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The map label for this gene is metR [H]

Identifier: 126454621

GI number: 126454621

Start: 2931914

End: 2932975

Strand: Direct

Name: metR [H]

Synonym: BURPS1106A_2986

Alternate gene names: 126454621

Gene position: 2931914-2932975 (Clockwise)

Preceding gene: 126454018

Following gene: 126453482

Centisome position: 73.51

GC content: 67.23

Gene sequence:

>1062_bases
GTGCGGTGGTCATCTCGATCCTCCAGAAGTGACCGGCAGTATCGGATTTGCCCTATCATTACTCAAACGAAAGTTTTTGC
CGAACAACATGAATTTTTTTCAACATCATTCGCCGCGACGCACACTGCGATGATTCGCTCCCCGCTCGAATTCCGGCATC
TGCAGACGCTCGTCGCGCTGCGCGATACCGGCAACCTGTCGCGCGCCGCGCAGGTGCTGTGCCTCACGCAATCGGCGCTG
TCGCATCAGTTGAAGGCGCTCGAAACGCATTTCGGGCTGCCGCTGTTCGTGCGCAAATCCGCCCCGCTCACGTTCACCGC
GGCCGGCAAGCGGCTGCTCGCGCTCGCCGAGCAGGTCGTGCCCGCGATCGAGGAAGCCGAGCGCGACATCGCGCGCCTCG
CGCTCGGCACGGGCGGCGCGTTGCGGATCGCGGTCGAGTGCCACACCTGCTTCGATTGGCTGATGCCCGCGATGGACGCG
TTCCGGCAGCGCTGGCCGGAAGTGGAGCTCGACATCGTGTCGGGCTTTCACGCGGATCCGATCGGCCTGCTGCACCAGGA
TCGCGCGGATCTCGCGATCGTCGCCGAGGCCGATGCCGACGAGGCCGTCGACTATCACCCGCTCTTTCGCTTCCAGATCG
TCGGGCTCGTCGGCAACGACCACGCGCTCGCGCACCAGCCGTCGCTCACGGCCGCCGATTTCGCCGACGAGACGCTGATC
ACGTACCCGGTGCCCGACGAGATGCTCGACATCGTCCGGCAAGTGCTCAAGCCTGCCGGCATCGAGCCGAAGCGGCGCAC
GTCGGAGCTGACGATCGCGATCCTGCAGCTCGTCGCGAGCCGGCGCGGCGTGGCGGCGCTGCCGCTGTGGGCGGTGGCCA
CCTACCTCGACAAGCGCTACGTGAGCGCGCGCCCCGTGCTGCGCGCCGACGGCTCGACGCTGTCGGGCGAGCTCTACGCG
GCGACGCTGCCGGCGTTCTCGACGCGCGCGTACGCGGCCGATTTCGTCGCGACGATGCGCGAGACGAGCGCGGCGTCGCT
GCCCGAGATCGAGCTGCTGTAA

Upstream 100 bases:

>100_bases
AGCGCGCGCTCGGCGTCGGCCGACGCGCCGTCGCGCCAGTAGCGCTCGAGAGCGAACTTCAGTTCCCGTTGCGCGCCGAT
GCGCGGAAAACCCAGGATGT

Downstream 100 bases:

>100_bases
GCGGCGCGCCGCACGCCGCTTGCCCCCCGTTTTCGCCGAAAAACCGTCGGCCGCCGGTCGCCGCGGGTAAAATCGAGCCT
ATTCCTATCCCAACATCCCA

Product: transcriptional activator MetR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 353; Mature: 353

Protein sequence:

>353_residues
MRWSSRSSRSDRQYRICPIITQTKVFAEQHEFFSTSFAATHTAMIRSPLEFRHLQTLVALRDTGNLSRAAQVLCLTQSAL
SHQLKALETHFGLPLFVRKSAPLTFTAAGKRLLALAEQVVPAIEEAERDIARLALGTGGALRIAVECHTCFDWLMPAMDA
FRQRWPEVELDIVSGFHADPIGLLHQDRADLAIVAEADADEAVDYHPLFRFQIVGLVGNDHALAHQPSLTAADFADETLI
TYPVPDEMLDIVRQVLKPAGIEPKRRTSELTIAILQLVASRRGVAALPLWAVATYLDKRYVSARPVLRADGSTLSGELYA
ATLPAFSTRAYAADFVATMRETSAASLPEIELL

Sequences:

