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The map label for this gene is emrA [H]

Identifier: 126454488

GI number: 126454488

Start: 1727607

End: 1728842

Strand: Reverse

Name: emrA [H]

Synonym: BURPS1106A_1767

Alternate gene names: 126454488

Gene position: 1728842-1727607 (Counterclockwise)

Preceding gene: 126452748

Following gene: 126451616

Centisome position: 43.35

GC content: 68.04

Gene sequence:

>1236_bases
ATGAGCGACCCTCAACAAAACGCAGCGCCCGCGCAGCCGCAGAACAACGGCAAGCGCAAGCGGATGATGACGCTGCTCGT
CGTGGTGATCGCGATCGCCGCGATCGCATACGGCCTTTATTACCTGCTCGTCGCGCGCTTTCACGAAACCACCGATGACG
CCTACGTGAACGGCAACGTCGTGCAGATCACCCCGCAGGTGACGGGCACCGTGATCGCGGTGAAGGCGGACGACACGCAG
ACCGTGAAGTCGGGCGACCCGCTCGTCGTGCTCGATCCGGCCGATTCGCAGGTCGCGCTGCAGCAGGCCGAGGCGAATCT
CGCGCAGACGGTGCGCCAGGTGCGCGGCCTCTATGTGAACGACGATCAGTACCGCGCGCAGGTCGCGCTGCGCCAGTCGG
ATCTGTCGAAGGCGCAGGACGATCTGCGCCGCCGGCTCGCCGTCGCGCAGACGGGCGCCGTCTCGCAGGAAGAAATCTCG
CACGCGCGCGACGCGGTGAAGGCCGCGCAGGCATCGCTCGACGCCGCCGGTCAGCAGCTCGCGTCGAACCGCGCGCTCAC
CGCGAACACGACCGTCGCCGACCACCCGAACGTGCTCGCCGCCGCCGCGAAGGTCCGCGACGCCTACCTGAACAATGCGC
GCAACACGCTGCCCGCGCCCGTCACGGGCTACGTCGCGAAGCGCTCGGTGCAGGTGGGCCAGCGCGTGTCGCCGGGCACG
CCGCTGATGTCGGTCGTGCCGCTGAACGCCGTGTGGGTCGACGCGAACTTCAAGGAAGTGCAGTTGAAGCACATGCGGAT
CGGCCAGCCGGTGGAACTGACGGCCGACATCTACGGCTCGTCGGTCAAATACCACGGCAAGGTCATCGGCTTCTCGGCGG
GCACGGGCGCGGCGTTCTCGCTGCTGCCGGCGCAGAACGCGACGGGCAACTGGATCAAGGTCGTCCAGCGCCTGCCGGTG
CGCGTCGAGCTCGATCCGAAGGAACTGAAGGAGCACCCGCTGCGCATCGGCCTGTCGATGCAGGTCGATGTCGACATCAA
GGACGAAAGCGGCAACCAGCTCGGCAACGTGCAGAACACCGTCTACGAAACCGACGTGTTCGCGAAGTACGGCGACGAGG
CGGACGCCGAGATCGCTCGCATCATCGCGCAGAACGCGGGCGGCGGCGCGGCGGGCGGCGCGAGCGCGCCCACGCCGGCG
GCGAAGGTCGTCGGCCGCGCATCGAACCTGATGTAA

Upstream 100 bases:

>100_bases
CCGGCCGCGCCCGCGCAGCACGCATCGAACTGAACCGAATCATTTCCGGCATGCCGGACCCTCGCTTCAATCGCTTAGAT
ACAAGACGGAGAAACTCGCC

Downstream 100 bases:

>100_bases
GCGTCGCGCGCTCGGCCCCAGCATGGCACAGCCACACGCTCCCCTTCCTCCGCTCGCGGGCGGACAACTGATACTCGGCA
CGATCGCGGTATCGCTCGCC

Product: multidrug resistance protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 411; Mature: 410

Protein sequence:

>411_residues
MSDPQQNAAPAQPQNNGKRKRMMTLLVVVIAIAAIAYGLYYLLVARFHETTDDAYVNGNVVQITPQVTGTVIAVKADDTQ
TVKSGDPLVVLDPADSQVALQQAEANLAQTVRQVRGLYVNDDQYRAQVALRQSDLSKAQDDLRRRLAVAQTGAVSQEEIS
HARDAVKAAQASLDAAGQQLASNRALTANTTVADHPNVLAAAAKVRDAYLNNARNTLPAPVTGYVAKRSVQVGQRVSPGT
PLMSVVPLNAVWVDANFKEVQLKHMRIGQPVELTADIYGSSVKYHGKVIGFSAGTGAAFSLLPAQNATGNWIKVVQRLPV
RVELDPKELKEHPLRIGLSMQVDVDIKDESGNQLGNVQNTVYETDVFAKYGDEADAEIARIIAQNAGGGAAGGASAPTPA
AKVVGRASNLM

Sequences:

