCACCTGCACAGCGAACTGGGGCACCGTTGCCGCGGCGCGCGTGTCGACGGCGCGATGG
TGCCGCTCAACACGCAGCTTGCGAACGGCCAGACGGTCGAGATCGTCGCGGTGAAGGAGGGCGGCCCGTCGCGCGACTGG
CTCAACCCGCAGCTCGGCTATCTGCACAGCTCACGGGCGCGCCAGAAGGTGCGCGCATGGTTCAACGCGGTCGATCAGCA
GGAGAACGTCGCGCACGGCCGCGCGCTCGTCGAAAAGACGCTGCAGCGCGAAGGCAAGACGTCGGTGAATCTCGAGCATC
TCGCGGCGAAGCTCGGCTTCAAGTCGCCGGACGAACTGTTTTCGGTCGTCGGCAAGGAAGAGTTCAGCCTGCGCAACGTC
GAGCAGGCGCTGTCCGATGCGCCGGCGCCCGAACCCGAGCCGGAGGCGCCCGCGAACTTCGAGAAGCGCGCGAGCGGCGC
GAACGTCGCGCACGGCGCGTCGGCGGGGGTGCTCGTCGTCGGCGTCGACGCGCTTCTCACCCAGCTCGCCCGCTGCTGCC
GGCCGGCGCCGCCCGATCCGATCAGCGGCTTCGTCACGCGCGGCAAGGGGATGTCGATCCATCGCAGCGATTGCGCGACC
TTCCGCCGGATGGCCGAGCGCGCGCCCGAGCGCGTGCTGCAGACCACCTGGTCCGCCGACGTGCTGGGCGGGCGGGGCGC
GTCCGTCTACCCGGTCGACCTGATGATCGAGGCGACCGACCGGCAAGGGCTGTTGCGCGACATCTCCGAAGTGTTTGCGC
GCGAGAAGATGAACGTGATCGGCGTGAAGACGCAAAGTCGCCGCAACGCGGCCTTCATGCAATTCACGGTCGAGGTGTCG
AGTGCGTCGCAGGTGCAGCGCGCGTGCACGCTGCTTGGCGAGATTCAGGGCGTCGTTCGGGCGGCCCGCAAGGCGTGA

Upstream 100 bases:

>100_bases
TCGCGAACCCCGCTTGCCTCGTCGAGGTGGTGGTGGTCGCCGCGCAACGCGGCTGAGCCGGCGCGCGCACGTTTTTTCAG
GCAACTGGCCATACCCGACG

Downstream 100 bases:

>100_bases
GCGCCGCCGGTGGGCCGCGGCGCGGCAACGGCTTGCGAATTTTCCCGAACGAAATGCACGAAACCACTTGCCAAGGCAAA
AAGAGCTCCATATAATTTCA

Product: GTP diphosphokinase

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 745; Mature: 744

Protein sequence:

>745_residues
MTADSASTAAAPSLDDVLAFVREHAGDARLSSGERLADHAAGTSTIMQRLNVDPPATQAAALFALAPYLSDPDKQIAEHF
GDEVAHLVADVRKLLRLGTVSLRAAQSAPVDAGRDAQAERRAQIEALRKMLLAFAQDIRVVLIRLASRLQSLRYYAAAKI
EPPPDVARETLEIYAPLANRLGIWQLKWELEDLAFRFEDPVTYKRIAKLLDEKRVEREAYVAGAIERLQHELAAAHIQAE
VSGRPKHIYSIWRKMRGKELDFSELYDVRAFRVIVPDIKDCYTVLGIVHHLWQPVPKEFDDYISRPKPNGYKSLHTVVIG
DDGRAFEVQIRTQEMHRFAEYGVAAHWRYKEAGARGYGGQFSASEKYDEKIAWLRQLLAWKDEIADGGGAEVSGQQAWAQ
LREATLDDDHIYVLTPQARVIALPQGATPVDFAYHLHSELGHRCRGARVDGAMVPLNTQLANGQTVEIVAVKEGGPSRDW
LNPQLGYLHSSRARQKVRAWFNAVDQQENVAHGRALVEKTLQREGKTSVNLEHLAAKLGFKSPDELFSVVGKEEFSLRNV
EQALSDAPAPEPEPEAPANFEKRASGANVAHGASAGVLVVGVDALLTQLARCCRPAPPDPISGFVTRGKGMSIHRSDCAT
FRRMAERAPERVLQTTWSADVLGGRGASVYPVDLMIEATDRQGLLRDISEVFAREKMNVIGVKTQSRRNAAFMQFTVEVS
SASQVQRACTLLGEIQGVVRAARKA

