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The map label for this gene is hisM [H]

Identifier: 126454676

GI number: 126454676

Start: 2749633

End: 2750346

Strand: Reverse

Name: hisM [H]

Synonym: BURPS1106A_2790

Alternate gene names: 126454676

Gene position: 2750346-2749633 (Counterclockwise)

Preceding gene: 126453531

Following gene: 126454373

Centisome position: 68.96

GC content: 66.53

Gene sequence:

>714_bases
ATGATCGAGATCCTGCAGGAGTTCGGGCGGGCGTTCCTCTACTGGGACGGCCAGCGCATGTCGGGGCTCGCCGTCACGCT
GTGGCTGCTCGTCGCGTCGCTCGGCGCCGGCTTCGTCTGCGCGGTGCCGCTCGCCGTCGCGCGGGTGTCGAAGAACCGCT
GGCTGTCGACGCCCGTGCGCTTCTATACGTACGTGTTCCGCGGCACGCCGCTCTACGTGCAGTTGCTGCTCCTCTATACG
GGGATGTACAGCCTCGCGTTCGTTCGCGAGCACGCGTGGCTCGATGCGTTCTTCCGCAGCGGCTTTCATTGCGCGATTCT
CGCGTTCGCGCTGAACACCTGCGCATACACGACCGAGATCTTCGCGGGCGCGATCCGCGCGATTGCGCACGGCGAGGTGG
AGGCCGCGCGCGCGTACGGAATGAGCCCGTTCACGATGTATCGCCGGGTGATCCTGCCGTCCTCGCTGCGCCGCGCGCTG
CCGCTCTACAGCAACGAGGTGATCCTGATGCTGCATGCGACGACGGTGGCGTTCACGGCGACCGTGCCCGACATCCTGAA
GGTCGCGCGCGACGCGAATTCGGCGACGTACATGGCGTTCCAGTCGTTCGGAATCGCCGCGCTGATCTATCTTGCGGTAT
CGTTCGCACTCGTCGCGGCCTTTCGTCGGGCCGAGCGCCACTGGCTCGCGTATCTCGCGGCCGGCCGTCATTGA

Upstream 100 bases:

>100_bases
TCGTCGCGGCGCTCATCTACCTGGCGATCACGACGGCCTCCAATCTCGTGCTCAGGCAACTCGAGAAACGTTATTCCATC
GGCGTGAGGCACGCGGAACT

Downstream 100 bases:

>100_bases
TTTCACTCCAGGGAGAGCCAGTTGGCAGAGACCACGACCACGAATGCCGCGTGCAAGCTCGAGGCACGGGACATCCATAA
GCGCTACGGCGACAACGAGG

Product: histidine ABC transporter, permease protein HisM

Products: ADP; phosphate; L-histidine [Cytoplasm]; ADP; L-ornithine [Cytoplasm]; L-arginine [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MIEILQEFGRAFLYWDGQRMSGLAVTLWLLVASLGAGFVCAVPLAVARVSKNRWLSTPVRFYTYVFRGTPLYVQLLLLYT
GMYSLAFVREHAWLDAFFRSGFHCAILAFALNTCAYTTEIFAGAIRAIAHGEVEAARAYGMSPFTMYRRVILPSSLRRAL
PLYSNEVILMLHATTVAFTATVPDILKVARDANSATYMAFQSFGIAALIYLAVSFALVAAFRRAERHWLAYLAAGRH

Sequences:

>Translated_237_residues
MIEILQEFGRAFLYWDGQRMSGLAVTLWLLVASLGAGFVCAVPLAVARVSKNRWLSTPVRFYTYVFRGTPLYVQLLLLYT
GMYSLAFVREHAWLDAFFRSGFHCAILAFALNTCAYTTEIFAGAIRAIAHGEVEAARAYGMSPFTMYRRVILPSSLRRAL
PLYSNEVILMLHATTVAFTATVPDILKVARDANSATYMAFQSFGIAALIYLAVSFALVAAFRRAERHWLAYLAAGRH
>Mature_237_residues
MIEILQEFGRAFLYWDGQRMSGLAVTLWLLVASLGAGFVCAVPLAVARVSKNRWLSTPVRFYTYVFRGTPLYVQLLLLYT
GMYSLAFVREHAWLDAFFRSGFHCAILAFALNTCAYTTEIFAGAIRAIAHGEVEAARAYGMSPFTMYRRVILPSSLRRAL
PLYSNEVILMLHATTVAFTATVPDILKVARDANSATYMAFQSFGIAALIYLAVSFALVAAFRRAERHWLAYLAAGRH

Specific function: Part of the binding-protein-dependent transport system for histidine; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG4160

COG function: function code E; ABC-type arginine/histidine transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788645, Length=232, Percent_Identity=61.2068965517241, Blast_Score=302, Evalue=1e-83,
Organism=Escherichia coli, GI1787086, Length=214, Percent_Identity=35.981308411215, Blast_Score=117, Evalue=8e-28,
Organism=Escherichia coli, GI1788226, Length=194, Percent_Identity=35.5670103092784, Blast_Score=100, Evalue=6e-23,
Organism=Escherichia coli, GI1787030, Length=209, Percent_Identity=29.1866028708134, Blast_Score=87, Evalue=8e-19,
Organism=Escherichia coli, GI1788646, Length=198, Percent_Identity=28.7878787878788, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1787087, Length=209, Percent_Identity=26.3157894736842, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1786873, Length=212, Percent_Identity=26.4150943396226, Blast_Score=67, Evalue=8e-13,
Organism=Escherichia coli, GI1786874, Length=210, Percent_Identity=25.7142857142857, Blast_Score=64, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010065
- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 26474; Mature: 26474

Theoretical pI: Translated: 9.88; Mature: 9.88

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEILQEFGRAFLYWDGQRMSGLAVTLWLLVASLGAGFVCAVPLAVARVSKNRWLSTPVR
CHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCHH
FYTYVFRGTPLYVQLLLLYTGMYSLAFVREHAWLDAFFRSGFHCAILAFALNTCAYTTEI
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
FAGAIRAIAHGEVEAARAYGMSPFTMYRRVILPSSLRRALPLYSNEVILMLHATTVAFTA
HHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHHHHHH
TVPDILKVARDANSATYMAFQSFGIAALIYLAVSFALVAAFRRAERHWLAYLAAGRH
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIEILQEFGRAFLYWDGQRMSGLAVTLWLLVASLGAGFVCAVPLAVARVSKNRWLSTPVR
CHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCHH
FYTYVFRGTPLYVQLLLLYTGMYSLAFVREHAWLDAFFRSGFHCAILAFALNTCAYTTEI
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
FAGAIRAIAHGEVEAARAYGMSPFTMYRRVILPSSLRRALPLYSNEVILMLHATTVAFTA
HHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHHHHHH
TVPDILKVARDANSATYMAFQSFGIAALIYLAVSFALVAAFRRAERHWLAYLAAGRH
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-histidine [Periplasm]; H2O; ATP; L-ornithine [Periplasm]; L-arginine [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: ATP + L-histidine [Periplasm] + H2O = ADP + phosphate + L-histidine [Cytoplasm] ATP + L-ornithine [Periplasm] + H2O = ADP + phosphate + L-ornithine [Cytoplasm] ATP + L-arginine [Periplasm] + H2O = ADP + phosphate + L-arginine [Cytoplasm] ATP + L-lysine [P

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]