>Translated_411_residues
MSDPQQNAAPAQPQNNGKRKRMMTLLVVVIAIAAIAYGLYYLLVARFHETTDDAYVNGNVVQITPQVTGTVIAVKADDTQ
TVKSGDPLVVLDPADSQVALQQAEANLAQTVRQVRGLYVNDDQYRAQVALRQSDLSKAQDDLRRRLAVAQTGAVSQEEIS
HARDAVKAAQASLDAAGQQLASNRALTANTTVADHPNVLAAAAKVRDAYLNNARNTLPAPVTGYVAKRSVQVGQRVSPGT
PLMSVVPLNAVWVDANFKEVQLKHMRIGQPVELTADIYGSSVKYHGKVIGFSAGTGAAFSLLPAQNATGNWIKVVQRLPV
RVELDPKELKEHPLRIGLSMQVDVDIKDESGNQLGNVQNTVYETDVFAKYGDEADAEIARIIAQNAGGGAAGGASAPTPA
AKVVGRASNLM
>Mature_410_residues
SDPQQNAAPAQPQNNGKRKRMMTLLVVVIAIAAIAYGLYYLLVARFHETTDDAYVNGNVVQITPQVTGTVIAVKADDTQT
VKSGDPLVVLDPADSQVALQQAEANLAQTVRQVRGLYVNDDQYRAQVALRQSDLSKAQDDLRRRLAVAQTGAVSQEEISH
ARDAVKAAQASLDAAGQQLASNRALTANTTVADHPNVLAAAAKVRDAYLNNARNTLPAPVTGYVAKRSVQVGQRVSPGTP
LMSVVPLNAVWVDANFKEVQLKHMRIGQPVELTADIYGSSVKYHGKVIGFSAGTGAAFSLLPAQNATGNWIKVVQRLPVR
VELDPKELKEHPLRIGLSMQVDVDIKDESGNQLGNVQNTVYETDVFAKYGDEADAEIARIIAQNAGGGAAGGASAPTPAA
KVVGRASNLM

Specific function: The emr locus confers resistance to substances of high hydrophobicity. EmrA probably participate in a transport system to extrude toxins and drugs from the cell [H]

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789041, Length=357, Percent_Identity=52.1008403361345, Blast_Score=365, Evalue=1e-102,
Organism=Escherichia coli, GI1788711, Length=377, Percent_Identity=45.0928381962865, Blast_Score=330, Evalue=1e-91,
Organism=Escherichia coli, GI1790519, Length=308, Percent_Identity=31.4935064935065, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI87081951, Length=309, Percent_Identity=28.1553398058252, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1789637, Length=317, Percent_Identity=27.7602523659306, Blast_Score=82, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 43728; Mature: 43597

Theoretical pI: Translated: 8.64; Mature: 8.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDPQQNAAPAQPQNNGKRKRMMTLLVVVIAIAAIAYGLYYLLVARFHETTDDAYVNGNV
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCE
VQITPQVTGTVIAVKADDTQTVKSGDPLVVLDPADSQVALQQAEANLAQTVRQVRGLYVN
EEEECCCCEEEEEEECCCCCEECCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCEEEC
DDQYRAQVALRQSDLSKAQDDLRRRLAVAQTGAVSQEEISHARDAVKAAQASLDAAGQQL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ASNRALTANTTVADHPNVLAAAAKVRDAYLNNARNTLPAPVTGYVAKRSVQVGQRVSPGT
HCCCCEEECCEECCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCC
PLMSVVPLNAVWVDANFKEVQLKHMRIGQPVELTADIYGSSVKYHGKVIGFSAGTGAAFS
CCEEEEECEEEEECCCHHHHHHHHHCCCCCCEEEHHHCCCCEEECCEEEEEECCCCCEEE
LLPAQNATGNWIKVVQRLPVRVELDPKELKEHPLRIGLSMQVDVDIKDESGNQLGNVQNT
EECCCCCCCHHHHHHHHCCCEEEECHHHHHCCCEEEEEEEEEEEEEECCCCCCCCCCHHH
VYETDVFAKYGDEADAEIARIIAQNAGGGAAGGASAPTPAAKVVGRASNLM
HHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
SDPQQNAAPAQPQNNGKRKRMMTLLVVVIAIAAIAYGLYYLLVARFHETTDDAYVNGNV
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCE
VQITPQVTGTVIAVKADDTQTVKSGDPLVVLDPADSQVALQQAEANLAQTVRQVRGLYVN
EEEECCCCEEEEEEECCCCCEECCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCEEEC
DDQYRAQVALRQSDLSKAQDDLRRRLAVAQTGAVSQEEISHARDAVKAAQASLDAAGQQL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ASNRALTANTTVADHPNVLAAAAKVRDAYLNNARNTLPAPVTGYVAKRSVQVGQRVSPGT
HCCCCEEECCEECCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCC
PLMSVVPLNAVWVDANFKEVQLKHMRIGQPVELTADIYGSSVKYHGKVIGFSAGTGAAFS
CCEEEEECEEEEECCCHHHHHHHHHCCCCCCEEEHHHCCCCEEECCEEEEEECCCCCEEE
LLPAQNATGNWIKVVQRLPVRVELDPKELKEHPLRIGLSMQVDVDIKDESGNQLGNVQNT
EECCCCCCCHHHHHHHHCCCEEEECHHHHHCCCEEEEEEEEEEEEEECCCCCCCCCCHHH
VYETDVFAKYGDEADAEIARIIAQNAGGGAAGGASAPTPAAKVVGRASNLM
HHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1409590; 9205837; 9278503; 8203018 [H]