Sequences:

>Translated_745_residues
MTADSASTAAAPSLDDVLAFVREHAGDARLSSGERLADHAAGTSTIMQRLNVDPPATQAAALFALAPYLSDPDKQIAEHF
GDEVAHLVADVRKLLRLGTVSLRAAQSAPVDAGRDAQAERRAQIEALRKMLLAFAQDIRVVLIRLASRLQSLRYYAAAKI
EPPPDVARETLEIYAPLANRLGIWQLKWELEDLAFRFEDPVTYKRIAKLLDEKRVEREAYVAGAIERLQHELAAAHIQAE
VSGRPKHIYSIWRKMRGKELDFSELYDVRAFRVIVPDIKDCYTVLGIVHHLWQPVPKEFDDYISRPKPNGYKSLHTVVIG
DDGRAFEVQIRTQEMHRFAEYGVAAHWRYKEAGARGYGGQFSASEKYDEKIAWLRQLLAWKDEIADGGGAEVSGQQAWAQ
LREATLDDDHIYVLTPQARVIALPQGATPVDFAYHLHSELGHRCRGARVDGAMVPLNTQLANGQTVEIVAVKEGGPSRDW
LNPQLGYLHSSRARQKVRAWFNAVDQQENVAHGRALVEKTLQREGKTSVNLEHLAAKLGFKSPDELFSVVGKEEFSLRNV
EQALSDAPAPEPEPEAPANFEKRASGANVAHGASAGVLVVGVDALLTQLARCCRPAPPDPISGFVTRGKGMSIHRSDCAT
FRRMAERAPERVLQTTWSADVLGGRGASVYPVDLMIEATDRQGLLRDISEVFAREKMNVIGVKTQSRRNAAFMQFTVEVS
SASQVQRACTLLGEIQGVVRAARKA
>Mature_744_residues
TADSASTAAAPSLDDVLAFVREHAGDARLSSGERLADHAAGTSTIMQRLNVDPPATQAAALFALAPYLSDPDKQIAEHFG
DEVAHLVADVRKLLRLGTVSLRAAQSAPVDAGRDAQAERRAQIEALRKMLLAFAQDIRVVLIRLASRLQSLRYYAAAKIE
PPPDVARETLEIYAPLANRLGIWQLKWELEDLAFRFEDPVTYKRIAKLLDEKRVEREAYVAGAIERLQHELAAAHIQAEV
SGRPKHIYSIWRKMRGKELDFSELYDVRAFRVIVPDIKDCYTVLGIVHHLWQPVPKEFDDYISRPKPNGYKSLHTVVIGD
DGRAFEVQIRTQEMHRFAEYGVAAHWRYKEAGARGYGGQFSASEKYDEKIAWLRQLLAWKDEIADGGGAEVSGQQAWAQL
REATLDDDHIYVLTPQARVIALPQGATPVDFAYHLHSELGHRCRGARVDGAMVPLNTQLANGQTVEIVAVKEGGPSRDWL
NPQLGYLHSSRARQKVRAWFNAVDQQENVAHGRALVEKTLQREGKTSVNLEHLAAKLGFKSPDELFSVVGKEEFSLRNVE
QALSDAPAPEPEPEAPANFEKRASGANVAHGASAGVLVVGVDALLTQLARCCRPAPPDPISGFVTRGKGMSIHRSDCATF
RRMAERAPERVLQTTWSADVLGGRGASVYPVDLMIEATDRQGLLRDISEVFAREKMNVIGVKTQSRRNAAFMQFTVEVSS
ASQVQRACTLLGEIQGVVRAARKA

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1789147, Length=705, Percent_Identity=40.8510638297872, Blast_Score=542, Evalue=1e-155,
Organism=Escherichia coli, GI1790082, Length=700, Percent_Identity=34.5714285714286, Blast_Score=377, Evalue=1e-105,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 82346; Mature: 82215