>Translated_353_residues
MRWSSRSSRSDRQYRICPIITQTKVFAEQHEFFSTSFAATHTAMIRSPLEFRHLQTLVALRDTGNLSRAAQVLCLTQSAL
SHQLKALETHFGLPLFVRKSAPLTFTAAGKRLLALAEQVVPAIEEAERDIARLALGTGGALRIAVECHTCFDWLMPAMDA
FRQRWPEVELDIVSGFHADPIGLLHQDRADLAIVAEADADEAVDYHPLFRFQIVGLVGNDHALAHQPSLTAADFADETLI
TYPVPDEMLDIVRQVLKPAGIEPKRRTSELTIAILQLVASRRGVAALPLWAVATYLDKRYVSARPVLRADGSTLSGELYA
ATLPAFSTRAYAADFVATMRETSAASLPEIELL
>Mature_353_residues
MRWSSRSSRSDRQYRICPIITQTKVFAEQHEFFSTSFAATHTAMIRSPLEFRHLQTLVALRDTGNLSRAAQVLCLTQSAL
SHQLKALETHFGLPLFVRKSAPLTFTAAGKRLLALAEQVVPAIEEAERDIARLALGTGGALRIAVECHTCFDWLMPAMDA
FRQRWPEVELDIVSGFHADPIGLLHQDRADLAIVAEADADEAVDYHPLFRFQIVGLVGNDHALAHQPSLTAADFADETLI
TYPVPDEMLDIVRQVLKPAGIEPKRRTSELTIAILQLVASRRGVAALPLWAVATYLDKRYVSARPVLRADGSTLSGELYA
ATLPAFSTRAYAADFVATMRETSAASLPEIELL

Specific function: Control of the last step in methionine biosynthesis; metR is a positive activator of the metA, metE and metH genes [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790262, Length=303, Percent_Identity=38.9438943894389, Blast_Score=214, Evalue=9e-57,
Organism=Escherichia coli, GI1787879, Length=250, Percent_Identity=27.6, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1788296, Length=198, Percent_Identity=32.3232323232323, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1786401, Length=157, Percent_Identity=31.8471337579618, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI157672245, Length=247, Percent_Identity=26.7206477732794, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI87082132, Length=259, Percent_Identity=26.6409266409266, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1788887, Length=186, Percent_Identity=29.5698924731183, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1790208, Length=150, Percent_Identity=30, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI145693105, Length=241, Percent_Identity=23.6514522821577, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1789283, Length=109, Percent_Identity=41.2844036697248, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1787530, Length=181, Percent_Identity=27.6243093922652, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1789173, Length=108, Percent_Identity=31.4814814814815, Blast_Score=62, Evalue=6e-11,
Organism=Escherichia coli, GI1788297, Length=167, Percent_Identity=28.1437125748503, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 38943; Mature: 38943

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRWSSRSSRSDRQYRICPIITQTKVFAEQHEFFSTSFAATHTAMIRSPLEFRHLQTLVAL
CCCCCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
RDTGNLSRAAQVLCLTQSALSHQLKALETHFGLPLFVRKSAPLTFTAAGKRLLALAEQVV
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCEEEEHHHHHHHHHHHHHH
PAIEEAERDIARLALGTGGALRIAVECHTCFDWLMPAMDAFRQRWPEVELDIVSGFHADP
HHHHHHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCC
IGLLHQDRADLAIVAEADADEAVDYHPLFRFQIVGLVGNDHALAHQPSLTAADFADETLI
CCHHCCCCCCEEEEEECCCCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCHHHCCCCCEE
TYPVPDEMLDIVRQVLKPAGIEPKRRTSELTIAILQLVASRRGVAALPLWAVATYLDKRY
EECCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
VSARPVLRADGSTLSGELYAATLPAFSTRAYAADFVATMRETSAASLPEIELL
HCCCCEEECCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCEECC
>Mature Secondary Structure
MRWSSRSSRSDRQYRICPIITQTKVFAEQHEFFSTSFAATHTAMIRSPLEFRHLQTLVAL
CCCCCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
RDTGNLSRAAQVLCLTQSALSHQLKALETHFGLPLFVRKSAPLTFTAAGKRLLALAEQVV
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCEEEEHHHHHHHHHHHHHH
PAIEEAERDIARLALGTGGALRIAVECHTCFDWLMPAMDAFRQRWPEVELDIVSGFHADP
HHHHHHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCC
IGLLHQDRADLAIVAEADADEAVDYHPLFRFQIVGLVGNDHALAHQPSLTAADFADETLI
CCHHCCCCCCEEEEEECCCCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCHHHCCCCCEE
TYPVPDEMLDIVRQVLKPAGIEPKRRTSELTIAILQLVASRRGVAALPLWAVATYLDKRY
EECCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
VSARPVLRADGSTLSGELYAATLPAFSTRAYAADFVATMRETSAASLPEIELL
HCCCCEEECCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]