Theoretical pI: Translated: 7.55; Mature: 7.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTADSASTAAAPSLDDVLAFVREHAGDARLSSGERLADHAAGTSTIMQRLNVDPPATQAA
CCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHCCHHHHHHHHCCCCCHHHHH
ALFALAPYLSDPDKQIAEHFGDEVAHLVADVRKLLRLGTVSLRAAQSAPVDAGRDAQAER
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHH
RAQIEALRKMLLAFAQDIRVVLIRLASRLQSLRYYAAAKIEPPPDVARETLEIYAPLANR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHC
LGIWQLKWELEDLAFRFEDPVTYKRIAKLLDEKRVEREAYVAGAIERLQHELAAAHIQAE
CCEEEEEEEHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSGRPKHIYSIWRKMRGKELDFSELYDVRAFRVIVPDIKDCYTVLGIVHHLWQPVPKEFD
CCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHCCCCHHHH
DYISRPKPNGYKSLHTVVIGDDGRAFEVQIRTQEMHRFAEYGVAAHWRYKEAGARGYGGQ
HHHCCCCCCCCCCEEEEEECCCCCEEEEEEEHHHHHHHHHCCCHHEEEEHHCCCCCCCCC
FSASEKYDEKIAWLRQLLAWKDEIADGGGAEVSGQQAWAQLREATLDDDHIYVLTPQARV
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCEE
IALPQGATPVDFAYHLHSELGHRCRGARVDGAMVPLNTQLANGQTVEIVAVKEGGPSRDW
EEECCCCCCHHHHHHHHHHHHHHHCCCCCCCEEECCCCEECCCCEEEEEEEECCCCCCCC
LNPQLGYLHSSRARQKVRAWFNAVDQQENVAHGRALVEKTLQREGKTSVNLEHLAAKLGF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCC
KSPDELFSVVGKEEFSLRNVEQALSDAPAPEPEPEAPANFEKRASGANVAHGASAGVLVV
CCHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCEEEE
GVDALLTQLARCCRPAPPDPISGFVTRGKGMSIHRSDCATFRRMAERAPERVLQTTWSAD
EHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCC
VLGGRGASVYPVDLMIEATDRQGLLRDISEVFAREKMNVIGVKTQSRRNAAFMQFTVEVS
CCCCCCCEEEEEEEEEEECCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCEEEEEEEECC
SASQVQRACTLLGEIQGVVRAARKA
CHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TADSASTAAAPSLDDVLAFVREHAGDARLSSGERLADHAAGTSTIMQRLNVDPPATQAA
CCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHCCHHHHHHHHCCCCCHHHHH
ALFALAPYLSDPDKQIAEHFGDEVAHLVADVRKLLRLGTVSLRAAQSAPVDAGRDAQAER
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHH
RAQIEALRKMLLAFAQDIRVVLIRLASRLQSLRYYAAAKIEPPPDVARETLEIYAPLANR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHC
LGIWQLKWELEDLAFRFEDPVTYKRIAKLLDEKRVEREAYVAGAIERLQHELAAAHIQAE
CCEEEEEEEHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSGRPKHIYSIWRKMRGKELDFSELYDVRAFRVIVPDIKDCYTVLGIVHHLWQPVPKEFD
CCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHCCCCHHHH
DYISRPKPNGYKSLHTVVIGDDGRAFEVQIRTQEMHRFAEYGVAAHWRYKEAGARGYGGQ
HHHCCCCCCCCCCEEEEEECCCCCEEEEEEEHHHHHHHHHCCCHHEEEEHHCCCCCCCCC
FSASEKYDEKIAWLRQLLAWKDEIADGGGAEVSGQQAWAQLREATLDDDHIYVLTPQARV
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCEE
IALPQGATPVDFAYHLHSELGHRCRGARVDGAMVPLNTQLANGQTVEIVAVKEGGPSRDW
EEECCCCCCHHHHHHHHHHHHHHHCCCCCCCEEECCCCEECCCCEEEEEEEECCCCCCCC
LNPQLGYLHSSRARQKVRAWFNAVDQQENVAHGRALVEKTLQREGKTSVNLEHLAAKLGF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCC
KSPDELFSVVGKEEFSLRNVEQALSDAPAPEPEPEAPANFEKRASGANVAHGASAGVLVV
CCHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCEEEE
GVDALLTQLARCCRPAPPDPISGFVTRGKGMSIHRSDCATFRRMAERAPERVLQTTWSAD
EHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCC
VLGGRGASVYPVDLMIEATDRQGLLRDISEVFAREKMNVIGVKTQSRRNAAFMQFTVEVS
CCCCCCCEEEEEEEEEEECCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCEEEEEEEECC
SASQVQRACTLLGEIQGVVRAARKA
CHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7928955 [H]